Article
Cell Biology
Shangang Zhao, Qian Lin, Wei Xiong, Li Li, Leon Straub, Dinghong Zhang, Rizaldy Zapata, Qingzhang Zhu, Xue-Nan Sun, Zhuzhen Zhang, Jan-Bernd Funcke, Chao Li, Shiuhwei Chen, Yi Zhu, Nisi Jiang, Guannan Li, Ziying Xu, Steven C. Wyler, May-Yun Wang, Juli Bai, Xianlin Han, Christine M. Kusminski, Ningyan Zhang, Zhiqiang An, Joel K. Elmquist, Olivia Osborn, Chen Liu, Philipp E. Scherer
Summary: Antipsychotic drugs can cause weight gain and diabetes, and hyperleptinemia plays a key role. Suppression of leptin rise can reduce the adverse effects of these drugs.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Clinical Neurology
Sandra K. Bopp, Urs Heilbronner, Peter Schlattmann, Pichit J. Buspavanich, Undine E. Lang, Andreas Heinz, Thomas G. Schulze, Mazda Adli, Thomas W. Muhleisen, Roland Ricken
Summary: Patients treated with lithium often experience weight gain, and genetic variations at the leptin gene locus may be involved in lithium augmentation-associated weight gain in major depressive disorder. A recent study identified a polymorphism at the leptin gene locus associated with circulating leptin protein levels.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Anna Partyka, Katarzyna Gorecka, Joanna Gdula-Argasinska, Natalia Wilczynska-Zawal, Magdalena Jastrzebska-Wiesek, Anna Wesolowska
Summary: Patients taking antipsychotic drugs have a higher likelihood of developing metabolic syndrome, characterized by abdominal obesity, elevated glucose levels, and dyslipidemia. Current treatments for the metabolic side effects of antipsychotic drugs are not satisfactory. Ligands of the serotonin 6 receptor may offer a promising supplement to antipsychotic therapy. This study examined the effects of different antipsychotic drugs alone and in combination with a selective 5-HT6 agonist or antagonist on weight gain, food intake, lipid profile, glucose level, and adipose and gastrointestinal hormones in rats.
Review
Psychology, Multidisciplinary
Yanisa Wannasuphoprasit, Stig Ejdrup Andersen, Maria J. Arranz, Rosa Catalan, Gesche Jurgens, Sanne Maartje Kloosterboer, Henrik Berg Rasmussen, Anjali Bhat, Haritz Irizar, Dora Koller, Renato Polimanti, Baihan Wang, Eirini Zartaloudi, Isabelle Austin-Zimmerman, Elvira Bramon
Summary: The CYP2D6 genetic variation may influence weight gain in individuals taking antipsychotic medications, but further large-scale studies are needed to confirm the association.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Pharmacology & Pharmacy
Albert Martinez-Pinteno, Patricia Gasso, Llucia Prohens, Alex G. Segura, Mara Parellada, Jeronimo Saiz-Ruiz, Manuel J. Cuesta, Miguel Bernardo, Amalia Lafuente, Sergi Mas, Natalia Rodriguez
Summary: This study identified EP300 as a key gene involved in the metabolic abnormalities induced by antipsychotic drugs. Modulating EP300 levels may be beneficial in mitigating treatment side effects. However, further research is needed to determine the exact role of this gene in the mechanism of action of medications.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Maarten Bak, Marjan Drukker, Shauna Cortenraad, Emma Vandenberk, Sinan Guloksuz
Summary: This meta-analysis found that antipsychotics are associated with body weight gain, regardless of psychiatric diagnosis.
Article
Pharmacology & Pharmacy
Farhana Islam, Xiaoyu Men, Kazunari Yoshida, Clement C. Zai, Daniel J. Mueller
Summary: Pharmacogenetics research has shown that genetic factors influence the efficacy and tolerability of antipsychotic treatment, with the most robust findings related to associations between polymorphisms in CYP2D6 and exposure and response to specific antipsychotics. Product labels and guidelines have provided dosing recommendations based on CYP2D6 metabolizer phenotypes.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Health Care Sciences & Services
Gesche Jurgens, Benjamin Skov Kaas-Hansen, Merete Nordentoft, Thomas Werge, Stig Ejdrup Andersen
Summary: This study found an association between genetically predicted CYP2D6 metabolic capacity and antipsychotic-induced weight gain. The results showed significant weight gain in both CYP2D6 poor metabolizers and ultrarapid metabolizers after taking antipsychotic drugs.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
M. A. Galindo-Caceres, R. Parra-Unda, J. Murillo-Llanes, F. Morgan-Ortiz, J. G. Rendon-Maldonado, K. Y. Osuna-Espinoza, I. Osuna-Ramirez
Summary: The study explores the relationship between maternal weight, leptin receptor expression in maternal peripheral blood mononuclear cells (PBMC), and placental tissue to analyze its impact on birth outcomes. The results suggest that maternal nutrition status can affect fetal development and birth outcomes through leptin receptor expression.
Article
Pharmacology & Pharmacy
Vera S. Dobrodeeva, Natalia A. Shnayder, Maxim A. Novitsky, Azat R. Asadullin, Elena E. Vaiman, Marina M. Petrova, Oleg V. Limankin, Nikolay G. Neznanov, Natalia P. Garganeeva, Regina F. Nasyrova
Summary: This study revealed a significant association between the major allele C of SNP rs11100494 of the NPY5R gene and AP-induced weight gain in Russian patients with SSDs, suggesting its predictive role in the development of weight gain. Additionally, first-generation APs were more likely to increase serum transaminase levels, while second-generation APs were more likely to cause weight gain and changes in serum glucose levels.
Review
Endocrinology & Metabolism
Douglas Tremblay, Mikaela Dougherty, John Mascarenhas, Emily Jane Gallagher
Summary: Weight gain is a common side effect of ruxolitinib, and this study suggests that it may be related to changes in whole body energy expenditure.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Psychiatry
Yuying Qiu, Meijuan Li, Yonghui Zhang, Ying Liu, Yongping Zhao, Jing Zhang, Qiong Jia, Jie Li
Summary: Berberine could reduce weight gain in schizophrenia patients, with significant weight loss observed in the berberine group compared to placebo. The effect may be related to the regulation of leptin levels.
ASIAN JOURNAL OF PSYCHIATRY
(2022)
Article
Psychology, Developmental
Hua Chen, Ning Lyu, Wenyaw Chan, Austin De La Cruz, Chadi Calarge
Summary: This study examines the utilization and predictors of adjuvant metformin among pediatric recipients of second-generation antipsychotics. The findings suggest that the utilization of adjuvant metformin is uncommon among pediatric SGA recipients, and early introduction of the medication among nonobese children is rare.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Review
Endocrinology & Metabolism
Helene Speyer, Casper Westergaard, Nikolai Albert, Mette Karlsen, Anne Emilie Sturup, Merete Nordentoft, Jesper Krogh
Summary: The study found that reducing dosage, discontinuing medication, or switching to a partial agonist can lead to a small but significant weight loss of around 1.5 kg. The overall weight change from pre to post intervention was a reduction of 1.13 kg.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Psychiatry
Kenn Lee, Seri Abraham, Robert Cleaver
Summary: This study evaluated the efficacy of licensed weight loss medications (WLMs) for treating antipsychotic-induced weight gain (AIWG) and obesity in schizophrenia and psychosis. The findings showed that liraglutide had the strongest evidence compared to other licensed WLMs in improving weight, BMI, waist circumference, HbA1c, cholesterol, and LDL readings. This evidence supports the use of liraglutide in treating AIWG and OSP.
GENERAL HOSPITAL PSYCHIATRY
(2022)
Article
Neurosciences
Prabhjot Dhami, Lena C. Quilty, Benjamin Schwartzmann, Rudolf Uher, Timothy A. Allen, Stefan Kloiber, Raymond W. Lam, Glenda MacQueen, Benicio N. Frey, Roumen Milev, Daniel J. Mueller, Stephen C. Strother, Pierre Blier, Claudio N. Soares, Sagar V. Parikh, Gustavo Turecki, Jane A. Foster, Susan Rotzinger, Sidney H. Kennedy, Faranak Farzan
Summary: The neurobiological correlates of response inhibition can predict the response of patients with major depressive disorder (MDD) to pharmacological and cognitive behavioral therapy treatment. The integrity of response inhibition may be crucial for the success of treatment for MDD. Electrophysiological correlates of response inhibition may serve as a general prognostic marker for treatment response in MDD.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2023)
Article
Psychology, Clinical
Julius Steding, Franziska Ritschel, Ilka Boehm, Daniel Geisler, Joseph A. King, Veit Roessner, Michael N. Smolka, Florian Daniel Zepf, Stefan Ehrlich
Summary: This study investigated the neural responses related to reward processing in individuals with a history of anorexia nervosa (recAN) during acute tryptophan depletion (ATD). The results suggested a normalization of reward-related neural responses in recAN during ATD.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Clinical
Mehri Sajjadian, Rudolf Uher, Keith Ho, Stefanie Hassel, Roumen Milev, Benicio N. Frey, Faranak Farzan, Pierre Blier, Jane A. Foster, Sagar Parikh, Daniel J. Mueller, Susan Rotzinger, Claudio N. Soares, Gustavo Turecki, Valerie H. Taylor, Raymond W. Lam, Stephen C. Strother, Sidney H. Kennedy
Summary: Predicting treatment outcomes for major depressive disorder can be improved by combining clinical, neuroimaging, and molecular data. Early measurement during treatment can increase precision, but adding more features does not necessarily enhance prediction accuracy.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Clinical
Marie-Louis Wronski, Daniel Geisler, Fabio Bernardoni, Maria Seidel, Klaas Bahnsen, Arne Doose, Jonas L. Steinhaeuser, Franziska Gronow, Luisa V. Boeldt, Franziska Plessow, Elizabeth A. Lawson, Joseph A. King, Veit Roessner, Stefan Ehrlich
Summary: This study is the first to investigate amygdala nuclei volumes in patients with anorexia nervosa (AN). The results show that the volumes of several specific nuclei in the amygdala are significantly reduced in AN patients compared to healthy individuals, while others are less affected. Additionally, the study finds a positive association between leptin levels and alterations in certain nuclei.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Biology
Jadna Bogado Lopes, Anna N. Senko, Klaas Bahnsen, Daniel Geisler, Eugene Kim, Michel Bernanos, Diana Cash, Stefan Ehrlich, Anthony C. Vernon, Gerd Kempermann
Summary: By continuously tracking the behavioral activity of mice in an enriched environment for 3 months and using ex vivo structural magnetic resonance imaging, it was found that behavioral activity can shape the connectivity of the mouse brain. Furthermore, there are differences in brain structural covariance between mice with different behavioral trajectories.
Review
Clinical Neurology
Ashley D. Harris, Houshang Amiri, Mariana Bento, Ronald Cohen, Christopher R. K. Ching, Christina Cudalbu, Emily L. Dennis, Arne Doose, Stefan Ehrlich, Ivan I. Kirov, Ralf Mekle, Georg Oeltzschner, Eric Porges, Roberto Souza, Friederike I. Tam, Brian Taylor, Paul M. Thompson, Yann Quide, Elisabeth A. Wilde, John Williamson, Alexander P. Lin, Brenda Bartnik-Olson
Summary: Magnetic resonance spectroscopy (MRS) is a powerful and non-invasive imaging technique that quantitatively measures brain metabolites and has utility in diagnosing and characterizing neurological diseases. However, its impact has been limited by small sample sizes, methodological variability, and intrinsic limitations. This manuscript provides an overview of MRS data harmonization, including key considerations for retrospective and prospective studies, and various approaches to harmonization. The goal is to provide knowledge for conducting MRS data harmonization studies.
FRONTIERS IN NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Victoria-Luise Batury, Friederike I. Tam, Inger Hellerhoff, Marie-Louis Wronski, Katrin Borucki, Kerstin Weidner, Veit Roessner, Wei Gao, Stefan Ehrlich
Summary: Anorexia nervosa (AN) is a complex psychiatric disorder that affects endocrine system. Previous short-term measurement methods have shown altered levels of sex steroid hormones in AN patients. This study aimed to use hair-based assessments to investigate sex steroid hormone levels in underweight AN patients compared to healthy controls, as well as the changes in hormone levels during inpatient treatment. The results indicate that hair hormone levels of DHEA were similar between the groups, but progesterone was suppressed in underweight AN patients. There was no significant change in hair hormone levels during weight restoration. Hair analysis can be used to detect suppressed progesterone levels in severe AN patients.
Correction
Biochemistry & Molecular Biology
Sean R. McWhinney, Katharina Brosch, Vince D. Calhoun, Benedicto Crespo-Facorro, Nicolas A. Crossley, Udo Dannlowski, Erin Dickie, Lorielle M. F. Dietze, Gary Donohoe, Stefan Du Plessis, Stefan Ehrlich, Robin Emsley, Petra Furstova, David C. Glahn, Alfonso Gonzalez-Valderrama, Dominik Grotegerd, Laurena Holleran, Tilo T. J. Kircher, Pavel Knytl, Marian Kolenic, Rebekka Lencer, Igor Nenadic, Nils Opel, Julia-Katharina Pfarr, Amanda L. Rodrigue, Kelly Rootes-Murdy, Alex J. Ross, Kang Sim, Antonin Skoch, Filip Spaniel, Frederike Stein, Patrik Svancer, Diana Tordesillas-Gutierrez, Juan Undurraga, Javier Vaquez-Bourgon, Aristotle Voineskos, Esther Walton, Thomas W. Weickert, Cynthia Shannon Weickert, Paul M. Thompson, Theo G. M. van Erp, Jessica A. Turner, Tomas Hajek
MOLECULAR PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Jiayuan Xu, Nana Liu, Elli Polemiti, Liliana Garcia-Mondragon, Jie Tang, Xiaoxuan Liu, Tristram Lett, Le Yu, Markus M. Noethen, Jianfeng Feng, Chunshui Yu, Andre Marquand, Gunter Schumann
Summary: Analyses of data from the UK Biobank reveal that different urban living environments are associated with affective, anxiety, and emotional instability symptom groups in adults. These associations are mediated by distinct neurological and genetic pathways. Using data from 156,075 participants, researchers found that social deprivation, air pollution, street network, and urban land-use density were positively correlated with affective symptoms. On the other hand, greenness and generous destination accessibility were negatively correlated with anxiety symptoms. The study suggests that urban living environments may influence specific psychiatric symptom groups through different neurobiological pathways.
Article
Genetics & Heredity
Kazunari Yoshida, Victoria S. Marshe, Samar S. M. Elsheikh, Malgorzata Maciukiewicz, Arun K. Tiwari, Eva J. Brandl, Jeffrey A. Lieberman, Herbert Y. Meltzer, James L. Kennedy, Daniel J. Mueller
Summary: This study investigated the association between polygenic risk scores (PRS) for various psychiatric and metabolic traits and antipsychotic-induced weight gain (AIWG). The results showed nominal associations between PRSs for BMI, CAD, LDL-C, type 1 diabetes, and SCZ with AIWG. Although these associations became non-significant after multiple testing correction, these preliminary findings suggest that PRS analyses may help identify risk factors for AIWG and elucidate the underlying mechanisms.
PHARMACOGENOMICS JOURNAL
(2023)
Article
Psychology, Clinical
Inger Hellerhoff, Fabio Bernardoni, Klaas Bahnsen, Joseph A. King, Arne Doose, Sophie Pauligk, Friederike I. Tam, Merle Mannigel, Katrin Gramatke, Veit Roessner, Katja Akguen, Tjalf Ziemssen, Stefan Ehrlich
Summary: This study investigated the potential association between serum-based protein markers of brain damage and cortical thinning in patients with acute anorexia nervosa (AN). The results showed a correlation between higher baseline levels of neurofilament light (NF-L), an established marker of axonal damage, and lower cortical thickness in several regions. This association was not found in the control group.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Marie-Louis Wronski, Charlotte Hohnemann, Fabio Bernardoni, Klaas Bahnsen, Arne Doose, Dominic Arold, Katrin Borucki, Laura M. Holsen, Elizabeth A. Lawson, Franziska Plessow, Kerstin Weidner, Veit Roessner, Stefan Diestel, Joseph A. King, Maria Seidel, Stefan Ehrlich
Summary: This study provides first evidence for the relevance of specific amygdala substructure reductions regarding cognitive symptom severity in AN and points toward novel mechanistic insight into the relationship between hypoleptinemia and rumination, which might involve the amygdaloid complex.
ACTA PSYCHIATRICA SCANDINAVICA
(2023)
Article
Psychology, Clinical
Fabio Bernardoni, Joseph A. King, Inger Hellerhoff, Martin Schoemann, Maria Seidel, Daniel Geisler, Ilka Boehm, Sophie Pauligk, Arne Doose, Julius Steding, Katrin Gramatke, Veit Roessner, Stefan Scherbaum, Stefan Ehrlich
Summary: People with anorexia nervosa show more stable decision conflict in delay-discounting tasks, which might help them achieve their long-term weight goals.
INTERNATIONAL JOURNAL OF EATING DISORDERS
(2023)
Editorial Material
Biochemistry & Molecular Biology
Tomislav Majic, Stefan Ehrlich
Summary: For individuals with anorexia nervosa, the use of psilocybin therapy carries specific risks and concerns; however, an encouraging phase 1 trial highlights the need for further research into classic psychedelics to address the urgent need for effective treatments.
Article
Psychology, Clinical
Martin Zack, Daniela Lobo, Candice Biback, Tim Fang, Kelly Smart, Daniel Tatone, Aditi Kalia, Daniel Digiacomo, James L. Kennedy
Summary: This study aimed to investigate the effects of gambling-specific priming manipulations and the pharmacological basis on risk-taking in a Game of Dice Task (GDT). The results showed that both gambling and AMPH increased risk-taking, with a stronger effect observed in individuals with gambling disorder. The outcomes varied with pre-treatment, and cognitive inflexibility and symptom severity moderated the effects.
JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY
(2023)
Article
Clinical Neurology
Nadia Deflorin, Ulrike Ehlert, Rita T. Amiel Castro
Summary: Changes in the gut microbiome of infants have been associated with maternal psychological symptoms during pregnancy. This study found that maternal prenatal depressive symptoms are associated with lower diversity of the infant's microbiome, while maternal saliva cortisol levels are linked to increased diversity and changes in specific bacterial groups. Further research is needed to understand the implications of these microbiota alterations for child health.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zheng Ma, Hui-Xia Zhou, Da-Chun Chen, Dong-Mei Wang, Xiang-Yang Zhang
Summary: The impaired glucose metabolism in drug-na & iuml;ve schizophrenia patients is strongly associated with suicidal behavior, suggesting that glucose metabolism abnormalities may be potential biomarkers of suicide in schizophrenia patients. Regular monitoring of glucose metabolism variables is essential for suicide prevention.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Katie M. Lavigne, Jiaxuan Deng, Delphine Raucher-Chene, Adele Hotte-Meunier, Chloe Voyer, Lisa Sarraf, Martin Lepage, Genevieve Sauve
Summary: Psychiatric disorders are characterized by cognitive deficits and cognitive biases, which are associated with specific symptoms. While cognitive biases are present across diagnoses, their severity varies.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Yong-Yu Yin, Jiao-Zhao Yan, Shi-Xin Lai, Qian-Qian Wei, Si-Rui Sun, Li-Ming Zhang, Yun-Feng Li
Summary: This study found that gamma oscillations are closely associated with depression and may serve as predictive biomarkers of depression. Chronic restraint stress and lipopolysaccharide induced significant depression-like behaviors in mice and reduced gamma oscillations in the medial prefrontal cortex. Administration of ketamine, scopolamine, or fluoxetine increased gamma oscillations and exhibited rapid-acting antidepressant effects.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Veronica Begni, Moira Marizzoni, Kerstin Camile Creutzberg, Diana Morena Silipo, Mariusz Papp, Annamaria Cattaneo, Marco Andrea Riva
Summary: Exposure to stressful experiences is a significant risk factor for mental disorders, and pharmacological interventions targeting stress-induced alterations can help restore brain function. Lurasidone, an antipsychotic drug, has been shown to normalize the impairments caused by stress exposure and could be a valuable treatment for stress-induced mental illnesses. However, the mechanisms underlying the therapeutic effects of lurasidone are not well understood. This study found that chronic lurasidone treatment counteracted some of the transcriptional changes induced by chronic mild stress exposure, providing new insights into the potential therapeutic effects of lurasidone.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Esther E. Palacios-Barrios, Kunal Patel, Jamie L. Hanson
Summary: This review examines the association between early life interpersonal stress (ELIS) and depression, as well as the underlying mechanisms. The research shows that ELIS affects how youth respond to social rewards, and similar impairments in social reward processing are observed in youth with depression. The authors propose a preliminary model that suggests neurobehavioral disruptions in social reward processing as a mediating factor in the connection between ELIS and depression.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Rui Li, Jiaming Tang, Yizhuo Wang, Ying Wang, Hua Yang, Hongen Wei
Summary: Restricted and repetitive behaviors (RRBs) are characteristic features of neuropsychiatric disorders. This study focused on repetitive self-grooming behavior and investigated the involvement of the Pax2 gene in its control. Through the use of Pax2 neuron-specific deletion mice, the study found that the deletion of Pax2 gene affects the expression of the Arc gene in the prefrontal cortex, leading to impaired synaptic plasticity and excitatory/inhibitory imbalance, thereby contributing to the occurrence of repetitive self-grooming behavior.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Sara Derosa, Paulina Misztak, Jessica Mingardi, Giulia Mazzini, Heidi Kaastrup Muller, Laura Musazzi
Summary: This study investigated the involvement of neurotrophic signaling pathways in stress vulnerability/resilience and fast antidepressant response/non-response to ketamine in a rat model of depression. The findings showed that stress and ketamine induced specific changes in these pathways in different brain areas and subcellular fractions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Georgia F. Caruana, Sean P. Carruthers, Michael Berk, Susan L. Rossell, Tamsyn E. Van Rheenen
Summary: Cognitive impairment is related to both white matter macrostructure and microstructure in bipolar disorder patients. However, there is inconsistency in the results of the studies examining this relationship. Some studies have found an association between higher fractional anisotropy in white matter and better complex attention skills and executive functioning in bipolar disorder patients, while others have found no associations. Further research with increased statistical power and standardized methods is needed.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Alberto Galimberti, Martin Tik, Giovanni Pellegrino, Anna-Lisa Schuler
Summary: This study provides a systematic review and meta-analysis on the effectiveness of repetitive transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) for post-traumatic brain injury (TBI) symptoms. The results show that non-invasive brain stimulation techniques have a small overall effect on TBI sequelae, with significant effects observed for anxiety and headache. However, larger randomized controlled trials with longer follow-ups, optimized stimulation parameters, and standardized methodology are needed to establish the efficacy of these techniques in addressing TBI sequelae.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Amanda J. Sales, Pedro H. Gobira, Joa F. C. Pedrazzi, Joao R. Silveia, Elaine Del Bel, Felipe V. Gomes, Francisco S. Guimaraes
Summary: The study found that doxycycline can inhibit metalloproteinase in the brain and attenuate the rewarding effects and locomotor sensitization of drug abuse. This suggests that doxycycline could be repurposed for the treatment of substance use disorders.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Alejandro Borrego-Ruiz, Juan J. Borrego
Summary: There is substantial evidence that the development of the nervous system is related to the composition and functions of the gut microbiome. The communication between the central nervous system (CNS) and the gut microbiota is bidirectional, with various routes such as immune, endocrine, and neural circuits. Dysbiosis of the gut microbiota has been associated with neuropsychiatric diseases and psychological disorders. Fecal microbiota transplantation (FMT) therapy has shown a causal-effect relationship between the gut microbiota and behavioral features. Interventions based on prebiotics, probiotics, or synbiotics have demonstrated their influence on neurological disorders through the synthesis of neuroactive compounds and regulation of inflammatory and endocrine processes. Further research is needed to explore the impact of gut microbiota dysbiosis on psychiatric and psychological disorders and the potential therapeutic role of microbiota-based interventions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zhinan Li, Zhuang Kang, Xiaowei Xia, Leijun Li, Junyan Wu, Jiamin Dai, Tong Liu, Cai Chen, Yong Qiu, Ming Chen, Yanxi Liu, Ziyi Zhang, Zili Han, Zhengjia Dai, Qinling Wei
Summary: This study found that patients with schizophrenia showed lower levels of resilience and cognitive functions compared to healthy controls, as well as abnormal global properties and nodal metrics in brain networks. Furthermore, characteristic path length might moderate the relationship between resilience and working memory in these patients.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
David H. Adamowicz, Tsung-Chin Wu, Rebecca Daly, Michael R. Irwin, Dilip Jeste, Xin M. Tu, Lisa T. Eyler, Ellen E. Lee
Summary: This study aimed to explore the relationship between executive functioning and inflammatory biomarkers in people with schizophrenia. The results showed that systemic inflammation did not predict long-term declines in executive functioning. This suggests the need for further research to better understand the relationship and mechanisms between inflammation and cognition in schizophrenia.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Nina Walter, Julian Wenzel, Shalaila S. Haas, Letizia Squarcina, Carolina Bonivento, Anne Ruef, Dominic Dwyer, Theresa Lichtenstein, Oeznur Bastruek, Alexandra Stainton, Linda A. Antonucci, Paolo Brambilla, Stephen J. Wood, Rachel Upthegrove, Stefan Borgwardt, Rebekka Lencer, Eva Meisenzahl, Raimo K. R. Salokangas, Christos Pantelis, Alessandro Bertolino, Nikolaos Koutsouleris, Joseph Kambeitz, Lana Kambeitz-Ilankovic
Summary: Clinical and neuroimaging data can be used to predict the potential of cognitive training to improve social functioning in recent onset psychosis patients. The use of multivariate pattern analysis and support vector machine classifier allows for the prediction of social functioning improvement based on baseline cognitive data. The findings suggest that cognitive data can provide a robust individual estimate of future social functioning for patients with recent onset psychosis.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
