Article
Multidisciplinary Sciences
Yosuke Funato, Daisuke Yamazaki, Daisuke Okuzaki, Nobuhiko Yamamoto, Hiroaki Miki
Summary: The study highlights the importance of renal TRPM6 in raising blood pressure by stimulating renin secretion, deficiency of TRPM6 leads to decreased blood pressure and disappearance of circadian variation, showing its crucial role in regulating blood pressure.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Marin-Aurel Trofin, Stefania Racovita, Silvia Vasiliu, Ana-Lavinia Vasiliu, Marcela Mihai
Summary: Crosslinked porous microparticles have gained significant attention as drug delivery systems due to their unique properties. In this study, novel porous zwitterionic microparticles with antifouling, antimicrobial and hydration properties were successfully prepared. The microparticles showed high drug loading and release capacities, and demonstrated antibacterial activity against Escherichia coli and Staphylococcus aureus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Polymer Science
Matthew F. I. Rix, Kyle Collins, Samuel J. Higgs, Eleanor M. Dodd, Simon J. Coles, Nathaniel M. Bingham, Peter J. Roth
Summary: This study demonstrates the various reactions of thionolactone DBT and its ability to introduce a degradable backbone. Additionally, through XRD structure analysis and DFT modeling, the higher reactivity of DBT is explained by its stabilization of the intermediate radical, increased ring strain, and better reinitiating efficiency.
Article
Biochemistry & Molecular Biology
Jiawei Xu, Wei Ye, Ting Ting Yang, Teng Yan, Haiyan Cai, Aiwu Zhou, Yufeng Yang
Summary: In this study, a bacterial serpin called chloropin was identified and its crystal structure was determined. Chloropin showed inhibitory activity against multiple proteases and could be accelerated by DNA. These findings suggest that DNA may be a natural modulator of chloropin and prokaryotic serpins have evolved to use different surface subsites for activity modulation.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Engineering, Environmental
Ivan Zapata-Gonzalez, Robin A. Hutchinson, Michael Buback, Axel Rivera-Magallanes
Summary: This study discusses the controversial phenomenon of retardation in dithiobenzoate-mediated polymerizations, introducing the Missing Step reaction (MSR) hypothesis to explain the kinetic picture. A detailed kinetic model based on the method of moments is developed and validated, demonstrating the accuracy of describing the behavior of propagating and intermediate radicals.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Chemistry, Applied
Linping Miao, Zhengjuan Yan, Xinlong Wang, Yanjun Zhong, Jingxu Yang, Dehua Xu
Summary: In this study, a new slow-release fertilizer was developed using waste materials. The fertilizer not only provides continuous nutrient supply, but also reduces nutrient leaching, resulting in improved agronomic benefits.
REACTIVE & FUNCTIONAL POLYMERS
(2022)
Editorial Material
Chemistry, Multidisciplinary
Benjamin A. Suslick, Robert B. Grubbs, Robert M. Waymouth, Jeffrey S. Moore
Summary: The authors of this tribute article are alumni of the Grubbs group, spanning multiple generations, who possess unique perspectives on Bob throughout his life and career. Despite working with Bob in different roles and at different times, they all fondly remember their time with him and wish to commemorate the profound impact he had on their lives and careers.
Article
Polymer Science
Glenn K. K. Clothier, Thiago R. Guimaraes, Graeme Moad, Per B. Zetterlund
Summary: Precise multiblock copolymer synthesis coupled with self-assembly provides control over the structure on length scales from nanometers to micrometers. The use of a nanoreactor concept in emulsion polymerization has expanded the scope of multiblock copolymer synthesis. However, the high glass transition temperature of some polymers has been a limitation. This study demonstrates that this limitation can be alleviated by choosing the appropriate radical initiator. More hydrophobic initiators resulted in narrower molecular weight distributions. These findings are expected to significantly expand the range of low-dispersity multiblock copolymers in aqueous emulsion via RAFT polymerization.
Article
Chemistry, Physical
Namitha Brijit Bejoy, Prahlad Roy Chowdhury, G. Naresh Patwari
Summary: The release of NO upon photodissociation of nitroaromatic compounds is influenced by the interaction between the NO2 group and substituent in the ortho position. Two distinct NO elimination channels are observed with a bimodal translational energy distribution of the NO photofragment. The hydrogen bonding ability of the ortho substituent regulates the ratio of slow-to-fast branching for NO release, with OH and NH2 favoring the roaming mechanism.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Carl C. L. Schuurmans, Arwin J. Brouwer, Jacobus A. W. Jong, Geert-Jan P. H. Boons, Wim E. Hennink, Tina Vermonden
Summary: This study investigates the hydrolytic stability of chondroitin sulfate (CS) and hyaluronic acid (HA) methacrylate (MA) hydrogels. It was found that hydrogels made with glycidyl methacrylate-derivatized CS (CSGMA) degraded in a pH-dependent manner, while HA methacrylate (HAMA) hydrogels remained stable. The absence of hydrogen bonds in CS(G)MA may lead to higher chain flexibility and hydration, increasing its sensitivity to ester hydrolysis.
Article
Multidisciplinary Sciences
Theodore Tyrikos-Ergas, Soeun Gim, Jhih-Yi Huang, Sandra Pinzon Martin, Daniel Varon Silva, Peter H. Seeberger, Martina Delbianco
Summary: Polysaccharide functionalization in bacterial biofilms alters their properties, and can be tuned using synthetic oligosaccharides. The study establishes a model system to explore the role of polysaccharides in biofilm-inspired assemblies.
NATURE COMMUNICATIONS
(2022)
Article
Polymer Science
Steffen M. Weidner, Andreas Meyer, Jana Falkenhagen, Hans R. Kricheldorf
Summary: This study investigated the polycondensation of ethyl l-lactate (ELA) using seven different tin catalysts and other compounds. The results showed successful synthesis of polylactide (PLA) and revealed the formation of polycondensation and cyclic structures through loops on the surface of crystallites in the solid state.
Article
Polymer Science
Quan V Vo, Le Thi Ngoc Van, Nguyen Thi Hoa, Adam Mechler
Summary: Iminostilbene is commonly used as a polymerization inhibitor to halt radical polymerization reactions and is known for its antioxidant properties. Computational methods were used to evaluate its antiradical activity against various radicals, with results showing effective scavenging activity in gas phase and in a benzene environment.
POLYMER DEGRADATION AND STABILITY
(2021)
Article
Chemistry, Multidisciplinary
Zhipeng Pei, Nicholas L. Magann, Madison J. Sowden, Rhys B. Murphy, Michael G. Gardiner, Michael S. Sherburn, Michelle L. Coote
Summary: The ground-state structure of p-QDM is typically represented as a closed shell cyclic compound, but it has been proposed to have an open shell aromatic singlet diradical form as well. Calculations reveal a 29% open-shell contribution to the structure, and dimerization occurs through a low barrier singlet diradical pathway. In contrast, TCNQ, despite having similar diradical character, shows no dimerization or reactivity with TEMPO.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Benfa Chu, Shuqi Jia, Tielei Li, Jin Zhu
Summary: A Rh(iii)-catalyzed hydrazine-directed C-H olefination approach was developed for the synthesis of amino-side-chained poly(phenylene vinylene) (PPV), resulting in a diverse portfolio of PPV candidates. The discovery of a significant Stokes shift, high fluorescence quantum yield, and solid-state fluorescence highlights the innovative potential of our synthetic protocol.
CHEMICAL COMMUNICATIONS
(2023)