Review
Biochemistry & Molecular Biology
Xiying Chen, Zhouyuanjing Shi, Feng Yang, Tianhua Zhou, Shanshan Xie
Summary: Cilia are microtubule-based organelles that play crucial roles in cellular signaling pathways and extracellular fluid movement. Defects in ciliary structures and functions are implicated in hereditary disorders known as ciliopathies. Proteomic studies provide important clues for understanding the physiological and pathological roles of cilia.
Review
Cell Biology
Anna Boccaccio, Anna Menini, Simone Pifferi
Summary: Odor perception starts from the detection of odorant molecules by the main olfactory epithelium in the nasal cavity. The molecules then activate a large family of G-protein-coupled odorant receptors and trigger a cAMP-mediated transduction cascade, converting the chemical stimulus into an electrical signal sent to the brain. Moreover, odorant receptors and cAMP signaling are key players in the development of olfactory sensory neurons and their axonal targeting to the olfactory bulb.
CELL AND TISSUE RESEARCH
(2021)
Article
Multidisciplinary Sciences
Andres Hernandez-Clavijo, Cesar Adolfo Sanchez Trivino, Giorgia Guarneri, Chiara Ricci, Fabian A. Mantilla-Esparza, Kevin Y. Gonzalez-Velandia, Paolo Boscolo-Rizzo, Margherita Tofanelli, Pierluigi Bonini, Michele Dibattista, Giancarlo Tirelli, Anna Menini
Summary: The COVID-19 pandemic highlighted our limited understanding of human olfactory physiology. By using acute slices of human olfactory epithelium and whole-cell patch-clamp technique, this study characterized the electrical properties of olfactory sensory neurons and supporting cells. The study also demonstrated the intact transduction cascade in this preparation through responses to odorant mixtures. This research provides valuable insights into human olfactory physiology and lays the foundation for future studies.
Review
Cell Biology
Michele Dibattista, Dolly Al Koborssy, Federica Genovese, Johannes Reisert
Summary: Olfactory marker protein (OMP) is expressed in olfactory receptor neurons in the nasal cavity and other chemosensory systems, playing a role in modulating odorant responses. Studies show that OMP is involved in regulating the kinetics of cAMP in olfactory transduction, but the specific mechanism is not fully understood yet.
CELL AND TISSUE RESEARCH
(2021)
Article
Multidisciplinary Sciences
Hai-Qian Zhou, Liu-Jing Zhuang, Hong-Qiang Bao, Sheng-Ju Li, Feng-Yan Dai, Ping Wang, Qian Li, Dong -Min Yin
Summary: Olfactory behavior is crucial for animal survival, and olfactory dysfunction is commonly seen in various diseases. This study reveals that mature olfactory sensory neurons (OSNs) express high levels of dopamine D2 receptor (Drd2), which can modulate odorant recognition response by inhibiting odor-induced signaling. Furthermore, nasal dopamine and DRD2 receptor are identified as potential peripheral targets for olfactory modulation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Developmental Biology
Julien C. Habif, Chao Xie, Carlos de Celis, Kirill Ukhanov, Warren W. Green, Jordan C. Moretta, Lian Zhang, Robert J. Campbell, Jeffrey R. Martens
Summary: Olfactory sensory neurons (OSNs) mature by developing glomeruli with multiple cilia, and a GTPase called ARL13B plays a crucial role in this maturation process. Loss of ARL13B in immature OSNs causes dysregulation of cellular homeostasis and delays the timing of maturation. Additionally, ARL13B is essential for the proper structure and innervation of glomeruli, contributing to odor detection and perception.
Article
Multidisciplinary Sciences
Shiuan-Tze Wu, Jen-Yung Chen, Vanessa Martin, Renny Ng, Ye Zhang, Dhruv Grover, Ralph J. Greenspan, Johnatan Aljadeff, Chih-Ying Su
Summary: This study reveals the existence of an olfactory valence map in Drosophila sensory hairs, which is organized by ephaptic coupling and plays a crucial role in regulating behavior and processing odor mixtures.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Thomas Offner, Lukas Weiss, Daniela Daume, Anna Berk, Tim Justin Inderthal, Ivan Manzini, Thomas Hassenkloever
Summary: In this study, the impact of the wiring between olfactory receptor neuron axons and mitral/tufted cell dendrites on glomerular module organization and odor representations in the Xenopus laevis olfactory bulb network was investigated. The results showed that amino acid odorants are not organized in a stereotypic or chemotopic manner on isolated glomeruli. It was concluded that odor map heterogeneity is caused by the coexistence of different intermingled glomerular modules, suggesting that the organization of the amphibian main olfactory system is not strictly based on uni-glomerular connectivity.
Article
Multidisciplinary Sciences
Kevin W. Zhu, Shawn D. Burton, Maira H. Nagai, Justin D. Silverman, Claire A. de March, Matt Wachowiak, Hiroaki Matsunami
Summary: This study utilized targeted spatial transcriptomics to map the distribution of olfactory receptors in the murine olfactory bulb and generated a 3D model. The findings revealed a relationship between receptors and odorants, providing significant insights into olfaction.
NATURE COMMUNICATIONS
(2022)
Review
Neurosciences
Federica Genovese, Johannes Reisert, Vladimir J. Kefalov
Summary: The past decades have seen significant progress in understanding the function of photoreceptors and olfactory sensory neurons. This progress has been driven by the combination of physiological experimental tools and genetic manipulations, which have allowed researchers to identify molecular players in sensory neuron transduction cascades, explore how properties impact stimulus detection and disease effects on vision and smell.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Review
Cell Biology
Dieter Wicher, Fabio Miazzi
Summary: The majority of insect olfactory receptors belong to two distinct protein families - ionotropic receptors (IRs) related to the ionotropic glutamate receptor family, and odorant receptors (ORs) evolved from the gustatory receptor family. Both types assemble into heteromeric ligand-gated cation channels, addressing environmental and ecological challenges insects face.
CELL AND TISSUE RESEARCH
(2021)
Article
Biology
Kaitlin Ching, Jennifer T. Wang, Tim Stearns, Danelle Devenport
Summary: This study discovered that centrioles migrate together during dendrite outgrowth in olfactory sensory neurons (OSNs) and form cilia during maturation. They are associated with microtubule nucleation factors and the parental centriole forms a cilium before other centrioles.
Article
Multidisciplinary Sciences
Rodi Topci, Mihai Alevra, Erik H. U. Rauf, Danielle de Jong-Bolm
Summary: This study investigated the activity of olfactory receptor neurons and their axon terminals in olfactory glomeruli using electrophysiological recordings and rapid 4D calcium imaging. While individual olfactory receptor neurons show diversity in their responses to the same odor stimulus at the soma level, the presynaptic calcium activity in the glomerulus is homogeneous. It was also found that by applying trains of olfactory stimuli with varying amino acid concentrations, it is possible to induce spatio-temporal presynaptic response inhomogeneities and visually distinguish different axon subgroups within the glomerulus.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Carl E. Schoonover, Sarah N. Ohashi, Richard Axel, Andrew J. P. Fink
Summary: The study found that although activity in the primary olfactory cortex could discriminate between odorants at any time, the odor-evoked responses drifted over days to weeks. Daily exposure to the same odorant slowed the rate of drift, but when exposure was halted the rate increased again. This instability may be related to the unstructured connectivity of the piriform cortex.
Article
Neurosciences
Kohei Koike, Seung-Jun Yoo, Katherin Bleymehl, Masayo Omura, Bolek Zapiec, Martina Pyrski, Thomas Blum, Mona Khan, Zhaodai Bai, Trese Leinders-Zufall, Peter Mombaerts, Frank Zufall
Summary: The study identifies an ultrasensitive olfactory sensor in mice for detecting hydrogen sulfide, which activates a specific type of sensory neurons and triggers defensive responses. This activation mechanism includes elevation of stress hormone levels, stress-related grooming behavior, and conditional avoidance of dangerous environments.
Article
Biochemistry & Molecular Biology
Nicole Ungerer, Norbert Muecke, Jana Broecker, Sandro Keller, Stephan Frings, Frank Moehrlen
Article
Developmental Biology
Ja-On Park, Jie Pan, Frank Moehrlen, Marcus-Oliver Schupp, Robert Johnsen, David L. Baillie, Richard Zapf, Donald G. Moerman, Harald Hutter
BMC DEVELOPMENTAL BIOLOGY
(2010)
Article
Cell Biology
Kristin Dauner, Judith Lissmann, Semir Jeridi, Stephan Frings, Frank Moehrlen
CELL AND TISSUE RESEARCH
(2012)
Article
Neurosciences
Philipp Daiber, Federica Genovese, Valentin A. Schriever, Thomas Hummel, Frank Moehrlen, Stephan Frings
EUROPEAN JOURNAL OF NEUROSCIENCE
(2013)
Review
Neurosciences
Daniel Klimmeck, Philipp C. Daiber, Anja Bruehl, Arnd Baumann, Stephan Frings, Frank Moehrlen
JOURNAL OF COMPARATIVE NEUROLOGY
(2009)
Article
Physiology
Clemens Waldeck, Kerstin Vocke, Nicole Ungerer, Stephan Frings, Frank Moehrlen
JOURNAL OF GENERAL PHYSIOLOGY
(2009)
Article
Physiology
Kerstin Vocke, Kristin Dauner, Anne Hahn, Anne Ulbrich, Jana Broecker, Sandro Keller, Stephan Frings, Frank Moehrlen
JOURNAL OF GENERAL PHYSIOLOGY
(2013)
Article
Neurosciences
Katharina Funk, Anne Woitecki, Christina Franjic-Wuertz, Thomas Gensch, Frank Moehrlen, Stephan Frings
Article
Neurosciences
D. Klimmeck, U. Mayer, N. Ungerer, U. Warnken, M. Schnoelzer, S. Frings, F. Moehrlen
Article
Multidisciplinary Sciences
Thomas Hengl, Hiroshi Kaneko, Kristin Dauner, Kerstin Vocke, Stephan Frings, Frank Moehrlen
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2010)
Article
Physiology
Franziska Neureither, Nadine Stowasser, Stephan Frings, Frank Moehrlen
PHYSIOLOGICAL REPORTS
(2017)
Article
Ophthalmology
Kristin Dauner, Carolin Moebus, Stephan Frings, Frank Moehrlen
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2013)
Article
Behavioral Sciences
Ulrich Mayer, Nicole Ungerer, Daniel Klimmeck, Uwe Warnken, Martina Schnoelzer, Stephan Frings, Frank Moehrlen
Article
Developmental Biology
Daniel Gilbert, Christina Franjic-Wuertz, Katharina Funk, Thomas Gensch, Stephan Frings, Frank Moehrlen
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
(2007)