Article
Oncology
Elahe Minaei, Simon A. Mueller, Bruce Ashford, Amarinder Singh Thind, Jenny Mitchell, Jay R. Perry, Benjamin Genenger, Jonathan R. Clark, Ruta Gupta, Marie Ranson
Summary: This study conducted gene expression and pathway analysis on primary and metastatic tumors of cutaneous squamous cell carcinoma (cSCC) in the head and neck region, as well as cognate lymph node metastases and matched sun-exposed skin. The analysis revealed the involvement of various genes and pathways in promoting matrix remodeling, cell survival and migration, and epithelial to mesenchymal transition in metastatic tumors. The overexpression of urokinase plasminogen activator receptor (uPAR) was validated and suggested as an important driver of metastasis in cSCC, making it a potential therapeutic target.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Liang Wang, Xite Lin, Pengming Sun
Summary: This review summarizes the function, signaling pathways, and targeted therapeutic strategies of uPAR in cancer, particularly focusing on immunotherapy targeting uPAR. It also objectively evaluates the value of this classic molecular pathway for future study, considering its differential roles in non-cancer and cancer tissues.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiuju Li, Benjamin Buckley, Konstantin Stoletov, Yang Jing, Marie Ranson, John D. Lewis, Mike Kelso, Larry Fliegel
Summary: This study examined the role of NHE1 and uPA in prostate cancer cell migration and colony formation, finding that only uPA activity played a critical role in cell migration and colony formation, while the effect of NHE1 was minor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Ashna A. Kumar, Benjamin J. Buckley, Marie Ranson
Summary: This review provides an overview of the role of the urokinase plasminogen activation system (uPAS) in pancreatic cancer, with a focus on pancreatic ductal adenocarcinoma (PDAC), and summarizes the substantial evidence supporting the role of uPAS components in this disease. The review further outlines the potential clinical utility of uPAS components as diagnostic and prognostic biomarkers for PDAC, as well as the rationale for developing novel uPAS-targeted therapeutics.
Article
Cell Biology
Ke-Fan Pan, Yu-Cheng Liu, Michael Hsiao, Tsu-Yao Cheng, Kuo-Tai Hua
Summary: Naa10p plays an oncogenic role in promoting esophageal cancer metastasis, with higher expression correlating with poorer patient survival. Transcription of NAA10 is regulated by the critical oncogene c-Myc. The enzymatic activity of Naa10p, along with Naa15p, inhibits the secretion of the protease inhibitor PAI1. These findings establish the significance of Naa10p in driving metastasis in esophageal cancer, suggesting its potential use as a prognostic biomarker and therapeutic target.
CELL DEATH & DISEASE
(2022)
Review
Engineering, Biomedical
Lara S. Costard, Ryan R. Hosn, Harumi Ramanayake, Fergal J. O'Brien, Caroline M. Curtin
Summary: The majority of in vitro cancer research studies are conducted in 2D and subsequently validated in animal models, but both models have limitations. The proposed solution to address these discrepancies is the use of 3D culture models, which have been shown to exhibit changes in cell behavior compared to 2D models. These changes include proliferation, gene expression, and chemosensitivity, and can provide better comparability to in vivo cells.
ACTA BIOMATERIALIA
(2021)
Review
Oncology
Carole Luthold, Tarek Hallal, David P. Labbe, Francois Bordeleau
Summary: Prostate cancer affects a large number of men worldwide. Understanding the mechanisms of disease progression and therapy resistance is crucial for developing effective treatments. Alterations in the extracellular matrix, particularly stiffening, play a role in prostate cancer progression. This review examines the association between extracellular matrix stiffening and disease progression and castration resistance in prostate cancer.
Review
Oncology
Zoi Piperigkou, Konstantina Kyriakopoulou, Christos Koutsakis, Stylianos Mastronikolis, Nikos K. Karamanos
Summary: Proteolytic enzymes and non-proteolytic enzymatic partners play crucial roles in cancer cell propagation and metastatic potential. This article revisits the functions of major matrix remodeling molecules and discusses their epigenetic regulation mechanisms, pharmacological targeting, and ongoing clinical trials. The importance of targeting matrix remodeling partners for cancer management is explored in relation to tissue homeostasis and ECM turnover.
Article
Biochemistry & Molecular Biology
Asif Amin, Asif Lone, Faizah Farooq, Umer Majeed Wani, Fizallah Kawoosa, Raies A. A. Qadri
Summary: The interaction between Tetranectin and plasminogen is crucial for extracellular matrix degradation, enabling tumor cell invasion and metastasis. This study aimed to target the carbohydrate recognition domain (CRD) of Tetranectin using natural bioactive compounds to inhibit its interaction with the Kringle-4 domain of plasminogen. Diosgenin and scytonemin exhibited favorable interactions with CRD, but diosgenin showed increased stability in the CRD binding pocket compared to scytonemin. Diosgenin was found to exert a pronounced anti-proliferative effect on breast cancer cells and reduce their migration and invasiveness.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Pharmacology & Pharmacy
Qiushuang Wu, Pengchen Chen, Junnan Li, Ziqi Lin, Qingwen Zhang, Hang Fai Kwok
Summary: The use of immune checkpoint inhibitors and FGFR protein tyrosine kinase inhibitors has had a significant impact on bladder cancer therapy. However, drug resistance and inadequate responses to treatment remain challenges. Repurposing FDA-approved drugs and novel drug discovery strategies offer potential solutions.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Oncology
Juening Kang, Federico La Manna, Francesco Bonollo, Natalie Sampson, Ian L. Alberts, Clemens Mingels, Ali Afshar-Oromieh, George N. Thalmann, Sofia Karkampouna
Summary: During the progression of prostate cancer, particularly in bone metastases, the tumor microenvironment (TME) undergoes changes that support tumor spread and colonization at distant sites. This article discusses the profile of advanced metastatic prostate cancer and genetic alterations. It also explores the role of the TME, particularly the extracellular matrix and fibroblast cells, in different stages of metastatic spread and bone metastasis. Evidence of premetastatic niche formation, stromal similarities between primary prostate cancer and bone metastasis, and the contribution of the TME to androgen deprivation therapy resistance are presented. The article also provides an overview of transgenic mouse models for studying bone metastasis and current diagnostic and therapeutic strategies.
Review
Endocrinology & Metabolism
Prerna R. Nepali, Natasha Kyprianou
Summary: Prostate cancer is a common malignancy in males, and finding new therapeutic interventions is urgent due to high treatment resistance and mortality rates. Anoikis, a phenomenon where cells lose their attachment to the extracellular matrix (ECM), plays a role in tumor cell survival and metastatic progression. This review discusses recent advances in understanding the signaling effectors of anoikis in prostate cancer and how to translate this knowledge into therapeutic benefits.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Hematology
Marc V. A. van Moorsel, Steven de Maat, Kristof Vercruysse, Esther M. van Leeuwen, Charlene Jacqmarcq, Thomas Bonnard, Denis Vivien, H. Bart van der Worp, Rick M. Dijkhuizen, Coen Maas
Summary: Recombinant human tissue plasminogen activator (rh-tPA) and Microlyse are both important thrombolytic agents for the treatment of acute ischemic stroke, but they have different mechanisms. rh-tPA activates plasminogen by binding to fibrin, while Microlyse activates plasminogen by binding to von Willebrand factor (VWF). The study results show that both thrombolytic agents can increase cortical reperfusion and reduce cerebral lesion volume in different types of thrombus models. However, only Microlyse can reduce cerebral lesion volume in the platelet-rich model.
Review
Medicine, Research & Experimental
Tong-Yao Yu, Ge Zhang, Xiao-Xia Chai, Li Ren, Da-Chuan Yin, Chen-Yan Zhang
Summary: This review discusses the biological effects of extracellular matrix (ECM) in breast cancer metastasis and drug resistance, as well as the influence of ECM stiffness on these processes. The article provides an overview of relative signal transduction mechanisms, metastasis models, and targeted drug strategies centered around ECM stiffness, shedding light on the exploration and development of breast cancer treatment.
Review
Oncology
Kellen Wright, Thuc Ly, Matthew Kriet, Andras Czirok, Sufi Mary Thomas
Summary: Cancer cells rely on the tumor microenvironment (TME) for growth and metastasis. Among the components of TME, cancer-associated fibroblasts (CAFs) play a crucial role. CAFs are heterogeneous and can remodel the microenvironment, as well as communicate with immune cells to aid in immune evasion. This review focuses on the factors and signaling pathways of CAFs.
Article
Immunology
Philip A. Arlen, Michael Singleton, Jeffrey J. Adamovicz, Yi Ding, Abdolreza Davoodi-Semiromi, Henry Daniell
INFECTION AND IMMUNITY
(2008)
Review
Oncology
Rafael A. Madero-Visbal, Jimmie F. Colon, Ingrid C. Hernandez, Arati Limaye, Joshua Smith, Christopher M. Lee, Philip A. Arlen, Luis Herrera, Cheryl H. Baker
SURGICAL ONCOLOGY-OXFORD
(2012)
Article
Biotechnology & Applied Microbiology
Philip A. Arlen, Regina Falconer, Sri Cherukumilli, Amy Cole, Alexander M. Cole, Karen K. Oishi, Henry Daniell
PLANT BIOTECHNOLOGY JOURNAL
(2007)
Article
Virology
PA Arlen, DG Brooks, LY Gao, D Vatakis, HJ Brown, JA Zack
JOURNAL OF VIROLOGY
(2006)
Article
Multidisciplinary Sciences
DG Brooks, PA Arlen, LY Gao, CMR Kitchen, JA Zack
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2003)
Article
Immunology
DG Brooks, DH Hamer, PA Arlen, LY Gao, G Bristol, CMR Kitchen, EA Berger, JA Zack