期刊
PROSTATE
卷 73, 期 5, 页码 542-548出版社
WILEY-BLACKWELL
DOI: 10.1002/pros.22594
关键词
G84E mutation; HOXB13; prostate cancer
资金
- Polish Minstry of Science
- Higher Education [PBZ-MNiSW-05/I/2007/02]
BACKGROUND The G84E mutation in the HOXB13 gene has been associated with a high lifetime risk of prostate cancer in North America (about 20-fold). The geographical and ethnic extent of this recurrent allele has not yet been determined. METHODS We assayed for the presence of the G84E mutation in 3,515 prostate cancer patients and 2,604 controls from Poland and estimated the odds ratio for prostate cancer associated with the allele. RESULTS The G84E mutation was detected in 3 of 2,604 (0.1%) individuals from the general population in Poland and in 20 of 3,515 (0.6%) men with prostate cancer (Odds ratio [OR]=5.0; 95% CI: 1.516.7; P=0.008). The allele was present in 4 of 416 (1.0%) men with familial prostate cancer (OR=8.4, 95% CI: 1.937.7; P=0.005). CONCLUSIONS The G84E mutation predisposes to prostate cancer in Poland, but accounts for only a small proportion of cases. We expect that the G84E founder mutation might be present in other Slavic populations. Prostate 73: 542548, 2013. (c) 2013 Wiley Periodicals, Inc.
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