Article
Immunology
Aldair Darlan Santos-de-Araujo, Renan Shida-Marinho, Andre Pontes-Silva
Summary: Ford et al. provide an overview of the psychiatric features associated with encephalitis mediated by autoantibodies and emphasize the importance of heart rate variability assessment in research.
AUTOIMMUNITY REVIEWS
(2022)
Article
Geriatrics & Gerontology
Juleno Honorato Brito dos Santos, R. S. Passos, Ivna Vidal Freire, Icaro J. S. Ribeiro, Alinne Alves Oliveira, Cezar Augusto Casotti, Shaea A. Alkahtani, Ana Angelica Leal Barbosa, Rafael Pereira
Summary: The study compared autonomous heart control in older adults with different ACE I/D gene polymorphisms, finding that those with the DD genotype had statistically greater sympathetic modulation but the Bayesian analysis indicated only an anecdotal effect. Sympathetic predominance is recognized as a worrying condition, since it may predispose to cardiovascular risk.
EXPERIMENTAL GERONTOLOGY
(2021)
Article
Multidisciplinary Sciences
Camila B. Gardim, Ana Catarine Veiga, Bruno A. Aguilar, Stella V. Philbois, Hugo C. D. Souza
Summary: The combination of pyridostigmine bromide and physical training in spontaneously hypertensive rats (SHRs) resulted in significant hemodynamic changes and increased vagal influence on cardiac autonomic balance.
SCIENTIFIC REPORTS
(2021)
Review
Sport Sciences
Agustin Jesus Estevez-Gonzalez, Margarita Perez-Ruiz, Fernando Cobo-Vicente, Marcio Vinicius Fagundes Donadio, Eneko Larumbe-Zabala
Summary: This study analyzed the effects of physical training programs on heart rate variability in children and adolescents with chronic diseases. The results showed that exercise can moderately increase time-domain variables and have a moderate effect on some frequency-domain variables.
INTERNATIONAL JOURNAL OF SPORTS MEDICINE
(2022)
Article
Clinical Neurology
Beatrice R. Benjamin, Mathias Valstad, Torbjorn Elvsashagen, Erik G. Jonsson, Torgeir Moberget, Adriano Winterton, Marit Haram, Margrethe C. Hoegh, Trine Lagerberg, Nils Eiel Steen, Lars Larsen, Ole A. Andreassen, Lars T. Westlye, Daniel S. Quintana
Summary: Heart rate variability was significantly decreased in patients with schizophrenia and bipolar disorder, and was associated with disease severity, potentially serving as a biomarker for disease severity in SZ and BD.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Medicine, General & Internal
Monika Zawadka-Kunikowska, Lukasz Rzepinski, Malgorzata Tafil-Klawe, Jacek J. Klawe, Pawel Zalewski, Joanna Slomko
Summary: This study aimed to evaluate the cardiac and autonomic function in patients with myasthenia gravis (MG) and investigate its relationship with disease outcomes. The results showed that MG patients exhibited altered systolic blood pressure variability, reduced heart rate response to deep breathing test, increased sympathovagal balance after tilt, lower baroreflex sensitivity, and decreased hemodynamic parameters compared to controls. Disease severity was found to be associated with diminished vagal tone and increased sympathetic response. Age and sex were the main predictors of hemodynamic parameters. These findings highlight the importance of evaluating autonomic balance in MG patients, especially those at risk for cardiovascular disease.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Neurosciences
Diego Candia-Rivera, Vincenzo Catrambone, Riccardo Barbieri, Gaetano Valenza
Summary: The study of functional Brain-Heart Interplay (BHI) from non-invasive recordings has made significant progress, providing a new computational framework for the assessment of the interplay between cortical and cardiac neural control.
Article
Public, Environmental & Occupational Health
Barbara Csala, Renata Szemerszky, Janos Kormendi, Ferenc Koteles, Szilvia Boros
Summary: This study explored the effects of 10-week beginner level hatha yoga training on healthy young women, finding that weekly training 10 times can improve balance, flexibility, and core muscle strength. However, longer and/or more intense interventions are needed to change BMI, body fat percentage, resting heart rate, and heart rate variability.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Biophysics
Mimma Nardelli, Luca Citi, Riccardo Barbieri, Gaetano Valenza
Summary: Assessment of heartbeat dynamics can be used for non-invasive monitoring of cardiovascular and autonomic states. However, the non-specificity of such measurements limits their applicability in naturalistic conditions. In this study, we investigate the irregularity and complexity of cardiac sympathetic and vagal activity series in different populations. Our results show significant differences between pathological/old subjects and young subjects, providing new insights into physiology and improving the specificity of heartbeat-derived biomarkers.
PHYSIOLOGICAL MEASUREMENT
(2023)
Article
Cardiac & Cardiovascular Systems
Mathias Alstrup, Zarmiga Karunanithi, Marie O. Maagaard, Steen H. Poulsen, Vibeke E. Hjortdal
Summary: The study aimed to investigate autonomic cardiac function in adults with corrected atrial septal defects (ASDs) through heart rate variability (HRV) analysis. The results showed that adults with either surgically closed or percutaneously closed ASDs had impaired HRV compared to healthy controls, with surgically closed patients showing more severe impairment.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Medicine, General & Internal
Lukasz Rzepinski, Monika Zawadka-Kunikowska, Julia L. Newton, Pawel Zalewski
Summary: This study found that myasthenia gravis patients exhibited parasympathetic deficiency and sympathetic predominance during head-up tilt test, whereas relapsing-remitting multiple sclerosis patients showed dysfunction in both sympathetic and parasympathetic systems. There were no significant differences in cardiac autonomic parameters between the two patient groups.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Psychiatry
Sarah M. Haigh, Tabatha P. Walford, Pat Brosseau
Summary: In this study, suppressed HRV was found in adults with schizophrenia compared to controls, while those with autism showed slightly reduced HRV but no significant difference. The autism group reported feeling lonelier than the schizophrenia group, and HRV did not correlate with loneliness in any of the groups. However, in the schizophrenia group, suppressed HRV was linked to poorer performance on neuropsychological tests. This suggests that autonomic functioning abnormalities are more pronounced in schizophrenia than in autism and may reflect unique health factors associated with schizophrenia.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Psychiatry
Sarah J. Fendrich, Lauren R. Koralnik, Mharisi Bonner, Deborah Goetz, Peter Joe, Jakleen Lee, Bridget Mueller, Jessica Robinson-Papp, Oded Gonen, Jose C. Clemente, Dolores Malaspina
Summary: The study developed a gut-brain-axis questionnaire (GBAQ) to collect standardized person-specific review of systems data for microbiome-gut-brain-axis studies. The results showed that psychotic symptoms were associated with reduced gut motility, while activation factor was related to medical comorbidity and systemic inflammatory conditions. Only behavioral differences were observed in group level comparisons.
PSYCHIATRY RESEARCH
(2022)
Article
Engineering, Biomedical
Diego Candia-Rivera, Vincenzo Catrambone, Riccardo Barbieri, Gaetano Valenza
Summary: A novel model inspired by IPFM is proposed to accurately predict HRV, outperforming the standard method. By utilizing sympathetic and vagal dynamics for driving, it provides accurate RR interval predictions during resting and postural changes.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2021)
Article
Clinical Neurology
Jens Spiesshoefer, Nora Hegerfeld, Malte Frank Gerdes, Soeren Klemm, Martha Gorbachevski, Robert Radke, Izabela Tuleta, Claudio Passino, Xiaoyi Jiang, Paolo Sciarrone, Winfried Randerath, Michael Dreher, Matthias Boentert, Alberto Giannoni
Summary: Central apneas have different effects on sympathovagal balance during sleep depending on underlying systolic heart failure, with neutral effects in heart failure patients and increased sympathetic drive in those with idiopathic central apneas.
SLEEP AND BREATHING
(2021)
Article
Genetics & Heredity
Youngah Cho, Seunghyong Ryu, Iksoo Huh, Eun Young Cho, Hyeji Oh, Yu-Sang Lee, Woo Kyeong Lee, Taesung Park, Jun Soo Kwon, Kyung Sue Hong
PSYCHIATRIC GENETICS
(2015)
Article
Psychiatry
Jang Won Cho, Eun-Young Jang, Hyung-Jin Woo, Yong Chon Park, Seok Hyun Kim, Kyung Sue Hong, Yu Sang Lee, Jun Soo Kwon
PSYCHIATRY INVESTIGATION
(2018)
Article
Genetics & Heredity
Kyung Sue Hong, Hong-Hee Won, Eun-Young Cho, Hyun Ok Jeun, Sang-Seon Cho, Yu-Sang Lee, Dong Yeon Park, Yong Lee Jang, Kyeong-Sook Choi, Dongsoo Lee, Min-Ji Kim, Seonwoo Kim, Wou Sang Han, Jong-Won Kim
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
(2009)
Article
Genetics & Heredity
Ji Hyun Baek, Ji Sun Kim, Seunghyong Ryu, Sohee Oh, Jihae Noh, Woo Kyeong Lee, Taesung Park, Yu-Sang Lee, Dongsoo Lee, Jun Soo Kwon, Kyung Sue Hong
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
(2012)
Letter
Medicine, General & Internal
Yu Sang Lee, Jae-Jin Kim, Jun Soo Kwon
Article
Clinical Neurology
Jae Seung Chang, Samuel Suk-Hyun Hwang, Sang Hoon Yi, Yeni Kim, Yu-Sang Lee, Yong Sik Kim, Hee-Yeon Jung
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2015)
Article
Psychiatry
Seunghyong Ryu, Hong-Hee Won, Sohee Oh, Jong-Won Kim, Taesung Park, Eun-Young Cho, Youngah Cho, Dong Yeon Park, Yu-Sang Lee, Jun Soo Kwon, Kyung Sue Hong
PSYCHIATRY RESEARCH
(2013)
Article
Psychiatry
Hee Jung Nam, Nara Kim, Taesung Park, Sohee Oh, Hyun Ok Jeon, Se Chang Yoon, Yu-Sang Lee, Woo Kyeong Lee, Kyooseob Ha, Ji-Hae Kim, Kyung Sue Hong
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2009)
Article
Psychiatry
Ji Hyun Baek, Bora Lee, So Yung Yang, Sehyun Jeon, Sung-Lee Jang, Yujin Choi, Se Chang Yoon, Yu Sang Lee, Kyung Sue Hong
ASIAN JOURNAL OF PSYCHIATRY
(2020)
Article
Clinical Neurology
Ji Hyun Baek, Kyooseob Ha, Yongkang Kim, So Yung Yang, Eun-Young Cho, Yujin Choi, Seunghyong Ryu, Yu-Sang Lee, Taesung Park, Kyung Sue Hong
Article
Psychiatry
Yu Sang Lee, Ii Ho Park, Seon-Cheol Park, Jae-Jin Kim, Jun Soo Kwon
ASIAN JOURNAL OF PSYCHIATRY
(2014)
Article
Genetics & Heredity
Yong Lee Jang, Jong Won Kim, Yu-Sang Lee, Dong Yeon Park, Eun-Young Cho, Hyun Ok Jeun, Dongsoo Lee, Kyung Sue Hong
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
(2007)
Article
Genetics & Heredity
Kyeong-Sook Choi, Hyun Ok Jeon, Yu-Sang Lee, Yong Lee Jang, Chang-Hyun Kim, Kyoo-Seob Ha, Myung-Hee Shin, Kyung Sue Hong
PSYCHIATRIC GENETICS
(2007)
Article
Genetics & Heredity
JW Kim, YS Lee, EY Cho, YL Jang, DY Park, KS Choi, HO Jeun, SH Cho, SY Jang, KS Hong
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
(2006)
Article
Clinical Neurology
Nadia Deflorin, Ulrike Ehlert, Rita T. Amiel Castro
Summary: Changes in the gut microbiome of infants have been associated with maternal psychological symptoms during pregnancy. This study found that maternal prenatal depressive symptoms are associated with lower diversity of the infant's microbiome, while maternal saliva cortisol levels are linked to increased diversity and changes in specific bacterial groups. Further research is needed to understand the implications of these microbiota alterations for child health.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zheng Ma, Hui-Xia Zhou, Da-Chun Chen, Dong-Mei Wang, Xiang-Yang Zhang
Summary: The impaired glucose metabolism in drug-na & iuml;ve schizophrenia patients is strongly associated with suicidal behavior, suggesting that glucose metabolism abnormalities may be potential biomarkers of suicide in schizophrenia patients. Regular monitoring of glucose metabolism variables is essential for suicide prevention.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Katie M. Lavigne, Jiaxuan Deng, Delphine Raucher-Chene, Adele Hotte-Meunier, Chloe Voyer, Lisa Sarraf, Martin Lepage, Genevieve Sauve
Summary: Psychiatric disorders are characterized by cognitive deficits and cognitive biases, which are associated with specific symptoms. While cognitive biases are present across diagnoses, their severity varies.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Yong-Yu Yin, Jiao-Zhao Yan, Shi-Xin Lai, Qian-Qian Wei, Si-Rui Sun, Li-Ming Zhang, Yun-Feng Li
Summary: This study found that gamma oscillations are closely associated with depression and may serve as predictive biomarkers of depression. Chronic restraint stress and lipopolysaccharide induced significant depression-like behaviors in mice and reduced gamma oscillations in the medial prefrontal cortex. Administration of ketamine, scopolamine, or fluoxetine increased gamma oscillations and exhibited rapid-acting antidepressant effects.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Veronica Begni, Moira Marizzoni, Kerstin Camile Creutzberg, Diana Morena Silipo, Mariusz Papp, Annamaria Cattaneo, Marco Andrea Riva
Summary: Exposure to stressful experiences is a significant risk factor for mental disorders, and pharmacological interventions targeting stress-induced alterations can help restore brain function. Lurasidone, an antipsychotic drug, has been shown to normalize the impairments caused by stress exposure and could be a valuable treatment for stress-induced mental illnesses. However, the mechanisms underlying the therapeutic effects of lurasidone are not well understood. This study found that chronic lurasidone treatment counteracted some of the transcriptional changes induced by chronic mild stress exposure, providing new insights into the potential therapeutic effects of lurasidone.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Esther E. Palacios-Barrios, Kunal Patel, Jamie L. Hanson
Summary: This review examines the association between early life interpersonal stress (ELIS) and depression, as well as the underlying mechanisms. The research shows that ELIS affects how youth respond to social rewards, and similar impairments in social reward processing are observed in youth with depression. The authors propose a preliminary model that suggests neurobehavioral disruptions in social reward processing as a mediating factor in the connection between ELIS and depression.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Rui Li, Jiaming Tang, Yizhuo Wang, Ying Wang, Hua Yang, Hongen Wei
Summary: Restricted and repetitive behaviors (RRBs) are characteristic features of neuropsychiatric disorders. This study focused on repetitive self-grooming behavior and investigated the involvement of the Pax2 gene in its control. Through the use of Pax2 neuron-specific deletion mice, the study found that the deletion of Pax2 gene affects the expression of the Arc gene in the prefrontal cortex, leading to impaired synaptic plasticity and excitatory/inhibitory imbalance, thereby contributing to the occurrence of repetitive self-grooming behavior.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Sara Derosa, Paulina Misztak, Jessica Mingardi, Giulia Mazzini, Heidi Kaastrup Muller, Laura Musazzi
Summary: This study investigated the involvement of neurotrophic signaling pathways in stress vulnerability/resilience and fast antidepressant response/non-response to ketamine in a rat model of depression. The findings showed that stress and ketamine induced specific changes in these pathways in different brain areas and subcellular fractions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Georgia F. Caruana, Sean P. Carruthers, Michael Berk, Susan L. Rossell, Tamsyn E. Van Rheenen
Summary: Cognitive impairment is related to both white matter macrostructure and microstructure in bipolar disorder patients. However, there is inconsistency in the results of the studies examining this relationship. Some studies have found an association between higher fractional anisotropy in white matter and better complex attention skills and executive functioning in bipolar disorder patients, while others have found no associations. Further research with increased statistical power and standardized methods is needed.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Alberto Galimberti, Martin Tik, Giovanni Pellegrino, Anna-Lisa Schuler
Summary: This study provides a systematic review and meta-analysis on the effectiveness of repetitive transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) for post-traumatic brain injury (TBI) symptoms. The results show that non-invasive brain stimulation techniques have a small overall effect on TBI sequelae, with significant effects observed for anxiety and headache. However, larger randomized controlled trials with longer follow-ups, optimized stimulation parameters, and standardized methodology are needed to establish the efficacy of these techniques in addressing TBI sequelae.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Amanda J. Sales, Pedro H. Gobira, Joa F. C. Pedrazzi, Joao R. Silveia, Elaine Del Bel, Felipe V. Gomes, Francisco S. Guimaraes
Summary: The study found that doxycycline can inhibit metalloproteinase in the brain and attenuate the rewarding effects and locomotor sensitization of drug abuse. This suggests that doxycycline could be repurposed for the treatment of substance use disorders.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Alejandro Borrego-Ruiz, Juan J. Borrego
Summary: There is substantial evidence that the development of the nervous system is related to the composition and functions of the gut microbiome. The communication between the central nervous system (CNS) and the gut microbiota is bidirectional, with various routes such as immune, endocrine, and neural circuits. Dysbiosis of the gut microbiota has been associated with neuropsychiatric diseases and psychological disorders. Fecal microbiota transplantation (FMT) therapy has shown a causal-effect relationship between the gut microbiota and behavioral features. Interventions based on prebiotics, probiotics, or synbiotics have demonstrated their influence on neurological disorders through the synthesis of neuroactive compounds and regulation of inflammatory and endocrine processes. Further research is needed to explore the impact of gut microbiota dysbiosis on psychiatric and psychological disorders and the potential therapeutic role of microbiota-based interventions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zhinan Li, Zhuang Kang, Xiaowei Xia, Leijun Li, Junyan Wu, Jiamin Dai, Tong Liu, Cai Chen, Yong Qiu, Ming Chen, Yanxi Liu, Ziyi Zhang, Zili Han, Zhengjia Dai, Qinling Wei
Summary: This study found that patients with schizophrenia showed lower levels of resilience and cognitive functions compared to healthy controls, as well as abnormal global properties and nodal metrics in brain networks. Furthermore, characteristic path length might moderate the relationship between resilience and working memory in these patients.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
David H. Adamowicz, Tsung-Chin Wu, Rebecca Daly, Michael R. Irwin, Dilip Jeste, Xin M. Tu, Lisa T. Eyler, Ellen E. Lee
Summary: This study aimed to explore the relationship between executive functioning and inflammatory biomarkers in people with schizophrenia. The results showed that systemic inflammation did not predict long-term declines in executive functioning. This suggests the need for further research to better understand the relationship and mechanisms between inflammation and cognition in schizophrenia.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Nina Walter, Julian Wenzel, Shalaila S. Haas, Letizia Squarcina, Carolina Bonivento, Anne Ruef, Dominic Dwyer, Theresa Lichtenstein, Oeznur Bastruek, Alexandra Stainton, Linda A. Antonucci, Paolo Brambilla, Stephen J. Wood, Rachel Upthegrove, Stefan Borgwardt, Rebekka Lencer, Eva Meisenzahl, Raimo K. R. Salokangas, Christos Pantelis, Alessandro Bertolino, Nikolaos Koutsouleris, Joseph Kambeitz, Lana Kambeitz-Ilankovic
Summary: Clinical and neuroimaging data can be used to predict the potential of cognitive training to improve social functioning in recent onset psychosis patients. The use of multivariate pattern analysis and support vector machine classifier allows for the prediction of social functioning improvement based on baseline cognitive data. The findings suggest that cognitive data can provide a robust individual estimate of future social functioning for patients with recent onset psychosis.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)