期刊
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
卷 80, 期 1, 页码 19-26出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.plefa.2008.10.002
关键词
Suicide; Adolescent; Gender; Prefrontal cortex; Postmortem brain; Omega-3 fatty acid; Docosahexaenoic acid (DHA); Arachidonic acid
资金
- National Institute of Mental Health [MH073704, MH074858, R01 MH48153]
- NATIONAL INSTITUTE OF MENTAL HEALTH [R21MH074858, R21MH073704, R01MH048153] Funding Source: NIH RePORTER
Prior epidemiological, prospective intervention, and peripheral and central fatty acid composition studies suggest that omega-3 fatty acid deficiency may be associated with the pathoaetiology of depression and suicide. In the present study, we determined the fatty acid composition of the postmortem prefrontal cortex (PFC) of adolescent male and female suicide victims and age-matched controls. Fatty acid composition (wt% total fatty acids) and concentrations (mu mol/g) were determined in the postmortem PFC (Brodmann area 10) of male and female adolescent (aged 13-20 years) suicide victims (n = 20) and age-matched controls (n = 20) by gas chromatography. None of the major polyunsaturated fatty acids including the principle brain omega-3 fatty acid, docosahexaenoic acid (DHA), monounsaturated fatty acids, or saturated fatty acids differed significantly between adolescent suicide victims and controls before or after segregation by gender. The arachidonic acid (AA, 20:4n-6): DHA ratio and adrenic acid (22:4n-6) composition were negatively correlated with age at death in controls but not in suicides, and males exhibited a greater AA:DHA ratio irrespective of cause-of-death. These results demonstrate that adolescent male and female suicide victims do not exhibit DHA deficits in the postmortem PFC relative to age-matched controls, and suggest that suicide victims do not exhibit the normal age-related decrease in adrenic acid composition and the AA:DHA ratio. (C) 2008 Elsevier Ltd. All rights reserved.
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