Review
Pediatrics
Fushuang Yang, Jinpu Zhu, Zhongtian Wang, Lei Wang, Tianhui Tan, Liping Sun
Summary: This systematic review and meta-analysis found a significant association between maternal folic acid supplementation during pregnancy and the risk of childhood asthma. Folic acid supplementation during different stages of pregnancy (first trimester, third trimester, and entire pregnancy) was significantly correlated with asthma risk. Additionally, the dose-response analysis revealed a nonlinear relationship between maternal folic acid intake during pregnancy and the risk of childhood asthma.
FRONTIERS IN PEDIATRICS
(2022)
Article
Multidisciplinary Sciences
Mohammed Oumer, Anteneh Ayelign Kibret, Amanuel Girma, Ashenafi Tazebew, Mezgebu Silamsaw
Summary: This study focused on determining the birth prevalence of anencephaly in Africa, finding that it occurs at least in one per thousand births. Higher burden of anencephaly was detected in countries like Ethiopia, Algeria, and Eritrea. The research showed that studies conducted after 2010 and including both live births and stillbirths reported a higher prevalence of anencephaly.
SCIENTIFIC REPORTS
(2021)
Review
Nutrition & Dietetics
Catherine Friel, Alastair H. Leyland, Jana J. Anderson, Alexandra Havdahl, Tiril Borge, Michal Shimonovich, Ruth Dundas
Summary: This study reviewed the relationship between prenatal multivitamin supplements and offspring autism, finding a trend of reduced autism risk in high-quality observational studies but no overall robust association. However, the application of causal inference was limited, and the quality of evidence needs to be improved.
Review
Food Science & Technology
Hanxiao Chen, Lang Qin, Rui Gao, Xiaolei Jin, Kemin Cheng, Sirui Zhang, Xiao Hu, Wenming Xu, Hongjing Wang
Summary: In this study, a systematic review and meta-analysis were conducted to investigate the impact of maternal folic acid supplementation on postnatal neurodevelopmental outcomes. The findings suggest that prenatal folic acid supplementation has positive effects on offspring's neurodevelopment, including improved intellectual development and reduced risk of autism traits, ADHD, behavioral, and language problems. However, excessive folic acid supplementation may not improve offspring's brain development and may even have negative impacts on neurodevelopmental outcomes.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Nutrition & Dietetics
Omid Asbaghi, Damoon Ashtary-Larky, Reza Bagheri, Seyedeh Parisa Moosavian, Behzad Nazarian, Reza Afrisham, Mahnaz Rezaei Kelishadi, Alexei Wong, Frederic Dutheil, Katsuhiko Suzuki, Amirmansour Alavi Naeini
Summary: This study found that folic acid supplementation may improve inflammation by reducing serum concentrations of CRP, but had no significant effects on IL-6 and TNF-alpha. Dose-response analysis showed a significant relationship between higher doses of folic acid supplementation and lower CRP concentrations. Future RCTs with larger sample sizes and more diverse populations are needed to confirm and expand these findings.
Review
Food Science & Technology
Omid Asbaghi, Sara Salehpour, Mahnaz Rezaei Kelishadi, Reza Bagheri, Damoon Ashtary-Larky, Behzad Nazarian, Delsa Mombaini, Matin Ghanavati, Cain C. T. Clark, Alexei Wong, Amirmansour Alavi Naeini
Summary: This systematic review and meta-analysis summarizes the effects of folic acid supplementation on blood pressure. The results show that folic acid supplementation significantly decreases both systolic and diastolic blood pressure, making it beneficial for individuals with hypertension and cardiovascular disease.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Multidisciplinary Sciences
Tiwabwork Tekalign, Tesfanesh Lemma, Mulualem Silesh, Eyasu Alem Lake, Mistire Teshome, Tesfaye Yitna, Nefsu Awoke
Summary: This study aimed to estimate the pooled prevalence of utilization of preconception care and associated factors in Africa. The overall pooled prevalence of utilization of preconception care among pregnant women in Africa was found to be 18.72%. Factors such as knowledge of preconception care, preexisting medical conditions, and pregnancy intention were significantly associated with the utilization of preconception care.
Review
Nutrition & Dietetics
Omid Asbaghi, Damoon Ashtary-Larky, Reza Bagheri, Seyedeh Parisa Moosavian, Hadi Pourmirzaei Olyaei, Behzad Nazarian, Mahnaz Rezaei Kelishadi, Alexei Wong, Darren G. Candow, Frederic Dutheil, Katsuhiko Suzuki, Amirmansour Alavi Naeini
Summary: Folic acid supplementation significantly reduces some markers of glycemic control in adults, but the effects are relatively small, which may limit clinical applications for adults with type II diabetes. Further research is needed to confirm these findings.
Review
Biochemistry & Molecular Biology
Omid Asbaghi, Matin Ghanavati, Damoon Ashtary-Larky, Reza Bagheri, Mahnaz Rezaei Kelishadi, Behzad Nazarian, Michael Nordvall, Alexei Wong, Frederic Dutheil, Katsuhiko Suzuki, Amirmansour Alavi Naeini
Summary: Folic acid supplementation significantly increased serum concentrations of glutathione and total antioxidant capacity, while decreasing serum concentrations of malondialdehyde.
Review
Psychology, Clinical
Gang Ye, David S. Baldwin, Ruihua Hou
Summary: This study found a significantly higher prevalence of anxiety symptoms and comorbid anxiety disorders in asthma patients compared to non-asthma controls through a meta-analysis. This highlights the importance of appropriate assessments for these comorbid conditions.
PSYCHOLOGICAL MEDICINE
(2021)
Review
Clinical Neurology
Abdul Gofir, Samekto Wibowo, Muhammad Hakimi, David Dwi Putera, Irawan Satriotomo, Mustofa Mustofa
Summary: This study conducted a systematic review and meta-analysis on folic acid treatments for vascular cognitive impairment. The findings suggest that folic acid can effectively lower plasma homocysteine concentration, but it has limited impact on cognitive function.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2022)
Review
Respiratory System
Jingwen Zhang, Jennifer L. Perret, Anne B. Chang, Nur S. Idrose, Dinh S. Bui, Adrian J. Lowe, Michael J. Abramson, E. Haydn Walters, Caroline J. Lodge, Shyamali C. Dharmage
Summary: The study systematically synthesized evidence on etiological risk factors for chronic cough in adult patients, finding that asthma, persistent smoking, and lower education/socioeconomic status were associated with an increased risk. Further investigation is needed for longitudinal associations between other factors mentioned, with the recommendation of objective and standardized measurement methods.
Review
Medicine, General & Internal
Leicia Iris de Assuncao Prado, Ana Lucia Junger, Leonardo Ferreira Caixeta, Matias Noll, Cesar de Oliveira, Erika Aparecida Silveira
Summary: This study aims to assess the effectiveness of treating dementia and cognitive decline with methylfolate supplementation in older adults. The main outcomes analyzed will be dementia and changes in cognitive function. Secondary outcomes, such as inflammatory markers and folic acid levels, will also be assessed.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Berhe Gebremichael, Hirbo Shore Roba, Alemeshet Getachew, Dejene Tesfaye, Haftu Asmerom
Summary: This systematic review and meta-analysis estimated the pooled prevalence of folate deficiency (FD) among women of reproductive age in Ethiopia. The results showed that FD is a significant public health issue among women of reproductive age in Ethiopia. It is recommended to promote the consumption of folate-rich foods, strengthen folic acid supplementation and adherence, and swiftly implement mandatory folic acid fortification.
Review
Nutrition & Dietetics
Zhengpei Cheng, Rui Gu, Zenglin Lian, Harvest F. Gu
Summary: The study found that maternal FA supplementation is associated with a decreased risk of CHD. However, there is high heterogeneity in the association between FA supplementation and CHD, and high-dose FA intake may be positively associated with atrial septal defect.