Article
Clinical Neurology
Ta-Chuan Yeh, Mu-Hong Chen, Ya-Mei Bai, Shih-Jen Tsai, Ju-Wei Hsu, Kai-Lin Huang, Tung-Ping Su, Tzeng-Ji Chen, Chih-Sung Liang
Summary: This large-scale longitudinal study using the Taiwan National Health Insurance Research Database found that children and adolescents with ASD are more likely to be diagnosed with anxiety disorder in late childhood, and with schizophrenia, bipolar disorder, depressive disorder, and OCD in adolescence.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Oncology
Zhuo-Fan Xu, Jing Ruan, Long Chang, Sijin Wu, Jinkai Lin, Wei Wang, XinXin Cao, Lu Zhang, Jian Li, Daobin Zhou, Wei Zhang
Summary: This article reports three cases of TEMPI syndrome and their treatment response. The study found various clinical features and treatment responses of TEMPI syndrome, as well as some symptoms not previously associated with the condition.
FRONTIERS IN ONCOLOGY
(2022)
Article
Health Care Sciences & Services
Antonio Del Casale, Leda Marina Pomes, Luca Bonanni, Federica Fiasche, Clarissa Zocchi, Alessio Padovano, Ottavia De Luca, Gloria Angeletti, Roberto Brugnoli, Paolo Girardi, Robert Preissner, Marina Borro, Giovanna Gentile, Maurizio Pompili, Maurizio Simmaco
Summary: Pharmacogenomics-guided treatment may be effective in the cure of treatment-resistant depression. This study evaluated the clinical changes after PGT in patients with TRD and found that the PGT group showed significant improvements in efficacy index and clinical global impression compared to the control group.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Clinical Neurology
Christoph Stenzel, Nina Dalkner, Human -Friedrich Unterrainer, Armin Birner, Susanne A. Bengesser, Frederike T. Fellendorf, Andreas Fink, Eva Fleischmann, Melanie Lenger, Alexander Maget, Martina Platzer, Robert Queissner, Elena Schonthaler, Adelina Tmava-Berisha, Eva Z. Reininghaus
Summary: The prevalence of metabolic syndrome and overweight/obesity is increased in bipolar disorder (BD) compared to the general population and is related to suicidality. This study found that there is a difference in suicidal ideation based on body mass index (BMI) categories, but no association between suicide attempts and metabolic syndrome or serum lipid levels in individuals with BD.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Wen Liu, Xiaowei Jiang, Yide Xin, Zijing Deng, Yu Xie, Yifang Zhou, Yifan Wu, Qikun Sun, Lingtao Kong, Feng Wu, Yanqing Tang
Summary: This study identified differences in dynamic amplitude low-frequency fluctuations (dALFF) between patients with major depressive disorder (MDD) and those who converted to bipolar disorder (BD), and described the role of sex effects in differentiating the two disorders. A positive correlation was found between dALFF values and WCST scores in MDD patients, and this correlation was observed only in female MDD patients in the occipital gyrus.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Che-Sheng Chu, Shih-Jen Tsai, Ju-Wei Hsu, Kai-Lin Huang, Chih-Ming Cheng, Tung-Ping Su, Tzeng-Ji Chen, Ya-Mei Bai, Chih-Sung Liang, Mu-Hong Chen
Summary: The study found that the progression rate from ADHD to BD is 5.12% among adolescents and young adults. Risk factors for progression include older age, comorbidity with other mental disorders, and alcohol use. Protective factors identified were male sex and certain personality disorders.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
Hua-Meng Shi, De-Guo Jiang
Summary: This study found that mood-incongruent psychosis during the first manic episode of bipolar disorder appears to predict an increased likelihood of persistent psychotic symptoms over the subsequent 24 months. This persistence of psychosis is associated with a worse overall course of illness.
ASIAN JOURNAL OF PSYCHIATRY
(2022)
Review
Biology
Brett D. M. Jones, Salman Farooqui, Stefan Kloiber, Muhammad Omair Husain, Benoit H. Mulsant, Muhammad Ishrat Husain
Summary: Major depressive disorder (MDD) and bipolar disorder (BD) are often chronic and associated with metabolic dysfunction, leading to increased interest in novel treatments targeting metabolic pathways. However, current evidence on the effects of lipid lowering agents and anti-diabetics drugs on mood symptoms is conflicting, necessitating further studies.
Article
Nutrition & Dietetics
Karolina Bilska, Monika Dmitrzak-Weglarz, Przemyslaw Osip, Joanna Pawlak, Elzbieta Paszynska, Agnieszka Permoda-Pachuta
Summary: Metabolic syndrome is a growing health problem that coexists with nearly half of all patients with affective disorders. This study found that the adiponectin/leptin ratio is associated with metabolic syndrome in female patients with bipolar depression, and it has a negative correlation with certain biological parameters.
Article
Psychology, Clinical
Camilla Barthel Flaaten, Ingrid Melle, Erlend Gardsjord, Thomas Bjella, Magnus Johan Engen, Anja Vaskinn, Gina Asbo, Kristin Fjelnseth Wold, Line Widing, Siv Hege Lyngstad, Beathe Haatveit, Carmen Simonsen, Torill Ueland
Summary: IQ levels in schizophrenia and bipolar disorder patients show changes before and after illness onset, with steeper declines in schizophrenia patients and milder declines in bipolar patients. Over time, all groups showed increases in IQ. However, patients still lag behind healthy controls in terms of IQ levels.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Neurosciences
Nina Dalkner, Susanne A. Bengesser, Armin Birner, Frederike T. Fellendorf, Eva Fleischmann, Katja Grossschaedl, Melanie Lenger, Alexander Maget, Martina Platzer, Robert Queissner, Elena Schonthaler, Adelina Tmava-Berisha, Eva Z. Reininghaus
Summary: The study revealed a higher prevalence of metabolic syndrome in patients with bipolar disorder and impaired executive function in those with comorbid metabolic syndrome. However, no effects of metabolic syndrome were found in attention/processing speed and verbal learning/memory.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Psychiatry
Kyara Rodrigues de Aguiar, Bruno Braga Montezano, Jacson Gabriel Feiten, Devon Watts, Aline Zimerman, Thaise Campos Mondin, Ricardo Azevedo da Silva, Luciano Dias de Mattos Souza, Flavio Kapczinski, Taiane de Azevedo Cardoso, Karen Jansen, Ives Cavalcante Passos
Summary: Machine learning techniques were used to predict functional impairment in patients with mood disorders. The study found that variables such as sexual abuse, severity of depressive symptoms, anxiety symptoms, and somatic symptoms were important for predicting functional impairment. However, the model may not generalize to older individuals with mood disorders.
PSYCHIATRY RESEARCH
(2023)
Article
Clinical Neurology
Patricia Correa-Ghisays, Joan Vicent Sanchez-Orti, Vicent Balanza-Martinez, Gabriel Selva-Vera, Joan Vila-Frances, Rafael Magdalena-Benedito, Victor M. Victor, Irene Escribano-Lopez, Antonio Hernandez-Mijares, Juliana Vivas-Lalinde, Constanza San-Martin, Benedicto Crespo-Facorro, Rafael Tabares-Seisdedos
Summary: The study revealed overlapping neurocognitive impairments across somatic and psychiatric disorders, as well as social functioning impairment in almost all disorders. Transdiagnostic deficits remained stable over a 1-year follow-up and accurately differentiated individuals with somatic and psychiatric disorders.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Maya Kuperberg, Ole Kohler-Forsberg, Alec P. Shannon, Nevita George, Sophie Greenebaum, Charles L. Bowden, Joseph R. Calabrese, Michael Thase, Richard C. Shelton, Melvin McInnis, Thilo Deckersbach, Mauricio Tohen, James H. Kocsis, Terence A. Ketter, Edward S. Friedman, Dan Iosifescu, Michael J. Ostacher, Louisa G. Sylvia, Susan L. McElroy, Andrew A. Nierenberg
Summary: The study found that patients with bipolar disorder have an increased cardiometabolic risk associated with symptom severity, and treatment with quetiapine can worsen cardiometabolic markers. The results highlight the importance of monitoring cardiometabolic risks during treatment.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Jake Prillo, Jocelyn Fotso Soh, Haley Park, Serge Beaulieu, Outi Linnaranta, Soham Rej
Summary: Bipolar disorder patients have a high prevalence of obesity and metabolic syndrome, but this is not significantly associated with lithium use. Patients using lithium also have a lower prevalence of type II diabetes compared to those not on lithium. Further research with larger sample sizes is needed to explore the relationship between lithium and insulin resistance.