期刊
PROTEOMICS
卷 10, 期 22, 页码 4098-4116出版社
WILEY
DOI: 10.1002/pmic.201000210
关键词
Bacteria; Interaction; Microbiology; Phagosome
资金
- NIAID NIH HHS [T32 AI055449] Funding Source: Medline
Phagosomal proteome characterization has contributed significantly to the understanding of host pathogen interaction and the mechanism of infectious diseases caused by intracellular bacteria. The latex bead-containing phagosome has been widely used as a model system to study phagosomal proteomes at a global level. In contrast, the study of bacteria-containing phagosomes at a similar level has just begun. A number of intracellular microbial species are studied for their proteomes during the invasion of a host, providing insight into their metabolic adaptation in host cells and interaction with host-cell antimicrobial environments. In this review, we attempt to summarize the most recent advancements in the proteomic study of microbial phagosomes, especially those originating from mouse or human cells. We also briefly describe the proteomics of latex bead-containing phagosomes because they are often used as model phagosomes for study. We provide descriptions on major biological and technological components in phagosomal proteome studies. We also discuss the role of phagosomal proteome study in the broader horizon of systems biology and the technological challenges in phagosomal proteome characterization.
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