Article
Medicine, Research & Experimental
Matthew Weichseldorfer, Yutaka Tagaya, Marvin Reitz, Anthony L. DeVico, Olga S. Latinovic
Summary: This study aims to understand the different conformations of CCR5 involved in HIV entry and identify the specific CCR5 populations that are best targeted to inhibit HIV-1 entry. Through quantification and visualization, it was found that a decreased surface presence of certain CCR5 subpopulations after infection represents a highly relevant target for future antiviral therapy strategies. The findings will contribute to the development of inhibitors to block CCR5 usage by HIV-1 and inform future HIV-1 vaccine design.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Genetics & Heredity
Dalin Su, Yanhong Ai, Guoyong Zhu, Yubiao Yang, Pengyi Ma
Summary: In this two-sample Mendelian randomization (MR) study, we confirmed a causal relationship between circulating levels of inflammatory factors and osteoarthritis risk. We used genetic variants associated with cytokine circulation levels as instrumental variables and obtained data from the United Kingdom Biobank. Through various analyses, we found causal associations between macrophage inflammatory protein-1beta (MIP-1 beta), tumour necrosis factor beta (TNF-beta), and osteoarthritis risk, as well as a suggestive association between C-C motif chemokine ligand 5(CCL5) and osteoarthritis risk. These findings have implications for the development of new therapeutic targets in osteoarthritis.
FRONTIERS IN GENETICS
(2023)
Article
Microbiology
Yueqi Du, Ellen Wu, Xiang Gao, Jie Zhang, John C. Martin, Bruce A. Rosa, Makedonka Mitreva, Lee Ratner
Summary: This study provides a deeper understanding of the viral genetic determinants of coreceptor shift by combining single-genome sequence analysis and next-generation sequencing. It highlights the importance of low-frequency mutants in the development of drug resistance and the role of specific amino acid substitutions outside the V3 region. Additionally, it emphasizes the significance of residues in the V1/V2, V4, C3, and C4 domains in coreceptor shift.
MICROBIOLOGY SPECTRUM
(2022)
Article
Biochemistry & Molecular Biology
Anju Krishnan Anitha, Pratibha Narayanan, Neethu Ajayakumar, Krishnankutty Chandrika Sivakumar, Kesavakurup Santhosh Kumar
Summary: This study designed and generated peptide ligands targeting CCR5, which showed significant CCR5 specificity and did not mediate migration of responsive cells.
JOURNAL OF BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Pooja Singh, Vikas Kumar, Gihwan Lee, Tae Sung Jung, Min Woo Ha, Jong Chan Hong, Keun Woo Lee
Summary: This study utilized a ligand-based pharmacophore model to identify potential CCR5 inhibitors and investigated their binding mechanism through computational methods. The findings suggested that Hit1 and Hit2 may be potential candidates for CCR5 inhibition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Virology
Farzaneh Ghasabi, Ava Hashempour, Nastaran Khodadad, Shokufeh Akbarinia, Mohammadreza Heydari, Zohre Foroozanfar
Summary: The HIV-V3 sequence plays a role in determining the tropism of HIV, but no consistent sequence can explain the tropism of R5 or X4 virus. This study found that R5 tropic viruses were predominant in the samples studied, but X4 tropism may increase the risk of treatment failure. There was good agreement between the DNA/RNA tropism results.
Article
Virology
Marta Colomer-Lluch, Athina Kilpelainen, Maria Pernas, Ruth Pena, Dan Ouchi, Esther Jimenez-Moyano, Judith Dalmau, Concepcion Casado, Cecilio Lopez-Galindez, Bonaventura Clotet, Javier Martinez-Picado, Julia G. Prado
Summary: This study identified for the first time the loss of CD4(+) T-cell homeostasis (LoH) in two viremic nonprogressors (VNPs) after more than 13 years. The findings suggest that HIV-1 evolution toward highly pathogenic CXCR4 strains may be a potential driver of LoH in VNPs.
JOURNAL OF VIROLOGY
(2022)
Article
Multidisciplinary Sciences
Sijia He, Jia Guo, Yajing Fu, Mark Spear, Chaolong Qin, Shuai Fu, Zongqiang Cui, Wenwen Jin, Xuehua Xu, Wanjun Chen, Hong Shang, Yuntao Wu
Summary: CD2 is identified as a novel target for blocking HIV-1 infection of blood resting T cells. CD2 binding initiates competitive signaling leading to cofilin activation and localized actin polymerization, spatially inhibiting HIV-1-initiated local actin polymerization required for viral nuclear migration.
Review
Biotechnology & Applied Microbiology
Andrew J. Atkins, Alexander G. Allen, Will Dampier, Elias K. Haddad, Michael R. Nonnemacher, Brian Wigdahl
Summary: CRISPR/Cas9 proviral targeting stands out among HIV-1 cure strategies by directly addressing the integrated provirus without requiring an immune response. Each discussed strategy in this review has shown potential for curative or adjuvant therapy, but CRISPR/Cas9 uniquely targets the root of the problem, integrated proviral DNA, with the ability to permanently eliminate or deactivate the source of HIV-1 resurgence.
EXPERT OPINION ON BIOLOGICAL THERAPY
(2021)
Article
Immunology
Barbara Weiser, Binshan Shi, Kimdar Kemal, Harold Burger, Howard Minkoff, Qiuhu Shi, Wei Gao, Esther Robison, Susan Holman, Tamara Schroeder, Alissa Gormley, Kathryn Anastos, Christina Ramirez
Summary: Long-term combination antiretroviral therapy (cART) greatly reduces the detrimental effects of X4-tropic HIV-1 on AIDS morbidity and mortality. Duration of viral suppression through at least 10 semiannual cART visits mitigates the harmful effect of X4-tropic strains.
Article
Virology
Lok Yan Yim, Ka Shing Lam, Tsz-Yat Luk, Yufei Mo, Xiaofan Lu, Jinlin Wang, Ka-Wai Cheung, Grace Chung Yan Lui, Denise Pui Chung Chan, Bonnie Chun Kwan Wong, Thomas Tsz-Kan Lau, Chiu Bong Ngan, Dongyan Zhou, Yik Chun Wong, Zhiwu Tan, Li Liu, Hao Wu, Tong Zhang, Shui Shan Lee, Zhiwei Chen
Summary: The study reveals that plasma transforming growth factor beta (TGF-beta) is elevated during acute HIV-1 infection in men who have sex with men (MSM). TGF-beta signaling plays a crucial role in mediating HIV-1 infection of activated and resting memory CD4(+) T cells by upregulating the HIV-1 coreceptor CCR5. TGF-beta also increases CCR7 and CXCR3 expression on memory CD4(+) T cells, potentially promoting viral infection and latency establishment.
JOURNAL OF VIROLOGY
(2023)
Article
Infectious Diseases
Yuting Tan, Shi Zou, Wei Guo, Yanni Xiang, Yu Dong, Qi Zhu, Songjie Wu, Mingqi Luo, Ling Shen, Ke Liang
Summary: The frequency of peripheral TCR alpha beta(+) DNT cells is increased in HIV/TB co-infection, and reduced apoptosis may contribute to this increase. TCR alpha beta(+) DNT cells may play a cytotoxic T cells-like function in HIV/TB co-infection.
BMC INFECTIOUS DISEASES
(2022)
Article
Neurosciences
Biju Bhargavan, Shawna M. Woollard, Jo Ellyn McMillan, Georgette D. Kanmogne
Summary: The study revealed that HIV-1 infection in humanized mice led to a decrease in human CD4+ T cells, alterations in BBB TJ proteins, increased HLA-DR+ cells in brain tissues, and elevated levels of Aβ-42 and phospho-Tau. However, treatment with maraviroc significantly reduced viral loads, preserved BBB integrity and neuronal markers, and decreased Aβ-42 accumulation.
MOLECULAR NEURODEGENERATION
(2021)
Article
Biochemical Research Methods
George Khelashvili, Kevin Dorff, Jufang Shan, Marta Camacho-Artacho, Lucy Skrabanek, Bas Vroling, Michel Bouvier, Lakshmi A. Devi, Susan R. George, Jonathan A. Javitch, Martin J. Lohse, Graeme Milligan, Richard R. Neubig, Krzysztof Palczewski, Marc Parmentier, Jean-Philippe Pin, Gerrit Vriend, Fabien Campagne, Marta Filizola
Article
Hematology
Sofie Struyf, Laura Salogni, Marie D. Burdick, Jo Vandercappellen, Mieke Gouwy, Sam Noppen, Paul Proost, Ghislain Opdenakker, Marc Parmentier, Craig Gerard, Silvano Sozzani, Robert M. Strieter, Jo Van Damme
Review
Biochemistry & Molecular Biology
Benjamin Bondue, Valerie Wittamer, Marc Parmentier
CYTOKINE & GROWTH FACTOR REVIEWS
(2011)
Article
Biochemistry & Molecular Biology
Denis Sohy, Hideaki Yano, Patricia de Nadai, Eneko Urizar, Aude Guillabert, Jonathan A. Javitch, Marc Parmentier, Jean-Yves Springael
JOURNAL OF BIOLOGICAL CHEMISTRY
(2009)
Article
Endocrinology & Metabolism
Laurie Rouger, G. Raphael Denis, Souphalone Luangsay, Marc Parmentier
JOURNAL OF ENDOCRINOLOGY
(2013)
Article
Immunology
Cristina Albanesi, Claudia Scarponi, Sabatino Pallotta, Roberta Daniele, Daniela Bosisio, Stefania Madonna, Paola Fortugno, Safiye Gonzalvo-Feo, Jean-Denis Franssen, Marc Parmentier, Ornella De Pita, Giampiero Girolomoni, Silvano Sozzani
JOURNAL OF EXPERIMENTAL MEDICINE
(2009)
Article
Immunology
Sofie Struyf, Samuel Noppen, Tamara Loos, Anneleen Mortier, Mieke Gouwy, Hannelien Verbeke, Dana Huskens, Souphalone Luangsay, Marc Parmentier, Karel Geboes, Dominique Schols, Jo Van Damme, Paul Proost
JOURNAL OF IMMUNOLOGY
(2009)
Article
Immunology
Thalie Devosse, Raphael Dutoit, Isabelle Migeotte, Patricia De Nadai, Virginie Imbault, David Communi, Isabelle Salmon, Marc Parmentier
JOURNAL OF IMMUNOLOGY
(2011)
Article
Urology & Nephrology
Giuseppe De Palma, Giuseppe Castellano, Annalisa Del Prete, Silvano Sozzani, Nicoletta Fiore, Antonia Loverre, Marc Parmentier, Loreto Gesualdo, Giuseppe Grandaliano, Francesco P. Schena
KIDNEY INTERNATIONAL
(2011)
Editorial Material
Biochemical Research Methods
Marc Parmentier
Article
Multidisciplinary Sciences
Benjamin Bondue, Olivier De Henau, Souphalone Luangsay, Thalie Devosse, Patricia de Nadai, Jean-Yves Springael, Marc Parmentier, Olivier Vosters
Article
Multidisciplinary Sciences
Cedric de Poorter, Kevin Baertsoen, Vincent Lannoy, Marc Parmentier, Jean-Yves Springael
Article
Microbiology
Benjamin Bondue, Olivier Vosters, Patricia de Nadai, Stephanie Glineur, Olivier De Henau, Souphalone Luangsay, Frederic Van Gool, David Communi, Paul De Vuyst, Daniel Desmecht, Marc Parmentier
Article
Peripheral Vascular Disease
Cyrine Ben Dhaou, Kamel Mandi, Mickael Frye, Angela Acheampong, Ayoub Radi, Benjamin De Becker, Mathieu Antoine, Nicolas Baeyens, Valerie Wittamer, Marc Parmentier
Summary: Chemerin is a multifunctional protein that inhibits tumor vascularization and promotes endothelial cell apoptosis and vessel pruning through the CMKLR1 receptor. PTEN and FOXO1 antagonists can restore retinal vascular density, suggesting the involvement of the PI3-kinase/AKT pathway in chemerin-induced vessel regression.
Article
Oncology
Francesca Sozio, Tiziana Schioppa, Mattia Laffranchi, Valentina Salvi, Nicola Tamassia, Francisco M. Bianchetto-Aguilera, Laura Tiberio, Raffaella Bonecchi, Daniela Bosisio, Marc Parmentier, Barbara Bottazzi, Roberto Leone, Eleonora Russo, Giovanni Bernardini, Stefano Garofalo, Cristina Limatola, Angela Gismondi, Giuseppe Sciume, Alberto Mantovani, Annalisa Del Prete, Silvano Sozzani
Summary: Patterns of receptors play a crucial role in regulating the homing of leukocytes. A study reveals that the CCRL2/chemerin/CMKLR1 axis acts as a selective pathway for the homing of NK cells to the lung. Inactivation of CCRL2 or its ligand chemerin promotes lung tumor growth by affecting the recruitment of NK cells, while other receptors identified in lung-infiltrating NK cells are dispensable for this process.
CANCER IMMUNOLOGY RESEARCH
(2023)