Article
Endocrinology & Metabolism
Martha Hanschkow, Nathalie Boulet, Elena Kempf, Anne Bouloumie, Wieland Kiess, Robert Stein, Antje Korner, Kathrin Landgraf
Summary: MSCA1 and CD36 are associated with obesity-related alterations in children's adipose tissue, with CD36 expression predicting the adipogenic potential of SVF cells.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Immunology
Md Shamim Rahman, Heejin Jun
Summary: This review explains the impact of fat types and tissue microenvironment on energy expenditure, focusing on the role and regulation of macrophages in adaptive thermogenic fat.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Spectroscopy
Erica Gianazza, Maura Brioschi, Sonia Eligini, Cristina Banfi
Summary: Adipose tissue is not only the primary site of lipid storage but also an endocrine organ that plays a crucial role in cardiovascular health. Mass spectrometry-based studies have allowed us to characterize the size and components of the human secretome, providing insights into the molecular mechanisms controlling the crosstalk between adipose tissue and the cardiovascular system.
MASS SPECTROMETRY REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Kathrin Landgraf, Andreas Kuhnapfel, Maria Schlanstein, Ronald Biemann, Berend Isermann, Elena Kempf, Holger Kirsten, Markus Scholz, Antje Korner
Summary: This study found that childhood obesity is associated with dysfunction and early signs of metabolic disease in adipose tissue. By analyzing gene expression profiles in adipose tissue samples from obese children, the researchers identified genes that are associated with obesity and related parameters. They also discovered that EGFL6 gene may play a role in the pathogenesis of metabolic disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
Sufen Wang, Yifan Liu, Jiaqi Chen, Yuejing He, Wanrui Ma, Xinguang Liu, Xuerong Sun
Summary: Adipocytes have important roles in regulating nutrition, energy balance, metabolism, hormone secretion, and immune regulation. Different types of adipocytes contribute differently to the body, with white adipocytes storing energy, brown adipocytes generating heat, and beige adipocytes having the potential to produce heat.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Christy M. Gliniak, Line Pedersen, Philipp E. Scherer
Summary: The prevalence of obesity is increasing exponentially worldwide. The lack of effective long-term weight loss treatment options has made the problem even more significant. Research has shown that adipose tissue has a biological memory, which is a crucial determinant of long-term weight maintenance. Maladaptive cellular responses in adipose tissue lead to inflammation and fibrosis, explaining the link between obesity and insulin resistance, type 2 diabetes, cardiovascular disease, and fatty liver disease.
JOURNAL OF ENDOCRINOLOGY
(2023)
Review
Cell Biology
Ursula White
Summary: White adipose tissue (WAT) expansion plays a crucial role in metabolic health, and impaired WAT expansion can lead to metabolic disorders. While increased hyperplasia is considered important for healthy WAT expansion, the role of adipogenesis remains debated. This mini-review will summarize recent developments and highlight the significance of WAT expansion in obesity and disease.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Medicine, General & Internal
Oscar Osorio-Conles, Josep Vidal, Ana de Hollanda
Summary: Bariatric surgery is the most effective intervention for significant and sustained weight loss in severe obesity, as it can improve white adipose tissue function beyond reducing fat depot sizes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Rheumatology
Neza Brezovec, Blaz Burja, Katja Lakota
Summary: This review highlights the recent research progress on the role of adipose tissue in systemic sclerosis, including the involvement of adipocytes in AMT, effects on stromal cell differentiation, and the impact of adipose tissue secretome on pathology. Novel findings have identified new populations of fibroblasts and confirmed the contribution of lipolysis to fibrogenesis through AMT and the imbalance of fatty acid metabolism in SSc. Studies have also shown the importance of adipose tissue secretome molecules in the pro-/antifibrotic balance.
CURRENT OPINION IN RHEUMATOLOGY
(2021)
Review
Cell Biology
Qian Li, Kirsty L. Spalding
Summary: Adipocytes undergo extensive cytoskeletal remodeling to accommodate their dramatic morphological changes. Cell growth-related signaling pathways are activated to meet the increasing cellular needs. Continued expansion of adipocytes can lead to metabolic dysfunction.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Endocrinology & Metabolism
Hong-Jin Chen, Ting Meng, Ping-Jin Gao, Cheng-Chao Ruan
Summary: BAT, primarily composed of brown adipocytes and stromal vascular fraction, plays a crucial role in regulating cardiovascular health and diseases. It enhances energy expenditure by promoting glucose and lipid metabolism and secreting adipokines in an autocrine and/or paracrine fashion to protect the cardiovascular system.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Sara Leo, Elena Tremoli, Letizia Ferroni, Barbara Zavan
Summary: Obesity and insulin resistance are risk factors for cardiovascular diseases, associated with inflamed and defective adipose tissue. Extracellular vesicles, involved in insulin resistance, diabetes, and CVDs, play a role in the onset and development of these pathologies. Inflammation triggers the transition of adipose tissue secretome, leading to an increase in pro-inflammatory mediators.
Review
Physiology
Hongbing Song, Xiaohan Zhang, Jing Wang, Yanling Wu, Taimin Xiong, Jieqiong Shen, Ruiyi Lin, Tianfang Xiao, Weimin Lin
Summary: Adipose tissue is crucial for maintaining energy balance and dysfunctional adipose tissue is linked to obesity-related metabolic diseases. Mitochondria in adipocytes play a key role in energy metabolism and interact with other organelles to regulate metabolic processes and reduce the occurrence of obesity-related diseases.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sarah Abdul Majeed, Helene Dunzendorfer, Juliane Weiner, John T. T. Heiker, Wieland Kiess, Antje Korner, Kathrin Landgraf
Summary: Obesity in children is associated with adipose tissue dysfunction and metabolic disease, increasing the risk of premature death. The brown adipose tissue (BAT), known for its energy-dissipating function, has been suggested to protect against obesity and metabolic dysfunction. Through genome-wide expression profiling, we identified several genes, including COBL, MKX, and MYOC, which have not been previously characterized in BAT biology and examined their functional role in BAT development. Our findings also reveal an association between the expression of these genes and early metabolic dysfunction in children.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Endocrinology & Metabolism
Ivonne Palacios-Marin, Dolors Serra, Josep. C. C. Jimenez-Chillaron, Laura Herrero, Marijana Todorcevic
Summary: Obesity is a major risk factor for type 2 diabetes and cardiovascular diseases. Childhood obesity is a concerning health challenge as it often persists into adulthood and increases the risk of morbidity and mortality. The mechanisms through which adipose tissue expands and its implications on metabolic health are still unclear, and more research is urgently needed to understand the development of adipose tissue in healthy and obese children.
Article
Oncology
Laia Simo-Riudalbas, Montserrat Perez-Salvia, Fernando Setien, Alberto Villanueva, Catia Moutinho, Anna Martinez-Cardus, Sebastian Moran, Maria Berdasco, Antonio Gomez, Enrique Vidal, Marta Soler, Holger Heyn, Alejandro Vaquero, Carolina de la Torre, Silvia Barcelo-Batllori, August Vidal, Luca Roz, Ugo Pastorino, Katalin Szakszon, Guntram Borck, Conceicao S. Moura, Fatima Carneiro, Ilse Zondervan, Suvi Savola, Reika Iwakawa, Takashi Kohno, Jun Yokota, Manel Esteller
Article
Cell Biology
Eugenia Mato, Silvia Barcelo-Batllori, Irene Orera, Laia Selva, Martina Corra, Cintia Gonzalez, Olga Bell, Enrique Lerma, Antonio Moral, Jose Ignacio Perez, Alberto de Leiva
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2015)
Article
Biochemical Research Methods
Vital Vialas, Nuria Colome-Calls, Joaquin Abian, Kerman Aloria, Gloria Alvarez-Llamas, Oreto Antunez, Jesus M. Arizmendi, Mikel Azkargorta, Silvia Barcelo-Batllori, Maria G. Barderas, Francisco Blanco, J. Ignacio Casal, Vanessa Casas, Carolina de la Torre, Eduardo Chicano-Galvez, Felix Elortza, Guadalupe Espadas, Josep M. Estanyol, Joaquin Fernandez-Irigoyen, Patricia Fernandez-Puente, Maria Jose Fidalgo, Manuel Fuentes, Marina Gay, Concha Gil, Alexandre Hainard, Maria Luisa Hernaez, Nieves Ibarrola, Arthur T. Kopylov, Antonio Lario, Juan Antonio Lopez, Maria Lopez-Lucendo, Miguel Marcilla, Anabel Marina-Ramirez, Gyorgy Marko-Varga, Luna Martin, Maria I. Mora, Esperanza Morato-Lopez, Javier Munoz, Maria Antonia Odena, Eliandre de Oliveira, Irene Orera, Ignacio Ortea, Carla Pasquarello, Kevin B. Ray, Melinda Rezeli, Isabel Ruppen, Eduard Sabido, Manuel M. Sanchez del Pino, Jaime Sancho, Enrique Santamaria, Jesus Vazquez, Marta Vilasecar, Fernando Vivanco, James J. Walters, Victor G. Zgoda, Fernando J. Corrales, Francesc Canals, Alberto Paradela
JOURNAL OF PROTEOMICS
(2017)
Article
Multidisciplinary Sciences
Irene Santos-Barriopedro, Laia Bosch-Presegue, Anna Marazuela-Duque, Carolina de la Torre, Carlota Colomer, Berta N. Vazquez, Thomas Fuhrmann, Barbara Martinez-Pastor, Wenfu Lu, Thomas Braun, Eva Bober, Thomas Jenuwein, Lourdes Serrano, Manel Esteller, Zhenbang Chen, Silvia Barcelo-Batllori, Raul Mostoslavsky, Lluis Espinosa, Alejandro Vaquero
NATURE COMMUNICATIONS
(2018)
Article
Biology
Barbara Baro, Soraya Jativa, Ines Calabria, Judith Vinaixa, Joan-Josep Bech-Serra, Carolina de LaTorre, Joao Rodrigues, Maria Luisa Hernaez, Concha Gil, Silvia Barcelo-Batllori, Martin R. Larsen, Ethel Queralt
Article
Endocrinology & Metabolism
M. Amigo-Correig, S. Barcelo-Batllori, S. Piquer, M. Soty, G. Pujadas, R. Gasa, A. Bortolozzi, M. C. Carmona, R. Gomis
DIABETES OBESITY & METABOLISM
(2011)
Article
Endocrinology & Metabolism
Rita Malpique, Hugo Figueiredo, Yaiza Esteban, Sandra A. Rebuffat, Felicia A. Hanzu, Maria Vinaixa, Oscar Yanes, Xavier Correig, Silvia Barcelo-Batllori, Rosa Gasa, Susana G. Kalko, Ramon Gomis
Article
Endocrinology & Metabolism
M. C. Carmona, M. Amigo, S. Barcelo-Batllori, M. Julia, Y. Esteban, S. Moreno, R. Gomis
INTERNATIONAL JOURNAL OF OBESITY
(2009)
Article
Biochemical Research Methods
Victor Segura, Juan Alberto Medina-Aunon, Maria I. Mora, Salvador Martinez-Bartolome, Joaquin Abian, Kerman Aloria, Oreto Antunez, Jesus M. Arizmendi, Mikel Azkargorta, Silvia Barcelo-Batllori, Jabier Beaskoetxea, Joan J. Bech-Serra, Francisco Blanco, Mariana B. Monteiro, David Caceres, Francesc Canals, Monserrat Carrascal, Jose Ignacio Casal, Felipe Clemente, Nuria Colome, Noelia Dasilva, Paula Diaz, Felix Elortza, Patricia Fernandez-Puente, Manuel Fuentes, Oscar Gallardo, Severine I. Gharbi, Concha Gil, Carmen Gonzalez-Tejedo, Maria Luisa Hernaez, Manuel Lombardia, Maria Lopez-Lucendo, Miguel Marcilla, Jose M. Mato, Marta Mendes, Eliandre Oliveira, Irene Orera, Alberto Pascual-Montano, Gorka Prieto, Cristina Ruiz-Romero, Manuel M. Sanchez del Pino, Daniel Tabas-Madrid, Maria L. Valero, Vital Vialas, Joan Villanueva, Juan Pablo Albar, Fernando J. Corrales
JOURNAL OF PROTEOME RESEARCH
(2014)
Article
Biochemical Research Methods
Adela Ramirez-Torres, Silvia Barcelo-Batllori, Erika Fernandez-Vizarra, Maria A. Navarro, Carmen Arnal, Natalia Guillen, Sergio Acin, Jesus Osada
JOURNAL OF PROTEOMICS
(2012)
Article
Biochemical Research Methods
Adela Ramirez-Torres, Silvia Barcelo-Batllori, Roberto Martinez-Beamonte, Maria A. Navarro, Joaquin C. Surra, Carmen Arnal, Natalia Guillen, Sergio Acin, Jesus Osada
JOURNAL OF PROTEOMICS
(2012)
Article
Multidisciplinary Sciences
Marta Amigo-Correig, Silvia Barcelo-Batllori, Guadalupe Soria, Alice Krezymon, Alexandre Benani, Luc Penicaud, Raul Tudela, Anna Maria Planas, Eduardo Fernandez, Maria del Carmen Carmona, Ramon Gomis
Article
Biochemical Research Methods
Sarah Fiddyment, Silvia Barcelo-Batllori, Miguel Pocovi, Angel-Luis Garcia-Otin
PROTEIN EXPRESSION AND PURIFICATION
(2011)
Article
Biochemistry & Molecular Biology
Jordi Guiteras, Laura De Ramon, Elena Crespo, Nuria Bolanos, Silvia Barcelo-Batllori, Laura Martinez-Valenzuela, Pere Fontova, Marta Jarque, Alba Torija, Oriol Bestard, David Resina, Josep M. Grinyo, Joan Torras
Summary: The study demonstrates the efficacy of HYBRI, a fusion protein containing CTLA4 and PD-L2 domains, in reducing inflammation and improving survival in rat kidney models of injury and transplant rejection. HYBRI shows promise as a potential therapeutic intervention for ischemia-reperfusion injury and solid organ transplantation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)