Article
Endocrinology & Metabolism
Lijuan Quan, Yue Zhao, Jinping Yi, Xiao-Dong Shi, Yingjun Zhong, Lingling Liu
Summary: This study found that serum adiponectin levels are decreased in children with ASD compared to healthy children, and there is an inverse association between serum adiponectin levels and severity of symptoms in ASD.
METABOLIC BRAIN DISEASE
(2021)
Article
Endocrinology & Metabolism
Yaxin Guan, Fan Zuo, Juan Zhao, Xin Nian, Li Shi, Yushan Xu, Jingshan Huang, Tsutomu Kazumi, Bin Wu
Summary: This study aims to compare the differences in circulating adiponectin levels and their relationships to regional adiposity, insulin resistance, serum lipid, and inflammatory factors in young, healthy Japanese women with different physical activity statuses. The results suggest that regardless of insulin sensitivity and physical activity status, adiponectin is primarily associated with regional adiposity and HDL-C.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Mohsen Mazidi, Niloofar Shekoohi, Niki Katsiki, Michal Rakowski, Dimitri P. Mikhailidis, Maciej Banach
Summary: This study investigated the causal associations between inflammatory markers and telomere length using Mendelian randomization. The results suggest that both anti-inflammatory and pro-inflammatory markers tested did not have any significant causal effect on telomere length. The causal role of bilirubin on telomere length still requires further investigation.
ARCHIVES OF MEDICAL SCIENCE
(2021)
Article
Endocrinology & Metabolism
Kyoung Eun Joung, Sheryl L. Rifas-Shiman, Emily Oken, Christos S. Mantzoros
Summary: The study found a positive association between maternal prepregnancy BMI and the risk of ASD in children, and a negative association between higher levels of adiponectin during pregnancy and the risk of ASD in children.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Medicine, General & Internal
Sul-Hee Lee, Youin Bae, Young-Lip Park
Summary: This study found a negative correlation between serum adiponectin levels and disease severity and pruritus in AD patients. However, no significant effects were observed with biologic treatment for AD. Therefore, adiponectin may serve as a potential biomarker for severity assessment in AD.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biology
Amir Najafi, Iman Mohammadi, Masoud Sadeghi, Annette Beatrix Bruhl, Dena Sadeghi-Bahmani, Serge Brand
Summary: This study conducted a systematic review and meta-analysis to evaluate plasma/serum adiponectin levels in adult patients with obstructive sleep apnea syndrome (OSAS). The results showed significantly reduced levels of adiponectin in OSAS cases compared to controls, suggesting a potential role of adiponectin in the pathogenesis of OSAS.
Article
Pediatrics
Benjamin Gesundheit, Philip David Zisman, Leah Hochbaum, Yehudit Posen, Avraham Steinberg, Gerald Friedman, Hersh D. Ravkin, Eitan Rubin, Ouriel Faktor, Ronald Ellis
Summary: The aim of this study was to identify diagnostic biomarkers for autism spectrum disorder (ASD) that could distinguish between ASD and typically developing children. By analyzing blood samples from 102 children with ASD and 97 typically developing children, 12 biomarkers were identified that achieved an accuracy of 82% in diagnosing ASD with a threshold of 0.5. These biomarkers have the potential to serve as an objective assay for early and accurate diagnosis of ASD.
FRONTIERS IN PEDIATRICS
(2023)
Article
Environmental Sciences
Jiao Bi, Fei Wang, Yue Wei, Ying Zhang, Chengyong Jia, Jia He, Jinqiu Yao, Zefang Zhang, Zhaoyang Li, Peiwen Li, Meian He
Summary: This study found a positive association between serum bisphenol A (BPA) and incident overweight and obesity risk in a non-monotonic pattern in the Chinese population. Adiponectin may mediate the association.
Article
Endocrinology & Metabolism
Shiro Fukuda, Shunbun Kita, Kazuya Miyashita, Masahito Iioka, Jun Murai, Tadashi Nakamura, Hitoshi Nishizawa, Yuya Fujishima, Jun Morinaga, Yuichi Oike, Norikazu Maeda, Iichiro Shimomura
Summary: Three novel forms of soluble T-cad were identified in human serum. The importance of these forms as disease markers and/or biomarkers of adiponectin function, as well as the potential bioactivity of the respective molecules, require further investigation.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Health Care Sciences & Services
Giorgia Leodori, Chiara Pellicano, Valerio Basile, Amalia Colalillo, Luca Navarini, Antonietta Gigante, Francesca Gulli, Mariapaola Marino, Umberto Basile, Edoardo Rosato
Summary: This study aimed to evaluate the longitudinal association between basal serum adiponectin and skin thickness in systemic sclerosis (SSc) patients. The results showed a correlation between decreased serum adiponectin levels and increased skin thickness.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Han Na Jung, Chang Hee Jung
Summary: The global burden of obesity has increased due to its rapidly growing prevalence and related morbidity and mortality. Anti-inflammatory adipokines in adipose tissue play a crucial role in improving cardiometabolic complications, making them potential therapeutic targets for cardiovascular and metabolic disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Alexia Blandin, Jeremy Amosse, Josy Froger, Gregory Hilairet, Maeva Durcin, Lionel Fizanne, Valentine Ghesquiere, Xavier Prieur, Julien Chaigneau, Luisa Vergori, Cedric Dray, Jean-Philippe Pradere, Stephanie Blandin, Joelle Dupont, Pierre-Henri Ducluzeau, Severine Dubois, Jerome Boursier, Bertrand Cariou, Soazig Le Lay
Summary: Recent evidence has shown that adipose tissue-derived extracellular vesicles (EVs) carry an important part of the adipose tissue secretome. These EVs show a high secretion ability, which is further increased in cases of obesity. The study also found that oligomeric forms of adiponectin are enriched in small EVs, and these EVs act as stable conveyors of adiponectin in the blood circulation. Furthermore, the adoption of adiponectin-enriched EVs has been shown to prevent weight gain, improve insulin resistance and tissue inflammation in high-fat-diet-fed mice, with significant effects observed in adipose tissue and liver. Therefore, this study provides valuable information regarding the metabolic effects of adiponectin by highlighting EVs as delivery platforms for active adiponectin molecules.
Review
Endocrinology & Metabolism
Jiangna Wang, Shiwei Liu, Yuxiang Zhao, Syed Shah Zaman Haider Naqvi, Ruixue Duan
Summary: This meta-analysis explores the relationship between adipokines levels (leptin, adiponectin, and chemerin) and the incidence of senile osteoporosis. The findings indicate that older individuals with lower levels of leptin and higher levels of chemerin are more likely to have senile osteoporosis. Additionally, there is a significant positive correlation between levels of leptin and adiponectin and body mass index.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Chemistry, Analytical
Bahar Ince, Mustafa Kemal Sezginturk
Summary: This study developed a novel biosensor for detecting adiponectin levels, aiming to prevent and treat cardiovascular diseases, immune disorders, and joint disorders related to obesity. By using PET sheets covered with ITO as the working electrode and stabilizing a layer of anti-adiponectin using 3-GOPS, the immunosensor preparation was proven successful under optimal conditions. The designed biosensor showed a wide response range to adiponectin concentrations and was applied successfully to real human serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Medicinal
Sumin Lee, Duc-Vinh Pham, Pil-Hoon Park
Summary: The study demonstrates that in macrophages, globular adiponectin modulates cell survival and anti-inflammatory responses by activating the sestrin2 signaling pathway. The induction of sestrin2 is crucial for autophagy activation and enhanced cell viability by adiponectin.
ARCHIVES OF PHARMACAL RESEARCH
(2022)
Article
Pediatrics
Yuuka Ishikawa-Omori, Tomoko Nishimura, Atsuko Nakagawa, Akemi Okumura, Taeko Harada, Chikako Nakayasu, Toshiki Iwabuchi, Yuko Amma, Haruka Suzuki, Mohammad Shafiur Rahman, Ryuji Nakahara, Nagahide Takahashi, Yoko Nomura, Kenji J. Tsuchiya
Summary: This study aimed to investigate the impact of early temperament on children's language acquisition. The results showed that higher motor activation at 18 months was associated with lower language skills at 40 months, while higher perceptual sensitivity was associated with higher language skills.
Article
Multidisciplinary Sciences
Megumi Ueda, Kenji J. Tsuchiya, Chizuko Yaguchi, Naomi Furuta-Isomura, Yoshimasa Horikoshi, Masako Matsumoto, Misako Suzuki, Tomoaki Oda, Kenta Kawai, Toshiya Itoh, Madoka Matsuya, Megumi Narumi, Yukiko Kohmura-Kobayashi, Naoaki Tamura, Toshiyuki Uchida, Hiroaki Itoh
Summary: This study investigates the association between placental pathological findings and infantile neurodevelopment during the early 40 months of life. The results show that certain placental pathological findings are bidirectionally associated with infantile neurodevelopment.
SCIENTIFIC REPORTS
(2022)
Article
Psychiatry
Tomoko Nishimura, Takeo Kato, Akemi Okumura, Taeko Harada, Toshiki Iwabuchi, Md. Shafiur Rahman, Tomoya Hirota, Michio Takahashi, Masaki Adachi, Hitoshi Kuwabara, Shu Takagai, Yoko Nomura, Nagahide Takahashi, Atsushi Senju, Kenji J. Tsuchiya
Summary: This study investigated trajectory patterns and sex differences in adaptive behaviors in the general population. The results showed that there were differences between males and females in adaptive behaviors, with females scoring higher in the communication domain. In the daily living skills and socialization domains, males and females in the higher adaptive classes had similar trajectories, while in the lower adaptive behavior classes, females scored higher than males. Furthermore, different trajectories were found between females and males, suggesting the need for sex-specific adjustments when standardizing scores for better early detection of skill impairment.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychiatry
Toshiki Iwabuchi, Nagahide Takahashi, Tomoko Nishimura, Md Shafiur Rahman, Taeko Harada, Akemi Okumura, Hitoshi Kuwabara, Shu Takagai, Yoko Nomura, Hideo Matsuzaki, Norio Ozaki, Kenji J. Tsuchiya
Summary: The study found an association between umbilical cord leptin levels and autistic symptoms in children, while maternal metabolic conditions did not directly influence the outcome. Prenatal pro-inflammatory environments affected by maternal metabolic conditions may contribute to the development of autistic symptoms in children.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Endocrinology & Metabolism
Naoko Umeda, Takaharu Hirai, Takayo Ohto-Nakanishi, Kenji J. J. Tsuchiya, Hideo Matsuzaki
Summary: The study investigated the association between umbilical cord serum EpFA and low-birth-weight infants. Results showed significant correlations between linoleate diol concentrations and low-birth-weight. The study suggests that CYP and sEH involved in PUFA metabolism may influence infant birth weight.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Clinical Neurology
Tomoko Nishimura, Nagahide Takahashi, Akemi Okumura, Taeko Harada, Toshiki Iwabuchi, Chikako Nakayasu, Mohammad Shafiur Rahman, Satoshi Uchiyama, Manabu Wakuta, Yoko Nomura, Nori Takei, Atsushi Senju, Kenji J. Tsuchiya
Summary: This study aimed to explore early manifestations of autism spectrum disorders (ASD) in females and investigate sex differences in cognitive and motor functions and adaptive behaviors. The results showed that males with high autistic traits experienced a temporary decline in expressive language around the age of 2 years, while females in the high-autistic-trait group showed a downward trend in the adaptive behavior communication domain after 3.5 years. These findings suggest that females and males with higher autistic traits may have different phenotypes in certain neurodevelopmental domains during infancy and early childhood.
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2023)
Article
Multidisciplinary Sciences
Taeko Harada, Toshiki Iwabuchi, Atsushi Senju, Chikako Nakayasu, Ryuji Nakahara, Kenji J. Tsuchiya, Yoko Hoshi
Summary: The study found that rule selection, including prior evaluation of a stimulus, activated broader areas of the prefrontal and premotor regions than response selection based on a given rule.
SCIENTIFIC REPORTS
(2022)
Article
Pediatrics
Mika Sugiyama, Kenji J. Tsuchiya, Yusuke Okubo, Mohammad Shafiur Rahman, Satoshi Uchiyama, Taeko Harada, Toshiki Iwabuchi, Akemi Okumura, Chikako Nakayasu, Yuko Amma, Haruka Suzuki, Nagahide Takahashi, Barbara Kinsella-Kammerer, Yoko Nomura, Hiroaki Itoh, Tomoko Nishimura
Summary: This study explores the association between higher screen time at age 2 and neurodevelopmental outcomes at age 4, and whether outdoor play can mitigate this association. The findings suggest that more screen time is related to poorer communication skills, but frequent outdoor play can alleviate this effect. Outdoor play also has a mediating effect on daily living skills.
Article
Multidisciplinary Sciences
Kiran Acharya, Md. Shafiur Rahman, Md. Rashedul Islam, Stuart Gilmour, Bibha Dhungel, Rajendra P. P. Parajuli, Tomoko Nishimura, Atsushi Senju, Kenji J. J. Tsuchiya
Summary: Failure to meet early childhood developmental milestones can lead to difficulties in schooling and social functioning. This study examined the inequality in the prevalence of suspected developmental delays (SDD) among Nepalese children, focusing on socioeconomic and maternal education-based factors. The findings showed that the national prevalence of SDD was 34.8%, with higher rates in rural areas and Karnali Province. Poverty and low maternal education were identified as significant risk factors for SDD.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Masatoshi Yamashita, Kuriko Kagitani-Shimono, Yoshiyuki Hirano, Sayo Hamatani, Shota Nishitani, Akiko Yao, Sawa Kurata, Hirotaka Kosaka, Minyoung Jung, Tokiko Yoshida, Tsuyoshi Sasaki, Koji Matsumoto, Yoko Kato, Mariko Nakanishi, Masaya Tachibana, Ikuko Mohri, Kenji J. Tsuchiya, Tetsuya Tsujikawa, Hidehiko Okazawa, Eiji Shimizu, Masako Taniike, Akemi Tomoda, Yoshifumi Mizuno
Summary: This study aims to correct site differences in MRI scanners and clarify brain structure and network characteristics of children with ADHD and ASD using large samples collected in a multi-centre collaboration. Additionally, the relationship between these characteristics and genetic, epigenetic, biochemical markers, and behavioral and psychological measures will be investigated.
Letter
Pediatrics
Kenji J. Tsuchiya, Yusuke Okubo, Tomoko Nishimura
Article
Public, Environmental & Occupational Health
Naho Morisaki, Taku Obara, Aurelie Piedvache, Sumitaka Kobayashi, Chihiro Miyashita, Tomoko Nishimura, Mami Ishikuro, Fumihiro Sata, Reiko Horikawa, Chisato Mori, Hirohito Metoki, Kenji J. Tsuchiya, Shinichi Kuriyama, Reiko Kishi
Summary: This study examines the association between maternal smoking and hypertensive disorders in pregnancy and preeclampsia, and finds that the protective effects of smoking observed among Europeans and North Americans do not hold for the Japanese population.
JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Psychiatry
Nagahide Takahashi, Kenji J. Tsuchiya, Akemi Okumura, Taeko Harada, Toshiki Iwabuchi, Md Shafiur Rahman, Hitoshi Kuwabara, Yoko Nomura, Tomoko Nishimura
Summary: Using longitudinal cohort data, it was found that longer screen time in infancy was associated with increased genetic risk of autism spectrum disorder (ASD) and that an increase in screen time over time was associated with increased genetic risk of attention-deficit/hyperactivity disorder (ADHD). These findings suggest that prolonged screen time may not be a causal factor for genetic risk of neurodevelopmental disorders (NDDs), but rather an early sign of NDDs.
PSYCHIATRY RESEARCH
(2023)
Article
Pediatrics
Ippei Takahashi, Taku Obara, Mami Ishikuro, Keiko Murakami, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Genki Shinoda, Tomoko Nishimura, Kenji J. Tsuchiya, Shinichi Kuriyama
Summary: This study found that excessive screen time in 1-year-old children is associated with developmental delays in communication and problem-solving skills at the ages of 2 and 4.
Article
Immunology
Nagahide Takahashi, Tomoko Nishimura, Taeko Harada, Akemi Okumura, Toshiki Iwabuchi, Md Shafiur Rahman, Hitoshi Kuwabara, Shu Takagai, Noriyoshi Usui, Manabu Makinodan, Hideo Matsuzaki, Norio Ozaki, Hiroaki Itoh, Yoko Nomura, Jeffrey H. Newcorn, Kenji J. Tsuchiya
Summary: In this study, the relationship between perinatal inflammation and genetic risk for ADHD was examined in children aged 8-9. The results showed that perinatal inflammation and ADHD polygenic risk score (ADHD-PRS) were associated with ADHD symptoms, and there was an interaction between the two factors. The impact of perinatal inflammation on ADHD symptoms was particularly pronounced in children with a higher genetic risk for ADHD.
BRAIN, BEHAVIOR, & IMMUNITY - HEALTH
(2023)
Article
Clinical Neurology
Nadia Deflorin, Ulrike Ehlert, Rita T. Amiel Castro
Summary: Changes in the gut microbiome of infants have been associated with maternal psychological symptoms during pregnancy. This study found that maternal prenatal depressive symptoms are associated with lower diversity of the infant's microbiome, while maternal saliva cortisol levels are linked to increased diversity and changes in specific bacterial groups. Further research is needed to understand the implications of these microbiota alterations for child health.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zheng Ma, Hui-Xia Zhou, Da-Chun Chen, Dong-Mei Wang, Xiang-Yang Zhang
Summary: The impaired glucose metabolism in drug-na & iuml;ve schizophrenia patients is strongly associated with suicidal behavior, suggesting that glucose metabolism abnormalities may be potential biomarkers of suicide in schizophrenia patients. Regular monitoring of glucose metabolism variables is essential for suicide prevention.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Katie M. Lavigne, Jiaxuan Deng, Delphine Raucher-Chene, Adele Hotte-Meunier, Chloe Voyer, Lisa Sarraf, Martin Lepage, Genevieve Sauve
Summary: Psychiatric disorders are characterized by cognitive deficits and cognitive biases, which are associated with specific symptoms. While cognitive biases are present across diagnoses, their severity varies.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Yong-Yu Yin, Jiao-Zhao Yan, Shi-Xin Lai, Qian-Qian Wei, Si-Rui Sun, Li-Ming Zhang, Yun-Feng Li
Summary: This study found that gamma oscillations are closely associated with depression and may serve as predictive biomarkers of depression. Chronic restraint stress and lipopolysaccharide induced significant depression-like behaviors in mice and reduced gamma oscillations in the medial prefrontal cortex. Administration of ketamine, scopolamine, or fluoxetine increased gamma oscillations and exhibited rapid-acting antidepressant effects.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Veronica Begni, Moira Marizzoni, Kerstin Camile Creutzberg, Diana Morena Silipo, Mariusz Papp, Annamaria Cattaneo, Marco Andrea Riva
Summary: Exposure to stressful experiences is a significant risk factor for mental disorders, and pharmacological interventions targeting stress-induced alterations can help restore brain function. Lurasidone, an antipsychotic drug, has been shown to normalize the impairments caused by stress exposure and could be a valuable treatment for stress-induced mental illnesses. However, the mechanisms underlying the therapeutic effects of lurasidone are not well understood. This study found that chronic lurasidone treatment counteracted some of the transcriptional changes induced by chronic mild stress exposure, providing new insights into the potential therapeutic effects of lurasidone.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Esther E. Palacios-Barrios, Kunal Patel, Jamie L. Hanson
Summary: This review examines the association between early life interpersonal stress (ELIS) and depression, as well as the underlying mechanisms. The research shows that ELIS affects how youth respond to social rewards, and similar impairments in social reward processing are observed in youth with depression. The authors propose a preliminary model that suggests neurobehavioral disruptions in social reward processing as a mediating factor in the connection between ELIS and depression.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Rui Li, Jiaming Tang, Yizhuo Wang, Ying Wang, Hua Yang, Hongen Wei
Summary: Restricted and repetitive behaviors (RRBs) are characteristic features of neuropsychiatric disorders. This study focused on repetitive self-grooming behavior and investigated the involvement of the Pax2 gene in its control. Through the use of Pax2 neuron-specific deletion mice, the study found that the deletion of Pax2 gene affects the expression of the Arc gene in the prefrontal cortex, leading to impaired synaptic plasticity and excitatory/inhibitory imbalance, thereby contributing to the occurrence of repetitive self-grooming behavior.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Sara Derosa, Paulina Misztak, Jessica Mingardi, Giulia Mazzini, Heidi Kaastrup Muller, Laura Musazzi
Summary: This study investigated the involvement of neurotrophic signaling pathways in stress vulnerability/resilience and fast antidepressant response/non-response to ketamine in a rat model of depression. The findings showed that stress and ketamine induced specific changes in these pathways in different brain areas and subcellular fractions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Georgia F. Caruana, Sean P. Carruthers, Michael Berk, Susan L. Rossell, Tamsyn E. Van Rheenen
Summary: Cognitive impairment is related to both white matter macrostructure and microstructure in bipolar disorder patients. However, there is inconsistency in the results of the studies examining this relationship. Some studies have found an association between higher fractional anisotropy in white matter and better complex attention skills and executive functioning in bipolar disorder patients, while others have found no associations. Further research with increased statistical power and standardized methods is needed.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Alberto Galimberti, Martin Tik, Giovanni Pellegrino, Anna-Lisa Schuler
Summary: This study provides a systematic review and meta-analysis on the effectiveness of repetitive transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) for post-traumatic brain injury (TBI) symptoms. The results show that non-invasive brain stimulation techniques have a small overall effect on TBI sequelae, with significant effects observed for anxiety and headache. However, larger randomized controlled trials with longer follow-ups, optimized stimulation parameters, and standardized methodology are needed to establish the efficacy of these techniques in addressing TBI sequelae.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Amanda J. Sales, Pedro H. Gobira, Joa F. C. Pedrazzi, Joao R. Silveia, Elaine Del Bel, Felipe V. Gomes, Francisco S. Guimaraes
Summary: The study found that doxycycline can inhibit metalloproteinase in the brain and attenuate the rewarding effects and locomotor sensitization of drug abuse. This suggests that doxycycline could be repurposed for the treatment of substance use disorders.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Alejandro Borrego-Ruiz, Juan J. Borrego
Summary: There is substantial evidence that the development of the nervous system is related to the composition and functions of the gut microbiome. The communication between the central nervous system (CNS) and the gut microbiota is bidirectional, with various routes such as immune, endocrine, and neural circuits. Dysbiosis of the gut microbiota has been associated with neuropsychiatric diseases and psychological disorders. Fecal microbiota transplantation (FMT) therapy has shown a causal-effect relationship between the gut microbiota and behavioral features. Interventions based on prebiotics, probiotics, or synbiotics have demonstrated their influence on neurological disorders through the synthesis of neuroactive compounds and regulation of inflammatory and endocrine processes. Further research is needed to explore the impact of gut microbiota dysbiosis on psychiatric and psychological disorders and the potential therapeutic role of microbiota-based interventions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zhinan Li, Zhuang Kang, Xiaowei Xia, Leijun Li, Junyan Wu, Jiamin Dai, Tong Liu, Cai Chen, Yong Qiu, Ming Chen, Yanxi Liu, Ziyi Zhang, Zili Han, Zhengjia Dai, Qinling Wei
Summary: This study found that patients with schizophrenia showed lower levels of resilience and cognitive functions compared to healthy controls, as well as abnormal global properties and nodal metrics in brain networks. Furthermore, characteristic path length might moderate the relationship between resilience and working memory in these patients.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
David H. Adamowicz, Tsung-Chin Wu, Rebecca Daly, Michael R. Irwin, Dilip Jeste, Xin M. Tu, Lisa T. Eyler, Ellen E. Lee
Summary: This study aimed to explore the relationship between executive functioning and inflammatory biomarkers in people with schizophrenia. The results showed that systemic inflammation did not predict long-term declines in executive functioning. This suggests the need for further research to better understand the relationship and mechanisms between inflammation and cognition in schizophrenia.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Nina Walter, Julian Wenzel, Shalaila S. Haas, Letizia Squarcina, Carolina Bonivento, Anne Ruef, Dominic Dwyer, Theresa Lichtenstein, Oeznur Bastruek, Alexandra Stainton, Linda A. Antonucci, Paolo Brambilla, Stephen J. Wood, Rachel Upthegrove, Stefan Borgwardt, Rebekka Lencer, Eva Meisenzahl, Raimo K. R. Salokangas, Christos Pantelis, Alessandro Bertolino, Nikolaos Koutsouleris, Joseph Kambeitz, Lana Kambeitz-Ilankovic
Summary: Clinical and neuroimaging data can be used to predict the potential of cognitive training to improve social functioning in recent onset psychosis patients. The use of multivariate pattern analysis and support vector machine classifier allows for the prediction of social functioning improvement based on baseline cognitive data. The findings suggest that cognitive data can provide a robust individual estimate of future social functioning for patients with recent onset psychosis.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
