Article
Biochemistry & Molecular Biology
Marjan Moallem, Akhi Akhter, Giovanni L. Burke, John Babu, Benjamin G. Bergey, J. Bryan McNeil, Mohammad S. Baig, Emanuel Rosonina
Summary: Numerous proteins are sumoylated in normally growing yeast and SUMO conjugation levels rise upon exposure to several stress conditions. Reduced sumoylation is well-tolerated under nonstress conditions, but strains with reduced activity of Ubc9, the sole SUMO conjugase, are temperature-sensitive, implicating sumoylation in the heat stress response. Increased sumoylation is triggered by mild heat shock which requires functional levels of Ubc9 and decreased desumoylation. A ubc9 mutant strain with low sumoylation levels shows a growth defect, abnormal distribution of RNA polymerase II, and expanded redistribution of RNAPII after heat shock.
MOLECULAR AND CELLULAR BIOLOGY
(2023)
Article
Food Science & Technology
Shao-Shuai Bi, Hai-Tao Jin, Milton Talukder, Jing Ge, Cong Zhang, Mei-Wei Lv, Mamoon Ali Yaqoob Ismail, Jin-Long Li
Summary: The study demonstrates a potential protective effect of Nano-Se against Cd-induced cerebellar injury in chickens, enhancing the expression of heat shock factors and heat shock proteins and alleviating cerebellar cell degradation caused by Cd treatment.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Nicole Wesch, Frank Loehr, Natalia Rogova, Volker Doetsch, Vladimir V. Rogov
Summary: The study focused on the biophysical and biochemical characterization of the interaction between UBA5 and UFC1 in the ufmylation cascade. It found that the unstructured C-terminal region of UBA5 is crucial for binding to UFC1 and accelerating the transfer of UFM1. The solved complex structure of UBA5 and UFC1 revealed the mechanism of interaction and emphasized the importance of the C-terminal unstructured region in UBA5 for the ufmylation cascade.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Plant Sciences
Yunzhuan Zhou, Fuxiang Xu, Yanan Shao, Junna He
Summary: As global warming intensifies, the earth's average temperature continues to rise. Plants have developed two main mechanisms, the heat stress response and the thermomorphogenesis response, to cope with elevated temperatures. This review summarizes recent progress in understanding these heat-responsive molecular regulatory pathways in plants and discusses future perspectives in this field.
Review
Plant Sciences
Fengxia Tian, Xiao-Li Hu, Tao Yao, Xiaohan Yang, Jin-Gui Chen, Meng-Zhu Lu, Jin Zhang
Summary: Global warming poses a threat to plant life, with heat shock response (HSR) playing a crucial role in protecting cellular homeostasis, especially for perennial trees. Understanding the molecular mechanisms of HSR in woody plants is essential for predicting how they will respond to climate changes.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Plant Sciences
Wan-Peng Bai, Hu-Jun Li, Shelley R. Hepworth, Hai-Shuang Liu, Lin-Bo Liu, Gai-Ni Wang, Qing Ma, Ai-Ke Bao, Suo-Min Wang
Summary: This study characterized the acclimation of Zygophyllum xanthoxylum to heat using physiological measurements and transcriptome profiling. Moderate high temperature (40℃) enhanced photosynthetic capacity and plant performance, while severe high temperature (45℃) inhibited growth. Up-regulation of genes related to heat shock factors and heat shock proteins likely contribute to thermotolerance in Z. xanthoxylum.
Review
Biotechnology & Applied Microbiology
Wei Xiao, Jinping Zhang, Jian Huang, Caiyan Xin, Mujia Ji Li, Zhangyong Song
Summary: Fungi have a series of mechanisms to adapt and respond to the changing environmental temperatures, including a thermal response system, conservative signaling pathways, transcriptional regulatory systems, physiological and biochemical processes, and phenotypic changes. However, the accurate response and regulatory mechanisms are still a challenge, and the latest research progress on the heat resistance mechanism of pathogenic fungi has not been summarized. This review discusses recent research on temperature sensing, transcriptional regulation, and physiological, biochemical, and morphological responses of fungi to heat stress, with a focus on the specific thermal adaptation mechanism of pathogenic fungi in vivo.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Plant Sciences
Quanquan Shen, Qian Chen, Yang Liu, Xiang Xue, Xiaogang Shen, Qiang He, Guokun Wang, Fei Han
Summary: Aspirin can partially alleviate vascular smooth muscle cell (VSMC) calcification by regulating the expression of heat shock protein 70 (HSP70) and heat shock protein 90 (HSP90). Blocking HSP70 or HSP90 inhibitors can partially weaken the anti-calcification effect of aspirin.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zhenyu Ma, Mingyue Li, Huaning Zhang, Baihui Zhao, Zihui Liu, Shuonan Duan, Xiangzhao Meng, Guoliang Li, Xiulin Guo
Summary: High temperature reduces crop production, especially wheat. A novel splice variant, TaHsfA2-7-AS, was induced by heat and positively regulated thermotolerance in wheat. TaHsfA2-7-AS encodes a truncated isoform and its expression is up-regulated during heat shock.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ziva Zajec, Jaka Dernovsek, Martina Gobec, Tihomir Tomasic
Summary: Hsp90 is a promising target for cancer treatment. The discovery of a novel class of Hsp90 CTD inhibitors through virtual screening provides new starting points for further development, showing enhanced antiproliferative activities in breast cancer and sarcoma cell lines.
Article
Biochemistry & Molecular Biology
Hiral M. Sanghavi, Sharmistha Majumdar
Summary: This study reveals that human THAP9 can form homo-oligomerization in the nuclei of cells, partially mediated by DNA. Mutating leucines or deleting the predicted coiled coil region does not significantly affect this oligomerization. Hcf-1, THAP1, THAP10, and THAP11 are potential protein interaction partners of THAP9.
Article
Plant Sciences
Rashpal Kumar, Arindam Adhikary, Rashmi Saini, Shahied Ahmed Khan, Manisha Yadav, Sanjeev Kumar
Summary: Drought priming in wheat cultivars can enhance plants' defense response against heat stress and improve yield. In this study, two wheat cultivars were subjected to moderate drought stress, which reduced membrane damage and increased antioxidative enzyme activity under subsequent heat stress. Drought priming also upregulated the expression of certain genes and altered metabolic pathways, leading to improved thermotolerance and yield.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Review
Plant Sciences
Baptiste Bourgine, Anthony Guihur
Summary: Heat stress events limit crop productivity, leading plants to accumulate heat-shock proteins (HSPs) for thermal protection. HSP chaperones play a critical role in regulating protein folding and preventing misfolded protein formation, thereby avoiding heat-induced cell death. The HSP20 family is tightly repressed at low temperatures, suggesting a costly mechanism that can become detrimental under unnecessary conditions.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Plant Sciences
Kunliang Xie, Jinliang Guo, Shaoyu Wang, Wenjie Ye, Fengli Sun, Chao Zhang, Yajun Xi
Summary: This study identified the Hsf family in switchgrass and revealed its functional role in heat stress signal transduction and heat tolerance. PvHsf03 and PvHsf25 were found to play critical roles in the early and late stages of switchgrass response to heat stress, respectively, while HsfB mainly showed a negative response to heat stress. Additionally, ectopic expression of PvHsf03 significantly increased the heat resistance of Arabidopsis seedlings. This research provides a notable foundation for studying the regulatory network in response to deleterious environments and for further excavating tolerance genes in switchgrass.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Plant Sciences
Adity Majee, Diksha Kumari, Vidhu A. Sane, Rajesh Kumar Singh
Summary: The thermotolerant ability of heat shock factors (HSFs) and heat shock proteins (HSPs) in plants has been studied, with recent focus on their function in non-stress plant growth and development. Their involvement in flowering has been suggested, as lower levels of HSFs/HSPs affect flowering in Arabidopsis. Genetic and molecular studies of Arabidopsis mutants have identified an association between HSFs/HSPs and temperature-mediated regulation of flowering, but the underlying genetic mechanism remains unclear. This article outlines the possible integration between HSFs/HSPs and temperature-dependent pathways in plants regulating flowering, and discusses similar pathways in thermoperiodic geophytic plants.
