Article
Medicine, General & Internal
Dayoung Ko, Hee-Beom Yang, Joong Youn, Hyun-Young Kim
Summary: A study of 66 pediatric CIPO patients revealed a higher proportion of early-onset CIPO and patients with urologic symptoms, as well as a majority of cases with generalized involvement. Factors such as duration of PN, PN use, and home management were found to impact outcomes, while mortality was associated with pathologic type.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Pediatrics
Marie-Catherine Turcotte, Christophe Faure
Summary: Chronic intestinal pseudo-obstruction is a rare and severe gastrointestinal disorder, with significant differences between adult and pediatric patients. This article aims to provide pediatric healthcare professionals with an up to date review of PIPO, including etiology, clinical features, diagnostic and management approaches.
FRONTIERS IN PEDIATRICS
(2022)
Review
Biochemistry & Molecular Biology
Francesca Bianco, Giulia Lattanzio, Luca Lorenzini, Maurizio Mazzoni, Paolo Clavenzani, Laura Calza, Luciana Giardino, Catia Sternini, Anna Costanzini, Elena Bonora, Roberto De Giorgio
Summary: CIPO is a typical clinical phenotype of severe gut dysmotility characterized by changes in neuro-enteric innervation, interstitial cells of Cajal, and smooth muscle cells. Genetic studies have identified several genes associated with CIPO, paving the way for potential targeted therapies for gut dysmotility.
Review
Gastroenterology & Hepatology
Guido Basilisco, Margherita Marchi, Marina Coletta
Summary: Chronic intestinal pseudo-obstruction is a rare and heterogeneous syndrome characterized by recurrent symptoms of intestinal obstruction without any mechanical occlusive lesions. This condition can be associated with various diseases, and the treatment and prognosis depend on the underlying condition. Subgroups of patients can be determined based on the etiology, including those with autoimmune/inflammatory mechanisms or genetically determined neuromuscular changes.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Rheumatology
Ryan M. Close, Laura M. Close, Patrick Galdun, Stefanie Gerstberger, Matthew Rydberg, Lisa Christopher-Stine
Summary: Statin-associated autoimmune myopathy is a rare condition in American Indians, with potential risk factors requiring further investigation. Healthcare providers need to be aware of this possibility and familiarize themselves with its presentation for effective treatment.
Article
Gastroenterology & Hepatology
Jong Woo Hahn, Soo Young Moon, Min Soo Kim, Min Hyung Woo, Min Ji Sohn, Hyun-Young Kim, Moon-Woo Seong, Sung Sup Park, Sung-Hye Park, Jin Soo Moon, Jae Sung Ko
Summary: This study examined the clinical features and ACTG2 variants in Korean patients with CIPO. The results showed that ACTG2 missense variants were found in 50% of the patients. Genetic testing of ACTG2 should be considered for CIPO patients with megacystis and abnormal prenatal ultrasonography.
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Gastroenterology & Hepatology
Xiangqin He, Kunzhe Dong, Jian Shen, Guoqing Hu, James D. Mintz, Reem T. Atawia, Juanjuan Zhao, Xiuxu Chen, Robert W. Caldwell, Meixiang Xiang, David W. Stepp, David J. Fulton, Jiliang Zhou
Summary: This study reveals the critical role of Carmn, a specific long noncoding RNA (lncRNA), in regulating the contractility and phenotype of gastrointestinal smooth muscle cells (SMCs). Loss of Carmn function leads to impaired gastrointestinal motility and disease, indicating the essential role of Carmn in maintaining the function of SMCs in the gut.
Article
Gastroenterology & Hepatology
Zhiliang Wei, Lina Lu, Youjie Zheng, Weihui Yan, Yijng Tao, Yongtao Xiao, Wei Cai, Ying Wang
Summary: This study identified that variants affecting codon 257 of ACTG2 protein sequence were common in Chinese PIPO patients and discovered 4 novel variants in ACTG2 related to Chinese PIPO.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2021)
Article
Pediatrics
Xiaoyu Xiong, Jing Li, Chengjun Liu, Feng Xu
Summary: Visceral myopathy is a rare genetic disorder that primarily affects the digestive and renal systems. This study presents a case of pediatric intestinal pseudo-obstruction associated with a novel ACTG2 gene mutation that has not been previously described in patients with visceral myopathy.
TRANSLATIONAL PEDIATRICS
(2021)
Review
Pediatrics
Susan Nham, Alexander T. M. Nguyen, Andrew J. A. Holland
Summary: Paediatric intestinal pseudo-obstruction (PIPO) is a rare and challenging disorder to diagnose and treat, with management mainly relying on parenteral nutrition and intestinal transplantation, which may lead to serious complications in the long term.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Biochemistry & Molecular Biology
Supender Kaur, Yu Sang, Alejandro Aballay
Summary: The gene mtm-10, which encodes the myotubularin-related protein MTM-10, has been identified as playing an essential role in protecting dendrite morphology and function against the harmful effects of oxidative stress or infection. MTM-10 is expressed in the AWC neurons of Caenorhabditis elegans and functions in a cell autonomous manner to prevent dendrite degeneration caused by pathogen infection. This study reveals a novel mechanism underlying the link between microbial infections and neurodegenerative diseases.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Surgery
Sujith Philip, Mano Zac Mathews, Anna B. Pulimood, Bobby Johns
Summary: Chronic intestinal pseudo-obstruction (CIPO) is a rare disorder that causes severe impairment of gastrointestinal motility, resembling mechanical obstruction without any physical blockage in the gut. Symptoms include nausea, vomiting, abdominal pain, and abdominal distension. Visceral myopathy is a rare chronic bowel disease characterized by intermittent pseudo-obstruction. This report emphasizes the importance of considering visceral myopathy as a potential cause of acute-on-chronic intestinal pseudo-obstruction.
INDIAN JOURNAL OF SURGERY
(2023)
Review
Medicine, General & Internal
Emanuele Sinagra, Gaia Pellegatta, Marcello Maida, Francesca Rossi, Giuseppe Conoscenti, Socrate Pallio, Rita Alloro, Dario Raimondo, Andrea Anderloni
Summary: CIIPO is a disease characterized by symptoms of small bowel obstruction in the absence of mechanical obstruction, with a hypothesis that various viruses localized in the intestine may play a role in its pathogenesis. This review aims to summarize new perspectives in the etiology and pathophysiology of CIIPO.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Microbiology
Giulia Radocchia, Bruna Neroni, Massimiliano Marazzato, Elena Capuzzo, Simone Zuccari, Fabrizio Pantanella, Letizia Zenzeri, Melania Evangelisti, Francesca Vassallo, Pasquale Parisi, Giovanni Di Nardo, Serena Schippa
Summary: Chronic intestinal pseudo-obstruction (CIPO) is a rare clinical syndrome characterized by severe impairment of gastrointestinal motility, posing a significant challenge for diagnosis and therapy. This review aims to explore the relationship between CIPO patients and intestinal microbiota, with a focus on understanding the causes of gut motility dysfunction in these patients. Further studies on the role of the enteric nervous system and the intestinal endocrine system are essential for a deeper understanding of CIPO.
Article
Gastroenterology & Hepatology
Muhammad Zarrar Khan, Ruishen Lyu, John McMichael, Scott Gabbard
Summary: The study aims to explore the association and prevalence of hydrogen and methane subtypes of SIBO in patients with CIP. A retrospective chart review was conducted for 494 patients who underwent glucose breath tests (GBT) in 2019. The prevalence of methane-positive GBT was higher in CIP patients than in patients without CIP, suggesting a facilitative relationship between motility disorders and methanogen overgrowth.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Review
Chemistry, Medicinal
Irene Neri, Elisa Boschetti, Matilde Yung Follo, Roberto De Giorgio, Lucio Ildebrando Cocco, Lucia Manzoli, Stefano Ratti
Summary: Background: The gastrointestinal tract and central nervous system are bi-directionally connected through the gut-brain axis, which plays a role in neurodevelopment and physiology. Objective: This review focuses on the impact of gut microbiota on the integrity of intestinal and blood-brain barriers and explores potential markers for assessing their permeability. Conclusion: Evaluating the permeability of intestinal and blood-brain barriers in neurological patients can provide insights into central nervous system disorders and suggest new targets for treatment.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2023)
Article
Gastroenterology & Hepatology
Pasquale Mansueto, Aurelio Seidita, Maurizio Soresi, Alessandra Giuliano, Giorgia Riccio, Umberto Volta, Giacomo Caio, Francesco La Blasca, Rosaria Disclafani, Roberto De Giorgio, Antonio Carroccio
Summary: Non-celiac wheat sensitivity (NCWS) patients frequently suffer from extraintestinal symptoms, including anemia. This study aimed to investigate the prevalence and clinical features of anemia in NCWS patients. The results showed that the prevalence of anemia in NCWS patients was 34.8%, significantly higher than in irritable bowel syndrome (IBS) patients (17.4%), but not in celiac disease (CD) patients. The main features associated with anemia in NCWS patients were female sex, diagnostic delay, poly/hypermenorrhea, iron deficiency, and higher TSH values. Long-term strict wheat-free diet (WFD) significantly reduced anemia and improved iron metabolism. Therefore, NCWS should be considered in the differential diagnosis of anemic patients with functional gastrointestinal disorders.
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Gastroenterology & Hepatology
Giovanni Marasco, Cesare Cremon, Maria Raffaella Barbaro, Giulia Cacciari, Francesca Falangone, Anna Kagramanova, Dmitry Bordin, Vasile Drug, Egidia Miftode, Pietro Fusaroli, Salem Youssef Mohamed, Chiara Ricci, Massimo Bellini, Mohammed Masudur Rahman, Luigi Melcarne, Javier Santos, Beatriz Lobo, Serhat Bor, Suna Yapali, Deniz Akyol, Ferdane Pirincci Sapmaz, Yonca Yilmaz Urun, Tugce Eskazan, Altay Celebi, Huseyin Kacmaz, Berat Ebik, Hatice Cilem Binicier, Mehmet Sait Bugdayci, Munkhtsetseg Banzragch Yagci, Husnu Pullukcu, Berrin Yalinbas Kaya, Ali Tureyen, Ibrahim Hatemi, Elif Sitre Koc, Goktug Sirin, Ali Riza Caliskan, Goksel Bengi, Esra Ergun Alis, Snezana Lukic, Meri Trajkovska, Keren Hod, Dan Dumitrascu, Antonello Pietrangelo, Elena Corradini, Magnus Simren, Jessica Sjoelund, Navkiran Tornkvist, Uday C. Ghoshal, Olga Kolokolnikova, Antonio Colecchia, Jordi Serra, Giovanni Maconi, Roberto De Giorgio, Silvio Danese, Piero Portincasa, Antonio Di Sabatino, Marcello Maggio, Elena Philippou, Yeong Yeh Lee, Daniele Salvi, Alessandro Venturi, Claudio Borghi, Marco Zoli, Paolo Gionchetti, Pierluigi Viale, Vincenzo Stanghellini, Giovanni Barbara
Summary: This study aimed to evaluate the prevalence of gastrointestinal symptoms and post-COVID-19 disorders of gut-brain interaction among hospitalized patients with SARS-CoV-2 infection. The results showed that patients with COVID-19 had higher rates of gastrointestinal symptoms on hospital admission and lower rates of constipation and hard stools at 12 months post-infection compared to the control group. Additionally, the rate of irritable bowel syndrome was significantly higher in patients with COVID-19 than in controls.
Article
Virology
Irene Soffritti, Maria D'Accolti, Carla Gallenga, Roberto De Giorgio, Matteo Guarino, Martina Maritati, Francesca Bini, Eleonora Mazziga, Carlo Contini, Elisabetta Caselli
Summary: Secretory IgA (sIgA) was detected in the eye of COVID-19 patients, potentially playing a crucial role in early defense against SARS-CoV-2. This study analyzed tear samples from 77 COVID-19 patients to characterize sIgA mucosal immunity in the eye, including 63 vaccinated and 14 non-vaccinated subjects. The data showed significant differences in ocular sIgA response between vaccinated and non-vaccinated groups, suggesting the potential use of tear-based sIgA tests as a biomarker for assessing mucosal immunity development against SARS-CoV-2.
Article
Hematology
Francesco Lanza, Roberto De Giorgio, Giorgio Zavagli
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Medicine, General & Internal
Giovanna Ceccuzzi, Alessandro Rapino, Benedetta Perna, Roberto De Giorgio, Matteo Guarino
INTERNAL AND EMERGENCY MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Matteo Guarino, Benedetta Perna, Alice Eleonora Cesaro, Michele Domenico Spampinato, Rita Previati, Anna Costanzini, Martina Maritati, Carlo Contini, Roberto De Giorgio
Summary: This study found that capillary lactates can reliably predict 48-hour and 7-day mortality rates in sepsis patients, making them a valuable tool due to their affordability, speed, and reliability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Infectious Diseases
Martina Maritati, Alessandro Trentini, Gregory Michel, Stefania Hanau, Matteo Guarino, Roberto De Giorgio, Christelle Pomares, Pierre Marty, Carlo Contini
Summary: This study aimed to compare five serological tests for the diagnosis of visceral and asymptomatic leishmaniasis in southern France. The results showed that IFAT and TruQuick had the highest diagnostic performance for visceral leishmaniasis, while WB LDBio had the best diagnostic performance for asymptomatic carriers.
JOURNAL OF INFECTION IN DEVELOPING COUNTRIES
(2023)
Review
Nutrition & Dietetics
Lisa Lungaro, Francesca Manza, Anna Costanzini, Marianna Barbalinardo, Denis Gentili, Fabio Caputo, Matteo Guarino, Giorgio Zoli, Umberto Volta, Roberto De Giorgio, Giacomo Caio
Summary: Celiac disease (CD) is an autoimmune disorder caused by gluten ingestion in genetically predisposed individuals. Besides gastrointestinal symptoms, CD can also lead to low bone mineral density and osteoporosis. The bone lesions in CD are influenced by various factors, and not only mineral and vitamin D malabsorption. This review aims to provide an updated overview on CD-induced osteoporosis and highlight new aspects such as the impact of the intestinal microbiome and sex-related differences on bone health, in order to improve its management.
Review
Gastroenterology & Hepatology
Giovanni Di Nardo, Letizia Zenzeri, Matteo Guarino, Alessio Molfino, Pasquale Parisi, Giovanni Barbara, Vincenzo Stanghellini, Roberto De Giorgio
Summary: Chronic intestinal pseudoobstruction (CIPO) is a rare and severe form of gastrointestinal dysmotility, and the current treatment options are limited. There is a need for further research on new drugs and nutritional support strategies for these patients.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2023)
Editorial Material
Microbiology
Carlo Contini, John Charles Rotondo, Benedetta Perna, Matteo Guarino, Roberto De Giorgio
Article
Biochemistry & Molecular Biology
Martina Maritati, Marco Manfrini, Maria Rosa Iaquinta, Alessandro Trentini, Silva Seraceni, Matteo Guarino, Anna Costanzini, Roberto De Giorgio, Gustavo Alberto Zanoli, Alessandro Borghi, Elisa Mazzoni, Giuseppe De Rito, Carlo Contini
Summary: The aim of this study was to investigate the effect of Staphylococcus aureus (SA) producing the Panton-Valentine leukocidin (PVL) on the outcome of Prosthetic Joint Infection (PJI). The study found that SA strains positive for PVL genes resulted in a 100% failure rate in the treatment of acute PJI, while chronic PJI had a 100% eradication rate. Therefore, toxin research and targeted antibiotic therapy should be considered in the treatment of PJI caused by SA.
Article
Gastroenterology & Hepatology
Gaetano Gallo, Marta Goglia, Asha Senapati, Francesco Pata, Luigi Basso, Ugo Grossi
Summary: This study investigated the current management of pilonidal disease (PD) in European countries and found that most respondents recommended surgery as the initial treatment for PD, with primary closure as the preferred surgical technique. Conservative treatment was negatively associated with acutely presenting PD, and respondents who considered tailored surgery based on patient presentation tended to change their approach after a failed procedure.
COLORECTAL DISEASE
(2023)
Article
Geriatrics & Gerontology
Elisa Boschetti, Giacomo Caio, Carlo Cervellati, Anna Costanzini, Valentina Rosta, Fabio Caputo, Roberto De Giorgio, Giovanni Zuliani
Summary: This study found that serum zonulin levels change in older patients affected by different types of dementia or mild cognitive impairment (MCI). Serum zonulin increased in patients with late-onset AD, mixed dementia, and aMCI but not in VAD. In addition, serum zonulin levels were higher in aMCI converting to AD compared with stable aMCI, and inversely correlated with cognitive function.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Article
Nursing
Lesley Dibley, Ailsa Hart, Julie Duncan, Charles H. Knowles, Sally Kerry, Doris Lanz, Vladislav Berdunov, Vichithranie W. Madurasinghe, Tiffany Wade, Helen Terry, Azmina Verjee, Mandy Fader, Christine Norton
Summary: This study tested a noninvasive self-management intervention supported by specialist nurses for patients with inflammatory bowel disease (IBD) experiencing fecal incontinence. A qualitative evaluation of the trial was also conducted. The results showed low recruitment and high attrition, highlighting the challenges of conducting resource-heavy studies in busy health service environments.
JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
(2023)