Haploinsufficiency for BRCA1 leads to cell-type-specific genomic instability and premature senescence
出版年份 2015 全文链接
标题
Haploinsufficiency for BRCA1 leads to cell-type-specific genomic instability and premature senescence
作者
关键词
-
出版物
Nature Communications
Volume 6, Issue 1, Pages -
出版商
Springer Nature
发表日期
2015-06-24
DOI
10.1038/ncomms8505
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- BRCA1 haploinsufficiency for replication stress suppression in primary cells
- (2014) Shailja Pathania et al. Nature Communications
- The Luminal Progenitor Compartment of the Normal Human Mammary Gland Constitutes a Unique Site of Telomere Dysfunction
- (2013) Nagarajan Kannan et al. Stem Cell Reports
- Autophagy-dependent senescence in response to DNA damage and chronic apoptotic stress
- (2012) Kamini Singh et al. Autophagy
- Abstract 3790: Loss of BRCA1 regulates autophagy as a cellular stress response in breast and ovarian cancer cells
- (2012) Maggie Kei Shuen Tang et al. CANCER RESEARCH
- The Retinoblastoma Gene Undergoes Rearrangements inBRCA1-Deficient Basal-like Breast Cancer
- (2012) Göran Jönsson et al. CANCER RESEARCH
- Cyclin D1 Activity Regulates Autophagy and Senescence in the Mammary Epithelium
- (2012) N. E. Brown et al. CANCER RESEARCH
- Downregulation of stromal BRCA1 drives breast cancer tumor growth via upregulation of HIF-1α, autophagy and ketone body production
- (2012) Ahmed F. Salem et al. CELL CYCLE
- Evolutionary Pathways in BRCA1-Associated Breast Tumors
- (2012) Filipe C. Martins et al. Cancer Discovery
- A Twist of Cell Fate
- (2011) Thea D. Tlsty Cell Stem Cell
- Genetic Predisposition Directs Breast Cancer Phenotype by Dictating Progenitor Cell Fate
- (2011) Theresa A. Proia et al. Cell Stem Cell
- CpG island hypermethylation ofBRCA1and loss of pRb as co-occurring events in basal/triple-negative breast cancer
- (2011) Olafur Andri Stefansson et al. Epigenetics
- A continuum model for tumour suppression
- (2011) Alice H. Berger et al. NATURE
- Mutation of a single allele of the cancer susceptibility gene BRCA1 leads to genomic instability in human breast epithelial cells
- (2011) H. Konishi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Altered Gene Expression in Morphologically Normal Epithelial Cells from Heterozygous Carriers of BRCA1 or BRCA2 Mutations
- (2010) A. Bellacosa et al. Cancer Prevention Research
- BRCA1 and BRCA2 families and the risk of skin cancer
- (2010) Ophira M. Ginsburg et al. Familial Cancer
- The essence of senescence
- (2010) T. Kuilman et al. GENES & DEVELOPMENT
- SIRT1 contributes to telomere maintenance and augments global homologous recombination
- (2010) Jose A. Palacios et al. JOURNAL OF CELL BIOLOGY
- Preclinical mouse models for BRCA1-associated breast cancer
- (2009) R M Drost et al. BRITISH JOURNAL OF CANCER
- Molecular Distinctions between Stasis and Telomere Attrition Senescence Barriers Shown by Long-term Culture of Normal Human Mammary Epithelial Cells
- (2009) J. C. Garbe et al. CANCER RESEARCH
- Genomic alterations in histopathologically normal breast tissue fromBRCA1mutation carriers may be caused by BRCA1 haploinsufficiency
- (2009) Karin Rennstam et al. GENES CHROMOSOMES & CANCER
- Genetic Alterations and Oncogenic Pathways Associated with Breast Cancer Subtypes
- (2009) X. Hu et al. MOLECULAR CANCER RESEARCH
- Histone H4 lysine 16 acetylation regulates cellular lifespan
- (2009) Weiwei Dang et al. NATURE
- Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
- (2009) Francis Rodier et al. NATURE CELL BIOLOGY
- Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers
- (2009) Elgene Lim et al. NATURE MEDICINE
- Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo
- (2009) Florence Debacq-Chainiaux et al. Nature Protocols
- The longest telomeres: a general signature of adult stem cell compartments
- (2008) I. Flores et al. GENES & DEVELOPMENT
- Hereditary breast cancer: new genetic developments, new therapeutic avenues
- (2008) Philippe M. Campeau et al. HUMAN GENETICS
- Clinically Applicable Models to CharacterizeBRCA1andBRCA2Variants of Uncertain Significance
- (2008) Andrew D. Spearman et al. JOURNAL OF CLINICAL ONCOLOGY
- Interplay among BRCA1, SIRT1, and Survivin during BRCA1-Associated Tumorigenesis
- (2008) Rui-Hong Wang et al. MOLECULAR CELL
- VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400
- (2008) Arthur P. Young et al. NATURE CELL BIOLOGY
- Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
- (2008) Jean-Philippe Coppé et al. PLOS BIOLOGY
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started