期刊
PROGRESS IN NEUROBIOLOGY
卷 86, 期 3, 页码 129-140出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pneurobio.2008.09.007
关键词
Ion channels; Hippocampus; Epilepsy; I-h; HCN channels; Hyperpolarization; Hyperpolarization-activated; Development; Resonance; Seizures; Heteromerization; Synaptic plasticity
资金
- NIH [NS35439]
- Epilepsy Foundation of America
- American Epilepsy Society
Developing neuronal networks evolve continuously, requiring that neurons modulate both their intrinsic properties and their responses to incoming synaptic signals. Emerging evidence supports roles for the hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in this neuronal plasticity. HCN channels seem particularly suited for fine-tuning neuronal properties and responses because of their remarkably large and variable repertoire of functions, enabling integration of a wide range of cellular signals. Here, we discuss the involvement of HCN channels in cortical and hippocampal network maturation, and consider potential roles of developmental HCN channel dysregulation in brain disorders such as epilepsy. (C) 2008 Elsevier Ltd. All rights reserved.
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