期刊
PROTEIN AND PEPTIDE LETTERS
卷 17, 期 8, 页码 979-987出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/092986610791498939
关键词
Rhabdoviridae; replication complex; phosphoprotein; nucleoprotein; intrinsically disordered regions
资金
- CNRS
- French ANR [ANR-07-001-01 (ANRAGE)]
- Lyonbiopole
Rhabdoviridae are single stranded negative sense RNA viruses. The viral RNA condensed by the nucleoprotein (N), the phosphoprotein (P) and the large subunit (L) of the RNA-dependent RNA polymerase are the viral components of the transcription/replication machineries. Both P and N contain intrinsically disordered regions (IDRs) that play different roles in the virus life cycle. Here, we describe the modular organization of P based on recent structural, biophysical and bioinformatics data. We show how flexible loops in N participate in the attachment of P to the N-RNA template by an induced-fit mechanism. Finally, we discuss the roles of IDRs in the mechanism of replication/transcription, and propose a new model for the interaction of the L subunit with its N-RNA template.
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