Article
Psychology, Developmental
Hunter J. Bennett, Taylor Jones, Kevin A. Valenzuela, Justin A. Haegele
Summary: The study found that autistic adolescents exhibit increased coordination variability during running compared to matched controls, which may negatively impact their engagement in this form of physical activity.
Article
Rheumatology
Burcu Yagiz, Nihal Lermi, Belkis N. Coskun, Ediz Dalkilic, Sedat Kiraz, Abdulsamet Erden, Ihsan Ertenli, Emine Duran, Emre Bilgin, Recep Yilmaz, Askin Ates, Abdurrahman Tufan, Hamit Kucuk, Ridvan Mercan, Haluk Cinakli, Servet Akar, Nazife S. Yasar Bilge, Timucin Kasifoglu, Suemeyye M. Turk, Emel Orge Gonullu, Cemal Bes, Nilufer Alpay Kanitez, Hakan Emmungil, Umut Kalyoncu, Yavuz Pehlivan
Summary: This study aims to assess the clinical characteristics, predictive factors, and practical algorithms of paradoxical reactions, specifically paradoxical psoriasis. The results show that switching to another TNFi medication is effective in treating patients with paradoxical psoriasis. Pustular and palmoplantar psoriasis are the most common types of paradoxical reactions.
Article
Dermatology
Pauline Bataille, Richard Layese, Pascal Claudepierre, Nicolas Paris, Julien Dubiel, Aurelien Amiot, Emilie Sbidian
Summary: This study aimed to estimate the incidence of paradoxical reactions during biologic therapy and identify risk factors. The likelihood of paradoxical reactions was found to be associated with inflammatory bowel disease and a combination of at least two inflammatory diseases. Adding conventional synthetic disease-modifying antirheumatic drugs or corticosteroid therapy may reduce the risk of paradoxical reactions for high-risk patients.
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Article
Biophysics
Hunter J. Bennett, Justin A. Haegele
Summary: Research on gait biomechanics in individuals with ASD has shown differences in walking and running patterns compared to neurotypical controls. Adolescents with ASD demonstrated reduced stride length and vertical displacement during running, as well as differences in hip and knee moments and knee angles. Despite these differences, youth with ASD can safely engage in running as a physical activity.
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME
(2021)
Review
Biochemistry & Molecular Biology
Fumi Miyagawa
Summary: Targeted biologic agents have had a significant impact on the treatment of immune-mediated inflammatory diseases. While they can greatly improve clinical symptoms, they also come with adverse reactions, including paradoxical reactions. Their efficacy in targeting specific cytokines and the presence of paradoxical reactions have helped researchers understand the underlying molecular pathways of these diseases.
Review
Medicine, General & Internal
Igor Kremenevski, Oliver Sander, Michael Sticherling, Martin Raithel
Summary: Paradoxical reactions induced by biological agents are a problem confronting physicians in multiple specialties. Distinguishing them from infectious and neoplastic diseases and from autoimmune conditions of other types is crucial. The treatment options for paradoxical reactions include local treatment, symptomatic therapy, prednisolone administration, and the discontinuation or switching of the biological agent.
DEUTSCHES ARZTEBLATT INTERNATIONAL
(2022)
Article
Psychiatry
Christine Champion, Teddy Novais, Jean-Michel Dorey, Pierre Krolak-Salmon, Alexis Lepetit
Summary: The prevalence of paradoxical reactions to benzodiazepines is estimated at about 1% in the general population. Although advanced age and cognitive disorders are known risk factors, there is a lack of literature focusing on the elderly and patients with neurocognitive disorders. It is crucial to be aware of these paradoxical effects and be able to recognize and address them quickly, especially due to the potential high risk of iatrogeny.
GERIATRIE ET PSYCHOLOGIE NEUROPSYCHIATRIE DE VIEILLISSEMENT
(2021)
Article
Engineering, Marine
Daejeong Kim, Soonseok Song, Tahsin Tezdogan
Summary: Predicting ship manoeuvring characteristics in waves is challenging. Traditional methods fail to accurately consider the effect of waves, while unsteady Reynolds-Averaged Navier-Stokes (RANS) computations can resolve the interactions with high accuracy.
Article
Immunology
Ben J. Marais, Elaine Cheong, Shelanah Fernando, Santhosh Daniel, Matthew R. Watts, Lucinda J. Berglund, Simone E. Barry, George Kotsiou, Alex P. Headley, Richard A. Stapledon
Summary: This study found that infliximab had dramatic responses in cases of tuberculous meningitis with severe paradoxical reactions, despite initial treatment with high-dose steroids. However, delayed initiation of infliximab as a last resort may have adversely affected patient outcomes.
OPEN FORUM INFECTIOUS DISEASES
(2021)
Article
Optics
Justinas Pupeikis, Benjamin Willenberg, Francois Bruno, Mike Hettich, Alexander Nussbaum-Lapping, Matthias Golling, Carolin P. Bauer, Sandro L. Camenzind, Abdelmjid Benayad, Patrice Camy, Bertrand Audoin, Christopher R. Phillips, Ursula Keller
Summary: The research team developed a free-running 80-MHz dual-comb polarization-multiplexed solid-state laser for picosecond ultrasonic measurements with satisfactory results. They revealed the ultrasonic signatures in semiconductor multi-quantum-well structures and compared them with other techniques. The study showed that this free-running dual-comb laser performs well in picosecond ultrasonic measurements and offers cost and complexity savings.
Article
Psychiatry
Milla Karvonen, Kirstin Goth, Sami J. Eloranta, Riittakerttu Kaltiala
Summary: Adolescents with features of gender dysphoria (GD) show no significant problems in identity development, and may even have a better integration of their identity compared to the general population.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Clinical Neurology
Noreen Rahmani, Jessica Hatch, Mikaela Dimick, Melanie R. Naiberg, Lisa Fiksenbaum, Ana C. Andreazza, Christopher R. Bowie, Daniel P. Dickstein, Benjamin Goldstein
Summary: Inflammatory markers have an impact on neurocognitive function in adolescents with BD, with more balanced pro-to anti-inflammatory ratios associated with better neurocognitive flexibility. Prospective studies are needed to assess the direction of these findings.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Ryuji Furihata, Rei Otsuki, Naomi Hasegawa, Takashi Tsuboi, Shusuke Numata, Norio Yasui-Furukori, Hiroko Kashiwagi, Hikaru Hori, Shinichiro Ochi, Hiroyuki Muraoka, Toshiaki Onitsuka, Hiroshi Komatsu, Masahiro Takeshima, Akitoyo Hishimoto, Tatsuya Nagasawa, Yoshikazu Takaesu, Toshinori Nakamura, Takeshi Asami, Kenichiro Miura, Junya Matsumoto, Kazutaka Ohi, Yuka Yasuda, Hitoshi Iida, Kazuyoshi Ogasawara, Naoki Hashimoto, Kayo Ichihashi, Hisashi Yamada, Koichiro Watanabe, Ken Inada, Ryota Hashimoto
Summary: Prescription of hypnotic agents is highly frequent among inpatients with psychiatric disorders, especially those with schizophrenia and major depressive disorder. The use of two or more antipsychotic agents is commonly associated with the use of hypnotic medication.
Article
Optics
Qiuquan Yan, Yiming Li, Jun Zhang, Xin Zheng, Dan Wu, Ke Yin, Tian Jiang
Summary: This study introduces an intelligent temporal alignment (ITA) algorithm for the signal processing of a free-running dual-comb spectrometer, achieving good alignment results in gas absorption lines.
OPTICS AND LASER TECHNOLOGY
(2021)
Article
Engineering, Aerospace
Vaclav Navratil, Josef Krska, Frantisek Vejrazka
Summary: This article proposes a time-difference-of-arrival (TDoA) positioning approach in ultrawideband networks, where user tags localize themselves using broadcasted synchronization messages. The method eliminates errors caused by tag clock drifts and provides position estimation using extended Kalman filtering. The system performance is comparable to the common TDoA method, with the additional advantage of using synchronization messages for positioning. TDoA solutions achieved high accuracy in horizontal positioning.
IEEE TRANSACTIONS ON AEROSPACE AND ELECTRONIC SYSTEMS
(2022)