期刊
ACS CATALYSIS
卷 5, 期 10, 页码 5812-5821出版社
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.5b01113
关键词
chemicals from biomass; ethyl levulinate; reductive amination; Pt/TiO2 catalyst; N-substituted-5-methylpyrrolidones
资金
- Program Severo Ochoa
- Generalitat Valenciana (Prometeo program)
- Spanish MICINN [CTQ-2011-27550]
- Consolider-Ingenio (project MULTICAT)
N-substituted-5-methyl-2-piyrrolidones have been obtained by reductive amination of ethyl levulinate with amines in the presence of H-2 as reducing agent under solvent-free conditions. The process involves as a first step the formation of an imine intermediate followed by hydrogenation of the imine group and subsequent cyclization into pyrrolidone. Pt/TiO2 with Pt crystal faces decorated with TiOx is a very active and chemoselective catalyst, being possible to achieve high conversion and selectivity to the corresponding N-substituted-5-methyl-2-pyrrolidones even when other groups susceptible of hydrogenation such as vinyl, carbonyl, or cyano groups are present in the amine moiety. A kinetic study showed that the reaction-controlling step is the formation of the imine intermediate. The rate of formation is enhanced by the presence of protonic acid sites generated on the support by hydrogen dissociation on the metal, resulting in a true bifunctional catalyst for the reaction.
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