期刊
PROGRESS IN RETINAL AND EYE RESEARCH
卷 29, 期 6, 页码 476-486出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.preteyeres.2010.05.001
关键词
Visual Cycle; Retinoid Cycle; Zebrafish; Cone Photoreceptor; Muller Glia Cell; CRALBP
Vertebrate vision necessitates continuous recycling of the chromophore 11-cis retinal (RAL). The classical (or canonical) visual cycle employs a number of enzymes located in the photoreceptor outer segment and RPE (retinal pigment epithelium) of the retina to regenerate 11-cis RAL from all-trans RAL. Cone-dominant species are believed to utilize a second, intra-retinal, pathway for 11-cis RAL generation, involving retinal Muller glia cells. This review summarizes the efforts made in zebrafish to gain a better understanding of the role of these two visual cycles for rod and cone photoreceptor chromophore recycling. (C) 2010 Elsevier Ltd. All rights reserved.
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