Review
Biochemistry & Molecular Biology
Demitria M. Vasilatis, Christopher A. Lucchesi, Paramita M. Ghosh
Summary: Dogs naturally develop prostate cancer similar to aggressive forms found in humans. Prostate cancer samples in dogs often lack androgen receptor (AR), which can enhance our understanding of AR-indifferent prostate cancer in humans. This review highlights the molecular similarities between dog and human prostate cancer variants, suggesting the potential use of dogs as pre-clinical animal models for developing new therapies and diagnostics that can benefit both species.
Article
Multidisciplinary Sciences
Sheng-Feng Lin, Hsiu-Chen Lin, Mei-Yu Lee, Joseph Jordan Keller, Li-Hsuan Wang
Summary: This study found a decreased risk of atopic diseases in patients with prostate cancer treated with GnRH analogues. Further studies are warranted to verify the association between testosterone levels and atopic diseases.
Article
Medicine, General & Internal
Di Jin, Kun Jin, Bo Chen, Xianghong Zhou, Qiming Yuan, Zilong Zhang, Qiang Wei, Shi Qiu
Summary: This study compared the efficacy of castration alone with complete androgen blockade (CAB) in localized and locally advanced prostate cancer (PCa) patients undergoing radical prostatectomy (RP). The results showed that CAB achieved better biochemical recurrence outcomes compared with medical castration alone, but there was no significant difference in survival and clinical recurrence.
CHINESE MEDICAL JOURNAL
(2022)
Editorial Material
Cell Biology
Li Xin
Summary: EZH2 has been shown to promote the development of castration-resistant prostate cancer (CRPC) by interacting with the androgen receptor (AR) to reprogram its transcriptional activity, facilitating the transition of CRPC into a lineage infidelity state.
NATURE CELL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Margherita Corti, Stefano Lorenzetti, Alessandro Ubaldi, Romano Zilli, Daniele Marcoccia
Summary: The role of endocrine disruptors in the human prostate gland is overlooked, but they can influence the homeostasis and diseases of the prostate, including prostate cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Haozhe Zhang, Yi Zhou, Zengzhen Xing, Rajiv Kumar Sah, Junqi Hu, Hailiang Hu
Summary: This review discusses the close relationship between the evolution of prostate cancer and androgen levels and the status of the androgen receptor. It also explores how alterations in androgen metabolism contribute to the resistance to anti-androgen therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
A. I. Peltomaa, P. Raittinen, K. Talala, K. Taari, T. L. J. Tammela, A. Auvinen, T. J. Murtola
Summary: Statins have been found to improve the prognosis of prostate cancer patients undergoing androgen deprivation therapy, but only when used after the initiation of ADT, not before.
PROSTATE CANCER AND PROSTATIC DISEASES
(2021)
Article
Oncology
Andrei Sergeyev, Lin Gu, Amanda M. De Hoedt, Christopher L. Amling, William J. Aronson, Matthew R. Cooperberg, Christopher J. Kane, Zachary Klaassen, Martha K. Terris, Lourdes Guerrios-Rivera, Stephen J. Freedland, Ilona Csizmadi
Summary: The study found that diabetes identified by ICD-9/10 codes was associated with better overall survival in late-stage prostate cancer patients, while the "undiagnosed" diabetes identified by high HbA1c values was associated with an increase in all-cause mortality. In addition, the duration of diabetes prior to diagnosis was inversely associated with prostate cancer-specific mortality.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Medicine, General & Internal
Stuti Khare
Summary: Dr. SKS Hair Booster Serum was found to be a safe and effective treatment for androgenetic alopecia, with significant clinical efficacy.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Oncology
Zemin Hou, Shengsong Huang, Zhenfei Li
Summary: Androgens are crucial in the development of prostate cancer, and targeting steroidogenesis and the androgen receptor has been effective in delaying disease progression. New generation androgen receptor pathway inhibitors like abiraterone and enzalutamide continue to emphasize the role of the androgen-AR axis, even in cases of resistance. The importance of this axis in managing the disease after resistance to current treatments, particularly in neuroendocrine prostate cancer, remains uncertain.
Article
Endocrinology & Metabolism
Hengqing An, Dongsheng Ma, Yujie Mei, Lulu Wang, Abudukeyoumu Maimaitiyiming, Tao Zhuo, Renaguli Aihaiti, Ke Bu, Xin Huang, Kaige Zhang, Miao Yao, Chenyang Ling, Weizun Li, Ning Tao
Summary: This study aimed to investigate the relevance of metabolic syndrome (MetS) and metabolic scores to the occurrence, progression, and prognosis of metastatic prostate cancer (mPCA). The study found that patients with mPCA combined with MetS had more aggressive tumors, lower PSA remission rates, and shorter median survival times. There was a positive correlation between metabolic score and tumor progression, suggesting that MetS may affect the prognosis of mPCA.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Wei Tan, Liang Gao, Ye Yuan, Hao Huang, Yadong Li, Yuanqing Gou, Zili Hu
Summary: Research has shown a higher occurrence of bladder cancer in men compared to women, leading researchers to investigate the role of androgen in bladder cancer. A study was conducted with 147 patients diagnosed with primary bladder cancer and 154 non-tumor patients as the control group. The results revealed a significant correlation between serum total testosterone levels and the occurrence of bladder cancer, along with other factors such as hemoglobin, hypertension, diabetes, and smoking.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Po-Jen Yang, Chiao-Wen Lin, Chia-Yi Lee, Jing-Yang Huang, Ming-Ju Hsieh, Shun-Fa Yang
Summary: This study aimed to investigate the effect of androgen deprivation therapy (ADT) on the development of open angle glaucoma (OAG) in patients with prostate cancer. By analyzing data from the national health insurance research database (NHIRD) of Taiwan, the study found that prostate cancer patients with ADT had a lower risk of OAG development compared to those without ADT. Additionally, age over 50 years old was associated with a higher incidence of OAG development.
Article
Cardiac & Cardiovascular Systems
Chon-Seng Hong, Yi-Chen Chen, Chung-Han Ho, Kun-Lin Hsieh, Michael Chen, Jhih-Yuan Shih, Chun-Yen Chiang, Zhih-Cherng Chen, Wei-Ting Chang
Summary: This study examined the association between GnRH therapy and the risk of VTEs in prostate cancer patients. The results showed a borderline statistical significance in the risk of VTEs among GnRH users compared to non-users, with younger patients and those at an earlier stage being at a higher risk. This highlights concerns about the cardiac safety of GnRH therapies in prostate cancer patients at a relatively younger age or at an earlier stage.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Oncology
V Fay-Watt, S. O'Connor, D. Roshan, A. C. Romeo, V. D. Longo, F. J. Sullivan
Summary: This study investigated the effect of periodic fasting mimicking diet on metabolic health factors in prostate cancer patients. The results showed that the diet led to improvements in weight, abdominal circumference, and blood pressure, with more significant effects observed in patients at higher risk.
PROSTATE CANCER AND PROSTATIC DISEASES
(2023)
Article
Oncology
Maeve Kiely, Ginger L. Milne, Tsion Z. Minas, Tiffany H. Dorsey, Wei Tang, Cheryl J. Smith, Francine Baker, Christopher A. Loffredo, Clayton Yates, Michael B. Cook, Stefan Ambs
Summary: In this study, we found that high levels of TXB2 were associated with prostate cancer and poor outcomes in African American men, indicating a potential role of upregulated TXA2 synthesis in promoting disease progression and metastasis. Our findings suggest a potential benefit of aspirin in preventing lethal prostate cancer through inhibition of TXA2 synthesis, especially in high-risk populations like African American men.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2022)
Article
Urology & Nephrology
Burcu F. Darst, Raymond Hughley, Aaron Pfennig, Ujani Hazra, Caoqi Fan, Peggy Wan, Xin Sheng, Lucy Xia, Caroline Andrews, Fei Chen, Sonja Berndt, Zsofia Kote-Jarai, Koveela Govindasami, Jeannette T. Bensen, Sue A. Ingles, Benjamin A. Rybicki, Barbara Nemesure, Esther M. John, Jay H. Fowke, Chad D. Huff, Sara S. Strom, William B. Isaacs, Jong Y. Park, Wei Zheng, Elaine A. Ostrander, Patrick C. Walsh, John Carpten, Thomas A. Sellers, Kosj Yamoah, Adam B. Murphy, Maureen Sanderson, Dana C. Crawford, Susan M. Gapstur, William S. Bush, Melinda C. Aldrich, Olivier Cussenot, Gyorgy Petrovics, Jennifer Cullen, Christine Neslund-Dudas, Rick A. Kittles, Jianfeng Xu, Mariana C. Stern, Anand P. Chokkalingam, Luc Multigner, Marie-Elise Parent, Florence Menegaux, Geraldine Cancel-Tassin, Adam S. Kibel, Eric A. Klein, Phyllis J. Goodman, Janet L. Stanford, Bettina F. Drake, Jennifer J. Hu, Peter E. Clark, Pascal Blanchet, Graham Casey, Anselm J. M. Hennis, Alexander Lubwama, Ian M. Thompson, Robin J. Leach, Susan M. Gundell, Loreall Pooler, James L. Mohler, Elizabeth T. H. Fontham, Gary J. Smith, Jack A. Taylor, Laurent Brureau, William J. Blot, Richard Biritwum, Evelyn Tay, Ann Truelove, Shelley Niwa, Yao Tettey, Rohit Varma, Roberta McKean-Cowdin, Mina Torres, Mohamed Jalloh, Serigne Magueye Gueye, Lamine Niang, Olufemi Ogunbiyi, Michael Oladimeji Idowu, Olufemi Popoola, Akindele O. Adebiyi, Oseremen Aisuodionoe-Shadrach, Maxwell Nwegbu, Ben Adusei, Sunny Mante, Afua Darkwa-Abrahams, Edward D. Yeboah, James E. Mensah, Andrew Anthony Adjei, Halimatou Diop, Michael B. Cook, Stephen J. Chanock, Stephen Watya, Rosalind A. Eeles, Charleston W. K. Chiang, Joseph Lachance, Timothy R. Rebbeck, David Conti, Christopher A. Haiman
Summary: A specific germline deletion variant in HOXB13 (X285K) was found to be associated with an increased risk of prostate cancer in men of West African ancestry. This variant was more strongly associated with aggressive and advanced disease. Understanding who carries this variant can inform prostate cancer screening in men of West African ancestry.
Article
Oncology
Ebonee N. Butler, Cindy Ke Zhou, Michael Curry, Una McMenamin, Christopher Cardwell, Marie C. Bradley, Barry Graubard, Michael B. Cook
Summary: This study found an inverse association between testosterone therapy (TT) and the risk of distant-stage prostate and colorectal cancers, but a positive association with distant-stage melanoma. These findings suggest a potential role for TT in the etiology of these cancers or the presence of residual confounding.
BRITISH JOURNAL OF CANCER
(2023)
Article
Multidisciplinary Sciences
Cindy Ke Zhou, Monica M. Bennett, Carlos H. Villa, Kendall P. Hammonds, Yun Lu, Jason Ettlinger, Elisa L. Priest, Robert L. Gottlieb, Steven Davis, Edward Mays, Tainya C. Clarke, Azadeh Shoaibi, Hui-Lee Wong, Steven A. Anderson, Ronan J. Kelly
Summary: This study investigated the effectiveness and safety of COVID-19 convalescent plasma (CCP) in hospitalized COVID-19 patients in a multi-hospital healthcare system in Texas. The study found no significant difference in 28-day in-hospital all-cause mortality between the treatment and control groups, but CCP-treated patients were less likely to be discharged alive and more likely to receive mechanical ventilation. Safety outcomes were similar between the two groups.
Article
Multidisciplinary Sciences
Keran Moll, Shayan Hobbi, Cindy Ke Zhou, Kathryn Fingar, Timothy Burrell, Veronica Hernandez-Medina, Joyce Obidi, Nader Alawar, Steven A. Anderson, Hui-Lee Wong, Azadeh Shoaibi
Summary: This study evaluated the performance of ICD-10-CM diagnosis code U07.1 in identifying COVID-19 cases in claims databases and found that it performed well. The results indicate that the performance of U07.1 may vary across populations and time periods.
Article
Immunology
Patricia C. Lloyd, Mao Hu, Hui-Lee Wong, Azadeh Shoaibi, Cindy Ke Zhou, An-Chi Lo, Kandace Amend, Daniel C. Beachler, Cheryl N. McMahill-Walraven, Elizabeth R. Smith, John Seeger, Alex Secora, Djeneba Audrey Djibo, Joyce Obidi, Yuhui Feng, Jennifer Song, Christian Reich, Charalynn Harris, Sandia Akhtar, Robin Clifford, Nandini Selvam, Jennifer L. Pigoga, Yixin Jiao, Yoganand Chillarige, Thomas MaCurdy, Richard Forshee, Steven A. Anderson
Summary: This study utilized an early warning rapid surveillance system in three large commercial insurance databases to monitor safety outcomes following COVID-19 vaccination. The results identified signals for myocarditis/pericarditis and anaphylaxis as adverse outcomes of the vaccination. The findings provide valuable information for early detection of potential safety concerns.
Article
Immunology
Keran Moll, Bradley Lufkin, Kathryn R. Fingar, Cindy Ke Zhou, Ellen Tworkoski, Chianti Shi, Shayan Hobbi, Mao Hu, Minya Sheng, Jillian McCarty, Shanlai Shangguan, Timothy Burrell, Yoganand Chillarige, Jeff Beers, Patrick Saunders-Hastings, Stella Muthuri, Kathryn Edwards, Steven Black, Jeff Kelman, Christian Reich, Kandace L. Amend, Djeneba Audrey Djibo, Daniel Beachler, Rachel P. Ogilvie, Alex Secora, Cheryl N. McMahill-Walraven, John D. Seeger, Patricia Lloyd, Deborah Thompson, Rositsa Dimova, Thomas MaCurdy, Joyce Obidi, Steve Anderson, Richard Forshee, Hui-Lee Wong, Azadeh Shoaibi
Summary: The FDA conducts active surveillance of adverse events following COVID-19 vaccination for the BEST Initiative. The study found that the incidence rates of most adverse events increased with age, but Medicare enrollees had lower rates compared to commercially insured adults. From March to May 2020, the incidence rates of most adverse events decreased compared to the same period in 2019, but returned to pre-pandemic levels afterwards.
Article
Immunology
Hui-Lee Wong, Ellen Tworkoski, Cindy Ke Zhou, Mao Hu, Deborah Thompson, Bradley Lufkin, Rose Do, Laurie Feinberg, Yoganand Chillarige, Rositsa Dimova, Patricia C. Lloyd, Thomas MaCurdy, Richard A. Forshee, Jeffrey A. Kelman, Azadeh Shoaibi, Steven A. Anderson
Summary: This study evaluated the outcomes following COVID-19 vaccination in elderly persons and found a slight increase in the risk of pulmonary embolism, acute myocardial infarction, disseminated intravascular coagulation, and immune thrombocytopenia after receiving the BNT162b2 vaccine. However, after further evaluation, only the risk of pulmonary embolism still met the statistical threshold, while the risks of the other outcomes did not. More research is needed to determine the causal relationship between the vaccines and these outcomes.
Article
Public, Environmental & Occupational Health
Jillian H. H. Hurst, Amanda Brucker, Congwen Zhao, Hannah Driscoll, Haley P. P. Hostetler, Michael Phillips, Bari Rosenberg, Marc D. D. Samsky, Isaac Smith, Megan E. E. Reller, John J. J. Strouse, Cindy Ke Zhou, Graca M. Dores, Hui-Lee Wong, Benjamin A. A. Goldstein
Summary: Detecting adverse reactions to drugs and biologic agents is important for regulatory approval and post-market safety evaluation. Real-world data, including insurance claims and electronic health records data, are increasingly being used for evaluating potential safety outcomes. However, different types of data elements within these resources can affect the development and performance of computable phenotypes for identifying adverse events (AEs).
Article
Hematology
Yixin Jiao, Keran Moll, Graca M. Dores, Ellen Tworkoski, Cindy Ke Zhou, Dorothy Scott, Hui-Lee Wong, Kathryn Fingar, Timothy Burrell, Rowan McEvoy, Shayan Hobbi, Yoganand Chillarige, Joyce Obidi, Thomas MaCurdy, Jeffrey Kelman, Azadeh Shoaibi
Summary: This study describes the utilization patterns of immune globulins (IG) in the United States from 2009 to 2019, showing an overall increase in IG administrations, recipients, and doses. The main driver of this trend is the population of immunodeficient individuals.
Article
Immunology
Azadeh Shoaibi, Patricia C. Lloyd, Hui-Lee Wong, Tainya C. Clarke, Yoganand Chillarige, Rose Do, Mao Hu, Yixin Jiao, Andrew Kwist, Arnstein Lindaas, Kathryn Matuska, Rowan McEvoy, Michelle Ondari, Shruti Parulekar, Xiangyu Shi, Jing Wang, Yun Lu, Joyce Obidi, Cindy K. Zhou, Jeffrey A. Kelman, Richard A. Forshee, Steven A. Anderson
Summary: A self-controlled case series study of COVID-19 mRNA vaccines in U.S. Medicare beneficiaries aged > 65 years showed a slight increase in the risk of acute myocardial infarction and pulmonary embolism following vaccination. However, there was no evidence to support an increased risk of immune thrombocytopenia, disseminated intravascular coagulation, Bell's Palsy, and myocarditis/pericarditis associated with COVID-19 mRNA vaccines.
Article
Microbiology
Patrick Saunders-Hastings, Cindy Ke Zhou, Shayan Hobbi, Eva Boyd, Patricia Lloyd, Nader Alawar, Timothy Burrell, Jeff Beers, Tainya C. C. Clarke, Aaron Z. Z. Hettinger, Hui-Lee Wong, Azadeh Shoaibi
Summary: This study provides an overview of the demographics, clinical characteristics, treatments, and outcomes of hospitalized COVID-19 patients in the U.S. during the pre-vaccine phase. The majority of patients were over 30 years old and had comorbidities such as cardiovascular/respiratory diseases and diabetes. Anticoagulants were commonly used, and the administration of remdesivir increased over time. Patients showed higher disease severity after 14 days of admission compared to before admission. The median length of hospital stay was 4-6 days, and most patients were discharged alive.
Article
Medicine, General & Internal
Karen L. Schneider, Elizabeth J. Bell, C. K. Zhou, Grace Yang, Patricia Lloyd, Tainya C. Clarke, Michael Wilkinson, Emily E. Myers, Kandace L. Amend, John D. Seeger, Yoganand Chillarige, Richard A. Forshee, Azadeh Shoaibi, Steven A. Anderson, Hui-Lee Wong
Summary: This study evaluated the association between Immunization Information Systems (IIS) data and healthcare claims data to improve the accuracy of COVID-19 vaccine coverage estimation. The findings showed that supplementing claims data with IIS vaccination records substantially increased the number of individuals identified as vaccinated, but potential underrecording remained. Improvement in reporting vaccination data to IIS infrastructures could allow frequent updates of vaccination status for all individuals and all vaccines.
Article
Medicine, General & Internal
Shayan Hobbi, Patrick Saunders-Hastings, Cindy Ke Zhou, Jeffrey Beers, Ananth Srikrishnan, Aaron Hettinger, Aarthi Shenoy, Timothy Burrell, Keran Moll, Patricia C. Lloyd, Steven A. Anderson, Azadeh Shoaibi, Hui-Lee Wong
Summary: This study validates the accuracy of an ICD-10-CM-based algorithm for unusual site TTS, demonstrating a high positive predictive value for diagnosing unusual site TTS. The algorithm can be used in observational studies to actively monitor the safety and effectiveness of COVID-19 vaccines and other medical products.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2023)
Correction
Oncology
Lauren M. Hurwitz, Ilir Agalliu, Demetrius Albanes, Kathryn Hughes Barry, Sonja I. Berndt, Qiuyin Cai, Chu Chen, Iona Cheng, Jeanine M. Genkinger, Graham G. Giles, Jiaqi Huang, Corinne E. Joshu, Tim J. Key, Synnove Knutsen, Stella Koutros, HilDe langseth, Sherly X. Li, Robert J. MacInnis, Sarah C. Markt, Kathryn L. Penney, Aurora Perez-Cornago, Thomas E. Rohan, Stephanie A. Smith-Warner, Meir J. Stampfer, Konrad H. Stopsack, Catherine M. Tangen, Ruth C. Travis, Stephanie J. Weinstein, Lang Wu, Eric J. Jacobs, Lorelei A. Mucci, Elizabeth A. Platz, Michael B. Cook
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2022)