期刊
ACS CATALYSIS
卷 5, 期 9, 页码 5596-5606出版社
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.5b01291
关键词
cross-coupling catalysis; palladium; precatalyst; Suzuki-Miyaura reaction; catalyst activation; DFT calculations
资金
- Norwegian Research Council through Center of Excellence for Theoretical and Computational Chemistry (CTCC) [179568/V30]
- Norwegian Metacenter for Computational Science (NOTUR) [nn4654k]
- EU REA for a Marie Curie Fellowship [CompuWOC/618303]
- NSF
Complexes of the type (eta(3)-allyl)Pd(L)(Cl) (L = PR3 or NHC), have been used extensively as precatalysts for cross-coupling and related reactions, with systems containing substituents in the 1-position of the eta(3)-allyl ligand, such as (eta(3-)cinnamyl)Pd(L)(Cl), giving the highest activity. Recently, we reported a new precatalyst scaffold based on an eta(3)-indenyl ligand, (eta(3)-indenyl)Pd(L)(Cl), which typically provides higher activity than even eta(3)-cinnamyl supported systems. In particular, precatalysts of the type (eta(3)-1-Bu-t-indenyl)Pd(L)(Cl) give the highest activity. In cross-coupling reactions using this type of Pd(II) precatalyst, it is proposed that the active species is monoligated Pd(0), and the rate of reduction to Pd(0) is crucial. Here, we describe detailed experimental and computational studies which explore the pathway by which the Pd(II) complexes (eta(3)-allyl)Pd(IPr)(Cl) (IPr = 1,3-bis(2,6-diisopropylphenyl)-1,3-dihydro-2H-imidazol-2-ylidene), (eta(3)-cinnamyl)Pd(IPr)(Cl), (eta(3)-indenyl)Pd(IPr)(Cl) and (eta(3)-1-tBu-indenyl)Pd(IPr)(Cl) are reduced to Pd(0) in alcoholic solvents, which are commonly used in Suzuki-Miyaura and alpha-arylation reactions. The rates of reduction for the different precatalysts are compared and we observe significant variability based on the exact reaction conditions. However, in general, eta(3)-indenyl systems are reduced faster than eta(3)-indenyl-allyl systems, and DFT calculations show that this is in part due to the ability of the indenyl ligand to undergo facile ring slippage. Our results are consistent with the eta(3)-indenyl systems giving increased catalytic activity and provide fundamental information about how to design systems that will rapidly generate monoligated Pd(0) in the presence of alcohols.
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