Article
Neurosciences
Agata Ploska, Paulina Cieslik, Anna Siekierzycka, Leszek Kalinowski, Joanna M. Wieronska
Summary: The olfactory bulbectomized rat model can be used to study depression and Alzheimer's disease, with neurochemical changes in OBX animals resembling those associated with AD pathology. CDPPB can improve cognitive impairment in the passive avoidance test and partially reverse the changes in nitric oxide synthase expression induced by the lesion.
Article
Biochemistry & Molecular Biology
Lynnea D. Harris, Michael C. Regan, Scott J. Myers, Kelsey A. Nocilla, Nicholas S. Akins, Yesim A. Tahirovic, Lawrence J. Wilson, Ray Dingledine, Hiro Furukawa, Stephen F. Traynelis, Dennis C. Liotta
Summary: Many cases of accidental death associated with drug overdose are due to chronic opioid use, tolerance, and addiction. Analgesic tolerance is characterized by a decreased response to the analgesic effects of opioids, requiring increasingly higher doses to maintain the desired level of pain relief. The compound EU93-108, a GluN2Bselective negative allosteric modulator, has been found to have potent analgesic properties and potential in the treatment of pain.
ACS CHEMICAL NEUROSCIENCE
(2023)
Review
Neurosciences
Yevheniia Ishchenko, Melissa G. Carrizales, Anthony J. Koleske
Summary: Excitatory neurotransmission mediated by N-methyl-D-aspartate receptors (NMDARs) is essential for synapse development, function, and plasticity in the brain. Genetic variants in NMDAR subunit genes are associated with various neurodevelopmental and neuropsychiatric disorders. The carboxyl terminal domain (CTD) of NMDAR subunits plays a crucial role in regulating receptor functions.
Article
Neurosciences
Zhicheng Jin, Jianer Ling, Jing Yu, Mengzi He, Pingping Ni, Fang Zhang, Yizhen Wang
Summary: The study revealed that hypothyroidism induces depressive behaviors, with the influence of the serotonin system playing a significant role, and the decreased expression of the 5-HT2A receptor being a crucial factor in the depressive behaviors associated with hypothyroidism.
EXPERIMENTAL BRAIN RESEARCH
(2021)
Article
Neurosciences
Patrick R. Melugin, Fei Wu, Crystal Munoz, Aarron Phensy, Grishma Pradhan, Yi Luo, Abraham Nofal, Rohan Manepalli, Sven Kroener
Summary: Alcohol use disorder is associated with changes in the medial prefrontal cortex, including altered glutamatergic transmission and deficits in executive functions. Acamprosate can reduce alcohol craving and relapse by improving alcohol-induced dysregulation of glutamatergic signaling. This study found that acamprosate and its active moiety calcium can improve deficits in cognitive flexibility and altered glutamatergic signaling in mice that self-administered alcohol under goal-directed conditions. However, under conditions that bias behavior towards habitual responding, the effects of acamprosate and calcium on glutamatergic transmission were not observed.
Article
Pharmacology & Pharmacy
Tais da Silva Teixeira Rech, Dianer Nornberg Strelow, Leticia Devantier Kruger, Jose Sebastiao Santos Neto, Gustavo Bierhals Blodorn, Diego Alves, Cesar Augusto Bruning, Cristiani Folharini Bortolatto
Summary: This study aimed to evaluate the relationship between the antidepressant-like effect of 2-phenyl-3-(phenylselanyl)benzofuran (SeBZF1) and the glutamate pathway. The results showed that pretreatment of mice with drugs targeting glutamate receptors inhibited the antidepressant-like effect of SeBZF1. These findings contribute to a better understanding of the pharmacological effects of SeBZF1.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Behavioral Sciences
Josiane Budni, Morgana Moretti, Andiara E. Freitas, Vivian B. Neis, Camille M. Ribeiro, Grasiela de Oliveira Balen, Rodrigo B. Leal, Ana Lucia S. Rodrigues
Summary: This study found that folic acid can alleviate the depressive-like behavior induced by TNF-alpha, possibly through the activation of monoaminergic systems, inhibition of NMDA receptors and NO synthesis, as well as Akt modulation.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Integrative & Complementary Medicine
Sun Dan-chen, Wang Ran-ran, Xu Hao, Zhu Xue-hui, Sun Yan, Qiao Shi-qing, Qiao Wei
Summary: This study investigated the pharmacodynamic material basis, mechanism of actions, and targeted diseases of Salicornia europaea L. (SE) using the network pharmacology method. Pharmacological experiments verified the antidepressant-like effect of SE extract and suggested that it may regulate the Nrf2-ARE pathway and increase levels of dopamine and corticosterone in the hippocampus and cortex.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Najeeb Ur Rehman, Sulaiman Al-Shidhani, Nasiara Karim, Ajmal Khan, Imran Khan, Sobia Ahsan Halim, Sajid Khan Sadozai, Satya Kumar Avula, Rene Csuk, Ahmed Al-Harrasi
Summary: Through the study of derivatives of two active substances in the resin of Boswellia papyrifera, it is found that these derivatives have good anti-depressive properties and have great application potential. Further research indicates that these compounds produce GABAergic effects by binding to the GABA binding site of the GABA(A) receptor.
BIOORGANIC CHEMISTRY
(2022)
Article
Neurosciences
Arnab Nandi, Garima Virmani, Aatmika Barve, Swananda Marathe
Summary: FST and TST are common behavioral tests for screening antidepressant drugs and assessing non-motor symptoms in movement disorder animal models. Manual analysis of these tests is time-consuming with large variability, but the open-source program DBscorer provides automated and unbiased analysis, allowing for a nuanced understanding of behavioral despair expression.
Article
Neurosciences
Faizan Ul Haq, Mohammad Shoaib, Syed Wadood Ali Shah, Haya Hussain, Muhammad Zahoor, Riaz Ullah, Ahmed Bari, Amal Alotaibi, Muhammad Faisal Hayat
Summary: This study aimed to synthesize benzodiazepine derivatives and evaluate their antidepressant potentials. The results showed that compounds 2 and 5 exhibited significant antidepressant effects and increased GABA levels in the brain's hippocampus of experimental animals, indicating the possible involvement of the GABAergic mechanism.
Article
Biochemistry & Molecular Biology
Adel Alghamdi, Mansour Almuqbil, Mohammad A. Alrofaidi, Abdulhadi S. Burzangi, Ali A. Alshamrani, Abdullah R. Alzahrani, Mehnaz Kamal, Mohd. Imran, Sultan Alshehri, Basheerahmed Abdulaziz Mannasaheb, Nasser Fawzan Alomar, Syed Mohammed Basheeruddin Asdaq
Summary: This study found that apigenin has antidepressant properties in an experimental mouse model of chronic mild stress (CMS). Apigenin can alleviate stress-induced behavioral deficits and increase preference for sucrose. Additionally, apigenin can increase antioxidant levels and decrease plasma corticosterone and nitrite levels induced by chronic stress.
Article
Neurosciences
Tiziana Imbriglio, Remy Verhaeghe, Nico Antenucci, Stefania Maccari, Giuseppe Battaglia, Ferdinando Nicoletti, Milena Cannella
Summary: mGlu5 metabotropic glutamate receptors are highly expressed in the early postnatal life, positively modulating NMDA receptor function. Deletion of mGlu5 leads to transient overexpression of NMDA receptor subunits, compensating for the lack of mGlu5. Changes in interneuron-related gene expression were also observed across postnatal development, impacting the behavioral response to NMDA channel blocker MK-801.
Article
Behavioral Sciences
Aida A. C. Brandao, Deborah L. S. Deus, Luiz A. M. S. Duarte-Filho, Pedro M. N. Menezes, Ana B. R. Massaranduba, Fabricio S. Silva, Luciano A. A. Ribeiro
Summary: Through nebulization delivery, ketamine can significantly reduce depressive-like behaviors in mice, indicating that nebulization can be an effective and inexpensive route of drug administration for behavioral research.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2023)
Article
Behavioral Sciences
Cristina Maria de Arruda, Diego Luiz Doneda, Vinicius Vezzi de Oliveira, Rozielly Aparecida Lemes da Silva, Yohan Alves Victor de Matos, Isadora Luiza Fernandes, Christopher Alecsander Herane Rohden, Giordano Gubert Viola, Fabricio Rios-Santos, Eliangela de Lima, Ziliani da Silva Buss, Samuel Vandresen-Filho
Summary: This study found that vilazodone has antidepressant-like effects, which may be mediated through an interaction with the kynurenine pathway and N-methyl-D-aspartate receptors.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2022)
Article
Behavioral Sciences
Agnieszka Palucha-Poniewiera, Karolina Podkowa, Andrzej Pilc
BEHAVIOURAL PHARMACOLOGY
(2019)
Article
Pharmacology & Pharmacy
Joanna Kryst, Pawel Kawalec, Andrzej Pilc
EXPERT OPINION ON PHARMACOTHERAPY
(2020)
Article
Behavioral Sciences
Agnieszka Palucha-Poniewiera, Karolina Podkowa, Anna Rafalo-Ulinska, Piotr Branski, Grzegorz Burnat
BEHAVIOURAL PHARMACOLOGY
(2020)
Article
Pharmacology & Pharmacy
Joanna Kryst, Pawel Kawalec, Alicja Mikrut Mitoraj, Andrzej Pilc, Wladyslaw Lason, Tomasz Brzostek
PHARMACOLOGICAL REPORTS
(2020)
Article
Pharmacology & Pharmacy
Grzegorz Burnat, Piotr Branski, Joanna Solich, Magdalena Kolasa, Barbara Chruscicka, Marta Dziedzicka-Wasylewska, Andrzej Pilc
PHARMACOLOGICAL REPORTS
(2020)
Review
Pharmacology & Pharmacy
Malgorzata Panek, Pawel Kawalec, Andrzej Pilc, Wladyslaw Lason
EXPERT OPINION ON DRUG DISCOVERY
(2020)
Article
Psychiatry
Martina Ulivieri, Joanna Monika Wieronska, Luana Lionetto, Katiuscia Martinello, Paulina Cieslik, Agnieszka Chocyk, Martina Curto, Luisa Di Menna, Luisa Iacovelli, Anna Traficante, Francesca Liberatore, Giada Mascio, Nico Antenucci, Giuseppe Giannino, Matteo Vergassola, Anna Pittaluga, Valeria Bruno, Giuseppe Battaglia, Sergio Fucile, Maurizio Simmaco, Ferdinando Nicoletti, Andrzej Pilc, Francesco Fazio
SCHIZOPHRENIA BULLETIN
(2020)
Article
Clinical Neurology
Agnieszka Palucha-Poniewiera, Karolina Podkowa, Anna Rafalo-Ulinska
Summary: The study demonstrates that the mGlu2/3 receptor antagonist LY341495 has potential in treating depression, and when used in combination with ketamine, it can reduce the effective dose of ketamine and minimize potential side effects.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Medicine, General & Internal
Michal Skalski, Anna Mach, Piotr Januszko, Beata Ryszewska-Pokrasniewicz, Agata Biernacka, Gabriel Nowak, Andrzej Pilc, Ewa Poleszak, Maria Radziwon-Zaleska
Summary: The study aimed to evaluate the effects of psychotropic medications on the bioelectrical activity of the brain using pharmaco-EEG. Results showed the highest treatment response in the group receiving fluoxetine augmented with Mg ions, while the group receiving tricyclic antidepressants had the lowest response rates. Achieving remission was associated with a positive pharmaco-EEG profile 6 hours after administration of the first dose in the fluoxetine+Mg group.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Joanna Piotrowska, Agata Kryczyk-Poprawa, Bozena Muszynska, Andrzej Pilc, Wlodzimierz Opoka
Summary: Citicoline is a nootropic compound with neuroprotective properties that improve cognitive function. Its application benefits patients with conditions such as stroke, brain trauma, and Parkinson's disease, as well as enhancing memory and concentration in the elderly. Studies have shown its positive impact on motor function and vision parameters in various clinical entities.
ACTA POLONIAE PHARMACEUTICA
(2021)
Article
Biochemistry & Molecular Biology
Anna Stankiewicz, Katarzyna Kaczorowska, Ryszard Bugno, Aneta Koziol, Maria H. Paluchowska, Grzegorz Burnat, Barbara Chruscicka, Paulina Chorobik, Piotr Branski, Joanna M. Wieronska, Beata Duszynska, Andrzej Pilc, Andrzej J. Bojarski
Summary: This study developed a group of 1,2,4-oxadiazole derivatives that exhibited positive allosteric modulatory activity on mGlu(4) receptors. These derivatives were selectively active on mGlu(7) and mGlu(8) receptors and showed anxiolytic- and antipsychotic-like properties.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Anna Rafalo-Ulinska, Piotr Branski, Agnieszka Palucha-Poniewiera
Summary: This study investigated the antidepressant-like effects of low doses of two ketamine enantiomers in combination with a low-dose mGlu2/3 receptor antagonist LY341495. The results showed that coadministration of (R)-ketamine and LY341495 induced long-lasting anti-apathetic and anti-anhedonic effects. The mechanism of this drug combination may be related to BDNF and AMPA receptor activity, possibly occurring in the hippocampus.
Article
Chemistry, Medicinal
Agnieszka Palucha-Poniewiera, Bartosz Bobula, Anna Rafalo-Ulinska
Summary: The combination of (R)-ketamine and mGlu(2/3) receptor antagonist LY341495 (mixRL) has rapid and sustained effects in a mouse model of depression. It can reverse CUMS-induced memory deficits and alleviate depression-like effects. The mechanism may involve modulation of glutamatergic transmission and long-term potentiation in the PFC.
Review
Pharmacology & Pharmacy
Panek Malgorzata, Kawalec Pawel, Malinowska Lipien Iwona, Tomasz Brzostek, Pilc Andrzej
EXPERT OPINION ON THERAPEUTIC TARGETS
(2020)
Correction
Behavioral Sciences
A. Palucha-Poniewiera, K. Podkowa, A. Pilc
BEHAVIOURAL PHARMACOLOGY
(2020)
Article
Clinical Neurology
Nadia Deflorin, Ulrike Ehlert, Rita T. Amiel Castro
Summary: Changes in the gut microbiome of infants have been associated with maternal psychological symptoms during pregnancy. This study found that maternal prenatal depressive symptoms are associated with lower diversity of the infant's microbiome, while maternal saliva cortisol levels are linked to increased diversity and changes in specific bacterial groups. Further research is needed to understand the implications of these microbiota alterations for child health.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zheng Ma, Hui-Xia Zhou, Da-Chun Chen, Dong-Mei Wang, Xiang-Yang Zhang
Summary: The impaired glucose metabolism in drug-na & iuml;ve schizophrenia patients is strongly associated with suicidal behavior, suggesting that glucose metabolism abnormalities may be potential biomarkers of suicide in schizophrenia patients. Regular monitoring of glucose metabolism variables is essential for suicide prevention.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Katie M. Lavigne, Jiaxuan Deng, Delphine Raucher-Chene, Adele Hotte-Meunier, Chloe Voyer, Lisa Sarraf, Martin Lepage, Genevieve Sauve
Summary: Psychiatric disorders are characterized by cognitive deficits and cognitive biases, which are associated with specific symptoms. While cognitive biases are present across diagnoses, their severity varies.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Yong-Yu Yin, Jiao-Zhao Yan, Shi-Xin Lai, Qian-Qian Wei, Si-Rui Sun, Li-Ming Zhang, Yun-Feng Li
Summary: This study found that gamma oscillations are closely associated with depression and may serve as predictive biomarkers of depression. Chronic restraint stress and lipopolysaccharide induced significant depression-like behaviors in mice and reduced gamma oscillations in the medial prefrontal cortex. Administration of ketamine, scopolamine, or fluoxetine increased gamma oscillations and exhibited rapid-acting antidepressant effects.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Veronica Begni, Moira Marizzoni, Kerstin Camile Creutzberg, Diana Morena Silipo, Mariusz Papp, Annamaria Cattaneo, Marco Andrea Riva
Summary: Exposure to stressful experiences is a significant risk factor for mental disorders, and pharmacological interventions targeting stress-induced alterations can help restore brain function. Lurasidone, an antipsychotic drug, has been shown to normalize the impairments caused by stress exposure and could be a valuable treatment for stress-induced mental illnesses. However, the mechanisms underlying the therapeutic effects of lurasidone are not well understood. This study found that chronic lurasidone treatment counteracted some of the transcriptional changes induced by chronic mild stress exposure, providing new insights into the potential therapeutic effects of lurasidone.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Esther E. Palacios-Barrios, Kunal Patel, Jamie L. Hanson
Summary: This review examines the association between early life interpersonal stress (ELIS) and depression, as well as the underlying mechanisms. The research shows that ELIS affects how youth respond to social rewards, and similar impairments in social reward processing are observed in youth with depression. The authors propose a preliminary model that suggests neurobehavioral disruptions in social reward processing as a mediating factor in the connection between ELIS and depression.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Rui Li, Jiaming Tang, Yizhuo Wang, Ying Wang, Hua Yang, Hongen Wei
Summary: Restricted and repetitive behaviors (RRBs) are characteristic features of neuropsychiatric disorders. This study focused on repetitive self-grooming behavior and investigated the involvement of the Pax2 gene in its control. Through the use of Pax2 neuron-specific deletion mice, the study found that the deletion of Pax2 gene affects the expression of the Arc gene in the prefrontal cortex, leading to impaired synaptic plasticity and excitatory/inhibitory imbalance, thereby contributing to the occurrence of repetitive self-grooming behavior.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Sara Derosa, Paulina Misztak, Jessica Mingardi, Giulia Mazzini, Heidi Kaastrup Muller, Laura Musazzi
Summary: This study investigated the involvement of neurotrophic signaling pathways in stress vulnerability/resilience and fast antidepressant response/non-response to ketamine in a rat model of depression. The findings showed that stress and ketamine induced specific changes in these pathways in different brain areas and subcellular fractions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Georgia F. Caruana, Sean P. Carruthers, Michael Berk, Susan L. Rossell, Tamsyn E. Van Rheenen
Summary: Cognitive impairment is related to both white matter macrostructure and microstructure in bipolar disorder patients. However, there is inconsistency in the results of the studies examining this relationship. Some studies have found an association between higher fractional anisotropy in white matter and better complex attention skills and executive functioning in bipolar disorder patients, while others have found no associations. Further research with increased statistical power and standardized methods is needed.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Alberto Galimberti, Martin Tik, Giovanni Pellegrino, Anna-Lisa Schuler
Summary: This study provides a systematic review and meta-analysis on the effectiveness of repetitive transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) for post-traumatic brain injury (TBI) symptoms. The results show that non-invasive brain stimulation techniques have a small overall effect on TBI sequelae, with significant effects observed for anxiety and headache. However, larger randomized controlled trials with longer follow-ups, optimized stimulation parameters, and standardized methodology are needed to establish the efficacy of these techniques in addressing TBI sequelae.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Amanda J. Sales, Pedro H. Gobira, Joa F. C. Pedrazzi, Joao R. Silveia, Elaine Del Bel, Felipe V. Gomes, Francisco S. Guimaraes
Summary: The study found that doxycycline can inhibit metalloproteinase in the brain and attenuate the rewarding effects and locomotor sensitization of drug abuse. This suggests that doxycycline could be repurposed for the treatment of substance use disorders.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Alejandro Borrego-Ruiz, Juan J. Borrego
Summary: There is substantial evidence that the development of the nervous system is related to the composition and functions of the gut microbiome. The communication between the central nervous system (CNS) and the gut microbiota is bidirectional, with various routes such as immune, endocrine, and neural circuits. Dysbiosis of the gut microbiota has been associated with neuropsychiatric diseases and psychological disorders. Fecal microbiota transplantation (FMT) therapy has shown a causal-effect relationship between the gut microbiota and behavioral features. Interventions based on prebiotics, probiotics, or synbiotics have demonstrated their influence on neurological disorders through the synthesis of neuroactive compounds and regulation of inflammatory and endocrine processes. Further research is needed to explore the impact of gut microbiota dysbiosis on psychiatric and psychological disorders and the potential therapeutic role of microbiota-based interventions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zhinan Li, Zhuang Kang, Xiaowei Xia, Leijun Li, Junyan Wu, Jiamin Dai, Tong Liu, Cai Chen, Yong Qiu, Ming Chen, Yanxi Liu, Ziyi Zhang, Zili Han, Zhengjia Dai, Qinling Wei
Summary: This study found that patients with schizophrenia showed lower levels of resilience and cognitive functions compared to healthy controls, as well as abnormal global properties and nodal metrics in brain networks. Furthermore, characteristic path length might moderate the relationship between resilience and working memory in these patients.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
David H. Adamowicz, Tsung-Chin Wu, Rebecca Daly, Michael R. Irwin, Dilip Jeste, Xin M. Tu, Lisa T. Eyler, Ellen E. Lee
Summary: This study aimed to explore the relationship between executive functioning and inflammatory biomarkers in people with schizophrenia. The results showed that systemic inflammation did not predict long-term declines in executive functioning. This suggests the need for further research to better understand the relationship and mechanisms between inflammation and cognition in schizophrenia.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Nina Walter, Julian Wenzel, Shalaila S. Haas, Letizia Squarcina, Carolina Bonivento, Anne Ruef, Dominic Dwyer, Theresa Lichtenstein, Oeznur Bastruek, Alexandra Stainton, Linda A. Antonucci, Paolo Brambilla, Stephen J. Wood, Rachel Upthegrove, Stefan Borgwardt, Rebekka Lencer, Eva Meisenzahl, Raimo K. R. Salokangas, Christos Pantelis, Alessandro Bertolino, Nikolaos Koutsouleris, Joseph Kambeitz, Lana Kambeitz-Ilankovic
Summary: Clinical and neuroimaging data can be used to predict the potential of cognitive training to improve social functioning in recent onset psychosis patients. The use of multivariate pattern analysis and support vector machine classifier allows for the prediction of social functioning improvement based on baseline cognitive data. The findings suggest that cognitive data can provide a robust individual estimate of future social functioning for patients with recent onset psychosis.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)