Article
Chemistry, Multidisciplinary
Xiaotang Chu, Fangping Yang, Haoyu Tang
Summary: This review provides an overview of recent advancements in antibacterial polymer coatings for combating bacterial adhesion and biofilm formation on implantable devices. The mechanisms of bacterial adhesion and biofilm formation are summarized, guiding the design of antibacterial coatings. The structure-property relationships of these coatings are discussed, along with their applications in various medical devices. The future challenges and prospects of antibacterial polymer coatings are also addressed.
CHINESE JOURNAL OF CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Frida Wilske, Paul Skorup, Katja Hanslin, Helena Janols, Anders Larsson, Miklos Lipcsey, Jan Sjolin
Summary: Early secondary sepsis (ESS), occurring after recent inflammatory activation, is associated with a reduced inflammatory response. This study aimed to investigate whether this attenuation also leads to decreased bacterial killing and a greater need for antibiotic efficacy compared to primary sepsis (PS). The results showed that attenuated inflammation in ESS is associated with enhanced antibacterial capacities in the spleen, and the blood bacterial count is related to splenic killing in ESS and blood bactericidal capacity in PS. These findings suggest that there is no increased need for synergistic antibiotic combinations in ESS.
SCIENTIFIC REPORTS
(2023)
Review
Infectious Diseases
Klaus Brandenburg, Andra B. Schromm, Guenther Weindl, Lena Heinbockel, Wilmar Correa, Karl Mauss, Guillermo Martinez de Tejada, Patrick Garidel
Summary: This article highlights the challenges posed by Gram-negative bacterial infections due to increasing multi-resistance against traditional antibiotics and lack of new antimicrobials. It discusses existing therapeutic options and newer approaches for targeting and neutralizing endotoxins through in vitro, in vivo, and clinical studies, emphasizing the importance of addressing LPS neutralization in addition to bactericidal actions for effective treatment.
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
(2021)
Review
Immunology
Diana Ivonne Duarte-Mata, Mario Cesar Salinas-Carmona
Summary: Intracellular bacteria cause difficult-to-resolve infections, and standard therapy antibiotics are often ineffective due to poor cellular uptake. Antimicrobial peptides (AMPs) show promise as a therapeutic approach because of their bactericidal properties and ability to modulate immune responses. This review focuses on AMPs used to treat intracellular bacterial infections and their impact on immune mechanisms.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Peng Tan, Qi Tang, Shenrui Xu, Yucheng Zhang, Huiyang Fu, Xi Ma
Summary: In this study, self-assembling chimeric peptide nanoparticles with excellent stability have been constructed and applied to the treatment of bacterial infections. These nanoparticles show broad-spectrum antibacterial activity, desirable biocompatibility, and resistance to degradation. They can alleviate systemic bacterial infections with negligible toxicity, and their mechanism differs from antibiotics, reducing the risk of drug resistance.
Review
Biochemistry & Molecular Biology
Mahdi Asghari Ozma, Ehsaneh Khodadadi, Mohammad Ahangarzadeh Rezaee, Mohammad Asgharzadeh, Mohammad Aghazadeh, Elham Zeinalzadeh, Khudaverdi Ganbarov, Hossein Samadi Kafil
Summary: Bacteria build their structures using macromolecules such as proteins, polysaccharides, phospholipids, and nucleic acids, which are vital for their survival and pathogenesis. Genomic and proteomic methods are used to study these macromolecules, providing comprehensive information. These methods allow for the identification of proteins, analysis of bacterial structures and functions, and understanding of mechanisms underlying bacterial pathogenesis.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2022)
Article
Chemistry, Medicinal
Nauman Nazeer, Juan Carlos Rodriguez-Lecompte, Marya Ahmed
Summary: This study focuses on the design and development of disulfide bridge-linked antimicrobial peptides using Angiogenin 4 (chAng4) as a template. The results demonstrate that the synthetic mCA4 peptides show superior antibacterial efficacies, are non-toxic and non-hemolytic, and can mediate bacterial flocculation and killing without external stimuli.
Article
Fisheries
Qiang Wang, Zhonghe Sun, Shangshang Ma, Xiaoyong Liu, Hengchuan Xia, Keping Chen
Summary: This article summarizes the current research status of the antibacterial mechanism of silkworms, including infection routes, antibacterial mechanisms, and intestinal bacterial infections. Silkworms, as a model organism, contribute to the study of bacterial infectious diseases and the screening of antibacterial drugs.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Guihong Sun, Shanshan Jia, Xiaoyan Zhang, Zewen Kang, Malin Cui, Bingqing Wang, Bo Wang, Da-Peng Yang
Summary: Carbon-based nanomaterials have unique physicochemical properties and relatively higher biosafety, attracting much worldwide attention. This study successfully prepared carbon nanosheets decorated with core-shell Cu@Cu2O nanoparticles using a hydrothermal method, showing excellent antibacterial performance against E. coli and S. aureus. The study sheds light on the antibacterial mechanism of carbon-based nanomaterials, providing a simple strategy for preparing carbon-based antibacterial agents.
ACS APPLIED NANO MATERIALS
(2021)
Review
Biochemistry & Molecular Biology
Anupam Patra, Jhilik Das, Nupur Rani Agrawal, Gajraj Singh Kushwaha, Mrinmoy Ghosh, Young-Ok Son
Summary: Biofilms are assemblages of microorganisms enclosed in a composite extracellular polymeric matrix, causing biological fouling in various industries. Antimicrobial peptides (AMPs) have emerged as promising contenders to disrupt biofilms, offering broad-spectrum action and lack of antibiotic resistance. AMPs derived from marine sources may serve as natural inhibitors to bacterial proliferation and biofouling.
Review
Pharmacology & Pharmacy
Jiaqi Xuan, Weiguo Feng, Jiaye Wang, Ruichen Wang, Bowen Zhang, Letao Bo, Zhe-Sheng Chen, Hui Yang, Leming Sun
Summary: The long-term use of antibiotics leading to drug resistance has become a major concern. As the problem worsens, infections caused by multiple bacteria are increasing rapidly and posing serious threats to human health. Antimicrobial peptides (AMPs) offer a promising alternative to traditional antibiotics as they exhibit strong antimicrobial activity and unique mechanisms against drug-resistant bacterial infections. Current research on AMPs focuses on integrating new technologies, such as modifying the amino acid structure and exploring different delivery methods. This article provides valuable insights into the properties, mechanisms, and advancements of AMPs in combating drug-resistant bacterial infections.
DRUG RESISTANCE UPDATES
(2023)
Article
Acoustics
Pei-Yao Xu, Ranjith Kumar Kankala, Shi-Bin Wang, Ai-Zheng Chen
Summary: The rapid spread and uncontrollable evolution of antibiotic-resistant bacteria have become a global concern in the treatment of bacterial infections. Sonodynamic therapy, a noninvasive and effective therapeutic strategy using sonosensitizer and ultrasound, offers a new approach to combat antibiotic-resistant bacteria and biofilms. Researchers are designing sonosensitizer-loaded nanoplatforms with high SDT efficiency.
ULTRASONICS SONOCHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Tongyu Shi, Yuanyuan Cui, Huanxiang Yuan, Ruilian Qi, Yu Yu
Summary: This review summarizes the latest progress in antibacterial single-atom nanozymes (SAzymes), focusing on their action mechanism in wound disinfection, osteomyelitis treatment, and marine antibiofouling. It also discusses the challenges and future perspectives of SAzymes for practical antibacterial applications.
Article
Chemistry, Physical
Anju Tyagi, Abhijit Mishra
Summary: The synthesized amphiphilic water-soluble cationic copolymers showed significant antibacterial activity against S. aureus and E. coli, with AB-10 and AB-19 demonstrating the highest efficacy without inducing hemolysis. Observations suggest that these polymers primarily kill bacterial cells by disrupting the cytoplasmic membrane, and no resistant mutants of E. coli and S. aureus were obtained with AB-19 in a 30 day serial passage study.
Article
Dermatology
Ram P. Sahu, Chandan Goswami
Summary: This study demonstrates that the activation of TRPV3 by an endogenous ligand enhances wound healing and bacterial clearance in the skin. The researchers discovered that TRPV3 is expressed in macrophages and present in lysosomes and nucleoli. The study suggests that TRPV3 acts as a regulator and sensor for cellular stress.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Deepti S. Lele, Gagandeep Kaur, Menithalaxmi Thiruvikraman, Kanwal J. Kaur
GLYCOCONJUGATE JOURNAL
(2017)
Article
Food Science & Technology
Danielle R. Balay, Ramana V. Dangeti, Kamaljit Kaur, Lynn M. McMullen
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Pidathala R. V. Shabareesh, Ashish Kumar, Dinakar M. Salunke, Kanwal J. Kaur
JOURNAL OF PEPTIDE SCIENCE
(2017)
Article
Engineering, Electrical & Electronic
Jing Xie, Juan Carlos Bedoya, Chen-Ching Liu, Adam Hahn, Kudrat Jot Kaur, Rajveer Singh
IEEE TRANSACTIONS ON POWER SYSTEMS
(2018)
Article
Biochemistry & Molecular Biology
Deepali Verma, Sunita Gupta, Kanwal J. Kaur, Vibha Gupta
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2018)
Article
Pharmacology & Pharmacy
Hoda Soleymani Abyaneh, Amir Hassan Soleimani, Mohammad Reza Vakili, Rania Soudy, Kamaljit Kaur, Francesco Cuda, Ali Tavassoli, Afsaneh Lavasanifar
Proceedings Paper
Engineering, Electrical & Electronic
Kanwalinderjit Gagneja, Riley Kiefer
2020 SIXTH INTERNATIONAL CONFERENCE ON MOBILE AND SECURE SERVICES (MOBISECSERV))
(2020)
Proceedings Paper
Computer Science, Information Systems
Austin Sasko, Trevor Hillsgrove, Kanwalinderjit Gagneja, Udita Katugampola
FUTURE NETWORK SYSTEMS AND SECURITY, FNSS 2019
(2019)
Proceedings Paper
Engineering, Electrical & Electronic
Alexandro Riuz, Carloas Machdo, Kanwalinderjit Gagneja, Navninderjit Singh
2019 6TH INTERNATIONAL CONFERENCE ON SIGNAL PROCESSING AND INTEGRATED NETWORKS (SPIN)
(2019)
Proceedings Paper
Engineering, Electrical & Electronic
Keely Hill, Kanwalinderjit Kaur Gagneja, Navninderjit Singh
2019 6TH INTERNATIONAL CONFERENCE ON SIGNAL PROCESSING AND INTEGRATED NETWORKS (SPIN)
(2019)
Proceedings Paper
Engineering, Electrical & Electronic
Shawn Godwin, Brett Glendenning, Kanwalinderjit Gagneja
PROCEEDINGS OF THE 2019 FIFTH INTERNATIONAL CONFERENCE ON MOBILE AND SECURE SERVICES (MOBISECSERV)
(2019)
Proceedings Paper
Engineering, Electrical & Electronic
Keely Hill, Kanwalinderjit Gagneja
PROCEEDINGS OF THE 2018 FOURTH INTERNATIONAL CONFERENCE ON MOBILE AND SECURE SERVICES (MOBISECSERV)
(2018)
Proceedings Paper
Automation & Control Systems
Caleb Riggs, Tanner Douglas, Kanwalinderjit Gagneja
2018 THIRD INTERNATIONAL CONFERENCE ON SECURITY OF SMART CITIES, INDUSTRIAL CONTROL SYSTEM AND COMMUNICATIONS (SSIC)
(2018)
Proceedings Paper
Computer Science, Hardware & Architecture
Javier Campos, Slater Colteryahn, Kanwalinderjit Gagneja
2018 INTERNATIONAL CONFERENCE ON COMPUTING, NETWORKING AND COMMUNICATIONS (ICNC)
(2018)
Proceedings Paper
Computer Science, Information Systems
Kanwalinderjit Gagneja, Luis G. Jaimes
FUTURE NETWORK SYSTEMS AND SECURITY, FNSS 2017
(2017)