Article
Neurosciences
Faizan Ul Haq, Mohammad Shoaib, Syed Wadood Ali Shah, Haya Hussain, Muhammad Zahoor, Riaz Ullah, Ahmed Bari, Amal Alotaibi, Muhammad Faisal Hayat
Summary: This study aimed to synthesize benzodiazepine derivatives and evaluate their antidepressant potentials. The results showed that compounds 2 and 5 exhibited significant antidepressant effects and increased GABA levels in the brain's hippocampus of experimental animals, indicating the possible involvement of the GABAergic mechanism.
Article
Biochemistry & Molecular Biology
Nazli Turan Yucel, Ummuhan Kandemir, Umide Demir Ozkay, Ozgur Devrim Can
Summary: Vortioxetine, a multimodal antidepressant drug, exhibits analgesic effects by affecting central pathways carrying acute thermal and mechanical nociceptive stimuli, mediated by 5-HT1A serotonergic, alpha-adrenergic, and opioidergic receptors. The contributions of central serotonergic and catecholaminergic neurotransmissions are critical for this analgesic effect.
Article
Integrative & Complementary Medicine
Sun Dan-chen, Wang Ran-ran, Xu Hao, Zhu Xue-hui, Sun Yan, Qiao Shi-qing, Qiao Wei
Summary: This study investigated the pharmacodynamic material basis, mechanism of actions, and targeted diseases of Salicornia europaea L. (SE) using the network pharmacology method. Pharmacological experiments verified the antidepressant-like effect of SE extract and suggested that it may regulate the Nrf2-ARE pathway and increase levels of dopamine and corticosterone in the hippocampus and cortex.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2022)
Article
Behavioral Sciences
Aida A. C. Brandao, Deborah L. S. Deus, Luiz A. M. S. Duarte-Filho, Pedro M. N. Menezes, Ana B. R. Massaranduba, Fabricio S. Silva, Luciano A. A. Ribeiro
Summary: Through nebulization delivery, ketamine can significantly reduce depressive-like behaviors in mice, indicating that nebulization can be an effective and inexpensive route of drug administration for behavioral research.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2023)
Article
Neurosciences
Marcia Juciele da Rocha, Camila Simoes Pires, Marcelo Heinemann Presa, Evelyn Mianes Besckow, Gustavo D'Avila Nunes, Caroline Signorini Gomes, Filipe Penteado, Eder Joao Lenardao, Cristiani Folharini Bortolatto, Cesar Augusto Bruning
Summary: The compound MeSeI has shown antidepressant-like effects and may be considered as a potential treatment for depression.
PSYCHOPHARMACOLOGY
(2023)
Article
Behavioral Sciences
Marcela Pereira, Isadora P. Siba, Alexandra Acco, Diego Correia, Fernanda R. Lapa, Adair R. S. Santos, Ana P. Ruani, Moacir G. Pizzolatti, Roberto Andreatini
Summary: The study found that myricitrin can reverse depressive behavior induced by chronic mild stress and reduce adrenal hypertrophy and levels of the inflammatory cytokine IL-6 in the hippocampus. This suggests that myricitrin has antidepressant and anti-inflammatory effects.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Aleksandra Szopa, Mariola Herbet, Ewa Poleszak, Karolina Bogatko, Marta Ostrowska-Lesko, Katarzyna Swiader, Jaroslaw Szponar, Anna Serefko
Summary: The study determined that the co-administration of sodium selenite with selective adenosine A1 and A2A antagonists has antidepressant-like potential in mice, enhancing efficacy and altering gene expression levels. This combination may provide a new therapeutic strategy for patients with depression.
Article
Pharmacology & Pharmacy
Ana Belen Ramos-Hryb, Francis L. Pazini, Ana Paula Costa, Mauricio P. Cunha, Manuella P. Kaster, Ana Lucia S. Rodrigues
Summary: The study discovered the crucial role of HO-1 in mediating the antidepressant-like effects of UA, and revealed a synergistic antidepressant effect when UA was combined with CoPP. Interestingly, fluoxetine did not show a significant correlation with the activity of HO-1.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Anderson Camargo, Luis E. B. Bettio, Priscila B. Rosa, Julia M. Rosa, Glorister A. Alte, Ana Lucia S. Rodrigues
Summary: This study reveals the antidepressant-like effect of Guanosine and the modulation of A(1)R and A(2A)R in its antidepressant action. Guanosine interacts with A(1)R and A(2A)R at the adenosine binding site.
PURINERGIC SIGNALLING
(2023)
Article
Biochemistry & Molecular Biology
Patrizia Pignataro, Manuela Dicarlo, Roberta Zerlotin, Giuseppina Storlino, Angela Oranger, Lorenzo Sanesi, Roberto Lovero, Cinzia Buccoliero, Giorgio Mori, Graziana Colaianni, Silvia Colucci, Maria Grano
Summary: This study evaluated the potential antidepressant effects of irisin and found that it significantly reduced immobility time and displayed anxiolytic-like effects in mice. The study also identified potential molecular pathways underlying irisin's effects, including the upregulation of neurotrophic factors and modulation of cytokine expression. This research provides valuable insights for future preclinical studies on the use of irisin in humans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Rohit Pal, Bhupinder Kumar, P. M. Guruubasavaraja Swamy, Pooja A. Chawla
Summary: A series of substituted-N-(5,6-diphenyl-1,2,4-triazin-3-yl) benzamides were designed, synthesized, and evaluated for their antidepressant-like activity. Compound R:5 and R:9 exhibited potent MAO-A inhibition activity and significant antidepressant effects in FST and TST. ADME and docking studies further confirmed their pharmacological characteristics and binding abilities.
BIOORGANIC CHEMISTRY
(2023)
Article
Clinical Neurology
Gernot Fugger, Lucie Bartova, Chiara Fabbri, Giuseppe Fanelli, Raffaella Zanardi, Markus Dold, Alexander Kautzky, Dan Rujescu, Daniel Souery, Julien Mendlewicz, Joseph Zohar, Stuart Montgomery, Alessandro Serretti, Siegfried Kasper
Summary: A study found that European patients who were prescribed NaSSAs as first-line antidepressant treatment had characteristics such as older age, male gender, unemployment, additional melancholic and catatonic features, inpatient treatment, lower dosages of antidepressants but higher rates of augmentation with low-potency antipsychotics, and greater reductions of depressive symptoms during their current major depressive episodes.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Chemistry, Analytical
Imane Maliki, Imane Es-safi, Abdelfattah El Moussaoui, Hamza Mechchate, Yassine Oulad El Majdoub, Aziz Bouymajane, Francesco Cacciola, Luigi Mondello, Khalid Elbadaoui
Summary: This study found that the aqueous extracts of Salvia officinalis and Lippia triphylla have significant antidepressant effects in mice in the forced swimming test and tail suspension test.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Article
Pharmacology & Pharmacy
Gabriela Belen Martinez-Hernandez, Enrique Jimenez-Ferrer, Manases Gonzalez-Cortazar, Ruben Roman-Ramos, Jaime Tortoriello, Gabriela Vargas-Villa, Maribel Herrera-Ruiz
Summary: Salvia elegans, a plant with biological activities in central nervous system, was studied for its anxiolytic and antidepressant effects. Fractions and compounds isolated from the plant were evaluated in mice, showing that TM and OA have antidepressant and anxiolytic properties and can interact with serotoninergic drugs.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Walaa F. Alsanie, Abdulhakeem S. Alamri, Osama Abdulaziz, Abdulwahab Alamri, Syed Mohammed Basheeruddin Asdaq, Mohammed Hisham Alhomrani, Majid Alhomrani
Summary: This study investigated the antidepressant properties of crocin in a chronic mild stress-induced depression model in mice. The results showed that high doses of crocin significantly reduced immobility time in the tail suspension test, increased preference for sucrose solution, and improved spontaneous locomotor activity in mice. Additionally, crocin exhibited antioxidant potential by reducing malondialdehyde levels and catalase activity while increasing glutathione levels. These findings suggest that high doses of crocin may have antidepressant effects through multiple mechanisms. However, further studies are needed to explore the role of neurotransmitters in its antidepressant properties.
Article
Medicine, Research & Experimental
Marcelo Gomes de Gomes, Muriel Pando Pereira, Flavia Elizabete Guerra Teixeira, Felipe Carvalho, Anne Suely Pinto Savall, Diogo Ferreira Bicca, Eduarda Monteiro Fidelis, Paulo Emilio Botura, Francielli Weber Cibin, Simone Pinton, Sandra Elisa Haas
BIOMEDICINE & PHARMACOTHERAPY
(2020)
Article
Ophthalmology
Josiele da Silva Prade, Eveline Costeira Balsamo, Franciele Romero Machado, Marcia Rosula Poetini, Vandreza Cardoso Bortolotto, Stifani Machado Araujo, Larissa Londero, Silvana Peterini Boeira, Carla Pohl Sehn, Marcelo Gomes de Gomes, Marina Prigol, Leandro Cattelan Souza
CUTANEOUS AND OCULAR TOXICOLOGY
(2020)
Article
Neurosciences
Michelle S. Antunes, Leandro Cattelan Souza, Fernando Vagner Lobo Ladd, Aliny Antunes Barbosa Lobo Ladd, Amanda Lopez Moreira, Vandreza Cardoso Bortolotto, Marcia Rosula Poetini Silva, Stifani Machado Araujo, Marina Prigol, Cristina Wayne Nogueira, Silvana Peterini Boeira
MOLECULAR NEUROBIOLOGY
(2020)
Article
Materials Science, Biomaterials
Renata Bem dos Santos, Kelly Ayumi Nakama, Camila Oliveira Pacheco, Marcelo Gomes de Gomes, Jaqueline Ferreira de Souza, Ana Claudia de Souza Pinto, Fernanda Alice de Oliveira, Amanda Luisa da Fonseca, Fernando Varotti, Andre Ricardo Fajardo, Sandra Elisa Haas
Summary: The study successfully developed stable NCs loaded with curcumin using different coatings, maintaining the physicochemical properties of CCM and demonstrating significant activity against malaria.
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Pharmacology & Pharmacy
Marcelo Gomes de Gomes, Lucian Del Fabbro, Andre Rossito Goes, Leandro Cattelan Souza, Silvana Peterini Boeira, Cristiano Ricardo Jesse
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2020)
Article
Endocrinology & Metabolism
Michelle S. Antunes, Fernando Vagner Lobo Ladd, Aliny Antunes Barbosa Lobo Ladd, Amanda Lopez Moreira, Silvana Peterini Boeira, Leandro Cattelan Souza
Summary: Hesperidin mitigates the degeneration of dopaminergic neurons in the substantia nigra pars compacta by preventing mitochondrial dysfunction and modulating apoptotic pathways, thus improving behavioral alterations in a relevant preclinical model of Parkinson's disease.
METABOLIC BRAIN DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Micheli Stefani Zarzecki, Leandro Cattelan Souza, Renata Giacomeli, Marcia Rosula Poetini Silva, Marina Prigol, Silvana Peterini Boeira, Cristiano Ricardo Jesse
NEUROCHEMICAL RESEARCH
(2020)
Article
Pharmacology & Pharmacy
Felipe Barbosa de Carvalho, Marcelo Gomes de Gomes, Anne Suely Pinto Savall, Eduarda Monteiro Fidelis, Simone Pinton, Ana Claudia Funguetto Ribeiro, Felix Roman Munieweg, Carlos Alexandre Oelke, Sandra Elisa Haas
Summary: The study demonstrated that CUR-loaded NC with different coatings exhibited antiangiogenic and non-teratogenic effects in a chick embryo model, without altering markers of oxidative stress, representing an advancement in drug/nutraceutical delivery systems research.
PHARMACOLOGICAL REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Leandro Cattelan Souza, Maicon Lenon Otenio de Brito, Cristiano Ricardo Jesse, Silvana Peterini Boeira, Marcelo Gomes de Gomes, Andre Tiago Rossito Goes, Lucian Del Fabbro, Franciele Romero Machado, Marina Prigol, Cristina Wayne Nogueira
Article
Pharmacology & Pharmacy
Camila de Oliveira Pacheco, Marcelo Gomes de Gomes, Manoel Rodrigues da Silva Neto, Alcides Jose Martins Parisotto, Renata Bem dos Santos, Tamara Ramos Maciel, Ana Claudia Funguetto Ribeiro, Renata Giacomeli, Sandra Elisa Haas
Summary: The study developed charged polymeric nanocapsules with different coating materials, and the evaluation of biological effects showed that these nanocapsules have the ability to block specific behavioral changes.
PHARMACOLOGICAL REPORTS
(2022)
Article
Medicine, Research & Experimental
Renata Bem dos Santos, Ana Claudia Funguetto-Ribeiro, Tamara Ramos Maciel, Dyenefer Pereira Fonseca, Fernanda Reis Favarin, Daniele Rubert Nogueira-Librelotto, Marcelo Gomes de Gomes, Tania Ueda Nakamura, Clarice Madalena Bueno Rolim, Sandra Elisa Haas
Summary: This study evaluated the toxicity of blank nanocapsules with different surface characteristics in vitro and in vivo. The results showed that the nanocapsules had low toxicity against liver cancer cells and breast cancer cells, no significant antiviral effect against HSV-1, and low neurological effects in rats.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Franciele Romero Machado, Silvana Peterini Boeira, Vandreza Cardoso Bortolotto, Stifani Machado Araujo, Marcia Rosula Poetini, Cristini Escobar Viana, Marina Prigol, Leandro Cattelan Souza, Marcelo Gomes de Gomes
Summary: This study aimed to evaluate the effects of HDAC3 inhibition caused by RGFP966 on an animal model of obesity induced by high-fat diet. The results showed that RGFP966 administration protected against changes in body weight gain, glucose, insulin, lipid profile, adipokines, and hippocampal proinflammatory cytokines levels caused by high-fat diet.
PHARMACOLOGICAL REPORTS
(2023)
Article
Clinical Neurology
Karine Ramires Lima, Niege Alves, Luiza Freitas Lopes, Steffanie Severo Picua, Liane da Silva de Vargas, Leticia Rossi Dare, Bruna Ramborger, Rafael Roehrs, Marcelo Gomes de Gomes, Pamela Billig Mello-Carpes
Summary: Aversive memory extinction is a new learning tool that blocks the retrieval of traumatic memories and is effective in decreasing fear responses, but not in the long term due to memory recovery. Alternative strategies that strengthen extinction learning are essential. In this study, exposure to a novel context enhanced aversive memory extinction over days and required the involvement of the dopaminergic system. The findings suggest that novel context exposure promotes persistent aversive memory extinction through the dopaminergic system.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Chemistry, Medicinal
Lucian Del Fabbro, Marcelo Gomes de Gomes, Andre Rossito Goes, Cristiano Ricardo Jesse
Summary: This study evaluated the effect of nano-formulation of silymarin on prevention of radiotherapy induced mucositis in head and neck cancer patients. The results showed a non-significant decreasing trend in scores after 4 weeks of treatment with silymarin, while there was no significant difference at the end of the sixth week between silymarin and placebo groups.
Article
Clinical Neurology
Nadia Deflorin, Ulrike Ehlert, Rita T. Amiel Castro
Summary: Changes in the gut microbiome of infants have been associated with maternal psychological symptoms during pregnancy. This study found that maternal prenatal depressive symptoms are associated with lower diversity of the infant's microbiome, while maternal saliva cortisol levels are linked to increased diversity and changes in specific bacterial groups. Further research is needed to understand the implications of these microbiota alterations for child health.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zheng Ma, Hui-Xia Zhou, Da-Chun Chen, Dong-Mei Wang, Xiang-Yang Zhang
Summary: The impaired glucose metabolism in drug-na & iuml;ve schizophrenia patients is strongly associated with suicidal behavior, suggesting that glucose metabolism abnormalities may be potential biomarkers of suicide in schizophrenia patients. Regular monitoring of glucose metabolism variables is essential for suicide prevention.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Katie M. Lavigne, Jiaxuan Deng, Delphine Raucher-Chene, Adele Hotte-Meunier, Chloe Voyer, Lisa Sarraf, Martin Lepage, Genevieve Sauve
Summary: Psychiatric disorders are characterized by cognitive deficits and cognitive biases, which are associated with specific symptoms. While cognitive biases are present across diagnoses, their severity varies.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Yong-Yu Yin, Jiao-Zhao Yan, Shi-Xin Lai, Qian-Qian Wei, Si-Rui Sun, Li-Ming Zhang, Yun-Feng Li
Summary: This study found that gamma oscillations are closely associated with depression and may serve as predictive biomarkers of depression. Chronic restraint stress and lipopolysaccharide induced significant depression-like behaviors in mice and reduced gamma oscillations in the medial prefrontal cortex. Administration of ketamine, scopolamine, or fluoxetine increased gamma oscillations and exhibited rapid-acting antidepressant effects.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Veronica Begni, Moira Marizzoni, Kerstin Camile Creutzberg, Diana Morena Silipo, Mariusz Papp, Annamaria Cattaneo, Marco Andrea Riva
Summary: Exposure to stressful experiences is a significant risk factor for mental disorders, and pharmacological interventions targeting stress-induced alterations can help restore brain function. Lurasidone, an antipsychotic drug, has been shown to normalize the impairments caused by stress exposure and could be a valuable treatment for stress-induced mental illnesses. However, the mechanisms underlying the therapeutic effects of lurasidone are not well understood. This study found that chronic lurasidone treatment counteracted some of the transcriptional changes induced by chronic mild stress exposure, providing new insights into the potential therapeutic effects of lurasidone.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Esther E. Palacios-Barrios, Kunal Patel, Jamie L. Hanson
Summary: This review examines the association between early life interpersonal stress (ELIS) and depression, as well as the underlying mechanisms. The research shows that ELIS affects how youth respond to social rewards, and similar impairments in social reward processing are observed in youth with depression. The authors propose a preliminary model that suggests neurobehavioral disruptions in social reward processing as a mediating factor in the connection between ELIS and depression.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Rui Li, Jiaming Tang, Yizhuo Wang, Ying Wang, Hua Yang, Hongen Wei
Summary: Restricted and repetitive behaviors (RRBs) are characteristic features of neuropsychiatric disorders. This study focused on repetitive self-grooming behavior and investigated the involvement of the Pax2 gene in its control. Through the use of Pax2 neuron-specific deletion mice, the study found that the deletion of Pax2 gene affects the expression of the Arc gene in the prefrontal cortex, leading to impaired synaptic plasticity and excitatory/inhibitory imbalance, thereby contributing to the occurrence of repetitive self-grooming behavior.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Sara Derosa, Paulina Misztak, Jessica Mingardi, Giulia Mazzini, Heidi Kaastrup Muller, Laura Musazzi
Summary: This study investigated the involvement of neurotrophic signaling pathways in stress vulnerability/resilience and fast antidepressant response/non-response to ketamine in a rat model of depression. The findings showed that stress and ketamine induced specific changes in these pathways in different brain areas and subcellular fractions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Georgia F. Caruana, Sean P. Carruthers, Michael Berk, Susan L. Rossell, Tamsyn E. Van Rheenen
Summary: Cognitive impairment is related to both white matter macrostructure and microstructure in bipolar disorder patients. However, there is inconsistency in the results of the studies examining this relationship. Some studies have found an association between higher fractional anisotropy in white matter and better complex attention skills and executive functioning in bipolar disorder patients, while others have found no associations. Further research with increased statistical power and standardized methods is needed.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Alberto Galimberti, Martin Tik, Giovanni Pellegrino, Anna-Lisa Schuler
Summary: This study provides a systematic review and meta-analysis on the effectiveness of repetitive transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) for post-traumatic brain injury (TBI) symptoms. The results show that non-invasive brain stimulation techniques have a small overall effect on TBI sequelae, with significant effects observed for anxiety and headache. However, larger randomized controlled trials with longer follow-ups, optimized stimulation parameters, and standardized methodology are needed to establish the efficacy of these techniques in addressing TBI sequelae.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Amanda J. Sales, Pedro H. Gobira, Joa F. C. Pedrazzi, Joao R. Silveia, Elaine Del Bel, Felipe V. Gomes, Francisco S. Guimaraes
Summary: The study found that doxycycline can inhibit metalloproteinase in the brain and attenuate the rewarding effects and locomotor sensitization of drug abuse. This suggests that doxycycline could be repurposed for the treatment of substance use disorders.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Alejandro Borrego-Ruiz, Juan J. Borrego
Summary: There is substantial evidence that the development of the nervous system is related to the composition and functions of the gut microbiome. The communication between the central nervous system (CNS) and the gut microbiota is bidirectional, with various routes such as immune, endocrine, and neural circuits. Dysbiosis of the gut microbiota has been associated with neuropsychiatric diseases and psychological disorders. Fecal microbiota transplantation (FMT) therapy has shown a causal-effect relationship between the gut microbiota and behavioral features. Interventions based on prebiotics, probiotics, or synbiotics have demonstrated their influence on neurological disorders through the synthesis of neuroactive compounds and regulation of inflammatory and endocrine processes. Further research is needed to explore the impact of gut microbiota dysbiosis on psychiatric and psychological disorders and the potential therapeutic role of microbiota-based interventions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zhinan Li, Zhuang Kang, Xiaowei Xia, Leijun Li, Junyan Wu, Jiamin Dai, Tong Liu, Cai Chen, Yong Qiu, Ming Chen, Yanxi Liu, Ziyi Zhang, Zili Han, Zhengjia Dai, Qinling Wei
Summary: This study found that patients with schizophrenia showed lower levels of resilience and cognitive functions compared to healthy controls, as well as abnormal global properties and nodal metrics in brain networks. Furthermore, characteristic path length might moderate the relationship between resilience and working memory in these patients.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
David H. Adamowicz, Tsung-Chin Wu, Rebecca Daly, Michael R. Irwin, Dilip Jeste, Xin M. Tu, Lisa T. Eyler, Ellen E. Lee
Summary: This study aimed to explore the relationship between executive functioning and inflammatory biomarkers in people with schizophrenia. The results showed that systemic inflammation did not predict long-term declines in executive functioning. This suggests the need for further research to better understand the relationship and mechanisms between inflammation and cognition in schizophrenia.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Nina Walter, Julian Wenzel, Shalaila S. Haas, Letizia Squarcina, Carolina Bonivento, Anne Ruef, Dominic Dwyer, Theresa Lichtenstein, Oeznur Bastruek, Alexandra Stainton, Linda A. Antonucci, Paolo Brambilla, Stephen J. Wood, Rachel Upthegrove, Stefan Borgwardt, Rebekka Lencer, Eva Meisenzahl, Raimo K. R. Salokangas, Christos Pantelis, Alessandro Bertolino, Nikolaos Koutsouleris, Joseph Kambeitz, Lana Kambeitz-Ilankovic
Summary: Clinical and neuroimaging data can be used to predict the potential of cognitive training to improve social functioning in recent onset psychosis patients. The use of multivariate pattern analysis and support vector machine classifier allows for the prediction of social functioning improvement based on baseline cognitive data. The findings suggest that cognitive data can provide a robust individual estimate of future social functioning for patients with recent onset psychosis.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)