Article
Geriatrics & Gerontology
J. P. P. Richie Jr, R. Sinha, Z. Dong, S. N. Nichenametla, G. P. Ables, A. Ciccarella, I. Sinha, A. M. Calcagnotto, V. M. Chinchilli, L. Reinhart, D. Orentreich
Summary: Restricting dietary intake of methionine and cysteine can delay the aging process, improve glucose and fat metabolism, and reduce oxidative stress. This study found that feeding restricted methionine or total sulfur amino acids diets to healthy adults had no adverse effects and significantly improved biomarkers of cardiometabolic disease risk. These findings suggest the potential for further clinical development of this intervention.
JOURNAL OF NUTRITION HEALTH & AGING
(2023)
Article
Nutrition & Dietetics
Zhen Dong, Xiang Gao, Vernon M. Chinchilli, Raghu Sinha, Joshua Muscat, Renate Winkels, John P. Richie
Summary: The study found that high-SAA diets are associated with increased risk for diabetes mortality, and lowering intake towards Recommended Dietary Allowance levels could lead to reductions in lifetime risk.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Cell Biology
Sailendra N. Nichenametla, Dwight A. L. Mattocks, Diana Cooke, Vishal Midya, Virginia L. Malloy, Wilfredo Mansilla, Bente Ovrebo, Cheryl Turner, Nasser E. Bastani, Jitka Sokolova, Marketa Pavlikova, John P. Richie, Anna K. Shoveller, Helga Refsum, Thomas Olsen, Kathrine J. Vinknes, Viktor Kozich, Gene P. Ables
Summary: Decreasing the intake of methionine has significant anti-adiposity effects in rodents but only modest effects in humans. The study found that the anti-adiposity effects of dietary restriction were due to cysteine restriction, which increased serinogenesis and reduced fatty acid reesterification and triglyceride synthesis. This finding may have implications for the treatment of hypertriglyceridemia.
Article
Nutrition & Dietetics
Zhen Dong, John P. Richie, Xiang Gao, Laila Al-Shaar, Sailendra N. Nichenametla, Biyi Shen, David Orentreich
Summary: Excess intake of sulfur amino acids is associated with a higher risk of type 2 diabetes. Dietary patterns low in sulfur amino acids could help prevent type 2 diabetes.
JOURNAL OF NUTRITION
(2022)
Article
Environmental Sciences
Thaina Cavalleri Sousa, Leticia Pereira de Souza, Maria Luiza Silva Ricardo, Andreia Yuri Yoshigae, Karianne Delalibera Hinokuma, Ana Beatriz Ratto Gorzoni, Ariana Musa de Aquino, Wellerson Rodrigo Scarano, Anthony Cesar de Sousa Castillho, Maria Eduarda Almeida Tavares, Alice Santos Cruz Veras, Giovana Rampazzo Teixeira, Gisele Alborghetti Nai, Leonardo de Oliveira Mendes
Summary: Endocrine disruptors (ED) are compounds that can modify hormone biosynthesis, affecting hormone-dependent organs. Previous studies have mainly focused on evaluating the effects of single or small amounts of ED on humans, with short durations, without fully revealing human exposure. This study characterized the prostate histoarchitecture of rats exposed to an ED mixture (ED Mix) mimicking human exposure. The results showed that the ED Mix could cause alterations in the prostatic histoarchitecture and induce the appearance of preneoplastic lesions.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Fisheries
Romulo Jordao Neves Aroucha, Felipe Barbosa Ribeiro, Marcos Antonio Delmondes Bomfim, Jefferson Costa de Siqueira, Rafael Silva Marchao, Daphinne Cardoso Nagib do Nascimento
Summary: The study aimed to determine the requirement of digestible methionine plus cystine in the diet for tambaqui. The results showed that increasing the dietary digestible methionine plus cystine level influenced the growth performance of tambaqui. The estimated requirements for weight gain, specific growth rate, and feed conversion ratio were 0.876%, 0.883%, and 0.907% of digestible methionine plus cystine, respectively.
AQUACULTURE REPORTS
(2023)
Article
Environmental Sciences
Thaina Cavalleri Sousa, Leticia Pereira de Souza, Maria Luiza Silva Ricardo, Andreia Yuri Yoshigae, Karianne Delalibera Hinokuma, Ana Beatriz Ratto Gorzoni, Ariana Musa de Aquino, Wellerson Rodrigo Scarano, Anthony Cesar de Sousa Castillho, Maria Eduarda Almeida Tavares, Alice Santos Cruz Veras, Giovana Rampazzo Teixeira, Gisele Alborghetti Nai, Leonardo de Oliveira Mendes
Summary: This study characterized the effects of exposure to an endocrine disruptor mixture on the histoarchitecture of the prostate in rats. The results showed that the mixture caused a decrease in the epithelial compartment, an increase in fractal dimension, and the appearance of preneoplastic lesions.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Cajetan Neubauer, Hannah Landecker
Summary: Methionine, an essential amino acid, is tightly regulated in ecosystems but has become a mass commodity in the global economy for fortifying livestock feed. Research suggests that dietary methionine restriction can provide similar health benefits to calorie restriction, highlighting the importance of responsible use of methionine-augmentation technologies through interdisciplinary dialogue.
LANCET PLANETARY HEALTH
(2021)
Article
Biochemical Research Methods
Hao Yang, Haoyang Zheng, Yue Pan, Weiguo Zhang, Mengjing Yang, Huiling Du, Anan Yu, Ping Li, Xiaoyan Chen, Wei Xie, Kaiming Ren, Ying Zhao, Tianjiao Wang, Xiaoyan He, Zhaoli Zhou
Summary: The study demonstrated that deprivation of methionine and cystine inhibits the growth of A549 cells in vitro but does not have a significant effect in vivo. Deprivation was harmful to xenograft-bearing mice, resulting in weight loss and renal dysfunction. Changes in proteome profile and biological processes upon methionine and cystine deprivation were characterized in a xenograft mouse model.
Review
Endocrinology & Metabolism
Han Fang, Kirsten P. Stone, Laura A. Forney, Desiree Wanders, Thomas W. Gettys
Summary: FGF21 is a potent metabolic regulator that is influenced by dietary protein, specifically methionine restriction, leading to effects on energy balance, adipose tissue remodeling, and insulin sensitivity. Liver functions as a sentinel to detect changes in dietary amino acid composition and mobilizes FGF21 as a key element of the homeostatic response. Therapeutic diets could be developed to increase FGF21 levels through nutritional modulation for sustained biological effects.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, Research & Experimental
Emma Stolt, Thomas Olsen, Amany Elshorbagy, Viktor Kozich, Marleen van Greevenbroek, Bente Ovrebo, Magne Thoresen, Helga Refsum, Kjetil Retterstol, Kathrine J. Vinknes
Summary: This study will evaluate the effects of dietary sulfur amino acid (SAA) restriction on body weight and metabolic health through a double-blind 8-week dietary intervention involving 60 participants aged 18-45. Data will be analyzed using linear mixed model regression.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Julie Livingstone, Yu-Jia Shiah, Takafumi N. Yamaguchi, Lawrence E. Heisler, Vincent Huang, Robert Lesurf, Tsumugi Gebo, Benjamin Carlin, Stefan Eng, Erik Drysdale, Jeffrey Green, Theodorus van der Kwast, Robert G. Bristow, Michael Fraser, Paul C. Boutros
Summary: The study integrates telomere length, genomics, transcriptomics and proteomics in localized prostate cancer, revealing the links between telomere maintenance, disease drivers and clinical outcomes. Shorter tumor telomere lengths are associated with elevated genomic instability and genes involved in cell proliferation and signaling, while longer telomere lengths in non-tumor samples are associated with a lower rate of biochemical relapse.
NATURE COMMUNICATIONS
(2021)
Article
Agronomy
Andre Froes de Borja Reis, Luiz H. Moro Rosso, Dan Davidson, Peter Kovacs, Larry C. Purcell, Frederick E. Below, Shaun N. Casteel, Carrie Knott, Hans Kandel, Seth L. Naeve, Walter Carciochi, Willian J. Ross, Vitor Rampazzo Favoretto, Sotirios Archontoulis, Ignacio A. Ciampitti
Summary: This study utilized a meta-analytic model to quantify the effects of sulfur application at different growth stages on soybean yield and seed composition. Findings showed that applying sulfur at sowing can increase seed protein concentration, while sulfur amino acids concentration was not affected by the timing of fertilization. Additionally, soils with specific organic matter content displayed significant responses to sulfur application, while drought-stressed sites did not show significant changes in yield or seed composition due to sulfur fertilization.
EUROPEAN JOURNAL OF AGRONOMY
(2021)
Review
Oncology
Martin K. Thomsen, Morten Busk
Summary: The incidence of prostate cancer is increasing, especially among elderly men, and pre-clinical models have played a vital role in gaining insights into the molecular alterations that drive cancer progression. The mouse model, with genetically modified strains and the inoculation of prostate cancer cells, has been invaluable for studying prostate cancer. Advances in the development of pre-clinical models, including the use of specific promoters for gene manipulation and orthoptic delivery of viral particles, have enhanced our understanding of prostate cancer. Animal models, especially mice, provide important tools for studying complex mechanisms in prostate cancer and improving treatment options.
Article
Pathology
Erica Vormittag-Nocito, Andres M. Acosta, Shivangi Agarwal, Kunwar D. Narayan, Ravindra Kumar, Mohamed Rizwan H. Al Rasheed, Andre Kajdacsy-Balla, Frederick G. Behm, Gayatry Mohapatra
Summary: Previous studies have shown a concordance of genetic alterations between intraductal carcinoma (IDC) and high-grade invasive prostate cancer (PCa). This study used whole exome sequencing to evaluate the genomic relationship between high-grade prostatic intraepithelial neoplasia and IDC with invasive PCa. The results demonstrate common genetic variants and copy number alterations between IDC and invasive PCa, suggesting that IDC is a late event in tumor progression.
Review
Cardiac & Cardiovascular Systems
Ester S. Oh, Muzi Na, Connie J. Rogers
Summary: This study found that individuals with cardiometabolic disorders and CVD have a higher percentage of intermediate and non-classical monocytes compared to healthy controls, based on qualitative and meta-analysis of 27 studies.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Oncology
Tyler J. Bruinsma, Anne-Marie Dyer, Connie J. Rogers, Kathryn H. Schmitz, Kathleen M. Sturgeon
Summary: This study examined the effects of exercise and/or caloric restriction on adipokines, leptin, and various cytokines in breast cancer survivors. The results showed that exercise significantly reduced leptin levels in breast cancer survivors, suggesting a potential role in reducing the risk of breast cancer recurrence.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Article
Nutrition & Dietetics
Ester S. Oh, Kristina S. Petersen, Penny M. Kris-Etherton, Connie J. Rogers
Summary: The study found that consuming a medium-dose spice blend for four weeks reduced fasting plasma IL-6 and postprandial plasma IL-1 beta, IL-8, and TNF-alpha levels, as well as altering monocyte function.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Review
Nutrition & Dietetics
Janhavi J. Damani, Mary Jane De Souza, Hannah L. VanEvery, Nicole C. A. Strock, Connie J. Rogers
Summary: This article reviews the potential role of prunes in improving bone health, highlighting evidence that prunes can protect bone by modulating oxidative and inflammatory pathways. Osteoporosis is a common condition in postmenopausal women, and prunes are being studied as a nonpharmaceutical intervention.
ADVANCES IN NUTRITION
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Emily Van Syoc, Connie J. Rogers, Erika Ganda
Meeting Abstract
Biochemistry & Molecular Biology
Janhavi J. Damani, Nicole C. A. Strock, Mary Jane De Souza, Connie J. Rogers
Article
Multidisciplinary Sciences
Callum R. K. Arnold, Sreenidhi Srinivasan, Sophie Rodriguez, Natalie Rydzak, Catherine M. Herzog, Abhinay Gontu, Nita Bharti, Meg Small, Connie J. Rogers, Margeaux M. Schade, Suresh Kuchipudi, Vivek Kapur, Andrew F. Read, Matthew J. Ferrari
Summary: This study found that university students had a higher seroprevalence rate compared to community residents, indicating a potential source of transmission. Contact with known positive individuals and attendance at small gatherings were significant predictors of antibody detection among students.
SCIENTIFIC REPORTS
(2022)
Article
Nutrition & Dietetics
Mary Jane De Souza, Nicole C. A. Strock, Nancy Williams, Hang Lee, Kristen J. Koltun, Connie Rogers, Mario G. Ferruzzi, Cindy H. Nakatsu, Connie Weaver
Summary: This study evaluated the effects of prune consumption on bone mineral density in postmenopausal women and found that a daily dose of 50 grams of prunes can prevent a decrease in hip bone mineral density. This effect persisted for 12 months with high compliance and retention rates.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Medicine, General & Internal
Connie J. Rogers, Kristina Petersen, Penny M. Kris-Etherton
MEDICAL CLINICS OF NORTH AMERICA
(2022)
Article
Physiology
Emily Van Syoc, Evelyn Weaver, Connie J. Rogers, Justin D. Silverman, Ramesh Ramachandran, Erika Ganda
Summary: Studies suggest that dietary supplementation of metformin affects the gut microbiome of broiler breeder hens in a dose-dependent manner, with results consistent with the effects of metformin treatment in type 2 diabetes and polycystic ovary syndrome in humans. Metformin supplementation shows promise in improving gut health and reproductive efficiency in broiler breeder hens.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Immunology
Janhavi J. Damani, Mary Jane De Souza, Nicole C. A. Strock, Kristen J. Koltun, Nancy Williams, Connie Weaver, Connie J. Rogers
Summary: This study aimed to investigate the association between circulating inflammatory markers and bone outcomes in postmenopausal women. The findings showed a negative correlation between inflammatory markers and bone density, geometry, and strength, suggesting that inflammatory markers may play an important role in postmenopausal bone loss.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Sport Sciences
Dan Lin, Cheryl L. Thompson, Djibril M. Ba, Joshua E. Muscat, Shouhao Zhou, Connie J. Rogers, Kathleen M. Sturgeon
Summary: The study revealed an inverse association between leisure-time physical activity level and white blood cell count, as well as neutrophil-to-lymphocyte ratio, suggesting that higher levels of physical activity may lead to lower levels of inflammation, which could be important for future chronic disease outcomes.
SPORTS MEDICINE-OPEN
(2023)
Article
Biochemistry & Molecular Biology
Abigayle M. R. Simpson, Mary Jane De Souza, Janhavi Damani, Connie Rogers, Nancy I. Williams, Connie Weaver, Mario G. Ferruzzi, Sydney Chadwick-Corbin, Cindy H. Nakatsu
Summary: This study aims to characterize the effect of prune supplementation on the gut microbiome of postmenopausal women. The results show that prune consumption leads to a decrease in gut microbiome diversity, and different doses of prunes have different effects on the gut microbiome. In addition, prune consumption may enrich beneficial bacterial taxa and correlate with urinary phenolic metabolites and inflammatory markers. These findings suggest that prunes may exert health effects by modulating the gut microbiome.
Meeting Abstract
Geriatrics & Gerontology
M. J. De Souza, N. C. Strock, N. I. Williams, H. Lee, K. J. Koltun, C. Rogers, M. G. Ferruzzi, C. H. Nakatsu, C. Weaver
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Medicine, Research & Experimental
Mary Jane De Souza, Nicole C. A. Strock, Connie J. Rogers, Nancy I. Williams, Mario G. Ferruzzi, Cindy H. Nakatsu, Abigayle M. R. Simpson, Connie Weaver
Summary: This study is a randomized controlled trial aiming to investigate the effects of daily prune consumption on bone density, immune function, inflammation, and cardiovascular health in postmenopausal women. It also includes detailed phenolic and gut microbiota analyses. The findings will provide insights into the clinical implications and underlying mechanisms of prune as a functional food therapy.
CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS
(2022)