Article
Clinical Neurology
Daphne Voineskos, Daniel M. Blumberger, Nigel C. Rogasch, Reza Zomorrodi, Faranak Farzan, George Foussias, Tarek K. Rajji, Zafiris J. Daskalakis
Summary: The study found that repetitive transcranial magnetic stimulation (rTMS) can reduce neurophysiological markers of inhibition and excitability in treating treatment resistant depression (TRD), revealing potential important neurophysiological mechanisms of action for rTMS.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Psychology, Clinical
Jerome Brunelin, Filipe Galvao, Marine Mondino
Summary: This retrospective study investigated the therapeutic effect of repetitive transcranial magnetic stimulation (rTMS) in patients with treatment-resistant auditory verbal hallucinations. The results showed that low frequency rTMS could significantly decrease these symptoms.
INTERNATIONAL JOURNAL OF CLINICAL AND HEALTH PSYCHOLOGY
(2023)
Article
Psychiatry
Stephanie A. Chu, Reza Tadayonnejad, Juliana Corlier, Andrew C. Wilson, Cole Citrenbaum, Andrew F. Leuchter
Summary: Rumination is a common symptom of Major Depressive Disorder (MDD) and is associated with poorer treatment outcomes. This study aimed to investigate the impact of rumination on repetitive Transcranial Magnetic Stimulation (rTMS) treatment of MDD. The data from 155 patients with treatment-resistant MDD were analyzed, and it was found that rTMS treatment improved both depression and rumination symptoms, although improvement in rumination was not fully explained by reduction in depressive symptoms. The findings suggest that rumination should be specifically targeted with different rTMS treatment parameters.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Medicine, General & Internal
Piotr Plichta, Ernest Tyburski, Maksymilian Bielecki, Monika Mak, Jolanta Kucharska-Mazur, Piotr Podwalski, Katarzyna Rek-Owodzin, Katarzyna Waszczuk, Leszek Sagan, Anna Michalczyk, Blazej Misiak, Jerzy Samochowiec
Summary: This study compared cognitive domains between deficit schizophrenia (DS) and non-deficit schizophrenia (NDS) patients and healthy controls (HC), analyzing relationships between psychopathological dimensions and cognitive domains. The results showed that clinical groups performed poorer than HC groups in various cognitive domains, and DS patients scored poorer than NDS patients in all cognitive domains except for reasoning and problem solving. Psychopathological symptoms were only related to cognitive functions in NDS patients. The findings suggest that the MCCB battery is sensitive to detecting cognitive dysfunctions in both deficit and non-deficit schizophrenia.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Psychology, Clinical
Edward Millgate, Olga Hide, Stephen M. Lawrie, Robin M. Murray, James H. MacCabe, Eugenia Kravariti
Summary: This study systematically reviewed and meta-analyzed the neuropsychological differences between patients with treatment-resistant schizophrenia (TRS) and treatment-responsive controls. The results showed small-to-moderate effect sizes in all domains, with the largest effect size observed in verbal memory and learning.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Psychiatry
Gin S. Malhi, Erica Bell
Summary: The efficacy of repetitive transcranial magnetic stimulation (rTMS) in the treatment of depression is disputed due to insufficient high-quality studies and an undefined clinical profile. Another reason for questioning its efficacy is the belief that the clinical response to rTMS is mainly due to non-specific and placebo effects. Further research is needed to determine the true effectiveness of rTMS in treating depression.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2021)
Article
Psychiatry
Yaoyao Sun, Yuyanan Zhang, Zhe Lu, Hao Yan, Liangkun Guo, Yundan Liao, Tianlan Lu, Lifang Wang, Jun Li, Wenqiang Li, Yongfeng Yang, Hao Yu, Luxian Lv, Dai Zhang, Wenjian Bi, Weihua Yue
Summary: This study aimed to evaluate the changes in schizophrenia symptoms under different antipsychotic treatments by analyzing data from a multicenter clinical trial. The results identified central and bridge symptoms in the networks that changed over time. Acute antipsychotic treatment altered the network structure, and responsive patients showed lower global strength after treatment compared to resistant patients. The central and bridge symptoms remained prominent across different antipsychotics.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Psychiatry
Lu Wang, Qianqian Li, Yang Wu, Gong-jun Ji, Xingqi Wu, Guixian Xiao, Bensheng Qiu, Panpan Hu, Xingui Chen, Kongliang He, Kai Wang
Summary: This study aimed to improve visual-spatial working memory (vsWM) in treatment-resistant schizophrenia (TRS) through intermittent theta burst stimulation (iTBS) targeting the left dorsolateral prefrontal cortex. The results showed significant improvement in vsWM accuracy after 2 weeks of iTBS treatment, with a positive correlation between improvements and activity in the right visual cortex.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Medicine, General & Internal
Edward Millgate, Eugenia Kravariti, Alice Egerton, Oliver D. Howes, Robin M. Murray, Laura Kassoumeri, Jacek Donocik, Shon Lewis, Richard Drake, Stephen Lawrie, Anna Murphy, Tracy Collier, Jane Lees, Charlotte Stockton-Powdrell, James Walters, Bill Deakin, James MacCabe
Summary: This study found no significant differences in cognitive performance between antipsychotic non-responders and responders, suggesting a lack of clinical distinction between the two groups in the sample. Future research may benefit from using machine learning methods with longitudinal data to identify responder subtypes and explore how cognitive factors interact in schizophrenia.
Review
Psychiatry
Jyothsna Chinnapura Seetharam, Rituparna Maiti, Archana Mishra, Biswa Ranjan Mishra
Summary: Add-on sodium benzoate can significantly improve positive symptoms of schizophrenia but has no significant favourable effect on negative symptoms, general psychopathology, and total PANSS score. Extrapyramidal symptoms are significantly higher in the sodium benzoate group compared to the control group. Further studies are needed to evaluate long-term efficacy, safety, and use in specific subgroups of patients.
ASIAN JOURNAL OF PSYCHIATRY
(2022)
Article
Neuroimaging
Takashi Itahashi, Yoshihiro Noda, Yusuke Iwata, Ryosuke Tarumi, Sakiko Tsugawa, Eric Plitman, Shiori Honda, Fernando Caravaggio, Julia Kim, Karin Matsushita, Philip Gerretsen, Hiroyuki Uchida, Gary Remington, Masaru Mimura, Yuta Y. Aoki, Ariel Graff-Guerrero, Shinichiro Nakajima
Summary: Patients with treatment-resistant schizophrenia (TRS) and non-treatment-resistant schizophrenia (NTRS) can be differentiated from healthy controls based on cortical thickness analysis. The left planum temporale, left anterior insula/inferior frontal gyrus contributed to both NTRS and TRS classifiers. TRS presents unique cortical thickness features.
NEUROIMAGE-CLINICAL
(2021)
Article
Neurosciences
Preeti Chauhan, Shobit Garg, Sai Krishna Tikka, Sumit Khattri
Summary: The study focused on the effects of intermittent theta burst stimulation (iTBS) targeting midline cerebellum in treatment-resistant schizophrenia (TRS) patients, but did not find significant improvements in psychopathology, cognitive functions, and global improvement compared to sham stimulation. However, it was concluded that the iTBS method is safe and well tolerated, indicating the need for trials with better localization techniques, larger sample sizes, longer durations, and improved dosing protocols.
Article
Psychiatry
Simon S. Y. Lui, Stanley S. L. Yip, Ya Wang, Karen S. Y. Hung, Karen K. Y. Ho, Kirby C. M. Tsang, Hera K. H. Yeung, Eric F. C. Cheung, Raymond C. K. Chan
Summary: The study investigated the trajectory of neurological soft signs (NSS) in schizophrenia patients and found that NSS worsened over time in treatment-resistant patients. This suggests that NSS may be useful in identifying treatment resistance in first-episode schizophrenia patients, reflecting the development of underlying neuropathology.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Psychiatry
Chen Lin, Ke Chen, Jianjin Yu, Wei Feng, Weihong Fu, Fude Yang, Xiangyang Zhang, Dachun Chen
Summary: This study found that first-episode drug-naive schizophrenia patients had higher TNF-alpha levels before treatment, which were positively correlated with negative symptoms of the disease. In contrast, TNF-alpha levels in chronic patients were negatively correlated with general psychopathology subscales and total scores.
Article
Neurosciences
Mahmoud S. Abdallah, Esraa M. Mosalam, Ahmed Hassan, Ahmed N. Ramadan, Hend Omara-Reda, Abdel-Aziz A. Zidan, Waad A. Samman, Eman El-Berri
Summary: This study aimed to investigate the effectiveness and safety of pentoxifylline as an adjuvant to risperidone in mitigating the negative symptoms in patients with chronic schizophrenia. The results showed that pentoxifylline adjunctive therapy had a significant effect in reducing PANSS-negative subscale scores, PANSS general psychopathology subscale scores, and PANSS total scores. Furthermore, it also led to an increase in cAMP serum level and a decrease in TNF-alpha and IL-6 serum levels.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Clinical Neurology
Yong-Ku Kim, Meysam Amidfar, Eunsoo Won
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2019)
Review
Clinical Neurology
Kyu-Man Han, Domenico De Berardis, Michele Fornaro, Yong-Ku Kim
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2019)
Review
Clinical Neurology
Yong-Ku Kim, Byung-Joo Ham, Kyu-Man Han
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2019)
Editorial Material
Clinical Neurology
Kyu-Man Han, Yong-Ku Kim
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2019)
Review
Psychiatry
Seon-Cheol Park, Yong-Ku Kim
PSYCHIATRY INVESTIGATION
(2019)
Review
Pharmacology & Pharmacy
Carmine Tomasetti, Chiara Montemitro, Annastasia L. C. Fiengo, Cristina Santone, Laura Orsolini, Alessandro Valchera, Alessandro Carano, Maurizio Pompili, Gianluca Serafini, Giampaolo Perna, Federica Vellante, Giovanni Martinotti, Massimo D. Giannantonio, Yong-Ku Kim, Marco D. Nicola, Antonello Bellomo, Antonio Ventriglio, Michele Fornaro, Domenico D. Berardis
CURRENT PHARMACEUTICAL DESIGN
(2019)
Article
Psychiatry
Ana C. Andreazza, Isabelle Laksono, Brisa S. Fernandes, Catherine Toben, Piotr Lewczuk, Peter Riederer, Sidney H. Kennedy, Dimitrios Kapogiannis, Florence Thibaut, Manfred Gerlach, Carla Gallo, Yong-Ku Kim, Edna Grunblatt, Lakshmi Yatham, Michael Berk, Bernhard T. Baune
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2019)
Article
Clinical Neurology
Jeong-Kyung Ko, Kyu-Man Han, Cheolmin Shin, Seung-Hoon Lee, Changsu Han, Yong-Ku Kim, Ho-Kyong Yoon, Young-Hoon Ko
JOURNAL OF AFFECTIVE DISORDERS
(2019)
Editorial Material
Neurosciences
Youn Jung Lee, Yong-Ku Kim
CURRENT NEUROPHARMACOLOGY
(2020)
Article
Pharmacology & Pharmacy
Cheolmin Shin, Yong-Ku Kim
CURRENT OPINION IN PHARMACOLOGY
(2019)
Article
Clinical Neurology
Cheolmin Shin, Moon Ho Park, Seung-Hoon Lee, Young-Hoon Ko, Yong-Ku Kim, Kyu-Man Han, Hyun-Ghang Jeong, Changsu Han
JOURNAL OF AFFECTIVE DISORDERS
(2019)
Review
Biochemistry & Molecular Biology
Eunsoo Won, Yong-Ku Kim
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Biochemistry & Molecular Biology
Junhyung Kim, Yong-Ku Kim
Summary: Alzheimer's disease is the most common type of dementia, with depression being a risk factor for its development. While depression patients often recover without residual symptoms, late-life depression patients may show residual cognitive impairment. Understanding how risk factors impact the course of Alzheimer's disease is crucial for its management.
Review
Biochemistry & Molecular Biology
Lorenza Lucidi, Mauro Pettorruso, Federica Vellante, Francesco Di Carlo, Franca Ceci, Maria Chiara Santovito, Ilenia Di Muzio, Michele Fornaro, Antonio Ventriglio, Carmine Tomasetti, Alessandro Valchera, Alessandro Gentile, Yong-Ku Kim, Giovanni Martinotti, Silvia Fraticelli, Massimo Di Giannantonio, Domenico De Berardis
Summary: The gut microbiota plays a crucial role in maintaining homeostasis, growth, and digestive processes. It also influences the intercommunication system between the gut and the brain, potentially impacting the pathogenesis and clinical management of Bipolar Disorder. Current literature suggests a relationship between compositional alterations in the gut microbiota and BD, with potential benefits in treating BD symptoms through modifications in the microbiota composition. Further research is needed to explore the potential of correcting gut microbiota alterations as a novel strategy in BD management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Eunsoo Won, Kyoung-Sae Na, Yong-Ku Kim
Summary: Inflammatory conditions and disruptions in circadian rhythms, including alterations in the melatonin system, have been suggested as mechanisms underlying major depressive disorder. Melatonin, with its immunological and non-immunological actions, can suppress inflammation and influence neuroinflammation and neurotoxicity, leading to alterations in brain regions implicated in depression. Further research on the associations between melatonin, immune markers, and brain structure and function may help identify potential biomarkers for MDD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Nadia Deflorin, Ulrike Ehlert, Rita T. Amiel Castro
Summary: Changes in the gut microbiome of infants have been associated with maternal psychological symptoms during pregnancy. This study found that maternal prenatal depressive symptoms are associated with lower diversity of the infant's microbiome, while maternal saliva cortisol levels are linked to increased diversity and changes in specific bacterial groups. Further research is needed to understand the implications of these microbiota alterations for child health.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zheng Ma, Hui-Xia Zhou, Da-Chun Chen, Dong-Mei Wang, Xiang-Yang Zhang
Summary: The impaired glucose metabolism in drug-na & iuml;ve schizophrenia patients is strongly associated with suicidal behavior, suggesting that glucose metabolism abnormalities may be potential biomarkers of suicide in schizophrenia patients. Regular monitoring of glucose metabolism variables is essential for suicide prevention.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Katie M. Lavigne, Jiaxuan Deng, Delphine Raucher-Chene, Adele Hotte-Meunier, Chloe Voyer, Lisa Sarraf, Martin Lepage, Genevieve Sauve
Summary: Psychiatric disorders are characterized by cognitive deficits and cognitive biases, which are associated with specific symptoms. While cognitive biases are present across diagnoses, their severity varies.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Yong-Yu Yin, Jiao-Zhao Yan, Shi-Xin Lai, Qian-Qian Wei, Si-Rui Sun, Li-Ming Zhang, Yun-Feng Li
Summary: This study found that gamma oscillations are closely associated with depression and may serve as predictive biomarkers of depression. Chronic restraint stress and lipopolysaccharide induced significant depression-like behaviors in mice and reduced gamma oscillations in the medial prefrontal cortex. Administration of ketamine, scopolamine, or fluoxetine increased gamma oscillations and exhibited rapid-acting antidepressant effects.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Veronica Begni, Moira Marizzoni, Kerstin Camile Creutzberg, Diana Morena Silipo, Mariusz Papp, Annamaria Cattaneo, Marco Andrea Riva
Summary: Exposure to stressful experiences is a significant risk factor for mental disorders, and pharmacological interventions targeting stress-induced alterations can help restore brain function. Lurasidone, an antipsychotic drug, has been shown to normalize the impairments caused by stress exposure and could be a valuable treatment for stress-induced mental illnesses. However, the mechanisms underlying the therapeutic effects of lurasidone are not well understood. This study found that chronic lurasidone treatment counteracted some of the transcriptional changes induced by chronic mild stress exposure, providing new insights into the potential therapeutic effects of lurasidone.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Esther E. Palacios-Barrios, Kunal Patel, Jamie L. Hanson
Summary: This review examines the association between early life interpersonal stress (ELIS) and depression, as well as the underlying mechanisms. The research shows that ELIS affects how youth respond to social rewards, and similar impairments in social reward processing are observed in youth with depression. The authors propose a preliminary model that suggests neurobehavioral disruptions in social reward processing as a mediating factor in the connection between ELIS and depression.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Rui Li, Jiaming Tang, Yizhuo Wang, Ying Wang, Hua Yang, Hongen Wei
Summary: Restricted and repetitive behaviors (RRBs) are characteristic features of neuropsychiatric disorders. This study focused on repetitive self-grooming behavior and investigated the involvement of the Pax2 gene in its control. Through the use of Pax2 neuron-specific deletion mice, the study found that the deletion of Pax2 gene affects the expression of the Arc gene in the prefrontal cortex, leading to impaired synaptic plasticity and excitatory/inhibitory imbalance, thereby contributing to the occurrence of repetitive self-grooming behavior.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Sara Derosa, Paulina Misztak, Jessica Mingardi, Giulia Mazzini, Heidi Kaastrup Muller, Laura Musazzi
Summary: This study investigated the involvement of neurotrophic signaling pathways in stress vulnerability/resilience and fast antidepressant response/non-response to ketamine in a rat model of depression. The findings showed that stress and ketamine induced specific changes in these pathways in different brain areas and subcellular fractions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Georgia F. Caruana, Sean P. Carruthers, Michael Berk, Susan L. Rossell, Tamsyn E. Van Rheenen
Summary: Cognitive impairment is related to both white matter macrostructure and microstructure in bipolar disorder patients. However, there is inconsistency in the results of the studies examining this relationship. Some studies have found an association between higher fractional anisotropy in white matter and better complex attention skills and executive functioning in bipolar disorder patients, while others have found no associations. Further research with increased statistical power and standardized methods is needed.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Alberto Galimberti, Martin Tik, Giovanni Pellegrino, Anna-Lisa Schuler
Summary: This study provides a systematic review and meta-analysis on the effectiveness of repetitive transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) for post-traumatic brain injury (TBI) symptoms. The results show that non-invasive brain stimulation techniques have a small overall effect on TBI sequelae, with significant effects observed for anxiety and headache. However, larger randomized controlled trials with longer follow-ups, optimized stimulation parameters, and standardized methodology are needed to establish the efficacy of these techniques in addressing TBI sequelae.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Amanda J. Sales, Pedro H. Gobira, Joa F. C. Pedrazzi, Joao R. Silveia, Elaine Del Bel, Felipe V. Gomes, Francisco S. Guimaraes
Summary: The study found that doxycycline can inhibit metalloproteinase in the brain and attenuate the rewarding effects and locomotor sensitization of drug abuse. This suggests that doxycycline could be repurposed for the treatment of substance use disorders.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Alejandro Borrego-Ruiz, Juan J. Borrego
Summary: There is substantial evidence that the development of the nervous system is related to the composition and functions of the gut microbiome. The communication between the central nervous system (CNS) and the gut microbiota is bidirectional, with various routes such as immune, endocrine, and neural circuits. Dysbiosis of the gut microbiota has been associated with neuropsychiatric diseases and psychological disorders. Fecal microbiota transplantation (FMT) therapy has shown a causal-effect relationship between the gut microbiota and behavioral features. Interventions based on prebiotics, probiotics, or synbiotics have demonstrated their influence on neurological disorders through the synthesis of neuroactive compounds and regulation of inflammatory and endocrine processes. Further research is needed to explore the impact of gut microbiota dysbiosis on psychiatric and psychological disorders and the potential therapeutic role of microbiota-based interventions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zhinan Li, Zhuang Kang, Xiaowei Xia, Leijun Li, Junyan Wu, Jiamin Dai, Tong Liu, Cai Chen, Yong Qiu, Ming Chen, Yanxi Liu, Ziyi Zhang, Zili Han, Zhengjia Dai, Qinling Wei
Summary: This study found that patients with schizophrenia showed lower levels of resilience and cognitive functions compared to healthy controls, as well as abnormal global properties and nodal metrics in brain networks. Furthermore, characteristic path length might moderate the relationship between resilience and working memory in these patients.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
David H. Adamowicz, Tsung-Chin Wu, Rebecca Daly, Michael R. Irwin, Dilip Jeste, Xin M. Tu, Lisa T. Eyler, Ellen E. Lee
Summary: This study aimed to explore the relationship between executive functioning and inflammatory biomarkers in people with schizophrenia. The results showed that systemic inflammation did not predict long-term declines in executive functioning. This suggests the need for further research to better understand the relationship and mechanisms between inflammation and cognition in schizophrenia.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Nina Walter, Julian Wenzel, Shalaila S. Haas, Letizia Squarcina, Carolina Bonivento, Anne Ruef, Dominic Dwyer, Theresa Lichtenstein, Oeznur Bastruek, Alexandra Stainton, Linda A. Antonucci, Paolo Brambilla, Stephen J. Wood, Rachel Upthegrove, Stefan Borgwardt, Rebekka Lencer, Eva Meisenzahl, Raimo K. R. Salokangas, Christos Pantelis, Alessandro Bertolino, Nikolaos Koutsouleris, Joseph Kambeitz, Lana Kambeitz-Ilankovic
Summary: Clinical and neuroimaging data can be used to predict the potential of cognitive training to improve social functioning in recent onset psychosis patients. The use of multivariate pattern analysis and support vector machine classifier allows for the prediction of social functioning improvement based on baseline cognitive data. The findings suggest that cognitive data can provide a robust individual estimate of future social functioning for patients with recent onset psychosis.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)