Article
Plant Sciences
Aryadeep Roychoudhury, Ankur Singh, Tariq Aftab, Poulomi Ghosal, Nilanjana Banik
Summary: The study illustrates that priming seedlings with sodium nitroprusside can enhance the survival capacity of salt-stressed Vigna radiata, reduce damage caused by oxidative and ionic stress, increase the activity of antioxidant enzymes, promote the accumulation of protective metabolites, and improve overall physiological traits of the seedlings.
JOURNAL OF PLANT GROWTH REGULATION
(2021)
Article
Biochemistry & Molecular Biology
Michael Maes, Decio Sabbatini Barbosa, Abbas F. Almulla, Buranee Kanchanatawan
Summary: This study aimed to develop a precision medicine model for temporal lobe epilepsy (TLE) and associated mental comorbidities. The results showed that oxidative stress and antioxidant biomarkers could explain a large part of the variability in TLE and psychopathology features. Based on these findings, a new phenotype class was constructed, characterized by increased severity of TLE, psychopathology, and oxidative stress features, and decreased antioxidant defenses. Furthermore, increased levels of malondialdehyde, decreased antioxidants, and nitric oxide metabolites were associated with increased episode frequency.
Review
Biochemistry & Molecular Biology
Angela Maria Amorini, Ilaria Listorti, Gabriele Bilotta, Romina Pallisco, Miriam Wissam Saab, Renata Mangione, Benedetta Manca, Giacomo Lazzarino, Barbara Tavazzi, Giuseppe Lazzarino, Pasquale Bilotta
Summary: The overproduction of ROS in semen of infertile males can cause permanent oxidative damage to biological molecules, negatively impacting sperm functionality and vitality. While studies on antioxidant-based therapies for male infertility have been conducted, results have shown mixed outcomes, indicating the need for further research to determine the efficacy of antioxidant administration in treating male infertility.
Article
Cell Biology
Hussein Kadhem Al-Hakeim, Mazin Fadhil Altufaili, Abbas F. Almulla, Shatha Rouf Moustafa, Michael Maes
Summary: MA dependence and acute intoxication are associated with increased oxidative stress and lowered antioxidant defenses, increasing the risk of MIP during acute intoxication.
Review
Immunology
Gerwyn Morris, Maria Gevezova, Victoria Sarafian, Michael Maes
Summary: The immune-inflammatory response is associated with increased nitro-oxidative stress. Redox-associated mechanisms play a crucial role in modulating various aspects of the immune response. Chronic nitro-oxidative stress can have detrimental effects on immune cells and their functions.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Review
Cell Biology
Gallayaporn Nantachai, Asara Vasupanrajit, Chavit Tunvirachaisakul, Marco Solmi, Michael Meas
Summary: This study systematically reviewed and meta-analyzed the nitro-oxidative stress (O&NS)/antioxidant (ANTIOX) ratio in the peripheral blood of individuals with mild cognitive impairment (MCI). The results showed that MCI individuals have higher O&NS/ANTIOX ratio, increased lipid peroxidation and O&NS-associated toxicity, and reduced glutathione defenses compared to healthy controls. MCI is also associated with increased homocysteine and decreased non-vitamin and vitamin antioxidant defenses. The findings suggest that MCI is partly attributed to neuro-oxidative toxicity and highlight the potential of lipid peroxidation and the glutathione system as targets for MCI treatment or prevention.
AGEING RESEARCH REVIEWS
(2022)
Article
Plant Sciences
Xueping Zhang, Mingjun Ma, Chengcheng Wu, Shoucheng Huang, Subhan Danish
Summary: Heat stress threatens plants in arid and semiarid regions, causing soil salinization and plant mortality. Researchers have explored using gibberellic acid (GA3) and sodium nitroprusside (SNP) to alleviate these effects. This study investigated the combined effects of GA3 and SNP on wheat plants under heat stress conditions. The results showed that the SNP + GA3 treatment significantly improved plant growth and antioxidant defense mechanisms compared to individual applications or control.
Article
Biotechnology & Applied Microbiology
Yan Jun Ma, Xin Ping Li, Yue Wang, Jian Wen Wang
Summary: The results illustrate that the use of sodium nitroprusside (SNP) can significantly enhance the biosynthesis of fungal secondary metabolite hypocrellin and regulate oxidative reactions and membrane lipid expression by releasing nitric oxide, thereby increasing production yield.
MICROBIAL CELL FACTORIES
(2021)
Review
Immunology
Muhammad Ikrann, Hyun Young Park, Tahir Ali, Myeong Ok Kim
Summary: Melatonin has shown potential regulatory effects against TBI-induced neurodegeneration, but further research is needed to better understand and utilize its therapeutic benefits.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Reproductive Biology
Vishwa Ranjan Upadhyay, Vikram Ramesh, Raju Kr Dewry, Dileep Kr Yadav, Perumal Ponraj
Summary: Reactive oxygen species (ROS) and reactive nitrogen species (RNS) have dual roles in sperm physiology, acting as molecular messengers at lower concentrations and inducing stress at higher concentrations. Deficiency in antioxidant defense and pathological conditions can lead to excessive generation of these species, disrupting normal sperm functions. The production of oxidants is mainly associated with pathological conditions and cryopreservation-induced injury. Nitric oxide (NO) has emerged as a potential regulator of sperm physiology, and optimal concentrations of NO compounds can maintain the homeostasis of the seminal plasma microenvironment. Optimized addition of NO donors and inhibitors in extenders can mitigate free radical-induced damage without inhibiting the essential physiological effects on fertilization and embryo development.
Article
Biochemistry & Molecular Biology
Barbara Choromanska, Piotr Mysliwiec, Jacek Dadan, Almantas Maleckas, Anna Zalewska, Mateusz Maciejczyk
Summary: This study found that redox homeostasis in obese patients is affected by age and gender, with oxidative and nitrosative stress being more intense in men than in women and increasing with age.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Multidisciplinary Sciences
Nidhi Verma, Sheo Mohan Prasad
Summary: The synergistic signaling between H2O2 and NO was found to enhance cyanobacterial tolerance to Cd stress, promoting growth and antioxidant defense system, ultimately improving soil fertility and productivity even under metal contamination.
SCIENTIFIC REPORTS
(2021)
Review
Chemistry, Medicinal
Kenan Ercan, Omer Faruk Gecesefa, Muhammed Enes Taysi, Omeed Akbar Ali Ali, Seyithan Taysi
Summary: Oxidative/nitrosative stress is caused by excessive production of ROS and RNS, altering the balance of oxidants and antioxidants in the body and affecting the functions of biological macromolecules. Consuming suitable fruits, herbs, spices, and vegetables with bioactive antioxidant compounds can strengthen the body's antioxidant defense system and help in preventing and treating diseases.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2021)
Article
Clinical Neurology
Kamila Landucci Bonifacio, Decio Sabbatini Barbosa, Estefania Gastaldello Moreira, Carine Farias Coneglian, Heber Odebrecht Vargas, Sandra Odebrecht Vargas Nunes, Juliana Brum Moraes, Michael Maes
Summary: The study found significant associations between nitro-oxidative stress toxicity, inflammatory pathways, atherogenicity, and mood disorders, especially in patients with mood disorders. Activated oxidative stress pathways play an important predictive role in increased blood pressure, especially through increased lipid peroxidation and protein oxidation.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Health Care Sciences & Services
Hussein Kadhem Al-Hakeim, Hadi Hasan Hadi, Ghoufran Akeel Jawad, Michael Maes
Summary: The present study investigated the biomarkers of affective symptoms in patients with type 2 diabetes, finding associations between copper, beta-arrestin-1, and calcium levels and these symptoms, while atherogenicity and insulin resistance played mediating roles.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Biotechnology & Applied Microbiology
Ali Raza, Javaria Tabassum, Ali Zeeshan Fakhar, Rahat Sharif, Hua Chen, Chong Zhang, Luo Ju, Vasileios Fotopoulos, Kadambot H. M. Siddique, Rakesh K. Singh, Weijian Zhuang, Rajeev K. Varshney
Summary: Climate change leads to various environmental stresses, including soil salinity, which negatively affects agricultural productivity. Plants respond to salinity stress by regulating ion homeostasis, inducing antioxidant defense systems, and producing phytohormones and osmoprotectants. Enhancing salt tolerance in plants is crucial for sustaining global agricultural productivity.
CRITICAL REVIEWS IN BIOTECHNOLOGY
(2023)
Article
Medical Laboratory Technology
Annie H. Ren, Panagiota S. Filippou, Antoninus Soosaipillai, Lampros Dimitrakopoulos, Dimitrios Korbakis, Felix Leung, Vathany Kulasingam, Marcus Q. Bernardini, Eleftherios P. Diamandis
Summary: This study explored the potential of using MUC13 as an ovarian cancer biomarker to complement CA125. The results showed that MUC13 could be used to detect non-serous ovarian carcinoma and early-stage disease, in addition to CA125.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Murad Awad, Georgios Giannopoulos, Photini V. Mylona, Alexios N. Polidoros
Summary: The relationships between epiphytic microbiomes of different Vitis vinifera cultivars in the same vineyard and terroir were investigated using metagenomic analysis. The results showed that grapevine genotype and phenological stage significantly influenced microbial diversity and structure. Microbiome analysis could be an important molecular fingerprint for cultivars and provide a management tool for traceability of wine and grape end products.
APPLIED SCIENCES-BASEL
(2023)
Article
Agronomy
Athanasios Mavromatis, Irini Nianiou-Obeidat, Alexios Polidoros, Zoi Parissi, Eleni Tani, Maria Irakli, Konstantinos A. Aliferis, Ioannis Zafeiriou, Photini V. Mylona, Efi Sarri, Evgenia-Anna Papadopoulou, Rafail Tagiakas, Leonidas Kougiteas, Stavroula Kostoula, Eleni M. Abraham
Summary: This research studied commercial cultivars and advanced breeding lines of Lupinus albus using phenotypical, molecular, and biochemical data for breeding projects. There are differences in yield and nutritional value between commercial cultivars and advanced breeding lines, which can be utilized in breeding programs.
Article
Agronomy
Ioannis Zafeiriou, Michalia Sakellariou, Photini V. Mylona
Summary: This study assessed the genetic diversity of 87 cowpea landraces from Greece. It revealed significant diversity in the local germplasm and detected high levels of genetic polymorphism. The study also identified alleles conferring aphid resistance in some landraces. This highlights the importance of cowpea germplasm collection for breeding efforts and food security in the face of climate change.
Article
Biotechnology & Applied Microbiology
Maria Kyriakou, Marianna Christodoulou, Andreas Ioannou, Vasileios Fotopoulos, Michalis Koutinas
Summary: This study determined the protective role of biochar immobilisation carrier against multiple stresses encountered by Saccharomyces cerevisiae. Immobilised cells showed higher bioethanol titre and productivity at elevated temperatures compared to suspended culture. Transcription analysis revealed different responses in gene expression between suspended and immobilised cells under inhibitory conditions. The study confirmed that S. cerevisiae immobilisation on biochar conferred cells with heat tolerance, ethanol tolerance, osmotolerance and improved fermentation capacity.
BIOCHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Physical
Dora Rasadean, Agathe Quesnel, Panagiota S. Filippou, G. Dan Pantos, Priyanka Dey
Summary: This study reports the strategic modification of quinoline and quinoline derivative nicotinamide, as well as their potential in diagnosis. The synthesized molecules showed strong fluorescence and chiroptical activities when functionalized onto gold nanostructures, with similar surface-enhanced Raman scattering (SERS) to a commercial quinoline thiol Raman probe. Unlike the commercially available quinoline thiol, the synthesized derivatives exhibited higher cell viability in both healthy and cancerous cells, and selectively killed cancer cells without negatively impacting healthy cells. This work highlights the potential of custom-designed molecules with multimodal functionality for wider applicability in cancer theranostics.
CHEMISTRY OF MATERIALS
(2023)
Article
Plant Sciences
Sima Panahirad, Mohammadreza Dadpour, Gholamreza Gohari, Ali Akbari, Gholamreza Mahdavinia, Hessam Jafari, Muhittin Kulak, Ruben Alcazar, Vasileios Fotopoulos
Summary: Due to their sessile nature, plants are unable to escape from stress factors in their environment, such as high levels of soil cadmium (Cd), which can cause heavy metal stress and impair agronomic performance. In order to mitigate the adverse effects of Cd stress, researchers have explored the use of novel nanoparticles, such as polyamines and carbon quantum dots. In this study, the researchers successfully synthesized a nanomaterial called Put-CQD NPs and found that it could enhance the performance of grapevines under Cd stress conditions.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Plant Sciences
Gholamreza Gohari, Sima Panahirad, Asghar Mohammadi, Muhittin Kulak, Mohamad Reza Dadpour, Zohreh Mehri Lighvan, Sina Sharifi, Bagher Eftekhari-Sis, Slawomir Szafert, Vasileios Fotopoulos, Ali Akbari
Summary: Salt stress is highly damaging to plants, but the use of nano-engineered particles shows promise in mitigating its effects. In this study, foliar application of Octa-aminopropyl polyhedral oligomeric silsesquioxanes nanoparticles (OA-POSS NPs) improved the growth of sweet basil plants under salt stress by increasing photosynthetic pigment content and triggering antioxidant components.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Plant Sciences
Stella Pegiou, Panagiotis Raptis, Ioannis Zafeiriou, Alexios N. Polidoros, Photini V. Mylona
Summary: Capparis spinosa, a widely distributed orphan shrub in the Mediterranean basin and Asia, has medicinal and culinary value. Due to limited cultivation efforts, caper parts are mainly collected from wild germplasm, leading to bottleneck events. Genetic diversity assessment of the species is crucial for conservation schemes. The study used DNA barcoding and molecular characterization to assess the genetic diversity of 8 C. spinosa populations in Greece. The results highlight the need for comprehensive caper germplasm characterization and conservation strategies.
JOURNAL OF APPLIED RESEARCH ON MEDICINAL AND AROMATIC PLANTS
(2023)
Article
Microbiology
Dalila Pasquini, Elisa Zampieri, Andreas Ioannou, Alexandros Spanos, Fabiano Sillo, Luca Giovannini, Vasileios Fotopoulos, Cecilia Brunetti, Erica Lumini, Raffaella Balestrini
Summary: Beneficial microorganisms such as mycorrhizal fungi have a positive impact on plant health and growth, improving nutrient acquisition and tolerance to stress. This study investigated the effects of different commercial AM fungal inocula on the morphology and production of polyphenols and biochemical compounds in rosemary and lavender.
Article
Chemistry, Multidisciplinary
Ekaterini Koura, Adamantia Pistikoudi, Margaritis Tsifintaris, George Tsiolas, Evangelia Mouchtaropoulou, Christos Noutsos, Triantafyllos Karantakis, Athanasios Kouras, Athanasios Karanikolas, Anagnostis Argiriou, Irini Nianiou-Obeidat, Photini V. Mylona, Alexios N. Polidoros
Summary: This study explored the impact of seed maturity stages and phosphorus fertilization levels on gene expression in lentils and found that the seed maturity stage significantly influenced phenylpropanoid genes, while phosphorus fertilizer had a targeted effect on specific genes and gene clusters. These findings provide valuable information for enhancing lentil product quality through breeding programs.
APPLIED SCIENCES-BASEL
(2023)
