Article
Neurosciences
Lidia Bravo, Patricia Mariscal, Meritxell Llorca-Torralba, Jose Maria Lopez-Cepero, Juan Nacher, Esther Berrocoso
Summary: This study examined the effects of neuropathic pain on noradrenergic neurons in the locus coeruleus (LC) and found that neuropathic pain leads to an increase in excitatory synapse markers and a decrease in mitochondrial and lysosomal densities. Long-term pain also activates apoptosis.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Cell Biology
Carla Cristina Miranda Castro, Sayonara Pereira Silva, Livia Nascimento Rabelo, Jose Pablo Goncalves Queiroz, Laura Damasceno Campos, Larissa Camila Silva, Felipe Porto Fiuza
Summary: The study found that there are regional alterations of specific cellular subpopulations in the aging human hippocampus, which are influenced by factors such as age, sex, education years, and the concentration of neuropathological and inflammatory proteins. These findings provide insights into the distinct physiological changes that occur in hippocampal sub-regions and neurotransmitter systems during normal aging.
Article
Cell Biology
Silas A. Buck, Thomas Steinkellner, Despoina Aslanoglou, Michael Villeneuve, Sai H. Bhatte, Victoria C. Childers, Sophie A. Rubin, Briana R. De Miranda, Emma O'Leary, Elizabeth G. Neureiter, Keri J. Fogle, Michael J. Palladino, Ryan W. Logan, Jill R. Glausier, Kenneth N. Fish, David A. Lewis, J. Timothy Greenamyre, Brian D. McCabe, Claire E. J. Cheetham, Thomas S. Hnasko, Zachary Freyberg
Summary: The study revealed the impact of age and sex differences on dopamine neuron vulnerability, with males exhibiting greater decreases in neuron number and locomotion during aging, and dynamic changes in VGLUT expression in dopamine neurons possibly serving as a compensatory mechanism. Female fruit flies were found to possess higher levels of VGLUT expression in dopamine neurons compared to males, and diminishing VGLUT expression eliminated their greater resilience to neuron loss. Optimal control over VGLUT expression in dopamine neurons was identified as essential for neuron survival and a potential therapeutic target for age- and PD-related neurodegeneration.
Article
Geriatrics & Gerontology
Bing Leng, Hairong Sun, Mengfan Li, Junwu Zhao, Xiaoxiao Liu, Ran Yao, Tengqun Shen, Zhenguang Li, Jinbiao Zhang
Summary: This study found that Parkinson's disease (PD) patients with rapid eye movement (REM) sleep behavior disorder (RBD) experience a greater decline in cognitive function. Blood neuroexosomal EAAT-2 levels are associated with cognitive decline in PD patients with RBD.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Neurosciences
Haiyan Li, Maia Datunashvili, Reno C. C. Reyes, Susan M. M. Voglmaier
Summary: Inositol pyrophosphates play a crucial role in cellular signaling and membrane trafficking, particularly in synaptic vesicle recycling. Two isoforms of Inositol hexakisphosphate kinases (IP6Ks), IP6K1 and IP6K3, are expressed in axons and regulate vesicle recycling through different endocytic pathways. IP6Ks also affect synaptic facilitation and glutamate signaling.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Zhiping Mi, Eric E. Abrahamson, Angela Y. Ryu, Michael Malek-Ahmadi, Julia K. Kofler, Kenneth N. Fish, Robert A. Sweet, Victor L. Villemagne, Julie A. Schneider, Elliott J. Mufson, Milos D. Ikonomovic
Summary: Altered glutamatergic neurotransmission may contribute to impaired default mode network function in Alzheimer's disease (AD). The frontal cortex (FC) may undergo a glutamatergic plasticity response in prodromal AD, while the status of glutamatergic synapses in the precuneus (PreC) during clinical-neuropathological AD progression is not known.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Neurosciences
Cynthia Moore, Mo Xu, Jerry K. Bohlen, Charles K. Meshul
Summary: The study found that there are differential changes in glutamate release from Vglut2+ nerve terminals synapsing within the substantia nigra pars compacta (SNpc) and pars reticulata (SNpr) following dopamine loss in Parkinson's disease. In the SNpc, there was an increase in glutamate release to TH(-) dendrites and a decrease in terminals contacting TH(+) dendrites. However, in the SNpr, there was a decrease in glutamate release to both TH(+) and TH(-) dendrites.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Yanan Wang, Nitin Khandelwal, Shuiqiao Liu, Mi Zhou, Lei Bao, Jennifer E. Wang, Ashwani Kumar, Chao Xing, Jay R. Gibson, Yingfei Wang
Summary: The lysine demethylase KDM6B plays a role in excitatory neurons, and its deficiency leads to reduced spine density, synaptic activity, and learning and memory. KDM6B regulates the expression of vesicular glutamate transporter 1 and 2 (VGLUT1/2) through epigenetic modification. Additionally, Tau interacts with KDM6B and participates in the regulation of VGLUT1/2 expression.
MOLECULAR PSYCHIATRY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Y. S. Cho, H. G. Ko, H. M. Han, S. K. Park, S. J. Moozhayil, S. Y. Choi, Y. C. Bae
Summary: The study examined the differences in types of VGLUT + axons that coexpress neuropeptides in rat and human dental pulp, suggesting potential variations in peripheral mechanisms of pulpal inflammatory pain between rats and humans.
INTERNATIONAL ENDODONTIC JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Tao Ke, Abel Santamaria, Fernando Barbosa, Joao B. T. Rocha, Anatoly Skalny, Alexey A. Tinkov, Aaron B. Bowman, Michael Aschner
Summary: Developmental methylmercury exposures have age-dependent neurotoxic effects on glutamatergic neurons in C. elegans, which may be related to age-dependent modulation in glutamatergic neurotransmission and metabolic pathways.
NEUROCHEMICAL RESEARCH
(2023)
Article
Cell Biology
Takuya Yokoyama, Yoshio Yamamoto, Masato Hirakawa, Tomoyuki Saino
Summary: The study revealed that afferent nerve terminals release glutamate through exocytosis to modulate chemosensory activity of a subpopulation of type I cells via GluN2A- and GluN2B-containing NMDA receptors.
HISTOCHEMISTRY AND CELL BIOLOGY
(2021)
Article
Clinical Neurology
Thomas Steinkellner, William S. Conrad, Imre Kovacs, Robert A. Rissman, Edward B. Lee, John Q. Trojanowski, Zachary Freyberg, Subhojit Roy, Kelvin C. Luk, Virginia M. Lee, Thomas S. Hnasko
Summary: VGLUT2-expressing dopamine neurons exhibit resilience to degeneration and may be part of a neuroprotective response in Parkinson's disease.
Article
Neurosciences
Maxime Fougere, Cornelis Immanuel van der Zouwen, Joel Boutin, Dimitri Ryczko
Summary: Recent studies have identified three distinct expression patterns in dopamine neurons in mice along the rostrocaudal brain axis, providing insights into the homology of dopamine nuclei across vertebrate species.
JOURNAL OF COMPARATIVE NEUROLOGY
(2021)
Article
Multidisciplinary Sciences
Aparna Shekar, Samuel J. Mabry, Mary H. Cheng, Jenny I. Aguilar, Shalin Patel, Daniele Zanella, David P. Saleeby, Yanqi Zhu, Tiziana Romanazzi, Paula Ulery-Reynolds, Ivet Bahar, Angela M. Carter, Heinrich J. G. Matthies, Aurelio Galli
Summary: Amphetamine is a commonly abused stimulant that increases dopamine neurotransmission. Phosphorylation of proteins like Syntaxin 1 plays a critical role in the nonvesicular dopamine release induced by amphetamine.
Article
Chemistry, Multidisciplinary
Soyeon Kim, Hee-Kyung Kim, Ah Rum Baek, Bokyung Sung, Byeong Woo Yang, Yeoun-Hee Kim, Jung-jin Lee, Ji-ung Yang, Chang-Hoon Shin, Hoesu Jung, Minsup Kim, Art E. Cho, Taekwan Lee, Yongmin Chang
Summary: The study developed a new multimodal gadolinium contrast agent targeting VGLUTs as a potential new diagnostic tool for AD. The Gd-DO3A-RB showed high affinity to VGLUT1 and demonstrated imaging capabilities in the AD animal model, suggesting its potential for clinical use in diagnosing AD.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2021)
Article
Clinical Neurology
Nadia Deflorin, Ulrike Ehlert, Rita T. Amiel Castro
Summary: Changes in the gut microbiome of infants have been associated with maternal psychological symptoms during pregnancy. This study found that maternal prenatal depressive symptoms are associated with lower diversity of the infant's microbiome, while maternal saliva cortisol levels are linked to increased diversity and changes in specific bacterial groups. Further research is needed to understand the implications of these microbiota alterations for child health.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zheng Ma, Hui-Xia Zhou, Da-Chun Chen, Dong-Mei Wang, Xiang-Yang Zhang
Summary: The impaired glucose metabolism in drug-na & iuml;ve schizophrenia patients is strongly associated with suicidal behavior, suggesting that glucose metabolism abnormalities may be potential biomarkers of suicide in schizophrenia patients. Regular monitoring of glucose metabolism variables is essential for suicide prevention.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Katie M. Lavigne, Jiaxuan Deng, Delphine Raucher-Chene, Adele Hotte-Meunier, Chloe Voyer, Lisa Sarraf, Martin Lepage, Genevieve Sauve
Summary: Psychiatric disorders are characterized by cognitive deficits and cognitive biases, which are associated with specific symptoms. While cognitive biases are present across diagnoses, their severity varies.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Yong-Yu Yin, Jiao-Zhao Yan, Shi-Xin Lai, Qian-Qian Wei, Si-Rui Sun, Li-Ming Zhang, Yun-Feng Li
Summary: This study found that gamma oscillations are closely associated with depression and may serve as predictive biomarkers of depression. Chronic restraint stress and lipopolysaccharide induced significant depression-like behaviors in mice and reduced gamma oscillations in the medial prefrontal cortex. Administration of ketamine, scopolamine, or fluoxetine increased gamma oscillations and exhibited rapid-acting antidepressant effects.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Veronica Begni, Moira Marizzoni, Kerstin Camile Creutzberg, Diana Morena Silipo, Mariusz Papp, Annamaria Cattaneo, Marco Andrea Riva
Summary: Exposure to stressful experiences is a significant risk factor for mental disorders, and pharmacological interventions targeting stress-induced alterations can help restore brain function. Lurasidone, an antipsychotic drug, has been shown to normalize the impairments caused by stress exposure and could be a valuable treatment for stress-induced mental illnesses. However, the mechanisms underlying the therapeutic effects of lurasidone are not well understood. This study found that chronic lurasidone treatment counteracted some of the transcriptional changes induced by chronic mild stress exposure, providing new insights into the potential therapeutic effects of lurasidone.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Esther E. Palacios-Barrios, Kunal Patel, Jamie L. Hanson
Summary: This review examines the association between early life interpersonal stress (ELIS) and depression, as well as the underlying mechanisms. The research shows that ELIS affects how youth respond to social rewards, and similar impairments in social reward processing are observed in youth with depression. The authors propose a preliminary model that suggests neurobehavioral disruptions in social reward processing as a mediating factor in the connection between ELIS and depression.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Rui Li, Jiaming Tang, Yizhuo Wang, Ying Wang, Hua Yang, Hongen Wei
Summary: Restricted and repetitive behaviors (RRBs) are characteristic features of neuropsychiatric disorders. This study focused on repetitive self-grooming behavior and investigated the involvement of the Pax2 gene in its control. Through the use of Pax2 neuron-specific deletion mice, the study found that the deletion of Pax2 gene affects the expression of the Arc gene in the prefrontal cortex, leading to impaired synaptic plasticity and excitatory/inhibitory imbalance, thereby contributing to the occurrence of repetitive self-grooming behavior.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Sara Derosa, Paulina Misztak, Jessica Mingardi, Giulia Mazzini, Heidi Kaastrup Muller, Laura Musazzi
Summary: This study investigated the involvement of neurotrophic signaling pathways in stress vulnerability/resilience and fast antidepressant response/non-response to ketamine in a rat model of depression. The findings showed that stress and ketamine induced specific changes in these pathways in different brain areas and subcellular fractions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Georgia F. Caruana, Sean P. Carruthers, Michael Berk, Susan L. Rossell, Tamsyn E. Van Rheenen
Summary: Cognitive impairment is related to both white matter macrostructure and microstructure in bipolar disorder patients. However, there is inconsistency in the results of the studies examining this relationship. Some studies have found an association between higher fractional anisotropy in white matter and better complex attention skills and executive functioning in bipolar disorder patients, while others have found no associations. Further research with increased statistical power and standardized methods is needed.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Alberto Galimberti, Martin Tik, Giovanni Pellegrino, Anna-Lisa Schuler
Summary: This study provides a systematic review and meta-analysis on the effectiveness of repetitive transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) for post-traumatic brain injury (TBI) symptoms. The results show that non-invasive brain stimulation techniques have a small overall effect on TBI sequelae, with significant effects observed for anxiety and headache. However, larger randomized controlled trials with longer follow-ups, optimized stimulation parameters, and standardized methodology are needed to establish the efficacy of these techniques in addressing TBI sequelae.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Amanda J. Sales, Pedro H. Gobira, Joa F. C. Pedrazzi, Joao R. Silveia, Elaine Del Bel, Felipe V. Gomes, Francisco S. Guimaraes
Summary: The study found that doxycycline can inhibit metalloproteinase in the brain and attenuate the rewarding effects and locomotor sensitization of drug abuse. This suggests that doxycycline could be repurposed for the treatment of substance use disorders.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Alejandro Borrego-Ruiz, Juan J. Borrego
Summary: There is substantial evidence that the development of the nervous system is related to the composition and functions of the gut microbiome. The communication between the central nervous system (CNS) and the gut microbiota is bidirectional, with various routes such as immune, endocrine, and neural circuits. Dysbiosis of the gut microbiota has been associated with neuropsychiatric diseases and psychological disorders. Fecal microbiota transplantation (FMT) therapy has shown a causal-effect relationship between the gut microbiota and behavioral features. Interventions based on prebiotics, probiotics, or synbiotics have demonstrated their influence on neurological disorders through the synthesis of neuroactive compounds and regulation of inflammatory and endocrine processes. Further research is needed to explore the impact of gut microbiota dysbiosis on psychiatric and psychological disorders and the potential therapeutic role of microbiota-based interventions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zhinan Li, Zhuang Kang, Xiaowei Xia, Leijun Li, Junyan Wu, Jiamin Dai, Tong Liu, Cai Chen, Yong Qiu, Ming Chen, Yanxi Liu, Ziyi Zhang, Zili Han, Zhengjia Dai, Qinling Wei
Summary: This study found that patients with schizophrenia showed lower levels of resilience and cognitive functions compared to healthy controls, as well as abnormal global properties and nodal metrics in brain networks. Furthermore, characteristic path length might moderate the relationship between resilience and working memory in these patients.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
David H. Adamowicz, Tsung-Chin Wu, Rebecca Daly, Michael R. Irwin, Dilip Jeste, Xin M. Tu, Lisa T. Eyler, Ellen E. Lee
Summary: This study aimed to explore the relationship between executive functioning and inflammatory biomarkers in people with schizophrenia. The results showed that systemic inflammation did not predict long-term declines in executive functioning. This suggests the need for further research to better understand the relationship and mechanisms between inflammation and cognition in schizophrenia.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Nina Walter, Julian Wenzel, Shalaila S. Haas, Letizia Squarcina, Carolina Bonivento, Anne Ruef, Dominic Dwyer, Theresa Lichtenstein, Oeznur Bastruek, Alexandra Stainton, Linda A. Antonucci, Paolo Brambilla, Stephen J. Wood, Rachel Upthegrove, Stefan Borgwardt, Rebekka Lencer, Eva Meisenzahl, Raimo K. R. Salokangas, Christos Pantelis, Alessandro Bertolino, Nikolaos Koutsouleris, Joseph Kambeitz, Lana Kambeitz-Ilankovic
Summary: Clinical and neuroimaging data can be used to predict the potential of cognitive training to improve social functioning in recent onset psychosis patients. The use of multivariate pattern analysis and support vector machine classifier allows for the prediction of social functioning improvement based on baseline cognitive data. The findings suggest that cognitive data can provide a robust individual estimate of future social functioning for patients with recent onset psychosis.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)