☆ 4.5 Review

Human serum/plasma lipoprotein analysis by NMR: Application to the study of diabetic dyslipidemia

PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY (2013)

期刊

PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

卷 70, 期 -, 页码 1-24

出版社

PERGAMON-ELSEVIER SCIENCE LTD

DOI: 10.1016/j.pnmrs.2012.09.001

关键词

Lipoprotein analysis; NMR spectroscopy; NMR diffusion; Diabetic dyslipidemia

类别

Chemistry, Physical Physics, Atomic, Molecular & Chemical Spectroscopy

资金

Universitat Rovira i Virgili
CIBER de Diabetes y Enfermedades Metabolicas Asociadas (ISCIII, Ministerio de Ciencia e Innovacion)
FIS [PI 081409]

向作者/读者索取更多资源

Protocol

Reagent

作者

我是这篇论文的作者

点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5

评分不足

次要评分

新颖性

-

重要性

-

科学严谨性

-

评价这篇论文

推荐

Article Health Care Sciences & Services

Risk Analysis and Assessment of Lipid Abnormalities as the Earliest Complication in Newly Diagnosed Diabetic and Non-Diabetic Individuals of a Local Population

Zunaira Ali Baig, Amir Rashid, Asifa Majeed, Zahra Masood, Asma Faryal, Zahra Arshad Khan, Aden Razaq

Summary: This study assessed lipid abnormalities in newly diagnosed diabetics and non-diabetics and found that regardless of type 2 diabetes, lipid levels can independently cause derangement, which serves as an early onset indicator rather than a later-stage complication. These derangements of lipid levels are an independent risk factor for future cardiovascular pathology.

HEALTHCARE (2022)

添加到收藏夹

Article Public, Environmental & Occupational Health

Apt interpretation of comprehensive lipoprotein data in large-scale epidemiology: disclosure of fundamental structural and metabolic relationships

Mika Ala-Korpela, Siyu Zhao, Marjo-Riitta Jarvelin, Ville-Petteri Makinen, Pauli Ohukainen

Summary: Quantitative analysis of lipoproteins using NMR spectroscopy is common in large-scale studies, with a methodology allowing for comprehensive characterization of lipoprotein subclasses. In this study, serum samples from two Finnish birth cohorts were analyzed using NMR, revealing the important relationship between lipoprotein particle concentrations and size. The findings suggest that lipoprotein particles are under strict metabolic constraints, impacting their composition and concentrations.

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY (2021)

添加到收藏夹

Article Medicine, General & Internal

Lipoprofiling Assessed by NMR Spectroscopy in Patients with Acute Coronary Syndromes: Is There a Need for Fasting Prior to Sampling?

Laura-Adina Stanciulescu, Alexandru Scafa, Catalin Duduianu, Raluca Stan, Alina Nicolescu, Calin Deleanu, Maria Dorobantu

Summary: Most patients with ACS in the emergency unit have multiple cardiovascular risk factors and fasting has some effects on blood metabolite concentrations and lipoprotein parameters, although the magnitude of the effect is low. Blood samples analyzed in any feeding status can provide valuable information.

DIAGNOSTICS (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

Sensitive, Efficient and Portable Analysis of Molecular Exchange Processes by Hyperpolarized Ultrafast NMR

Yashu Kharbanda, Mateusz Urbanczyk, Vladimir V. Zhivonitko, Sarah Mailhiot, Mikko Kettunen, Ville-Veikko Telkki

Summary: In this study, a method using low-cost, portable, single-sided NMR instruments for analyzing molecular exchange processes is introduced. By exploiting the inherent magnetic field inhomogeneity of the instruments, diffusion contrast of exchange sites and spatial encoding of 2D data can be achieved. The method, called ultrafast diffusion exchange spectroscopy, significantly shortens the experiment time and improves the sensitivity by several orders of magnitude. The feasibility of the method is demonstrated by quantifying intra- and extracellular exchange of water in a yeast cell suspension.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

添加到收藏夹

Article Peripheral Vascular Disease

Distinct Differences in Lipoprotein Particle Number Evaluation between GP-HPLC and NMR: Analysis in Dyslipidemic Patients Administered a Selective PPARα Modulator, Pemafibrate

Shizuya Yamashita, Mitsuyo Okazaki, Takeshi Okada, Daisaku Masuda, Koutaro Yokote, Hidenori Arai, Eiichi Araki, Shun Ishibashi

Summary: The study established a method to evaluate lipid concentrations, size, and particle numbers of lipoprotein subclasses using GP-HPLC and compared the results with NMR. The study found that GP-HPLC provided more accurate evaluation of lipoprotein particle numbers compared to NMR, suggesting its potential use in assessing the effects of lipid-lowering drugs on lipoprotein subclasses.

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS (2021)

添加到收藏夹

Article Chemistry, Analytical

NMR for Mixture Analysis: Concentration-Ordered Spectroscopy

Bin Yuan, Zhiming Zhou, Bin Jiang, Ghulam Mustafa Kamal, Xu Zhang, Conggang Li, Xin Zhou, Maili Liu

Summary: CORDY is a novel approach for NMR spectroscopy that utilizes concentration order to separate and quantify components in complex samples, by utilizing prior information of chemical shift distribution and line shape characteristics to shrink the solution space, it generates a pseudo-two-dimensional spectrum. The combination of CORDY and DOSY (CORDY-DOSY) has been found to be more efficient in resolving molecules with similar concentrations or self-diffusion coefficients.

ANALYTICAL CHEMISTRY (2021)

添加到收藏夹

Article Urology & Nephrology

Advanced lipoprotein parameters could better explain atheromatosis in non-diabetic chronic kidney disease patients

Marcelino Bermudez-Lopez, Hector Perpinan, Nuria Amigo, Eva Castro, Nuria Alonso, Didac Mauricio, Elvira Fernandez, Jose M. Valdivielso

Summary: The study found that chronic kidney disease patients have a higher risk of atheromatosis, and in non-diabetic individuals not on statin therapy, the quantity of triglyceride-loaded medium density LDL particles was higher and independently associated with atheromatosis.

CLINICAL KIDNEY JOURNAL (2021)

添加到收藏夹

Article Chemistry, Analytical

Exploration of Human Serum Lipoprotein Supramolecular Phospholipids Using Statistical Heterospectroscopy in n-Dimensions (SHY-n): Identification of Potential Cardiovascular Risk Biomarkers Related to SARS-CoV-2 Infection

Reika Masuda, Samantha Lodge, Luke Whiley, Nicola Gray, Nathan Lawler, Philipp Nitschke, Sze-How Bong, Torben Kimhofer, Ruey Leng Loo, Berin Boughton, Annie X. Zeng, Drew Hall, Hartmut Schaefer, Manfred Spraul, Girish Dwivedi, Bu B. Yeap, Tammo Diercks, Ganeko Bernardo-Seisdedos, Jose M. Mato, John C. Lindon, Elaine Holmes, Oscar Millet, Julien Wist, Jeremy K. Nicholson

Summary: SARS-CoV-2 infection leads to a decrease in lipoprotein-bound serum phospholipids, resulting in supra-molecular phospholipid composite (SPC) signals detected in diffusion and relaxation edited H-1 NMR spectra. This study utilized Statistical HeterospectroscoY in n-dimensions (SHYn) approach to identify the major phospholipid components contributing to the SPC signals and correlated them with lipoprotein and lipid measurements. The SPC3/SPC2 ratio was strongly correlated with the apolipoprotein B100/A1 ratio, indicating the potential of serum SPC measurement as a metric of cardiovascular risk based on a single NMR experiment.

ANALYTICAL CHEMISTRY (2022)

添加到收藏夹

Article Chemistry, Physical

NMR diffusion analysis of catalytic conversion mixtures from lignocellulose biomass using PSYCHE-iDOSY

Qi Zhao, Christian Marcus Pedersen, Jiamin Wang, Rui Liu, Yuanli Zhang, Xiuyin Yan, Zhenzhou Zhang, Xianglin Hou, Yingxiong Wang

Summary: The article introduces a high-resolution diffusion-related NMR technique that can effectively separate and identify individual compounds in complex mixtures of biomass. The technique can be applied to model and genuine mixture samples from cellulose, hemicellulose, and lignin, successfully separating isomers, homologous compounds, model compounds, and genuine reaction systems. The results show that this method can detect and separate the mixture components of C5/C6 sugar conversion products and their derivative hydrogenation/hydrogenolysis from lignocellulosic biomass.

GREEN ENERGY & ENVIRONMENT (2023)

添加到收藏夹

Article Chemistry, Physical

A General Reconstruction Method for Multidimensional Sparse Sampling Nuclear Magnetic Resonance Spectroscopy

Enping Lin, Zhemin Bai, Yifei Yuan, Zhiwei Chen, Yu Yang, Yuqing Huang, Zhong Chen

Summary: Multidimensional NMR spectroscopy is a powerful tool for structure elucidation and dynamic analysis of complex samples, particularly biological macromolecules. However, the reconstruction of Laplace-related NMR, which involves relaxation or diffusion detection, presents challenges due to its ill-posed property. Existing reconstruction methods for Laplace-related NMR sparse sampling suffer from poor resolution and possible artifacts, highlighting the need for more effective optimization algorithms.

JOURNAL OF PHYSICAL CHEMISTRY LETTERS (2021)

添加到收藏夹

Article Endocrinology & Metabolism

Outstanding improvement of the advanced lipoprotein profile in subjects with new-onset type 1 diabetes mellitus after achieving optimal glycemic control

Esmeralda Castelblanco, Marta Hernandez, Emilio Ortega, Nuria Amigo, Jordi Real, Minerva Granado-Casas, Inka Minambres, Carolina Lopez, Albert Lecube, Marcelino Bermudez-Lopez, Nuria Alonso, Josep Julve, Didac Mauricio

Summary: The study found that glycemic optimization in new-onset type 1 diabetes mellitus patients can reduce certain lipoprotein abnormalities and subsequently lower the cardiovascular risk associated with poorly controlled T1D.

DIABETES RESEARCH AND CLINICAL PRACTICE (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Pregnancy is accompanied by larger high density lipoprotein particles and compositionally distinct subspecies

John T. Melchior, Debi K. Swertfeger, Jamie Morris, Scott E. Street, Carri R. Warshak, Jeffrey A. Welge, Alan T. Remaley, Janet M. Catov, W. Sean Davidson, Laura A. Woollett

Summary: Pregnancy induces physiological changes that affect the health and development of both the fetus and mother, including alterations in plasma lipoproteins. This study found that pregnant women have an increase in larger HDL particles and significant changes in lipid-associated proteins within different HDL size fractions, which could have implications on HDL function during pregnancy.

JOURNAL OF LIPID RESEARCH (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Comparison of measured LDL cholesterol with calculated LDL-cholesterol using the Friedewald and Martin-Hopkins formulae in diabetic adults at Charlotte Maxeke Johannesburg Academic Hospital/NHLS Laboratory

Mogomotsi Dintshi, Ngalulawa Kone, Siyabonga Khoza

Summary: This study compared the calculated LDL-C using the Friedewald and Martin-Hopkins formulae to the measured LDL-C. The results showed that the Martin-Hopkins formula performed better at LDL-C treatment target <1.4 mmol/L and had lower positive bias in patients with hypertriglyceridemia.

PLOS ONE (2022)

添加到收藏夹

Article Chemistry, Physical

1H Detected Relayed Dynamic Nuclear Polarization

Pierrick Berruyer, Andrea Bertarello, Snaedis Bjoergvinsdottir, Moreno Lelli, Lyndon Emsley

Summary: Recently, methods based on the dynamics of 1H nuclear hyperpolarization in magic angle spinning (MAS) NMR experiments have been used to determine mesoscale structures in complex materials. However, these methods have low sensitivity and have only been feasible using indirect detection of 1H polarization through dilute heteronuclei. In this study, relayed-DNP (R-DNP) combined with fast MAS enables direct 1H detection, accelerating experiment times by a factor of 16. Varying the MAS rate allows for recording a series of independent R-DNP curves that can be jointly analyzed to accurately determine domain sizes.

JOURNAL OF PHYSICAL CHEMISTRY C (2022)

添加到收藏夹

Article Chemistry, Physical

Diffusion Analysis on Complex Mixtures under Adverse Magnetic Field Conditions by Spatially-Selective Pure Shift-Based DOSY

Haolin Zhan, Mengyou Hao, Ye Feng, Shuohui Cao, Zhikai Ni, Yuqing Huang, Zhong Chen

Summary: Diffusion-ordered NMR spectroscopy (DOSY) is a noninvasive method for studying intact mixtures and identifying individual components based on their diffusion behaviors. The strategy of spatially selective pure shift-based DOSY can help eliminate inhomogeneous line broadening and extract pure shift singlets, facilitating diffusion analyses on complex mixtures and potentially monitoring electrochemical reactions. This study demonstrates the potential of DOSY in complex mixture analysis and its applications in various fields.

JOURNAL OF PHYSICAL CHEMISTRY LETTERS (2021)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Implications of ACC/AHA Versus ESC/EAS LDL-C Recommendations for Residual Risk Reduction in ASCVD: A Simulation Study From DA VINCI

Antonio J. Vallejo-Vaz, Sarah Bray, Guillermo Villa, Julia Brandts, Gaia Kiru, Jennifer Murphy, Maciej Banach, Stefano De Servi, Dan Gaita, Ioanna Gouni-Berthold, G. Kees Hovingh, Jacek J. Jozwiak, J. Wouter Jukema, Robert Gabor Kiss, Serge Kownator, Helle K. Iversen, Vincent Maher, Luis Masana, Alexander Parkhomenko, Andre Peeters, Piers Clifford, Katarina Raslova, Peter Siostrzonek, Stefano Romeo, Dimitrios Tousoulis, Charalambos Vlachopoulos, Michal Vrablik, Alberico L. Catapano, Neil R. Poulter, Kausik K. Ray

Summary: In patients with atherosclerotic cardiovascular disease (ASCVD), achieving European Society of Cardiology/European Atherosclerosis Society (ESC/EAS) LDL-C goals may result in an additional 2% absolute risk reduction (ARR) over 10 years compared to the American College of Cardiology/American Heart Association (ACC/AHA) approach.

CARDIOVASCULAR DRUGS AND THERAPY (2023)

添加到收藏夹

Article Peripheral Vascular Disease

Glycoprotein Serum Concentrations Assessed By 1H-NMR are Increased in Patients With High Blood Pressure

Natalia Andreychuk, Didac Llop, Juan Moreno-Vedia, Josefa Girona, Daiana Ibarretxe, Celia Rodriguez-Borjabad, Nuria Plana, Lluis Masana

Summary: This study evaluated the impact of plasma concentrations of glycoproteins A, B, and F on patients with hypertension. The results showed that hypertensive patients had a higher prevalence of obesity, metabolic syndrome, and diabetes, and higher concentrations of glycoproteins A, B, and F. The study also found that glycoproteins A, B, and F were positively correlated with the occurrence of hypertension.

HYPERTENSION (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

PCSK9 Inhibitors Have Apolipoprotein C-III-Related Anti-Inflammatory Activity, Assessed by 1H-NMR Glycoprotein Profile in Subjects at High or very High Cardiovascular Risk

Pere Rehues, Josefa Girona, Montse Guardiola, Nuria Plana, Roberto Scicali, Salvatore Piro, Ovidio Muniz-Grijalvo, Jose Luis Diaz-Diaz, Lluis Recasens, Marta Pinyol, Roser Rosales, Yaiza Esteban, Nuria Amigo, Lluis Masana, Daiana Ibarretxe, Josep Ribalta

Summary: This study evaluated the effects of iPCSK9 on glycoproteins A, B, and F, and found that iPCSK9 therapy not only reduced LDL cholesterol, but also decreased 1H-NMR glycoprotein signals, which correlated with a decrease in triglycerides and apoC-III.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

添加到收藏夹

Article Multidisciplinary Sciences

Women with familial hypercholesterolemia phenotype are undertreated and poorly controlled compared to men

Alberto Zamora, Rafel Ramos, Marc Comas-Cufi, Maria Garcia-Gil, Ruth Marti-Lluch, Nuria Plana, Lia Alves-Cabratosa, Anna Ponjoan, Celia Rodriguez-Borjabad, Daiana Ibarretxe, Irene Roman-Degano, Jaume Marrugat, Roberto Elosua, Anabel Martin-Urda, Lluis Masana

Summary: Familial hypercholesterolemia (FH) is a common autosomal dominant disease associated with early coronary heart disease (CHD). A study of over 2 million individuals showed that women with FH are less likely to receive high-intensity lipid-lowering therapy (LLT) and have poorer adherence to LLT compared to men. Additionally, women have a lower probability of achieving their LDL-c goals, especially in secondary prevention.

SCIENTIFIC REPORTS (2023)

添加到收藏夹

Article Medicine, General & Internal

Glycoprotein and Lipoprotein Profiles Assessed by 1H-NMR and Its Relation to Ascending Aortic Dilatation in Bicuspid Aortic Valve Disease

Borja Antequera-Gonzalez, Marta Faiges, Neus Martinez-Micaelo, Laura Galian-Gay, Carmen Ligero, Maria Ferre-Vallverdu, Lluis Masana, Nuria Amigo, Arturo Evangelista, Josep M. Alegret

Summary: This study analyzed and compared the lipoprotein and glycoprotein profiles in 152 patients with bicuspid aortic valve (BAV) and ascending aorta dilatation (AAoD), and found that parameters related to lipoprotein profile and a novel inflammation biomarker were significantly increased in the dilated group. In long-term follow-up, proatherogenic lipoprotein parameters were associated with ascending aorta dilation velocity. Therefore, BAV patients with AAoD have a more pro-atherogenic profile, which appears to contribute to the increased growth rate of ascending aorta diameter.

JOURNAL OF CLINICAL MEDICINE (2023)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Impact of physician's perception about LDL cholesterol control in clinical practice when treating patients in Spain

Juan Cosin-Sales, Raquel Campuzano Ruiz, Jose Luis Diaz Diaz, Carlos Escobar Cervantes, Maria Rosa Fernandez Olmo, Juan Jose Gomez-Doblas, Jose Maria Mostaza, Juan Pedro-Botet, Nuria Plana Gili, Pedro Valdivielso

Summary: This study investigated the impact of physicians' perception about LDL-cholesterol control on the management of patients with dyslipidemia in Spain. The study found that most patients did not achieve the recommended LDLc goals due to physicians' misperception and lack of patient adherence.

ATHEROSCLEROSIS (2023)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Association between Nordic and Mediterranean diets with lipoprotein phenotype assessed by 1HNMR in children with familial hypercholesterolemia

Celia Rodriguez-Borjabad, Ingunn Narveud, Jacob Juel Christensen, Daiana Ibarretxe, Natalia Andreychuk, Josefa Girona, Kristin Torvik, Guro Folkedal, Martin P. Bogsrud, Kjetil Retterstol, Nuria Plana, Luis Masana, Kirsten B. Holven

Summary: A study on Spanish and Norwegian children showed that both Nordic and Mediterranean diets can improve the lipid metabolism of children with familial hypercholesterolemia, with the quantity and size of HDL and LDL particles being the main determining factors.

ATHEROSCLEROSIS (2023)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

2023 Update on European Atherosclerosis Society Consensus Statement on Homozygous Familial Hypercholesterolaemia: new treatments and clinical guidance

Marina Cuchel, Frederick J. Raal, Robert A. Hegele, Khalid Al-Rasadi, Marcello Arca, Maurizio Averna, Eric Bruckert, Tomas Freiberger, Daniel Gaudet, Mariko Harada-Shiba, Lisa C. Hudgins, Meral Kayikcioglu, Luis Masana, Klaus G. Parhofer, Jeanine E. Roeters van Lennep, Raul D. Santos, Erik S. G. Stroes, Gerald F. Watts, Albert Wiegman, Jane K. Stock, Lale S. Tokgoezoglu, Alberico L. Catapano, Kausik K. Ray

Summary: This 2023 statement provides updated clinical guidance for the management of homozygous familial hypercholesterolaemia (HoFH), including criteria for diagnosis, genetic testing interpretation, and treatment recommendations. The statement emphasizes the importance of considering both phenotype and genotype in the diagnosis of HoFH, with a LDL-C level >10 mmol/L (>400 mg/dL) being indicative of the condition. Combination therapy targeting LDL-C, including the use of novel therapies like proprotein convertase subtilisin/kexin type 9 inhibitors, is recommended to achieve LDL-C goals and reduce the need for lipoprotein apheresis. To improve HoFH care globally, the statement recommends the implementation of national screening programs, education to increase awareness, and management guidelines adapted to local healthcare systems.

EUROPEAN HEART JOURNAL (2023)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Lipoprotein profile assessed by 1H NMR, BMI and blood pressure are associated with vascular alterations in children with familial hypercholesterolaemia

D. Llop, A. Feliu, D. Ibarretxe, J. Escribano, N. Plana, C. Borjabad-Rodriguez, L. Masana, J. C. Vallve

Summary: This study examines the arterial structure and functional characteristics in children with familial hypercholesterolaemia (FH) and finds that alterations in lipoprotein parameters are associated with early arterial damage and stiffness. Body mass index (BMI) and blood pressure play a role in these associations. Therefore, early cardiovascular prevention should be implemented in children with FH, including adopting a healthy lifestyle.

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES (2023)

添加到收藏夹

Article Pharmacology & Pharmacy

Lipid lowering combination therapy: From prevention to atherosclerosis plaque treatment

Lluis Masana, Nuria Plana, Natalia Andreychuk, Daiana Ibarretxe

Summary: Statins have played a significant role in preventing atherosclerotic cardiovascular events and deaths by reducing LDL cholesterol levels. International guidelines recommend low LDL cholesterol goals for patients at high cardiovascular risk. However, these goals may not be attainable with statins alone. Recent trials have shown that nonstatin drugs like PCSK9 inhibitors, ezetimibe, bempedoic acid, and icosapent ethyl can also provide cardiovascular benefits. Physicians should use combination therapies based on a patient's risk and LDL cholesterol levels to achieve LDL cholesterol goals and improve cardiovascular outcomes.

PHARMACOLOGICAL RESEARCH (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

Fatty Acid Binding Proteins 3 and 4 Predict Both All-Cause and Cardiovascular Mortality in Subjects with Chronic Heart Failure and Type 2 Diabetes Mellitus

Ricardo Rodriguez-Calvo, Minerva Granado-Casas, Alejandra Perez-Montes de Oca, Maria Teresa Julian, Mar Domingo, Pau Codina, Evelyn Santiago-Vacas, German Cediel, Josep Julve, Joana Rossell, Lluis Masana, Didac Mauricio, Josep Lupon, Antoni Bayes-Genis, Nuria Alonso

Summary: This study aimed to explore the prognostic value of cardiac-specific fatty acid binding proteins (FABP3) and adipose-tissue-specific fatty acid binding proteins (FABP4) in chronic heart failure (CHF) patients, with and without type 2 diabetes mellitus (T2D). It was found that the concentrations of FABP3 and FABP4 were associated with all-cause and cardiovascular mortality, particularly in patients with T2D. The study suggests that serum FABP3 and FABP4 concentrations can serve as independent predictors for the occurrence of all-cause and cardiovascular mortality in ambulatory CHF subjects with T2D.

ANTIOXIDANTS (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

Plasma Expression of Carotid Plaque Presence-Related MicroRNAs Is Associated with Inflammation in Patients with Rheumatoid Arthritis

Didac Llop, Silvia Paredes, Daiana Ibarretxe, Delia Taverner, Nuria Plana, Roser Rosales, Lluis Masana, Joan Carles Vallve

Summary: The expression of microRNA-24, -146 and -Let7a is associated with inflammation and atherosclerosis in rheumatoid arthritis (RA) patients. These microRNAs may serve as potential therapeutic targets for RA.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

添加到收藏夹

Article Biochemical Research Methods

CloMet: A Novel Open-Source and Modular Software Platform That Connects Established Metabolomics Repositories and Data Analysis Resources

Jordi Rodeiro, Ester Vidana-Vila, Joan Navarro, Roger Mallol

Summary: This paper presents CloMet, a novel open-source modular software platform that contributes to standardization, reusability, and reproducibility in the metabolomics field. CloMet converts raw and NMR-based metabolomics data from MetaboLights and Metabolomics Workbench to a file format that can be used directly in MetaboAnalyst or Workflows4Metabolomics.

JOURNAL OF PROTEOME RESEARCH (2023)

添加到收藏夹

Article Health Care Sciences & Services

Economic Burden Associated with the Treatment with a Cardiovascular Polypill in Secondary Prevention in Spain: Cost-Effectiveness Results of the NEPTUNO Study

Alberto Cordero, Regina Dalmau Gonzalez-Gallarza, Lluis Masana, Valentin Fuster, Jose Ma Castellano, Jose Emilio Ruiz Olivar, Ilonka Zsolt, Antoni Sicras-Mainar, Jose Ramon Gonzalez Juanatey

Summary: The study aimed to estimate the utilization, costs, and cost-effectiveness of health-care resources associated with the use of CNIC-Polypill as secondary prevention of ASCVD compared to other treatments in Spain. A retrospective study using medical records was conducted, and the CNIC-Polypill was found to reduce recurrent cardiovascular events and costs, making it a cost-saving strategy for ASCVD secondary prevention.

CLINICOECONOMICS AND OUTCOMES RESEARCH (2023)

添加到收藏夹

Article Medicine, General & Internal

Lipidomics of triglyceride-rich lipoproteins derived from hyperlipidemic patients on inflammation

Juan Moreno-Vedia, Didac Llop, Ricardo Rodriguez-Calvo, Nuria Plana, Nuria Amigo, Roser Rosales, Yaiza Esteban, Lluis Masana, Daiana Ibarretxe, Josefa Girona

Summary: This study aimed to analyze the lipidome modifications of TRL particles enriched in TG in patients with hyperlipidemia and investigate their associations with a proinflammatory status. The results showed that higher TRL-TG levels were associated with higher circulating levels of glycoproteins. In vitro experiments demonstrated that TRL particles with higher cholesterol and phospholipid contents exerted a stronger proinflammatory effect.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2023)

添加到收藏夹

暂无数据

© Peeref 2019-2024. All rights reserved.