期刊
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
卷 34, 期 1, 页码 5-9出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pnpbp.2009.09.001
关键词
Ferulic acid; Memory; NCX 2057; Nitric oxide; Rat; Scopolamine
Nitric oxide (NO) is considered as an intracellular messenger in the brain. its involvement in learning and memory processes has been proposed. The present study was designed to investigate the effects of the NO-releasing derivative of ferulic acid NCX 2057 on rats' recognition memory. For this purpose the object recognition task was selected. Post-training treatment with NCX 2057 (10 mg/kg, i.p.) and with the reference compound, the NO donor molsidomine (4 mg/kg, i.p.), antagonized extinction of recognition memory in the normal rat. Conversely, animals treated with the parent compound ferulic acid (1.9, 6.2 and 18.7 mg/kg, i.p.) failed to do so. In addition, NCX 2057 (3 and 10 mg/kg, i.p) reversed the scopolamine (0.2 mg/kg, s.c.)-induced performance deficits in this recognition memory task. These results indicate that this novel NO donor may modulate different aspects of recognition memory and suggest that an interaction between the nitrergic and cholinergic system is relevant to cognition. (C) 2009 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据