Article
Oncology
Carlos Artigas, Romain Diamand, Qaid Ahmed Shagera, Nicolas Plouznikoff, Fabrice Fokoue, Francois-Xavier Otte, Thierry Gil, Alexandre Peltier, Dirk Van Gestel, Patrick Flamen
Summary: PSMA-PET/CT is an excellent imaging technique to detect OMD early in HSPC patients with BCR after RP, changing therapeutic management mostly into MDT.
Article
Oncology
Mame-Kany Diop, Roula Albadine, Andre Kougioumoutzakis, Nathalie Delvoye, Helene Hovington, Alain Bergeron, Yves Fradet, Fred Saad, Dominique Trudel
Summary: Intraductal carcinoma of the prostate (IDC-P) is associated with an increased risk of biochemical recurrence (BCR), but around 40% of men with IDC-P remain BCR-free five years after surgery. This retrospective study found that certain morphological criteria, such as irregular nuclear contours and blood vessels, were independently associated with an increased risk of BCR. Combining these criteria showed a stronger association with BCR, suggesting that IDC-P can be classified as low versus high-risk of recurrence.
Review
Oncology
Loic Ah-Thiane, Paul Sargos, Olivier Chapet, Marjory Jolicoeur, Mario Terlizzi, Carl Salembier, Jihane Boustani, Celia Prevostc Sonya Gaudioz, Talar Derashodian, Samuel Palumboi, Olivier De Hertoghj, Gilles Crehange, Thomas Zilli, Stephane Supiot
Summary: Up to 50% of patients who undergo radical surgery for localized prostate cancer may experience biochemical recurrence, requiring appropriate management. Molecular imaging, particularly positron emission tomography, has become an important tool for diagnosing recurrence. Prostate bed radiotherapy is a key treatment, often combined with androgen deprivation therapy. Researchers are currently exploring the best combination therapies, including next-generation hormone therapies, for the treatment of biochemical relapse in prostate cancer after radical surgery.
CANCER TREATMENT REVIEWS
(2023)
Review
Oncology
Michael Carrasquilla, Michael L. Creswell, Abigail N. Pepin, Edina Wang, Matthew Forsthoefel, Mary McGunigal, Elizabeth Bullock, Siyuan Lei, Brian T. Collins, Jonathan W. Lischalk, Giuseppe Esposito, Nima Aghdam, Deepak Kumar, Simeng Suy, Paul Leger, Ryan A. Hankins, Nancy A. Dawson, Sean P. Collins
Summary: Lymph node recurrent prostate cancer patients often receive systemic therapy like ADT, but localized therapy may help delay the initiation of systemic treatment. There is limited evidence on the optimal combination of local and systemic treatment in this patient population.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Zhengtong Lv, Jianlong Wang, Xuan Wang, Miao Mo, Guyu Tang, Haozhe Xu, Jianye Wang, Yuan Li, Ming Liu
Summary: A risk model containing nine ferroptosis-related genes was constructed in this study, demonstrating strong prognostic and therapeutic predictive power in prostate cancer. The higher risk score calculated by the model was significantly associated with adverse clinicopathological characteristics, immune infiltration, probability of biochemical recurrence, and treatment response in PCa. The findings provide new insights and potential clinical applications of ferroptosis in PCa.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Anesthesiology
Felipe P. Rangel, Jose O. C. Auler Jr, Maria J. C. Carmona, Mauricio D. Cordeiro, William C. Nahas, Rafael F. Coelho, Claudia M. Simoes
Summary: Intraoperative opioid use does not affect biochemical recurrence rates and biochemical recurrence-free survival in patients with intermediate and high D'Amico risk prostate cancer undergoing radical prostatectomy. Factors such as obesity, high D'Amico risk, laparoscopic surgery, stage 3 tumor pathology, N1 status, and positive surgical margins are associated with shorter biochemical recurrence-free survival.
BRITISH JOURNAL OF ANAESTHESIA
(2021)
Article
Oncology
Andrew J. Armstrong, Arun A. Azad, Taro Iguchi, Russell Z. Szmulewitz, Daniel P. Petrylak, Jeffrey Holzbeierlein, Arnauld Villers, Antonio Alcaraz, Boris Alekseev, Neal D. Shore, Francisco Gomez-Veiga, Brad Rosbrook, Fabian Zohren, Shunsuke Yamada, Gabriel P. Haas, Arnulf Stenzl
Summary: Clinical Trial Updates provide an opportunity to disseminate additional results from studies that have already reported their primary endpoint. This study demonstrates that enzalutamide plus androgen deprivation therapy significantly prolongs survival in patients with metastatic hormone-sensitive prostate cancer, and continues to improve other secondary endpoints.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Dennie Meijer, Pim J. van Leeuwen, Pepijn M. J. Oosterholt, Yves J. L. Bodar, Henk G. van der Poel, N. Harry Hendrikse, Maarten L. Donswijk, Maurits Wondergem, Annelies E. Vellekoop, R. Jeroen A. van Moorselaar, Jakko A. Nieuwenhuijzen, Daniela E. Oprea-Lager, Andre N. Vis
Summary: This study aimed to investigate the impact of F-18-DCFPyL PET/CT on the intended management of patients with biochemically recurrent hormone-sensitive prostate cancer. Positive F-18-DCFPyL PET/CT scan, positive pathological lymph node status, and negative surgical margin status were significantly associated with an increased likelihood of a change in management based on F-18-DCFPyL PET/CT findings.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Oncology
Gaohaer Kadeerhan, Bo Xue, Xiaolin Wu, Xiaofeng Hu, Jun Tian, Dongwen Wang
Summary: In this study, a robust 8-gene signature was established based on transcriptome profiles of prostate cancer for accurately predicting the risk of biochemical recurrence. PRAME, a risk-related gene, was found to be upregulated in high-risk prostate cancer samples and correlated with chemotherapeutic drug response. Knocking down PRAME reduced the proliferation, migration, and invasion of prostate cancer cells. This study provides a novel tool for stratifying high-risk prostate cancer patients and sheds light on the mechanism of prostate cancer progression.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Review
Oncology
Hengping Li, Mao Zhang, Xiangrong Wang, Yang Liu, Xuanpeng Li
Summary: The management of metastatic hormone-sensitive prostate cancer (mHSPC) has significantly improved in the last decade with the development of novel agents and combination therapies. Intense androgen deprivation therapy (ADT) combined with docetaxel and other hormonal therapy agents has shown to improve overall survival (OS) in mHSPC. Luteinizing hormone-releasing hormone (LHRH) antagonists have advantages over LHRH agonists in terms of cardiovascular side effects.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Guido Rovera, Serena Grimaldi, Sara Dall'Armellina, Roberto Passera, Marco Oderda, Giuseppe Carlo Iorio, Alessia Guarneri, Paolo Gontero, Umberto Ricardi, Desiree Deandreis
Summary: Prostate-specific-membrane-antigen/positron-emission-tomography (PSMA-PET) can accurately detect bone metastases in early-BCR/BCP hormone-sensitive PCa patients. T stage, clinical setting, and PSAdt were identified as significant predictors of bone metastases in these patients. These predictors can be used to refine the indication for PSMA-PET and improve the detection rates of bone disease, leading to more personalized treatments.
Review
Endocrinology & Metabolism
Jie Jiang, Xiaoxia Tang, Yongzhu Pu, Yong Yang, Conghui Yang, Fake Yang, Yadong Tian, Jindan Li, Hua Sun, Sheng Zhao, Long Chen
Summary: This article reviews the progress of PET/CT research in biochemical recurrence of prostate cancer, aiming to introduce new technologies and provide more direction for future research.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Bastiaan M. Prive, Steffie M. B. Peters, Constantijn H. J. Muselaers, Inge M. van Oort, Marcel J. R. Janssen, J. P. Michiel Sedelaar, Mark W. Konijnenberg, Patrik Zamecnik, Maike J. M. Uijen, Melline G. M. Schilham, Annemarie Eek, Tom W. J. Scheenen, J. Fred Verzijlbergen, Winald R. Gerritsen, Niven Mehra, Linda G. W. Kerkmeijer, Robert J. Smeenk, Diederik M. Somford, Jean-Paul A. Van Basten, Sandra Heskamp, Jelle O. Barentsz, Martin Gotthardt, J. Alfred Witjes, James Nagarajah
Summary: In this prospective study, Lu-177-PSMA appeared to be a feasible and safe treatment modality for patients with low-volume metastatic hormone-sensitive prostate cancer, showing good treatment effect and minimal adverse events.
CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Teng Ma, Peng Shi, Tianyi Ma, Mei Liang, Lulu Wang, Yafei Shi
Summary: This study aimed to develop a nomogram for predicting the probability of biochemical recurrence (BIR) and structural recurrence (STR) in patients with stage cN1 papillary thyroid carcinoma (PTC). By analyzing the data of 617 inpatients (training cohort) and 102 outpatients (validation cohort) in our hospital, the relationship between patient characteristics and the risk of recurrence was studied. The nomograms, constructed using the least absolute shrinkage and selection operator regression model, demonstrated good discrimination ability.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Savannah R. Duenweg, Samuel A. Bobholz, Michael J. Barrett, Allison K. Lowman, Aleksandra Winiarz, Biprojit Nath, Margaret Stebbins, John Bukowy, Kenneth A. Iczkowski, Kenneth M. Jacobsohn, Stephanie Vincent-Sheldon, Peter S. Laviolette
Summary: This study used radiomic features calculated from T2-weighted magnetic resonance imaging to predict biochemical recurrence (BCR) and prostate cancer presence. The research found that 10 radiomic features predicted BCR with an AUC of 0.97 and classified cancer with an accuracy of 89.9%. This study demonstrates the feasibility of a radiomic features-based tool for screening prostate cancer presence and assessing patient prognosis.
Article
Surgery
Eva Erne, Stephan Kruck, Tilman Todenhoefer, Stefan Aufderklamm, Bastian Amend, Jens Bedke, Arnulf Stenzl, Steffen Rausch
Summary: The study reported the use of Veriset (TM) hemostatic patch in LPN, showing that it can be successfully implemented in surgery and reduce operation time and WIT compared to conventional suture technique.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Oncology
Frank Paulsen, Jens Bedke, Daniel Wegener, Jolanta Marzec, Peter Martus, Dominik Nann, Arnulf Stenzl, Daniel Zips, Arndt-Christian Mueller
Summary: The extent of lymphadenectomy and clinical features can influence the risk of occult nodes in node-negative prostate cancer. A theoretical formula for estimation of the negative predictive value (npv) in pN0-staged prostate cancer patients was developed in this study, which should be used in a clinically experienced context before deciding on elective irradiation of pelvic lymph nodes or intensifying adjuvant systemic treatment.
STRAHLENTHERAPIE UND ONKOLOGIE
(2022)
Article
Urology & Nephrology
Niklas Harland, Giorgio I. Russo, Sascha Kaufmann, Bastian Amend, Steffen Rausch, Eva Erne, Marcus Scharpf, Konstantin Nikolaou, Arnulf Stenzl, Jens Bedke, Stephan Kruck
Summary: A new imaging method based on computed tomographic ultrasound supported by artificial neural network analysis has shown promising detection rates in patients with clinically significant prostate cancer. The combination of ultrasound imaging with ANNA has the potential to complement prostate cancer diagnosis.
UROLOGIA INTERNATIONALIS
(2022)
Article
Infectious Diseases
Peter Aaby, Heike Thoma, Klaus Dietz
Summary: This study examined measles mortality in an isolated German village, revealing that nearly all children under 14 years of age were affected by the epidemic. The overall case fatality ratio was 6.4%, with a higher rate of mortality observed among boys infected by girls in the household.
JOURNAL OF INFECTION
(2022)
Article
Oncology
Viktoria Stuehler, Lisa Herrmann, Steffen Rausch, Arnulf Stenzl, Jens Bedke
Summary: First-line immune-based combination therapy and nivolumab after first-line TKI-monotherapy prolong overall survival in metastatic renal cell carcinoma patients in a real-world setting.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Viktoria Stuhler, Lisa Herrmann, Steffen Rausch, Arnulf Stenzl, Jens Bedke
Summary: This study evaluated the predictive and prognostic value of the systemic immune-inflammation index (SII) in patients with metastatic renal cell carcinoma (mRCC) treated with first-line ipilimumab plus nivolumab. High SII score was associated with worse progression-free survival and overall survival, while a low SII index was associated with higher clinical benefit rate. An increase in SII after 12 weeks of therapy was significantly associated with tumor progression at first imaging. SII could be used to refine decision making in patients treated with ipilimumab plus nivolumab.
Article
Oncology
Dennis Guergen, Michael Becker, Mathias Dahlmann, Susanne Flechsig, Elke Schaeffeler, Florian A. Buettner, Christian Schmees, Regina Bohnert, Jens Bedke, Matthias Schwab, Johann J. Wendler, Martin Schostak, Burkhard Jandrig, Wolfgang Walther, Jens Hoffmann
Summary: This study establishes and molecularly characterizes a panel of patient-derived xenograft (PDX) models for renal cell carcinoma (RCC), which show stable cellular and pathological features over multiple passages. These models have high relevance in evaluating the efficacy of novel targeted therapies and their combinations in a personalized context, and exhibit response profiles similar to observations in patients. Additionally, PDX models from metastatic disease and multi-tumor regions from the same patient provide opportunities for studying intra-tumor heterogeneity (ITH).
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Alexandros Papachristofilou, Jens Bedke, Stefanie Hayoz, Ulrich Schratzenstaller, Miklos Pless, Marcus Hentrich, Susanne Krege, Anja Lorch, Daniel -M Aebersold, Paul Martin Putora, Dominik-R Berthold, Deborah Zihler, Friedemann Zengerling, Annette Dieing, Arndt -Christian Mueller, Corinne Schaer, Christine Biaggi, Silke Gillessen, Richard Cathomas
Summary: A novel approach combining de-escalated chemotherapy with de-escalated involved node radiotherapy resulted in a 3-year progression-free survival rate of 93.7% with minimal toxic effects. The primary endpoint was not met, but the findings suggest that this regimen could be an alternative to standard-of-care treatment. Further research is needed to confirm these results.
Article
Genetics & Heredity
Florian A. Buettner, Stefan Winter, Viktoria Stuehler, Steffen Rausch, Joerg Hennenlotter, Susanne Fuessel, Stefan Zastrow, Matthias Meinhardt, Marieta Toma, Carmen Jeronimo, Rui Henrique, Vera Miranda-Goncalves, Nils Kroeger, Silvia Ribback, Arndt Hartmann, Abbas Agaimy, Christine Stoehr, Iris Polifka, Falko Fend, Marcus Scharpf, Eva Comperat, Gabriel Wasinger, Holger Moch, Arnulf Stenzl, Marco Gerlinger, Jens Bedke, Matthias Schwab, Elke Schaeffeler
Summary: Accurate subtyping and personalized prognosis assessment are crucial for the treatment and personalized prognosis assessment of cancer patients. This study successfully classified renal cell carcinoma into different subtypes through molecular analysis, and identified some tumors with molecular heterogeneity that have worse prognosis. The prediction based on molecular subtypes can effectively predict the prognosis of renal cell carcinoma and provide support for personalized treatment strategies.
Article
Medicine, General & Internal
Niklas Harland, Mohammed Alfarra, Eva Erne, Moritz Maas, Bastian Amend, Jens Bedke, Arnulf Stenzl
Summary: This study presents a new technique, the peritoneal purse-string suture (PPSS), that reduces the rate of lymphoceles following retzius-sparing RARP with extended pelvic lymph node dissection (ePLND). The results show that the PPSS group had a lower incidence of lymphoceles and symptomatic lymphoceles compared to the control group.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Moritz Maas, Aymone Kurcz, Joerg Hennenlotter, Marcus Scharpf, Falko Fend, Simon Walz, Viktoria Stuehler, Tilman Todenhoefer, Arnulf Stenzl, Jens Bedke, Steffen Rausch
Summary: This study evaluated the expression of CXCR4 protein in renal cell carcinoma (RCC), and found differential expression in the primary tumor, metastatic tissue, and variant renal histologies. The study also confirmed the prognostic value of CXCR4 expression in organ-confined ccRCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Correction
Urology & Nephrology
Elizabeth R. Plimack, Thomas Powles, Viktor Stus, Rustem Gafanov, Dmitry Nosov, Tom Waddell, Boris Alekseev, Frederic Poulioti, Bohuslav Melichar, Denis Soulieres, Delphine Borchiellini, Raymond S. McDermott, Ihor Vynnychenko, Yen-Hwa Chang, Satoshi Tamada, Michael B. Atkins, Chenxiang Li, Rodolfo Perini, L. Rhoda Molife, Jens Bedke, Brian I. Riniu
Article
Urology & Nephrology
Elizabeth R. Plimack, Thomas Powles, Viktor Stus, Rustem Gafanov, Dmitry Nosov, Tom Waddell, Boris Alekseev, Frederic Pouliot, Bohuslav Melichar, Denis Soulieres, Delphine Borchiellini, Raymond S. Mcdermott, Ihor Vynnychenko, Yen-Hwa Chang, Satoshi Tamada, Michael B. Atkins, Chenxiang Li, Rodolfo Perini, L. Rhoda Molife, Jens Bedke, Brian I. Rini
Summary: This study reports the efficacy of pembrolizumab plus axitinib in patients with advanced clear cell renal cell carcinoma. Compared to the traditional treatment, pembrolizumab plus axitinib showed superior outcomes in overall survival, progression-free survival, and objective response rate.
Editorial Material
Medicine, General & Internal
Jens Bedke, Axel Bex
Article
Urology & Nephrology
Viktoria Stuhler, Lisa Herrmann, Moritz Maas, Simon Walz, Steffen Rausch, Arnulf Stenzl, Jens Bedke
Summary: Despite the progress of IO-based combination therapies in first line, complete metastasectomy remains an integral part of the multimodality treatment of metastatic RCC.
WORLD JOURNAL OF UROLOGY
(2022)