Structural analyses of the pre-mRNA splicing machinery

Crystal structure of Prp8 reveals active site cavity of the spliceosome

(2013) Wojciech P. Galej et al.   NATURE

Comprehensive in vivo RNA-binding site analyses reveal a role of Prp8 in spliceosomal assembly

(2013) Xueni Li et al.   NUCLEIC ACIDS RESEARCH

Structural analysis of the C-terminal domain of the spliceosomal helicase Prp22

(2012) Denis Kudlinzki et al.   BIOLOGICAL CHEMISTRY

Structure and assembly of the SF3a splicing factor complex of U2 snRNP

(2012) Pei-Chun Lin et al.   EMBO JOURNAL

Structural basis for functional cooperation between tandem helicase cassettes in Brr2-mediated remodeling of the spliceosome

(2012) K. F. Santos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the yeast U2/U6 snRNA complex

(2012) J. E. Burke et al.   RNA

The Structure of the Nuclear Pore Complex

(2011) André Hoelz et al.   Annual Review of Biochemistry

RNA helicases and remodeling proteins

(2011) Anna Marie Pyle   CURRENT OPINION IN CHEMICAL BIOLOGY

Structure of the spliceosomal U4 snRNP core domain and its implication for snRNP biogenesis

(2011) Adelaine K. W. Leung et al.   NATURE

A novel occluded RNA recognition motif in Prp24 unwinds the U6 RNA internal stem loop

(2011) Stephen Martin-Tumasz et al.   NUCLEIC ACIDS RESEARCH

Prp8, the pivotal protein of the spliceosomal catalytic center, evolved from a retroelement-encoded reverse transcriptase

(2011) M. Dlakic et al.   RNA

Functional organization of the Sm core in the crystal structure of human U1 snRNP

(2010) Gert Weber et al.   EMBO JOURNAL

Prp43p contains a processive helicase structural architecture with a specific regulatory domain

(2010) Hélène Walbott et al.   EMBO JOURNAL

Structural basis for the function of DEAH helicases

(2010) Yangzi He et al.   EMBO REPORTS

3D Cryo-EM Structure of an Active Step I Spliceosome and Localization of Its Catalytic Core

(2010) Monika M. Golas et al.   MOLECULAR CELL

Expansion of the eukaryotic proteome by alternative splicing

(2010) Timothy W. Nilsen et al.   NATURE

Role of the snRNAs in spliceosomal active site

(2010) Saba Valadkhan   RNA Biology

Structure and functional implications of a complex containing a segment of U6 RNA bound by a domain of Prp24

(2010) S. Martin-Tumasz et al.   RNA

Characterization of purified human Bact spliceosomal complexes reveals compositional and morphological changes during spliceosome activation and first step catalysis

(2010) S. Bessonov et al.   RNA

RNA helicases at work: binding and rearranging

(2010) Eckhard Jankowsky   TRENDS IN BIOCHEMICAL SCIENCES

The Spliceosome: Design Principles of a Dynamic RNP Machine

(2009) Markus C. Wahl et al.   CELL

Exon, intron and splice site locations in the spliceosomal B complex

(2009) Elmar Wolf et al.   EMBO JOURNAL

The ATPase and helicase activities of Prp43p are stimulated by the G-patch protein Pfa1p during yeast ribosome biogenesis

(2009) Simon Lebaron et al.   EMBO JOURNAL

Minimum-Energy Path for a U6 RNA Conformational Change Involving Protonation, Base-Pair Rearrangement and Base Flipping

(2009) Vincenzo Venditti et al.   JOURNAL OF MOLECULAR BIOLOGY

Common Design Principles in the Spliceosomal RNA Helicase Brr2 and in the Hel308 DNA Helicase

(2009) Vladimir Pena et al.   MOLECULAR CELL

The Evolutionarily Conserved Core Design of the Catalytic Activation Step of the Yeast Spliceosome

(2009) Patrizia Fabrizio et al.   MOLECULAR CELL

Crystal structure of human spliceosomal U1 snRNP at 5.5 Å resolution

(2009) Daniel A. Pomeranz Krummel et al.   NATURE

Structural evidence for consecutive Hel308-like modules in the spliceosomal ATPase Brr2

(2009) Lingdi Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Reconstitution of both steps of Saccharomyces cerevisiae splicing with purified spliceosomal components

(2009) Zbigniew Warkocki et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RNA recognition motifs: boring? Not quite

(2008) Antoine Cléry et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structure and function of an RNase H domain at the heart of the spliceosome

(2008) Vladimir Pena et al.   EMBO JOURNAL

Conservation of the Protein Composition and Electron Microscopy Structure of Drosophila melanogaster and Human Spliceosomal Complexes

(2008) N. Herold et al.   MOLECULAR AND CELLULAR BIOLOGY

A protein-based EM label for RNA identifies the location of exons in spliceosomes

(2008) Eric A Alcid et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural elucidation of a PRP8 core domain from the heart of the spliceosome

(2008) Dustin B Ritchie et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Localization of Prp8, Brr2, Snu114 and U4/U6 proteins in the yeast tri-snRNP by electron microscopy

(2008) Irina Häcker et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystal structure of the  -finger domain of Prp8 reveals analogy to ribosomal proteins

(2008) K. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of yeast U6 snRNPs: Arrangement of Prp24p and the LSm complex as revealed by electron microscopy

(2008) R. Karaduman et al.   RNA

Actin filament labels for localizing protein components in large complexes viewed by electron microscopy

(2008) M. E. Stroupe et al.   RNA