Review
Cell Biology
Carine Marmentini, Renato C. S. Branco, Antonio C. Boschero, Mirian A. Kurauti
Summary: Islet amyloid polypeptide is a hormone co-secreted with insulin by pancreatic beta-cells and is found in patients with type 2 diabetes. Investigating aspects related to amyloid formation is crucial for developing strategies towards beta-cell protection. Approaches to prevent islet amyloid cytotoxicity have shown promise in improving beta-cell function and preventing hyperglycemia.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Endocrinology & Metabolism
Austin J. Taylor, Evgeniy Panzhinskiy, Paul C. Orban, Francis C. Lynn, David F. Schaeffer, James D. Johnson, Janel L. Kopp, C. Bruce Verchere
Summary: Loss of IAPP signaling may not increase the risk of pancreatic cancer in individuals with diabetes.
MOLECULAR METABOLISM
(2022)
Review
Cell Biology
Sofia Ferreira, Ana F. Raimundo, Regina Menezes, Ivo C. Martins
Summary: This study discusses the association of IAPP with diabetes, Aβ, and dementia, elucidating the pathological role of IAPP in AD. Research has shown that IAPP not only contributes to cognitive decline, but also harms the blood-brain barrier, interacts directly with Aβ, and co-deposits with it, leading to diabetes-associated dementia.
NEURAL REGENERATION RESEARCH
(2021)
Article
Immunology
Anne-Cathrine S. Vogt, Elisa S. Roesti, Mona O. Mohsen, Ainars Leonchiks, Monique Vogel, Martin F. Bachmann
Summary: Type 2 Diabetes Mellitus is a chronic progressive disease characterized by insulin resistance and insufficient insulin secretion. Research suggests that monoclonal antibody therapy targeting amyloidogenic aggregates may be a potential treatment for T2DM.
Article
Biochemistry & Molecular Biology
Lucie Khemtemourian, Hebah Fatafta, Benoit Davion, Sophie Lecomte, Sabine Castano, Birgit Strodel
Summary: This study investigates the molecular details of IAPP binding to lipid membranes, revealing different membrane interaction modes and aggregation structures for different IAPP variants. Residue 18 plays a decisive role in the structure and membrane interaction of IAPP, making it a potential therapeutic target for inhibiting IAPP toxicity.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yeong-Min Yoo, Seong Soo Joo
Summary: The study compared amylin oligomerization/expression and signal transduction under endoplasmic reticulum (ER) stress and oxidative stress. Results showed that amylin undergoes oligomerization under ER stress in cells overexpressing pCMV-hIAPP, potentially leading to dysfunction of beta cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Angelina S. Bortoletto, Ronald J. Parchem
Summary: Patients with type 2 diabetes mellitus have a significantly higher risk of developing dementia, possibly due to increased secretion of amylin. This review summarizes the mechanisms by which amylin accumulation may cause neuronal damage and discusses the importance of investigating new therapeutic targets for treating dementia.
NEURAL REGENERATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Sanduni Wasana Jayaweera, Solmaz Surano, Nina Pettersson, Elvira Oskarsson, Lovisa Lettius, Anna L. Gharibyan, Intissar Anan, Anders Olofsson
Summary: The study demonstrates that TTR can interfere with IAPP amyloid-formation, prolonging the lag-phase and impairing elongation. The interfering ability correlates inversely with the thermodynamic stability of TTR, but not with kinetic stability. TTR's interference ability remains effective in the low pH environment of IAPP-containing granules, but TTR-stabilizing drugs partially weaken its efficacy.
Article
Biochemistry & Molecular Biology
Noe Quittot, Mathilde Fortier, Margaryta Babych, Phuong Trang Nguyen, Mathew Sebastiao, Steve Bourgault
Summary: The study reveals that GAGs exacerbate IAPP-induced cytotoxicity and membrane perturbation, increasing the local concentration of IAPP on the cell surface and promoting lipid bilayer disturbance and cell death.
Review
Food Science & Technology
Raliat O. Abioye, Chibuike C. Udenigwe
Summary: IAPP aggregation plays a crucial role in the development of type 2 diabetes by reducing insulin production and damaging pancreatic beta-cell function. Understanding the structure, function, aggregation mechanism, and inhibitors of IAPP provides insights for better management of T2D.
FOOD SCIENCE AND HUMAN WELLNESS
(2021)
Article
Biochemistry & Molecular Biology
Mikkel Christensen, Nils A. Berglund, Birgit Schiott
Summary: This study used atomistic, unbiased molecular dynamics simulations to investigate the effect of cholesterol on membrane bound IAPP. Results indicated that cholesterol decreased the insertion depth of IAPP compared to pure phospholipid membranes, while phosphatidylserine (PS) lipids counteracted the effect of cholesterol. The depletion of cholesterol in the vicinity of IAPP suggests that its effect is indirect.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Anns Mahboob, Degiri Kalana Lasanga Senevirathne, Pradipta Paul, Faisal Nabi, Rizwan Hasan Khan, Ali Chaari
Summary: Type 2 diabetes is a chronic metabolic disease with a significant global disease burden. Non-genetic risk factors for T2D include obesity, diet, physical activity, lifestyle, smoking, age, ethnicity, and mental stress. The aggregation and misfolding of hIAPP have detrimental effects on beta-cell function and health. Polyphenols have shown promising potential as natural therapeutics for inhibiting hIAPP aggregation and mitigating larger pathological effects of T2D, but further studies are needed to evaluate their mechanisms of action and ideal doses.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Mohammad Irshad Reza, Anees A. Syed, Sanjana Kumariya, Pragati Singh, Athar Husain, Jiaur R. Gayen
Summary: The research suggests that PST can induce the aggregation of IAPP in the pancreas, liver, and skeletal muscle, potentially leading to insulin resistance and type 2 diabetes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biophysics
Luis Mauricio T. R. Lima, Luis Pena Icart
Summary: The discovery of insulin a century ago has led to a substantial increase in therapeutic polypeptides targeting diabetes and obesity. The focus is now on highly pure recombinant insulin and other peptide-based hormones and analogs. Proper formulation, storage, manipulation, and usage are required in order to avoid aggregation into high molecular weight products.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Multidisciplinary Sciences
Nirmal Verma, Sarah Srodulski, Sathya Velmurugan, Amanda Hoskins, Vivek K. Pandey, Florin Despa, Sanda Despa
Summary: GDM complicating pregnancy may accelerate the development of pathological cardiac remodeling, likely through activation of the calcineurin/NFAT signaling pathway.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Shumin Bian, Bon W. Koo, Stephen Kelleher, Joseph Santos-Sacchi, Dhasakumar S. Navaratnam
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2010)
Article
Biochemistry & Molecular Biology
Bon W. Koo, James A. Hebda, Andrew D. Miranker
PROTEIN ENGINEERING DESIGN & SELECTION
(2008)
Article
Psychology, Multidisciplinary
Mark Wilson, Shruti Bathia, Linda Morell, Perman Gochyyev, Bon W. Koo, Rebecca Smith
Summary: The Likert item response format is widely used in social sciences for its simplicity and efficiency, but this article argues for the use of the Guttman response format for better interpretability in terms of internal structure validity evidence. The Guttman format is recommended for improving outcomes interpretability and can be used alongside Likert format items for balance between efficiency and interpretability.
PSYCHOLOGICAL METHODS
(2022)
Proceedings Paper
Audiology & Speech-Language Pathology
Shumin Bian, Bon W. Koo, Stephen Kelleher, Joseph Santos-Sacchi, Dhasakumar Navaratnam
WHAT FIRE IS IN MINE EARS: PROGRESS IN AUDITORY BIOMECHANICS: PROCEEDINGS OF THE 11TH INTERNATIONAL MECHANICS OF HEARING WORKSHOP
(2011)