Evolution of a new function in an esterase: simple amino acid substitutions enable the activity present in the larger paralog, BioH

Synthesis of the α,ω-dicarboxylic acid precursor of biotin by the canonical fatty acid biosynthetic pathway

(2011) John E Cronan et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Evolutionary Walk between (β/α)8 Barrels: Catalytic Migration from Triosephosphate Isomerase to Thiamin Phosphate Synthase

(2011) Gloria Saab-Rincón et al.   JOURNAL OF MOLECULAR BIOLOGY

Closing in on complete pathways of biotin biosynthesis

(2011) Steven Lin et al.   Molecular BioSystems

Enzyme Promiscuity: A Mechanistic and Evolutionary Perspective

(2010) Olga Khersonsky and Dan S. Tawfik   Annual Review of Biochemistry

Insights into the fatty acid chain length specificity of the carboxylesterase PA3859 from Pseudomonas aeruginosa: A combined structural, biochemical and computational study

(2010) Alessandro Pesaresi et al.   BIOCHIMIE

The α/β-Hydrolase Fold 3DM Database (ABHDB) as a Tool for Protein Engineering

(2010) Robert Kourist et al.   CHEMBIOCHEM

Biosynthesis of Rhizocticins, Antifungal Phosphonate Oligopeptides Produced by Bacillus subtilis ATCC6633

(2010) Svetlana A. Borisova et al.   CHEMISTRY & BIOLOGY

Biotin synthesis begins by hijacking the fatty acid synthetic pathway

(2010) Steven Lin et al.   Nature Chemical Biology

Mutational effects and the evolution of new protein functions

(2010) Misha Soskine et al.   NATURE REVIEWS GENETICS

Morphing Activity between Structurally Similar Enzymes: From Heme-Free Bromoperoxidase to Lipase

(2009) Bo Chen et al.   BIOCHEMISTRY

Protein Design through Systematic Catalytic Loop Exchange in the (β/α)8 Fold

(2009) Adrián Ochoa-Leyva et al.   JOURNAL OF MOLECULAR BIOLOGY

α/βHydrolase Fold: An Update

(2009) David L. Ollis et al.   PROTEIN AND PEPTIDE LETTERS

Loop Grafting of Bacillus subtilis Lipase A: Inversion of Enantioselectivity

(2008) Ykelien L. Boersma et al.   CHEMISTRY & BIOLOGY

Sensitive Genome-Wide Screen for Low Secondary Enzymatic Activities: The YjbQ Family Shows Thiamin Phosphate Synthase Activity

(2008) Enrique Morett et al.   JOURNAL OF MOLECULAR BIOLOGY

A Study in Molecular Contingency: Glutamine Phosphoribosylpyrophosphate Amidotransferase is a Promiscuous and Evolvable Phosphoribosylanthranilate Isomerase

(2008) Wayne M. Patrick et al.   JOURNAL OF MOLECULAR BIOLOGY