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Medicine, Research & Experimental
Mei Lin, Xiao-Long Zhang, Xiong Zou, Rui You, Qi Yang, Xiong Zou, Kai Yu, You-Ping Liu, Ru-Hai Zou, Yi-Jun Hua, Pei-Yu Huang, Jin Wang, Qi Zhao, Xiao-Bing Jiang, Jun Tang, Yang-Kui Gu, Tao Yu, Gui-Ping He, Yu-Long Xie, Zhi-Qiang Wang, Ting Liu, Si-Yuan Chen, Zhi-Xiang Zuo, Ming-Yuan Chen
Summary: By sequencing samples from 26 nasopharyngeal carcinoma patients, it was found that NPC has a higher neoantigen load compared to other cancers. Neoantigen depletion was more severe in metastatic sites, with the reduction occurring during metastasis.
Article
Cell Biology
Chun Cheng, Jun Yang, Si-Wei Li, Guofu Huang, Chenxi Li, Wei-Ping Min, Yi Sang
Summary: Histone deacetylases (HDACs) are involved in tumor progression, with HDAC4 playing a crucial role in promoting cell proliferation, migration, and invasion in nasopharyngeal carcinoma (NPC). High expression of HDAC4 in NPC tissues is associated with poor overall survival and progression-free survival. Inhibition of HDAC4 may present a potential therapeutic strategy for NPC patients.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Ana Montero-Calle, Sofia Jimenez de Ocana, Ruth Benavente-Naranjo, Raquel Rejas-Gonzalez, Ruben A. Bartolome, Javier Martinez-Useros, Rodrigo Sanz, Jana Dziakova, Maria Jesus Fernandez-Acenero, Marta Mendiola, Jose Ignacio Casal, Alberto Pelaez-Garcia, Rodrigo Barderas
Summary: SPRYD7 is a novel protein associated with CRC progression and metastasis, and its overexpression is associated with poor survival and an aggressive phenotype in CRC patients.
Article
Oncology
Dong-Hua Luo, Jia-Xin Li, Wan-Ping Guo, Chen-Guang Guo, Xiao-Han Meng, Pei-Jun Xie, Jie-Yi Lin, Hao-Yuan Mo, Qun Zhang, Yong Chen, Guo-Ping Shen
Summary: This study compared the metastatic patterns of synchronous bone metastasis (SBM) and metachronous bone metastasis (MBM) in nasopharyngeal carcinoma (NPC). The thoracic vertebra was the most common site of metastasis, and patients with SBM were more likely to have metastasis to the cervical vertebra. Patients with SBM had better overall survival. Age at bone metastasis detection, metastasis to other organs, and more bone metastasis locations were associated with worse prognosis. Attention should be paid to bone metastases during the first 2 years following NPC diagnosis.
Article
Oncology
Rentao Hou, Xiong Liu, Huiling Yang, Shuting Deng, Chao Cheng, Jiahao Liu, Yonghao Li, Yewei Zhang, Jingwen Jiang, Zhibo Zhu, Yun Su, Liyang Wu, Yingying Xie, Xiaoning Li, Wenmin Li, Zhen Liu, Weiyi Fang
Summary: In this study, cinobufagin (CB) was found to inhibit metastasis in nasopharyngeal carcinoma (NPC), and its therapeutic effect was enhanced when combined with cisplatin (DDP). CB induced the expression of ENKUR by deregulating the PI3K/AKT pathway and suppressing c-Jun, leading to the inhibition of NPC metastasis. ENKUR acted as a tumor suppressor by reducing MYH9 expression and preventing p53 ubiquitination degradation, thus suppressing epithelial-mesenchymal transition (EMT).
Review
Oncology
Xiaotao Geng, Furong Hao, Guiyan Han, Yaping Zhang, Peiyan Qin
Summary: Nasopharyngeal carcinoma rarely metastasizes to the dura and multiple locations in the brain, presenting challenges in diagnosis and treatment that may require a combination of therapy modalities such as radiotherapy and chemotherapy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Huali Ma, Yinyi Qiu, Haojiang Li, Fei Xie, Guangying Ruan, Lizhi Liu, Chunyan Cui, Annan Dong
Summary: Nodal matting was found to be an independent prognostic factor for distant metastasis-free survival in NPC patients, with potential to identify high-risk patients. The nomogram including nodal matting showed higher predictive accuracy compared to the nomogram without it.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Oncology
Shuo-Han Zheng, Yu-Tong Wang, Song-Ran Liu, Zi-Lu Huang, Guan-Nan Wang, Jin-Tao Lin, Shi-Rong Ding, Chen Chen, Yun-Fei Xia
Summary: The optimal treatment strategy for de novo metastatic nasopharyngeal carcinoma (mNPC) is a combination of palliative chemotherapy (PCT) followed by concurrent chemoradiotherapy. Specifically, concurrent chemoradiotherapy with single-agent platinum after 4-6 cycles of PCT is suggested to achieve better survival outcomes.
CANCER CELL INTERNATIONAL
(2022)
Article
Oncology
Xueshuo Sun, Kun Zhang, Xingzhi Peng, Peijun Zhou, Chunhui Qu, Lifang Yang, Liangfang Shen
Summary: Studies have shown that acetylation modification is important in tumor proliferation and metastasis. In this study, it was found that LHPP is downregulated in nasopharyngeal carcinoma (NPC) and overexpression of LHPP can inhibit the proliferation and invasion of NPC cells.
Article
Otorhinolaryngology
Chih-Wen Twu, Po-Ju Lin, Hsiao-Hui Tsou, Yi-Chun Liu, Rong-San Jiang, Kai-Li Liang, Tian-Yun Lin, Wen-Yi Wang, Jin-Ching Lin
Summary: This study investigated the survival impact and toxicity of maintenance metronomic chemotherapy in patients with metastatic/recurrent nasopharyngeal carcinoma. The results showed that maintenance chemotherapy significantly improved overall and progression-free survivals while demonstrating low toxicity.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Medicine, Research & Experimental
Hui Tian, Si Shi, Bo You, Qicheng Zhang, Miao Gu, Yiwen You
Summary: The study revealed that ERp44 is elevated in NPC tissues and correlated with clinical stages and patient survival. In vitro experiments showed that downregulation of ERp44 in NPC cells suppressed proliferation and migration. Interaction with ACLY and regulation of EMT were found to be crucial for ERp44 in promoting NPC progression. Furthermore, ERp44 was positively correlated with ACLY expression and promoted NPC cell growth in vivo.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Yongzhen Mo, Yumin Wang, Shuai Zhang, Fang Xiong, Qijia Yan, Xianjie Jiang, Xiangying Deng, Yian Wang, Chunmei Fan, Le Tang, Shanshan Zhang, Zhaojian Gong, Fuyan Wang, Qianjin Liao, Can Guo, Yong Li, Xiaoling Li, Guiyuan Li, Zhaoyang Zeng, Wei Xiong
Summary: Our study revealed that a novel circRNA, circRNF13, plays a crucial role in NPC development through the circRNF13-SUMO2-GLUT1 axis. CircRNF13 inhibits NPC proliferation and metastasis by activating SUMO2 and regulating the AMPK-mTOR pathway to inhibit glycolysis. This research provides a theoretical basis for further understanding NPC pathogenesis and developing targeted therapies.
Article
Medicine, Research & Experimental
Yali Xu, Taoyuan Huang, Min Mao, Jinming Zhai, Jinhai Chen
Summary: The study evaluated prognostic factors and distant metastatic patterns in de novo metastatic nasopharyngeal carcinoma patients, with liver metastasis identified as an independent predictor for poor cancer-specific survival and overall survival.
Article
Oncology
Xue-Fang Zhang, Yan Zhang, Xu-Wei Liang, Jia-Luo Chen, Sheng-Fang Zhi, Wen-Jing Yin, Meng-Yao Wang, En-Lai Dong, Dong-Ping Chen
Summary: This study retrospectively analyzed the distribution of distant lymph node metastasis in patients with metastatic NPC and its impact on prognosis. The results showed that subphrenic lymph node metastasis is associated with poor prognosis.
FRONTIERS IN ONCOLOGY
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Matthew Montanarella, Kimberly Boldig, Patrick Natter, Savas Ozdemir
Summary: Nasopharyngeal carcinoma (NC) is a rare epithelial tumor mostly found in East and Southeast Asia. Leptomeningeal metastasis in NC is a rare occurrence and has been sparsely described in literature. We present a case of a 33-year-old man with high-grade NC and leptomeningeal metastasis, with initial MRI lumbar spine showing subtle findings consistent with leptomeningeal disease. These findings were easily discernible on F-18-FDG PET/CT.
CLINICAL NUCLEAR MEDICINE
(2023)
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Biochemistry & Molecular Biology
Peng Luo, Yongbo Zhao, Dong Li, Tao Chen, Sanzhong Li, Xiaodong Chao, Wenbo Liu, Lei Zhang, Yan Qu, Xiaofan Jiang, Gang Lu, Waisang Poon, Zhou Fei
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Wei-ming Fu, Jin-fang Zhang, Hua Wang, Hong-sheng Tan, Wei-mao Wang, Shih-Chi Chen, Xiao Zhu, Tak-ming Chan, Ching-man Tse, Kwong-sak Leung, Gang Lu, Hong-xi Xu, Hsiang-fu Kung
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Behavioral Sciences
Yao Liu, Li Juan Ao, Gang Lu, Elizabeth Leong, Qiang Liu, Xiao Hong Wang, Xian Lun Zhu, Tin Fung David Sun, Zhou Fei, Tian Jiu, Xiang Hu, Wai Sang Poon
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(2013)
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Fengqiong Yin, Zhenhua Xu, Zifeng Wang, Hong Yao, Zan Shen, Fang Yu, Yiping Tang, Dengli Fu, Sheng Lin, Gang Lu, Hsiang-fu Kung, Wai Sang Poon, Yunchao Huang, Marie Chia-mi Lin
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2012)
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Neurosciences
Xiao Hong Wang, Gang Lu, Xiang Hu, Kam Sze Tsang, Wing Hang Kwong, Feng Xia Wu, Hai Wei Meng, Shu Jiang, Shu Wei Liu, Ho Keung Ng, Wai Sang Poon
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Oncology
Zifeng Wang, Hong Yao, Sheng Lin, Xiao Zhu, Zan Shen, Gang Lu, Wai Sang Poon, Dan Xie, Marie Chia-mi Lin, Hsiang-fu Kung
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Gastroenterology & Hepatology
Jin-fang Zhang, Ming-liang He, Wei-ming Fu, Hua Wang, Lian-zhou Chen, Xiao Zhu, Ying Chen, Dan Xie, Paul Lai, Gong Chen, Gang Lu, Marie C. M. Lin, Hsiang-fu Kung
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Biochemistry & Molecular Biology
Hongping Xia, William K. C. Cheung, Samuel S. Ng, Xiaochun Jiang, Songshan Jiang, Johnny Sze, Gilberto K. K. Leung, Gang Lu, Danny T. M. Chan, Xiu-Wu Bian, Hsiang-Fu Kung, Wai Sang Poon, Marie C. Lin
JOURNAL OF BIOLOGICAL CHEMISTRY
(2012)
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Acoustics
Guowei Tao, Gang Lu, Xinfeng Zhan, Jun Li, Lin Cheng, Kingyin Lee, Wai Sang Poon
JOURNAL OF CLINICAL ULTRASOUND
(2013)
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Medicine, Research & Experimental
Gaojian Chen, Jingying Yang, Gang Lu, Pi Chu Liu, Qianjin Chen, Zuowei Xie, Chi Wu
MOLECULAR PHARMACEUTICS
(2014)
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Neurosciences
Hongluan Yu, Qi Li, Defeng Wang, Lin Shi, Gang Lu, Lin Sun, Li Wang, Wei Zhu, Ying T. Mak, Naikei Wong, Yixiang Wang, Fang Pan, David T. Yew
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Multidisciplinary Sciences
Shen Gu, Hoi Hung Cheung, Tin Lap Lee, Gang Lu, Wai Sang Poon, Wai Yee Chan
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Biochemistry & Molecular Biology
Jin-fang Zhang, Wei-ming Fu, Ming-liang He, Wei-dong Xie, Qing Lv, Gang Wan, Guo Li, Hua Wang, Gang Lu, Xiang Hu, Su Jiang, Jian-na Li, Marie C. M. Lin, Ya-ou Zhang, Hsiang-fu Kung
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Gastroenterology & Hepatology
Lei Jiang, Yiu-Kay Lai, Jin-Fang Zhang, Chu-Yan Chan, Gang Lu, Marie C. M. Lin, Ming-Liang He, Ji-Cheng Li, Hsiang-Fu Kung
WORLD JOURNAL OF GASTROENTEROLOGY
(2012)
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Environmental Sciences
Deng Min, Wang Yi Xiang, James F. Griffith, Lu Gang, Anil T. Ahuja, Wai S. Poon
BIOMEDICAL AND ENVIRONMENTAL SCIENCES
(2012)