Editorial Material
Medicine, General & Internal
Jiwon Lee, Seoyeon Shin, Jin-Hwi Kim, Su Lim Lee, Yosep Chong, Kyung Jin Seo, Kwangil Yim
Summary: In this case study, a 49-year-old female patient with menorrhagia was initially suspected to have cervical squamous cell carcinoma based on magnetic resonance imaging (MRI) findings. However, histological examination confirmed the lesion to be angioleiomyoma after hysterectomy. This is the first reported case of angioleiomyoma presenting with MRI findings suggestive of uterine SCC. Recognizing the imaging mimics of angioleiomyomas can be beneficial for accurate diagnosis and appropriate treatment strategies.
Article
Oncology
Jin Li, Xiaohong Xue, Yan Zhang, Fengna Ding, Wenyan Wu, Cuicui Liu, Yang Xu, Hanlin Chen, Qiuxiang Ou, Yang Shao, Xinjun Li, Fei Wu, Xiaohua Wu
Summary: This multi-center study in Chinese cervical cancer patients highlights the immunologic and genomic differences between squamous cell carcinoma (SCC) and adenocarcinoma (AC). The study suggests that SCC may have better immunotherapy efficacy, while AC may be more favorable for targeted therapy. These findings are significant for guiding treatment strategies for different types of cervical cancer.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Pathology
Qingge Jia, Junyang Song, Tianqi Xu, Jin Liu, Jia Chai, Yanru Yang, Lingfei Li, Mingyang Li, Xinyuan Yang
Summary: ZIC5 expression is associated with clinical manifestations in cervical squamous cell carcinoma (CESC), and overexpression of ZIC5 promotes the proliferation and migration of CESC cells. ZIC5 may serve as a potential biomarker and therapeutic target for CESC patients.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Oncology
Boli Yang, Qiuyu Chen, Changshan Wan, Siyuan Sun, Lanping Zhu, Zhizhong Zhao, Weilong Zhong, Bangmang Wang
Summary: Transgelin is found to be expressed at low levels in ESCC, and its expression is positively correlated with the prognosis of ESCC patients. It inhibits the malignant progression of ESCC by suppressing the occurrence of EMT, as its overexpression significantly reduces cell invasion and proliferation abilities, while its knockdown promotes cell proliferation, migration, and invasion.
FRONTIERS IN ONCOLOGY
(2021)
Article
Pathology
Yanru Yang, Saijie Zuo, Wenqing Li, Man Di, Jin Liu, Jia Chai, Jingjing Wang, Yuan Yuan, Mingyang Li, Qingge Jia
Summary: TRIM21 is highly expressed in cervical squamous cell carcinoma (CESC) tissues compared with paracancerous tissues. The overexpression of TRIM21 promotes cell proliferation, migration, invasion, and stemness, while knockdown of TRIM21 inhibits tumor cell activities in CESC. Furthermore, TRIM21 expression levels are associated with individual prognostic factors and may serve as a poor predictor of prognosis for CESC.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Shuai Liu, Zheng Feng, Jiajia Zhang, Huijuan Ge, Xiaohua Wu, Shaoli Song
Summary: The study developed a predictive nomogram for preoperatively identifying pelvic lymph node metastasis in early-stage squamous cell cervical cancer, which showed improved sensitivity, specificity, and positive predictive value compared to traditional methods.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2021)
Article
Medicine, General & Internal
Rina Doukuni, Takuro Kobori, Chihiro Tanaka, Mayuka Tameishi, Yoko Urashima, Takuya Ito, Tokio Obata
Summary: Moesin may be a scaffold protein responsible for the plasma membrane expression of PD-L1 in human uterine cervical SCC.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Shaoqiu Zheng, Jing Luo, Shoucheng Xie, Shanming Lu, Qinghua Liu, Huanqin Xiao, Wenjuan Luo, Yanfang Huang, Kun Liu
Summary: Recent evidence suggests that cancer stem cells (CSCs) are the origin of cancers. This study investigated the relationship between tumor buds, which are hypothesized to represent epithelial-mesenchymal transition (EMT)-like CSCs, and EMT and CSC markers in cervical squamous cell carcinoma (CxSCC). The findings indicate that tumor buds in CxSCC may represent EMT-like CSCs in vivo.
Article
Oncology
Yuhei Miyasaka, Yuya Yoshimoto, Ken Ando, Kazutoshi Murata, Daisuke Irie, Hiro Sato, Shin-ei Noda, Hayato Ikota, Takashi Nakano, Hideaki Yokoo, Tatsuya Ohno
Summary: This study retrospectively investigated the prognostic factors in patients with squamous cell carcinoma of the uterine cervix undergoing definitive radiotherapy. The presence of CD8+ tumor-infiltrating lymphocytes (TILs) was found to be a favorable prognostic factor.
ANTICANCER RESEARCH
(2023)
Article
Infectious Diseases
Maria Jose Brito, Pedro Sequeira, Iryna Silva, Ana Quintas, Catarina Martins, Ana Felix
Summary: This study analyzed cervical lymphocytic populations in HIV+ and HIV- patients, finding an imbalance between CD4(+) and CD8(+) T lymphocytes in HIV+ patients with SIL and SCC. The results showed increased CD8+ infiltrate density with lesion severity, even in patients with immune system recovery under antiretroviral therapy.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Oncology
Yuta Inoue, Takeshi Fukuda, Shigenori Nanno, Yuichiro Awazu, Masahiro Shimomura, Hiroaki Matsubara, Makoto Yamauchi, Tomoyo Yasui, Toshiyuki Sumi
Summary: The study demonstrated a significant association between TBX2 expression levels and the efficacy of NAC in patients with locally advanced uterine cervical squamous cell carcinoma. Patients with lower TBX2 expression showed higher sensitivity to NAC and better prognosis.
Article
Oncology
Jeroen Meulemans, Jens Voortmans, Sandra Nuyts, Jean-Francois Daisne, Paul Clement, Annouschka Laenen, Pierre Delaere, Charlotte Van Lierde, Vincent Vander Poorten
Summary: This study evaluated the oncological outcomes of patients with cervical squamous cell carcinoma of unknown primary and identified potential prognostic factors. The results showed that negative p16 status and extranodal extension were associated with worse survival and recurrence rates. Radiological extranodal extension was identified as an independent negative predictor for all oncological outcomes.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Qiuyu Chen, Lingyun Zhang, Changshan Wan, Boli Yang, Xiangxu Kong, Xin Xu, Yu Gu, Chen Wang, Xiaotong Liu, Qian Ding, Lanping Zhu, Ying Li, Bangmao Wang, Weilong Zhong
Summary: The aim of this study was to investigate the role of transgelin (TAGLN) in the ferroptosis of esophageal squamous cell carcinoma (ESCC). TAGLN expression was negatively associated with ESCC prognosis. TAGLN overexpression inhibited the migration, invasion, viability, and proliferation of ESCC cells. TAGLN also promoted ferroptosis in ESCC by interacting with p53. These findings suggest that TAGLN may inhibit the malignant development of ESCC through the induction of ferroptosis.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Zhenming Wang, Junhong Dong, Wenxiu Tian, Sen Qiao, Hongmei Wang
Summary: TRPV1 is significantly reduced in cervical squamous cell carcinoma and inversely associated with cancer risk, potentially serving as a marker and drug candidate for cervical cancer.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Oncology
Shigemasa Takamizawa, Shu Yazaki, Yuki Kojima, Hiroshi Yoshida, Rui Kitadai, Tadaaki Nishikawa, Tatsunori Shimoi, Kazuki Sudo, Hitomi Sumiyoshi Okuma, Maki Tanioka, Emi Noguchi, Masaya Uno, Mitsuya Ishikawa, Tomoyasu Kato, Yasuhiro Fujiwara, Kan Yonemori
Summary: This study found that mesothelin is highly expressed in cervical cancer, especially in non-squamous cell carcinoma. High expression of mesothelin in the primary lesion is significantly associated with poor overall survival, and its expression is maintained in metastatic lesions. Therefore, mesothelin may be an attractive therapeutic target for cervical cancer.
