Article
Oncology
Philipp Mandel, Benedikt Hoeh, Felix Preisser, Mike Wenzel, Clara Humke, Maria-Noemi Welte, Inga Jerrentrup, Jens Koellermann, Peter Wild, Derya Tilki, Alexander Haese, Andreas Becker, Frederik C. Roos, Felix K. H. Chun, Luis A. Kluth
Summary: The study revealed a significant positive correlation between preoperative PSA and tumor weight in PCa patients undergoing RP, with an increase in PSA of almost 0.4 ng/ml per 1 g tumor weight. This finding could help estimate tumor burden before RP and in cases of biochemical recurrence.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Carlos David Cruz-Hernandez, Griselda Rodriguez-Martinez, Sergio A. Cortes-Ramirez, Miguel Morales-Pacheco, Marian Cruz-Burgos, Alberto Losada-Garcia, Juan Pablo Reyes-Grajeda, Imelda Gonzalez-Ramirez, Vanessa Gonzalez-Covarrubias, Ignacio Camacho-Arroyo, Marco Cerbon, Mauricio Rodriguez-Dorantes
Summary: Although some drugs can specifically inhibit the androgen receptor (AR), most prostate cancer (PCa) cases still progress to an androgen-independent stage. To address this issue, new tools based on nucleic acids technology, such as aptamers, have been developed. Aptamers are small oligonucleotides capable of interacting with various targets, including mammalian cells or viruses. Studies have shown that aptamers have potential in the diagnosis and treatment of PCa, but more research is needed to determine their clinical value.
Article
Multidisciplinary Sciences
Hwanik Kim, Gyoohwan Jung, Jin Hyuck Kim, Seok-Soo Byun, Sung Kyu Hong
Summary: PHI can predict GS upgrading in ISUP GG 1 & 2, in conjunction with PIRADS lesions >= 4. PHI alone can also evaluate the likelihood of high-risk PCa after surgery.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Johanna Classon, Margherita Zamboni, Camilla Engblom, Kanar Alkass, Giulia Mantovani, Christian Pou, Dieudonne Nkulikiyimfura, Petter Brodin, Henrik Druid, Jeff Mold, Jonas Frisen
Summary: The HLA-A * 02:01 and HLA-A * 11 alleles are independently associated with disease recurrence in prostate cancer patients. Patients with low-intermediate risk carrying the HLA-A * 02:01 gene and patients with high-risk carrying the HLA-A * 11 gene are more likely to experience disease recurrence. Furthermore, patients carrying HLA-A * 02:01 with detected anti-cytomegalovirus T-cell receptors are also at higher risk of recurrence.
MOLECULAR ONCOLOGY
(2022)
Review
Urology & Nephrology
Ekaterina Laukhtina, Reza Sari Motlagh, Keiichiro Mori, Fahad Quhal, Victor M. Schuettfort, Hadi Mostafaei, Satoshi Katayama, Nico C. Grossmann, Guillaume Ploussard, Pierre I. Karakiewicz, Alberto Briganti, Mohammad Abufaraj, Dmitry Enikeev, Benjamin Pradere, Shahrokh F. Shariat
Summary: Deferred radical prostatectomy does not appear to affect oncological survival outcomes in patients with intermediate- and high-risk prostate cancer, but its impact on biochemical recurrence rates remains controversial. Research shows that delaying surgery does not result in more aggressive pathological outcomes or the need for secondary treatments.
WORLD JOURNAL OF UROLOGY
(2021)
Article
Pathology
Yan-Ping Yu, Silvia Liu, Bao-Guo Ren, Joel Nelson, David Jarrard, James D. Brooks, George Michalopoulos, George Tseng, Jian-Hua Luo
Summary: This study examined the expressions of 14 fusion genes in 607 prostate cancer samples and developed machine-learning models to predict cancer recurrence after radical prostatectomy. The addition of fusion gene profiling improved the prediction accuracy rate of prostate cancer recurrence using Gleason score and serum prostate-specific antigen level.
AMERICAN JOURNAL OF PATHOLOGY
(2023)
Article
Multidisciplinary Sciences
Jaehun Jung, Gi Hwan Bae, Jae Heon Kim, Jaehong Kim
Summary: This study aimed to evaluate the clinical impact of robot-assisted radical prostatectomy (RARP) on health outcomes in Korean patients with prostate cancer (PCa). The study found that RARP had a higher risk of overall mortality within 3 and 12 months compared to radical prostatectomy (RP). The RARP group in hospitals with the largest PCa surgery volume had higher mortality rates and more surgical complications than the total RARP patients. The study suggests that RARP may not be superior to RP, possibly due to increased robotic surgery in the elderly.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Zezhen Liu, Jiehui Zhong, Jie Zeng, Xiaolu Duan, Jianming Lu, Xinyuan Sun, Qinwei Liu, Yingke Liang, Zhuoyuan Lin, Weide Zhong, Wenzheng Wu, Chao Cai, Guohua Zeng
Summary: This study identified three distinct m6A regulation patterns in PCa, each with specific characteristics related to patient prognosis and tumor immune microenvironment. Among these patterns, patients in the low-m6Ascore group were more likely to benefit from ICIs therapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Urology & Nephrology
Luigi Nocera, Mike Wenzel, Claudia Colla Ruvolo, Christoph Wurnschimmel, Zhe Tian, Giorgio Gandaglia, Nicola Fossati, Felix K. H. Chun, Vincenzo Mirone, Markus Graefen, Fred Saad, Shahrokh F. Shariat, Francesco Montorsi, Alberto Briganti, Pierre Karakiewicz
Summary: The study found that race/ethnicity may predispose to differences in clinical and pathological characteristics in intermediate risk prostate cancer patients. Specifically, even after full statistical adjustment, Hispanic/Latinos are at higher risk of upstaging and/or upgrading, while African-Americans are at lower risk.
WORLD JOURNAL OF UROLOGY
(2022)
Article
Oncology
Nicholas W. Eyrich, John T. Wei, Yashar S. Niknafs, Javed Siddiqui, Chad Ellimoottil, Simpa S. Salami, Ganesh S. Palapattu, Rohit Mehra, Lakshmi P. Kunju, Scott A. Tomlins, Arul M. Chinnaiyan, Todd M. Morgan, Jeffrey J. Tosoian
Summary: This study aimed to evaluate the association between urinary MyProstateScore (MPS) and pathologic grade group in men diagnosed with GG1 prostate cancer. The results showed that MPS was significantly associated with the cancer grade at surgery, with a higher discriminative ability compared to models based on PSA and PSAD.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2022)
Article
Medicine, Research & Experimental
Mohammad Alyamani, Patrick Michael, Daniel Hettel, Lewis Thomas, Scott D. Lundy, Mike Berk, Mona Patel, Jianbo Li, Hooman Rashidi, Jesse K. McKenney, Eric A. Klein, Nima Sharifi
Summary: This study reveals that some men have enriched levels of testosterone (T) in the prostate region, which is associated with higher rates of prostate cancer recurrence. These findings suggest that the role of local androgen delivery in prostate cancer has been underestimated.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Oncology
Donglin Sun, Ao Lin, Zhun Sun, Shuqi Yang, Yuexin Sun, Anning Chen, Guojun Qian, Zhonghua Ji, Li Wang
Summary: This study aimed to identify independent prognosis-associated factors of bone-metastatic prostate cancer and developed nomograms for prognostic evaluation. Results showed that radical prostatectomy and chemotherapy were strongly associated with the prognosis of bone-metastatic prostate cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Derya Tilki, Ming-Hui Chen, Jing Wu, Hartwig Huland, Markus Graefen, Anthony D'Amico
Summary: This study found that adjuvant therapy was associated with a decreased risk of all-cause mortality compared to early salvage radiation therapy in men with pN1 prostate cancer, and this reduction in risk increased with each additional positive pelvic lymph node.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Biology
Laura Nalleli Garrido Castillo, Arnaud Mejean, Philippe Vielh, Julien Anract, Alessandra Decina, Bertrand Nalpas, Naoual Benali-Furet, Isabelle Desitter, Patrizia Paterlini-Brechot
Summary: The preoperative detection of Circulating Tumor Cells (CTC) may serve as an interesting candidate predictive marker for cancer recurrence in patients with non-metastatic prostate cancer, according to this study.
Article
Surgery
Jinge Zhao, Guangxi Sun, Fengnian Zhao, Junru Chen, Sha Zhu, Nanwei Xu, Haoyang Liu, Jiayu Liang, Xu Hu, Xingming Zhang, Yuchao Ni, Jindong Dai, Zhipeng Wang, Pengfei Shen, Zhenhua Liu, Ni Chen, Jiyan Liu, Hao Zeng
Summary: This study aimed to investigate the treatment effect of radical prostatectomy (RP) and external beam radiation therapy (EBRT) in nonadenocarcinoma prostate cancer (PCa) patients. The results showed that patients with small cell neuroendocrine carcinoma (SCNC) and neuroendocrine differentiation (NED) had the worst prognosis, while patients with ductal carcinoma (DA) also had poorer survival outcomes. Patients with mucinous adenocarcinoma (MA) and signet ring cell carcinoma (SRCC) had comparable clinical outcomes to those with adenocarcinoma.
ASIAN JOURNAL OF SURGERY
(2023)
