期刊
PROTEOMICS
卷 11, 期 4, 页码 805-815出版社
WILEY
DOI: 10.1002/pmic.201000380
关键词
Animal proteomics; Chronic kidney disease; Fibrosis
资金
- Inserm
- Direction Regional Clinique (CHU de Toulouse, France)
- Fondation pour la Recherche Medicale
- ANR [ANR-07-PHYSIO-004-01]
- European FP7 program e-LICO
- General Secretariat of Research and Technology [03ED245]
- Bodosakis Foundation
- Biomedical Research Foundation of the Academy of Athens
Chronic kidney disease (CKD) is the end-point of a number of renal and systemic diseases. The high incidence and financial burden of CKD makes it imperative to diagnose CKD at early stages when therapeutic interventions are far more effective. A key component of CKD is the development of renal fibrosis. Renal fibrosis is a complex process, associated with many cell types and pathways, resulting in structural and functional alterations. Identification of specific biomarkers of renal fibrosis may thus not only help us to understand the pathophysiological mechanisms involved in this process, but also improve diagnosis in the clinic. In this review, the existing literature on proteomic approaches to study renal fibrosis is presented and evaluated. The importance of using animal models along with patient material is discussed and future directions, considered key to this field, are proposed.
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