Article
Biochemistry & Molecular Biology
Shaohua Zhang, Xiaoman Ju, Qihong Yang, Yiying Zhu, Dongmei Fan, Guifeng Su, Lingmei Kong, Yan Li
Summary: The upregulation of USP47 is associated with tumorigenesis and poor prognosis in clinical patients with colorectal cancer and is closely involved in the maintenance of the stemness of colorectal cancer stem cells (CCSCs). Silencing USP47 reduces proliferation and migration of colorectal cancer cells, suppresses the self-renewal of CCSCs, and induces apoptosis of CCSCs. Parthenolide (PTL) as a novel USP47 inhibitor shows potential in targeting CCSCs for colorectal cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Yazan Al Salhi, Manfredi Bruno Sequi, Fabio Maria Valenzi, Andrea Fuschi, Alessia Martoccia, Paolo Pietro Suraci, Antonio Carbone, Giorgia Tema, Riccardo Lombardo, Antonio Cicione, Antonio Luigi Pastore, Cosimo De Nunzio
Summary: Cancer stem cells (CSCs) are a small and elusive subpopulation of self-renewing cancer cells that have the remarkable ability to initiate, propagate, and spread malignant disease. Previous studies have focused on the role of CSCs in the development and progression of PCa. PCa CSCs typically originate from luminal prostate cells, and the Wnt, Sonic Hedgehog, and Notch signaling pathways are involved in their development. Epithelial mesenchymal transition and specific miRNAs also play important roles in this process. Targeting these pathways has shown promise in improving the management of PCa development and progression. CSCs in prostate cancer represent a significant and promising area of research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Ioannis M. Koukourakis, Kalliopi Platoni, Vassilis Kouloulias, Stella Arelaki, Anna Zygogianni
Summary: Under normal conditions, stem cells differentiate into mature organ/tissue-specific cells at a steady pace. However, their growth can be accelerated during tissue healing or in certain diseases. It is believed that the proliferation and growth of cancer cells are sustained by a vital cellular compartment resembling stem cells in normal tissues, known as cancer stem cells (CSCs). Mutations in prostate stem cells can lead to the formation of prostate cancer. Prostate CSCs (PCSCs) have been identified and characterized, expressing specific surface markers and over-activating signaling pathways. They are associated with radiotherapy and chemotherapy resistance, aggressive cancer behavior, and higher relapse rates. Developing treatment strategies to target PCSCs in tumors can improve the effectiveness of cytotoxic therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Isis Wolf, Christian Gratzke, Philipp Wolf
Summary: Despite research and improvements in diagnosis and therapy, prostate cancer (PC) remains a major challenge. Recent findings have highlighted the role of PC stem cells (PCSCs) in tumorigenesis, relapse, metastasis, and treatment resistance. This review discusses the impact of PCSCs in clinical practice and presents new therapeutic approaches to improve outcomes for PC patients.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Jianhui Yang, Omar Aljitawi, Peter Van Veldhuizen
Summary: This review summarizes the recent research progress on the role of CD133 in prostate cancer stem cells (PCSC), including its selective expression in undifferentiated cells, its correlation to treatment resistance, its gene regulation and functional analysis, and its targeted therapy in vitro, in vivo, and in clinical trials.
Article
Biochemistry & Molecular Biology
Larischa de Wet, Anthony Williams, Marc Gillard, Steven Kregel, Sophia Lamperis, Lisa C. Gutgesell, Jordan E. Vellky, Ryan Brown, Kelly Conger, Gladell P. Paner, Heng Wang, Elizabeth E. Platz, Angelo M. De Marzo, Ping Mu, Jonathan L. Coloff, Russell Z. Szmulewitz, Donald J. Vander Griend
Summary: This study investigated the impact of SOX2 expression on patient outcomes and its function within prostate cancer cells. The results revealed that SOX2 expression promotes metastatic progression and therapy resistance in prostate cancer, and affects the metabolic pathways and metabolites of cancer cells. These findings contribute to a better understanding of the role of SOX2 in prostate cancer and suggest its potential as a biomarker and pharmacologic target in clinical settings.
Review
Oncology
Jakob Pueschel, Anna Dubrovska, Ielizaveta Gorodetska
Summary: Cancer stem cells are the engine of tumor progression and a source of tumor regrowth after treatment. Targeting CSCs might be a powerful tool to overcome tumor resistance and increase the efficiency of current cancer treatment strategies, with high ALDH activity being a common marker of prostate CSCs.
Article
Cell Biology
Alberto Losada-Garcia, Ivan Salido-Guadarrama, Sergio Alberto Cortes-Ramirez, Marian Cruz-Burgos, Miguel Morales-Pacheco, Karla Vazquez-Santillan, Griselda Rodriguez-Martinez, Imelda Gonzalez-Ramirez, Vanessa Gonzalez-Covarrubias, Carlos Perez-Plascencia, Mauricio Rodriguez-Dorantes
Summary: Prostate cancer is the second most common cancer worldwide with a high mortality rate. This study investigates the role of SFRP1 in prostate cancer stem cell phenotype and reveals its involvement in disease progression and therapeutic failure through deregulation of the WNT/beta-catenin pathway. These findings enhance our molecular understanding of castration-resistant prostate cancer and may provide new insights for diagnosis and treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Oncology
Wen Jess Li, Xiaozhuo Liu, Emily M. Dougherty, Dean G. Tang
Summary: The article reviews the tumor suppressive role of miRNA-34a in prostate cancer and discusses therapeutic development strategies for advanced prostate cancer patients.
Review
Oncology
Lu Yao, Xiangyu Zhang
Summary: Prostate cancer is a common cancer that poses a serious threat with bone metastasis and drug resistance. The theoretical model of cancer stem cells explains the characteristics and challenges of cancer. Targeting cancer stem cells might be more effective in overcoming drug resistance and metastasis.
Review
Oncology
Pinaki Banerjee, Prachi Kapse, Shehnaz Siddique, Moumita Kundu, Jasoda Choudhari, Varshasnata Mohanty, Diksha Malhotra, Suresh W. Gosavi, Rajesh N. Gacche, Gopal C. Kundu
Summary: Prostate cancer is a heterogeneous disease involving multiple cell types, with tumor heterogeneity resulting from genomic instability and sub-clone differentiation. Prostate cancer stem cells (PCSCs), a small subset of cells with tumor-initiating and stem-like properties, play crucial roles in disease progression, drug resistance, and relapse. This review discusses the origin, hierarchy, and plasticity of PCSCs, methods for their isolation and enrichment, as well as cellular and metabolic signaling pathways involved in their induction and maintenance, and potential therapeutic targeting.
CANCER BIOLOGY & MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Yong Zhou, Tian Li, Man Jia, Rongyang Dai, Ronghao Wang
Summary: Prostate cancer remains a significant cause of cancer-related deaths in western countries, despite the use of androgen deprivation therapy or anti-androgen therapy. Researchers have identified prostate cancer stem cells as the cause of tumor recurrence, metastasis, and treatment failure. However, eliminating these cells is challenging due to their resistance to treatment and ability to adapt to the tumor microenvironment. Understanding the molecular biology of prostate cancer stem cells may lead to the development of targeted therapies. This review comprehensively summarizes the signaling pathways involved in regulating prostate cancer stem cells and discusses strategies for their elimination in clinical practice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Donatella Coradduzza, Sara Cruciani, Caterina Arru, Giuseppe Garroni, Aleksei Pashchenko, Mosab Jedea, Silvia Zappavigna, Michele Caraglia, Evzen Amler, Ciriaco Carru, Margherita Maioli
Summary: MicroRNAs play a significant role in the pathogenesis of prostate cancer and can be used as biomarkers. miR-145, 148, and 185 are associated with the development of prostate cancer and stem cell behavior, providing potential therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Integrative & Complementary Medicine
Meng Cui, Zhe Wang, Le-Tian Huang, Jia-He Wang
Summary: The study found that parthenolide has an anti-proliferative effect on thyroid cancer cells and affects their biological behavior by influencing the expression of proteins related to cell metabolism and DNA replication.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2022)
Article
Biochemistry & Molecular Biology
Taiga Seki, Yui Shimizu, Kyota Ishii, Yuzuki Takahama, Kazunori Kato, Tomohiro Yano
Summary: The study showed that NK cells can selectively target androgen-dependent prostate cancer stem-like cells via the TRAIL/DR5 pathway, providing a basis for developing strategies to eliminate prostate cancer stem cells.
Article
Multidisciplinary Sciences
Madhuri Kalathur, Alberto Toso, Jingjing Chen, Ajinkya Revandkar, Claudia Danzer-Baltzer, Ilaria Guccini, Abdullah Alajati, Manuela Sarti, Sandra Pinton, Lara Brambilla, Diletta Di Mitri, Giuseppina Carbone, R. Garcia-Escudero, Alessandro Padova, Letizia Magnoni, Alessia Tarditi, Laura Maccari, Federico Malusa, Ravi Kiran Reddy Kalathur, Lorenzo A. Pinna, Giorgio Cozza, Maria Ruzzene, Nicolas Delaleu, Carlo V. Catapano, Ian J. Frew, Andrea Alimonti
NATURE COMMUNICATIONS
(2015)
Review
Biochemistry & Molecular Biology
Madhuri Kalathur, Silvia Baiguera, Paolo Macchiarini
CELLULAR AND MOLECULAR LIFE SCIENCES
(2010)
Article
Cell Biology
Alberto Toso, Ajinkya Revandkar, Diletta Di Mitri, Ilaria Guccini, Michele Proietti, Manuela Sarti, Sandra Pinton, Jiangwen Zhang, Madhuri Kalathur, Gianluca Civenni, David Jarrossay, Erica Montani, Camilla Marini, Ramon Garcia-Escudero, Eugenio Scanziani, Fabio Grassi, Pier Paolo Pandolfi, Carlo V. Catapano, Andrea Alimonti
Article
Cell & Tissue Engineering
Benjamin T. Spike, Jonathan A. Kelber, Evan Booker, Madhuri Kalathur, Rose Rodewald, Julia Lipianskaya, Justin La, Marielle He, Tracy Wright, Richard Klemke, Geoffrey M. Wahl, Peter C. Gray
Article
Biochemistry & Molecular Biology
Brian T. Kawasaki, Tashan Mistree, Elaine M. Hurt, Madhuri Kalathur, William L. Farrar
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2007)