Article
Biochemistry & Molecular Biology
Shuai-Shuai Fu, Min Wen, Ying-Cai Zhao, Hao-Hao Shi, Yu-Ming Wang, Chang-Hu Xue, Zi-Hao Wei, Tian-Tian Zhang
Summary: A study found that dietary supplementation with EPA-pPE can significantly change the fatty acid composition in the brain and liver, especially in increasing the content of DHA. EPA-pPE has a more significant effect on increasing DHA compared to EPA-PC, making it a good nutritional supplement to increase DHA levels in n-3 PUFA-deficient offspring's brains.
Article
Agriculture, Multidisciplinary
Xiao-Yu Cui, Shan Jiang, Cheng-Cheng Wang, Jin-Yue Yang, Ying-Cai Zhao, Chang-Hu Xue, Yu-Ming Wang, Tian-Tian Zhang
Summary: The study demonstrated that EPA-PC, EPA-LPC, and DHA-LPC have different effects on DHA or EPA recovery and supplementation efficiency in different tissues, providing important references for understanding the time course of DHA or EPA recovery in phospholipid molecular species in different tissues.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Biology
Wang Ma, Mengzhen Liu, Zixu Zhang, Yingshuang Xu, Pengwei Huang, Dongsheng Guo, Xiaoman Sun, He Huang
Summary: In this study, a MetE-like complex was described for the first time, which can increase the content of EPA in Schizochytrium sp. and thus enhance its production. Lipidomics analysis revealed that EPA is more inclined to be stored as triglyceride. These findings suggest that Schizochytrium sp. has great potential for co-production of EPA and DHA.
COMMUNICATIONS BIOLOGY
(2022)
Article
Biology
Yohei Ishibashi, Hatsumi Goda, Rie Hamaguchi, Keishi Sakaguchi, Takayoshi Sekiguchi, Yuko Ishiwata, Yuji Okita, Seiya Mochinaga, Shingo Ikeuchi, Takahiro Mizobuchi, Yoshitake Takao, Kazuki Mori, Kosuke Tashiro, Nozomu Okino, Daiske Honda, Masahiro Hayashi, Makoto Ito
Summary: This study demonstrated that Parietichytrium sp. synthesizes DHA only through the elongase/desaturase pathway, and engineering this thraustochytrid allowed the production of EPA and n-3DPA. This system may provide a suitable solution for the large scale production of omega-3 fatty acids.
COMMUNICATIONS BIOLOGY
(2021)
Review
Agricultural Engineering
Parul Jakhwal, Jayanta Kumar Biswas, Archana Tiwari, Eilhann E. Kwon, Amit Bhatnagar
Summary: This review paper discusses recent developments in enhancing EPA and DHA production through non-genetic tailoring and genetic tailoring methods, and also summarizes legislation, public perception, and potential risks associated with using genetically modified microalgae for EPA and DHA production.
BIORESOURCE TECHNOLOGY
(2022)
Review
Nutrition & Dietetics
Clemens von Schacky
Summary: The structure and function of the brain rely on a sufficient supply of EPA and DHA through the bloodstream. Lower Omega-3 Index levels are associated with increased risks, highlighting the importance of adequate intake of these essential fatty acids for optimal brain health.
Article
Cardiac & Cardiovascular Systems
Frank Qian, Nathan Tintle, Paul N. Jensen, Rozenn N. Lemaitre, Fumiaki Imamura, Tobias Rudholm Feldreich, Sarah Oppeneer Nomura, Weihua Guan, Federica Laguzzi, Eunjung Kim, Jyrki K. Virtanen, Marinka Steur, Christian S. Bork, Yoichiro Hirakawa, Michelle L. O'Donoghue, Aleix Sala-Vila, Andres V. Ardisson Korat, Qi Sun, Eric B. Rimm, Bruce M. Psaty, Susan R. Heckbert, Nita G. Forouhi, Nicholas J. Wareham, Matti Marklund, Ulf Riserus, Lars Lind, Johan Arnlov, Parveen Garg, Michael Y. Tsai, James Pankow, Jeffrey R. Misialek, Bruna Gigante, Karin Leander, Julie A. Pester, Christine M. Albert, Maryam Kavousi, Arfan Ikram, Trudy Voortman, Erik B. Schmidt, Toshiharu Ninomiya, David A. Morrow, Antoni Bayes-Genis, James H. O'Keefe, Kwok Leung Ong, Jason H. Y. Wu, Dariush Mozaffarian, William S. Harris, David S. Siscovick
Summary: This study aimed to determine the associations of blood or adipose tissue levels of EPA, DPA, and DHA with incident AF. Using participant-level data from 17 prospective cohort studies, it was found that levels of omega-3 fatty acids, including EPA, DPA, DHA, and EPA+DHA, were not associated with increased risk of incident AF.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Food Science & Technology
Alejandra Valencia-Naranjo, Luz M. Manjarres-Correa, Juliana Bermudez-Cardona
Summary: This study aimed to evaluate the changes in the concentrations of EPA and DHA in the erythrocytes and breast milk of lactating women after three months of supplementation. The study found low consumption of omega-3 food sources and low EPA and DHA content initially. After supplementation, there was a significant increase in DHA levels in both erythrocytes and breast milk, while EPA levels did not change significantly.
CURRENT RESEARCH IN FOOD SCIENCE
(2022)
Article
Nutrition & Dietetics
Keyu Jia, Yao Feng, J. Thomas Brenna, Zhong-Cheng Luo, Jing Zhao, Hong Li, Peiqin Li, Qiuyi Zhang, Qianyu Zhao, Qi Dai, Yan Zhong, Tim Lambers, Hong Zhang, Hong Zhou, Ying Gao
Summary: The study found that higher levels of EPA in breast milk are beneficial for infants' attention, especially when EPA levels are below a certain threshold.
Review
Pharmacology & Pharmacy
Cristiana-Ioana Bercea, Graeme S. Cottrell, Francesco Tamagnini, Alister J. McNeish
Summary: Hypertension is characterised by impaired vasodilation, which can be improved by omega-3 polyunsaturated fatty acids such as DHA and EPA. These fatty acids also have vasodilatory effects on vascular smooth muscle cells (VSMCs) by opening potassium channels and possibly voltage-activated potassium channels, leading to hyperpolarisation and relaxation. Structural manipulation of omega-3 PUFAs may lead to novel therapeutic strategies.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yoichi Sunagawa, Ayumi Katayama, Masafumi Funamoto, Kana Shimizu, Satoshi Shimizu, Nurmila Sari, Yasufumi Katanasaka, Yusuke Miyazaki, Ryota Hosomi, Koji Hasegawa, Tatsuya Morimoto
Summary: This study found that both eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) suppress cardiomyocyte hypertrophy and the development of heart failure to the same extent through the inhibition of p300-histone acetyltransferase activity.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Review
Nutrition & Dietetics
Meghan Dempsey, Michelle S. Rockwell, Laurel M. Wentz
Summary: The majority of the population lack adequate omega-3 fatty acids (n-3 FA), leading to global deficiencies and poor omega-3 status. This study aimed to evaluate the effect of n-3 FA interventions on omega3-index (O3i) and estimate sufficient intake to meet recommendations.
FRONTIERS IN NUTRITION
(2023)
Article
Nutrition & Dietetics
Jing Chen, Johan Garssen, Frank Redegeld
Summary: The study showed cell type-dependent anticancer potential of DHA and EPA. Both compounds induced apoptosis in MM cells via multiple pathways and enhanced bortezomib chemosensitivity by activating NF-kappa B signaling pathway. Timing of concurrent treatment with bortezomib and DHA or EPA is crucial for optimal therapeutic outcomes.
CLINICAL NUTRITION
(2021)
Article
Biotechnology & Applied Microbiology
Anna-Lena Thurn, Anna Stock, Sebastian Gerwald, Dirk Weuster-Botz
Summary: By photoautotrophic co-cultivation of Tisochrysis lutea and Microchloropsis salina, it is possible to obtain microalgae biomass rich in both DHA and EPA while maintaining a balanced nutritional profile.
BIORESOURCES AND BIOPROCESSING
(2022)
Article
Nutrition & Dietetics
Peder L. Myhre, Trygve Berge, Are A. Kalstad, Sjur H. Tveit, Kristian Laake, Erik B. Schmidt, Svein Solheim, Harald Arnesen, Ingebjorg Selje, Arnljot Tveit
Summary: Recent clinical trials have raised concerns about the potential adverse effects of n-3 polyunsaturated fatty acid supplementation on atrial fibrillation (AF) risk. This study aimed to assess the risk and potential mediators of AF and 'micro-AF' from n-3 PUFA in post-MI patients. The results showed that supplementation of n-3 PUFA increased the risk of 'micro-AF' and AF, and changes in EPA seemed to play an important role in mediating this effect. Rating: 8 out of 10.
CLINICAL NUTRITION
(2023)
Article
Cardiac & Cardiovascular Systems
Wei Wu, Qun Lu, Shan Ma, Jin-Chan Du, Kevin Huynh, Thy Duong, Zhang-Da Pang, Daniel Donner, Peter J. Meikle, Xiu-Ling Deng, Xiao-Jun Du
Summary: Using an isoproterenol-induced mouse model of Takotsubo syndrome (TTS), we investigated the role of the O-adrenoceptors (OAR)-Hippo signaling pathway in mediating mitochondrial dysfunction. Our findings demonstrate that activation of OAR stimulates the Hippo pathway, which leads to mitochondrial dysfunction characterized by energy insufficiency and increased reactive oxygen species.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Endocrinology & Metabolism
Guillaume Treiber, Alice Guilleux, Kevin Huynh, Oriane Bonfanti, Ania Flaus-Furmaniuk, David Couret, Natalie Mellet, Celine Bernard, Nathalie Le-Moullec, Berenice Doray, Isabelle Jeru, Jean-Christophe Maiza, Bhoopendrasing Domun, Muriel Cogne, Olivier Meilhac, Corinne Vigouroux, Peter J. Meikle, Estelle Nobecourt
Summary: The study investigated glucose tolerance, insulin response, and metabolic markers in FPLD2 patients, revealing a high prevalence of diabetes and prediabetes. Early diagnosis and treatment are necessary.
DIABETES & METABOLISM
(2023)
Article
Nutrition & Dietetics
Brenan Durainayagam, Cameron J. J. Mitchell, Amber M. M. Milan, Marlena C. C. Kruger, Nicole C. C. Roy, Karl Fraser, David Cameron-Smith
Summary: The aim of this study was to examine the dynamic responses of plasma metabolome in overweight females in relation to meal glycaemic load (GL). The results showed that participants with Metabolic Syndrome (MetS) had lower concentrations of certain amino acids and metabolites related to energy metabolism after meals. However, the manipulation of meal GL had minimal impact on the postprandial metabolome, indicating that individual metabolic health has a greater influence.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Agriculture, Multidisciplinary
Gabriele Beltrame, Eija Ahonen, Annelie Damerau, Haraldur G. Gudmundsson, Gudmundur G. Haraldsson, Kaisa M. Linderborg
Summary: In this study, synthesized ABA- and AAB-type TAGs containing DHA and EPA were subjected to static in vitro digestion for the first time. It was found that the digestion process led to the degradation of hydroperoxides in DHA and EPA, particularly in tridocosahexaenoin. These findings are significant for the production of customized omega-3 structures.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Rhys Grinter, Ashleigh Kropp, Hari Venugopal, Moritz Senger, Jack Badley, Princess R. R. Cabotaje, Ruyu Jia, Zehui Duan, Ping Huang, Sven T. T. Stripp, Christopher K. K. Barlow, Matthew Belousoff, Hannah S. S. Shafaat, Gregory M. M. Cook, Ralf B. B. Schittenhelm, Kylie A. A. Vincent, Syma Khalid, Gustav Berggren, Chris Greening
Summary: Various aerobic bacteria use atmospheric H2 as an energy source. The Mycobacterium smegmatis hydrogenase Huc is an efficient oxygen-insensitive enzyme that can oxidize atmospheric H2 and transfer the derived electrons to the respiratory chain. This understanding provides a mechanistic basis for the important process of atmospheric H2 oxidation and opens up possibilities for catalyst development.
Article
Biology
Pablo M. Casillas-Espinosa, Alison Anderson, Anna Harutyunyan, Crystal Li, Jiyoon Lee, Emma L. Braine, Rhys D. Brady, Mujun Sun, Cheng Huang, Christopher K. Barlow, Anup D. Shah, Ralf B. Schittenhelm, Richelle Mychasiuk, Nigel C. Jones, Sandy R. Shultz, Terence J. O'Brien
Summary: This study found that sodium selenate treatment provides a sustained disease-modifying effect in chronically epileptic rats in the post-status epilepticus (SE) model of drug-resistant temporal lobe epilepsy (TLE). The treatment reduces the number of spontaneous seizures, cognitive dysfunction, and sensorimotor deficits. It is also associated with increased protein phosphatase 2A (PP2A) expression, reduced hyperphosphorylated tau, and reversed telomere length shortening.
Review
Biology
Aaron W. Jurrjens, Marcus M. Seldin, Corey Giles, Peter J. Meikle, Brian G. Drew, Anna C. Calkin
Summary: Cardiometabolic diseases result from genetic, environmental, and lifestyle factors and identifying those at high risk is challenging. Systems genetics, using population-based approaches, can elucidate the genetic and environmental causes of these diseases. Mouse genetic reference panels provide a complementary approach to human genome-wide association studies, allowing for controlled investigation of genetic and phenotypic variation. Integrating multi-omics data from human and mouse populations can advance our understanding of cardiometabolic diseases.
Article
Biochemistry & Molecular Biology
Dantong Zhu, Stephen T. Vernon, Zac D'Agostino, Jingqin Wu, Corey Giles, Adam S. Chan, Katharine A. Kott, Michael P. Gray, Alireza Gholipour, Owen Tang, Habtamu B. Beyene, Ellis Patrick, Stuart M. Grieve, Peter J. Meikle, Gemma A. Figtree, Jean Y. H. Yang
Summary: The current CAD risk scores based on traditional risk factors often fail individuals. We aim to identify lipidomic biomarkers using non-invasive imaging technology and advanced lipidomic measurement to enable intervention before cardiovascular events.
Article
Nutrition & Dietetics
Paige F. van der Pligt, Konsita Kuswara, Sarah A. Mcnaughton, Gavin Abbott, Sheikh Mohammed Shariful Islam, Kevin Huynh, Peter J. Meikle, Aya Mousa, Stacey J. Ellery
Summary: This study aimed to assess the relationship between early pregnancy maternal diet quality and maternal plasma lipids and indicators of cardiometabolic health. The results showed that maternal diet quality was inversely associated with multiple plasma triglycerides. This study provides novel insights into the relationship between diet quality, lipid biomarkers, and cardiometabolic health during pregnancy.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Gastroenterology & Hepatology
Ying Li, Bhagirath Chaurasia, M. Mahidur Rahman, Vincent Kaddai, J. Alan Maschek, Jordan A. Berg, Joseph L. Wilkerson, Ziad S. Mahmassani, James Cox, Peng Wei, Peter J. Meikle, Donald Atkinson, Liping Wang, Annelise M. Poss, Mary C. Playdon, Trevor S. Tippetts, Esraa M. Mousa, Kesara Nittayaboon, Pon Velayutham Anandh Babu, Micah J. Drummond, Hans Clevers, James A. Shayman, Yoshio Hirabayashi, William L. Holland, Jared Rutter, Bruce A. Edgar, Scott A. Summers
Summary: This study found that ceramides, as sphingolipid compounds, are associated with alimentary tract cancers. They function as signals of nutritional excess and can alter stem cell behaviors to influence cancer risk. The study also discovered that sphingolipid-producing enzymes are up-regulated in intestinal adenomas, leading to increased proliferation of intestinal progenitors through the stimulation of peroxisome-proliferator activated receptor-alpha and induction of fatty acid binding protein-1.
Article
Food Science & Technology
Sarah A. Marshall, Remy B. Young, Jessica M. Lewis, Emily L. Rutten, Jodee Gould, Christopher K. Barlow, Cristina Giogha, Vanessa R. Marcelino, Neville Fields, Ralf B. Schittenhelm, Elizabeth L. Hartland, Nichollas E. Scott, Samuel C. Forster, Emily L. Gulliver
Summary: Sulforaphane promotes the growth of specific gut microbiota and produces anti-inflammatory metabolites, providing a new mechanism for treating inflammatory states.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Multidisciplinary Sciences
Ebru Boslem, Saskia Reibe, Rodrigo Carlessi, Benoit Smeuninx, Surafel Tegegne, Casey L. Egan, Emma Mclennan, Lauren V. Terry, Max Nobis, Andre Mu, Cameron Nowell, Neil Horadagoda, Natalie A. Mellett, Paul Timpson, Matthew Jones, Elena Denisenko, Alistair R. R. Forrest, Janina E. E. Tirnitz-Parker, Peter J. Meikle, Stefan Rose-John, Michael Karin, Mark A. Febbraio
Summary: The incidence of hepatocellular carcinoma (HCC) is increasing due to obesity-related nonalcoholic steatohepatitis (NASH). In a mouse model mimicking NASH-driven HCC, activation of endoplasmic reticulum stress and inflammation was observed in hepatocytes. Treatment with an ER stress inhibitor and an anti-inflammatory drug reversed NASH and reduced NASH-driven HCC.
Article
Medicine, General & Internal
Taeho Jo, Junpyo Kim, Paula Bice, Kevin Huynh, Tingting Wang, Matthias Arnold, Peter J. Meikle, Corey Giles, Rima Kaddurah-Daouk, Andrew J. Saykin, Kwangsik Nho
Summary: This study introduces the Circular-Sliding Window Association Test (c-SWAT) to improve the classification accuracy in predicting Alzheimer's Disease (AD) using serum-based metabolomics data. The results show that c-SWAT is effective in improving classification accuracy and in identifying key lipids associated with AD.
Article
Engineering, Chemical
Dorota Ogrodowska, Annelie Damerau, Pawel Banaszczyk, Malgorzata Tanska, Iwona Z. Konopka, Beata Pilat, Fabian Dajnowiec, Kaisa M. Linderborg
Summary: This study compared the properties of emulsions and encapsulated powders containing different starches and maltodextrin and found that pregelatinized starch can improve the stability of emulsions and the encapsulation efficiency of capsules.
JOURNAL OF FOOD ENGINEERING
(2024)
Article
Food Science & Technology
Yuqing Zhang, Marika Kalpio, Lingwei Tao, Gudmundur G. Haraldsson, Haraldur G. Gudmundsson, Xiangrong Fang, Kaisa M. Linderborg, Yumei Zhang, Baoru Yang.
Summary: This study investigated the impact of the specific positions of docosahexaenoic acid (DHA) in dietary triacylglycerols (TAGs) on the fatty acid composition of tissues and organs in rats. The results showed that the position of DHA in TAGs influenced its accumulation in different tissues and organs, providing new insights into the bioavailability and metabolic fate of DHA.
FOOD RESEARCH INTERNATIONAL
(2023)
