Article
Chemistry, Medicinal
Gui-Long Tian, Chia-Ju Hsieh, Michelle Taylor, Aladdin A. Riad, Robert R. Luedtke, Robert H. Mach
Summary: The difference in the secondary binding site between D2R and D3R has been utilized to design compounds with selectivity for D3R. This study prepared a series of bitopic ligands based on Fallypride to improve the selectivity for D3R using various secondary binding fragments. The results showed that compounds with a small alkyl group containing a heteroatom exhibited improved D3R selectivity.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Boeun Lee, Michelle Taylor, Suzy A. Griffin, Tamara McInnis, Nathalie Sumien, Robert H. Mach, Robert R. Luedtke
Summary: The study showed that N-phenylpiperazine analogs can selectively bind to the human D3 dopamine receptor with significant D3 vs. D2 binding selectivity, potentially leading to the development of pharmacotherapeutics for levodopa-induced dyskinesia in patients with Parkinson's disease.
Article
Neurosciences
Yasuharu Yamamoto, Keisuke Takahata, Manabu Kubota, Harumasa Takano, Hiroyoshi Takeuchi, Yasuyuki Kimura, Yasunori Sano, Shin Kurose, Hiroshi Ito, Masaru Mimura, Makoto Higuchi
Summary: The study revealed a significant positive correlation between DA synthesis capacity and DA transporter availability in the putamen, but no significant correlation between DA synthesis capacity and D2 receptor availability in the striatum, indicating a relationship between DA synthesis capacity and reuptake, while the total abundance of D2 receptors may not directly participate in the regulatory mechanism.
Article
Neurosciences
Shin Kurose, Manabu Kubota, Keisuke Takahata, Yasuharu Yamamoto, Hironobu Fujiwara, Yasuyuki Kimura, Hiroshi Ito, Hiroyoshi Takeuchi, Masaru Mimura, Tetsuya Suhara, Makoto Higuchi
Summary: Studies on healthy humans have shown unique structural and functional corticostriatal associations involving D-2 receptors, which appear to be partially independent of the nigrostriatal pathway reflected by striatal DAT.
HUMAN BRAIN MAPPING
(2021)
Article
Neurosciences
Alice Servonnet, Florence Allain, Alice Gravel-Chouinard, Giovanni Hernandez, Casey Bourdeau Caporuscio, Mathilde Legrix, Daniel Levesque, Pierre-Paul Rompre, Anne-Noel Samaha
Summary: Antipsychotic treatment can induce dopamine supersensitivity in rats, leading to an enhanced response to D-amphetamine. After cessation of treatment, rats exhibit a supersensitive psychomotor response to the D2 agonist quinpirole, while D1 agonists and a dopamine reuptake blocker do not have the same effect.
Article
Chemistry, Medicinal
Milica Elek, Mariam Dubiel, Laura Mayer, Aleksandra Zivkovic, Thomas J. J. Mueller, Holger Stark
Summary: This article describes the use of BOPPY fluorophores for labeling dopamine D2 and D3 receptor ligands, obtaining compounds with fluorescent properties. This method is widely applicable.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Radomir Juza, Kristyna Stefkova, Wim Dehaen, Alena Randakova, Tomas Petrasek, Iveta Vojtechova, Tereza Kobrlova, Lenka Pulkrabkova, Lubica Muckova, Marko Mecava, Lukas Prchal, Eva Mezeiova, Kamil Musilek, Ondrej Soukup, Jan Korabecny
Summary: In this pilot study, a series of new 3,4-dihydroquinolin-2(1H)-one derivatives were synthesized and evaluated as potential dopamine receptor D-2 (D2R) modulators. Compound 5e showed the highest D2R affinity among the synthesized compounds, with low cytotoxicity and high blood-brain barrier penetration probability. However, molecular modelling simulation revealed a different binding mode of 5e compared to USC-D301, possibly explaining the reduced affinity of 5e towards D2R.
Review
Chemistry, Medicinal
Radomir Juza, Kamil Musilek, Eva Mezeiova, Ondrej Soukup, Jan Korabecny
Summary: Dopamine, a biologically active amine, acts by activating dopamine receptors in the nervous system. This review discusses the pharmacophore and critical moieties for high D2R affinity and summarizes the therapeutic potential of D2R modulators in schizophrenia, Parkinson's disease, depression, and anxiety. It also provides an overview of the dopaminergic pathway underlying these disorders.
MEDICINAL RESEARCH REVIEWS
(2023)
Article
Clinical Neurology
Bing Chen, Jiangang Xu, Simiao Chen, Tingting Mou, Ying Wang, Haojun Wang, Zhihan Zhang, Feifan Ren, Zheng Wang, Kangyu Jin, Jing Lu
Summary: This study found that dysregulation of the dopamine system contributes to depressive-like behaviors in rats, and the neurological functions regulated by hypocretin are severely affected in depression. It also found that suvorexant plays a role in alleviating depression by affecting the dopamine system.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Pharmacology & Pharmacy
Martina Di Bartolomeo, Tibor Stark, Oriana Maria Maurel, Fabio Arturo Iannotti, Martin Kuchar, Jana Ruda-Kucerova, Fabiana Piscitelli, Samuele Laudani, Vladimir Pekarik, Salvatore Salomone, Beatrice Arosio, Raphael Mechoulam, Mauro Maccarrone, Filippo Drago, Carsten T. Wotjak, Vincenzo Di Marzo, Matteo Vismara, Bernardo Dell'Osso, Claudio D'Addario, Vincenzo Micale
Summary: Perinatal exposure to THC affects brain development and increases the risk of psychopathology in adulthood, possibly due to dysregulation of endocannabinoid and dopaminergic systems. Cannabidiol treatment may normalize these abnormalities by modulating altered dopaminergic activity.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Psychiatry
Bela Kiss, Balazs Kramos, Istvan Laszlovszky
Summary: Dysfunctions of the dopaminergic system are believed to play a major role in schizophrenia symptoms. Antipsychotics target multiple receptors, including dopamine D-2 and D-3 receptors. While most antipsychotics have high/moderate in vitro affinity for D(2)Rs and D(3)Rs, only a few can significantly occupy D(3)Rs in vivo. The importance of endogenous extracellular dopamine levels and in vitro receptor affinity and selectivity for in vivo D(3)Rs occupancy by antipsychotics are discussed.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychology, Clinical
Kao Chin Chen, Yen Kuang Yang, Oliver D. Howes, I. Hui Lee, Tzung Lieh Yeh, Nan Tsing Chiu, Po See Chen, Anthony S. David, Elvira Bramon
Summary: Using [I-123] iodobenzamide (IBZM) SPECT, researchers found no significant difference in D-2/3 receptor availability between medication-naive patients with recent-onset schizophrenia and healthy controls. The study also showed a negative correlation between IBZM binding and age, with binding decreasing as age advances.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Peiyu Xu, Sijie Huang, Chunyou Mao, Brian E. Krumm, X. Edward Zhou, Yangxia Tan, Xi-Ping Huang, Yongfeng Liu, Dan-Dan Shen, Yi Jiang, Xuekui Yu, Hualiang Jiang, Karsten Melcher, Bryan L. Roth, Xi Cheng, Yan Zhang, H. Eric Xu
Summary: The study reported two cryo-EM structures of human D3R in complex with an inhibitory G protein and bound to D3R-selective agonists PD128907 and pramipexole, revealing distinct agonist binding modes and conformational signatures for ligand-induced receptor activation, providing insights for designing specific ligands to treat CNS diseases targeting the dopaminergic system.
Article
Chemistry, Multidisciplinary
Yonghao Mi, Enliang Wang, Zack Dube, Tian Wang, A. Y. Naumov, D. M. Villeneuve, P. B. Corkum, Andre Staudte
Summary: Using near-infrared, femtosecond laser pulses and coincidence momentum imaging, it is found that the dominant channel after photoionization of a deuterium molecular dimer (D-2-D-2) is the ejection of a deuterium atom within a few hundred femtoseconds, leading to the formation of D-3(+). This pathway of D-3(+) formation from ultracold D-2-D-2 gas may provide insights into the high abundance of H-3(+) in the interstellar medium.
Article
Biochemistry & Molecular Biology
Celine Legros, Anne Rojas, Clemence Dupre, Chantal Brasseur, Isabelle Riest-Fery, Olivier Muller, Jean-Claude Ortuno, Olivier Nosjean, Sophie-Penelope Guenin, Gilles Ferry, Jean A. Boutin
Summary: D3/D2 sub-specificity is a complex problem to solve due to the lack of easy structural biology of G-protein coupled receptors. This study used directed mutagenesis and basic binding experiments to explore a rational approach for the discovery of highly specific D3 ligands over D2 ligands. Stable expression of receptors in HEK cells was used to construct mutants and chimeras of D2 and D3 receptors, and their binding characteristics were analyzed using standard binding conditions. The study demonstrated the feasibility and potential of the approach.
Article
Psychology, Clinical
Cristina Varo, Silvia Amoretti, Giulio Sparacino, Esther Jimenez, Brisa Sole, Caterina del Mar Bonnin, Laura Montejo, Maria Serra, Carla Torrent, Estela Salagre, Antoni Benabarre, Pilar Salgado-Pineda, Irene Montoro Salvatierra, Pilar A. Saiz, Maria Paz Garcia-Portilla, Vanessa Sanchez-Gistau, Edith Pomarol-Clotet, Josep Antoni Ramos-Quiroga, Isabella Pacchiarotti, Clemente Garcia-Rizo, Juan Undurraga, Maria Reinares, Anabel Martinez-Aran, Eduard Vieta, Norma Verdolini
Summary: This study found that emotional intelligence is preserved in patients after a first episode mania, but deficits can be observed in patients with chronic bipolar disorder. The severity of the illness and neurocognitive decline may contribute to impairments in emotional intelligence.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Laura Ferraro, Diego Quattrone, Daniele La Barbera, Caterina La Cascia, Craig Morgan, James B. Kirkbride, Alastair G. Cardno, Pak Sham, Giada Tripoli, Lucia Sideli, Fabio Seminerio, Crocettarachele Sartorio, Andrei Szoke, Ilaria Tarricone, Miquel Bernardo, Victoria Rodriguez, Simona A. Stilo, Charlotte Gayer-Anderson, Lieuwe de Haan, Eva Velthorst, Hannah Jongsma, Rutten B. P. Bart, Alexander Richards, Celso Arango, Paulo Rossi Menezez, Antonio Lasalvia, Sarah Tosato, Andrea Tortelli, Cristina Marta Del Ben, Jean-Paul Selten, Peter B. Jones, Jim van Os, Marta Di Forti, Evangelos Vassos, Robin M. Murray
Summary: This study identified four distinct transdiagnostic clusters among first-episode psychosis patients based on their premorbid and cognitive abilities. The study also found differences in polygenic risk scores, patterns of cannabis use, and genetic predisposition to schizophrenia among these clusters.
SCHIZOPHRENIA BULLETIN
(2023)
Review
Biochemistry & Molecular Biology
Marco Solmi, Giovanni Croatto, Giada Piva, Stella Rosson, Paolo Fusar-Poli, Jose M. Rubio, Andre F. Carvalho, Eduard Vieta, Celso Arango, Nicole R. DeTore, Elizabeth S. Eberlin, Kim T. Mueser, Christoph U. Correll
Summary: Psychosocial interventions play an important role in schizophrenia and early psychosis. However, the literature on this topic is heterogeneous and contradictory. This umbrella review summarizes the findings from multiple meta-analyses comparing the effectiveness of different psychosocial interventions with standard treatment or other active interventions. The results suggest that early intervention services and cognitive behavioral therapy have significant effects on symptom reduction and functional improvement in early psychosis. For schizophrenia patients, cognitive behavioral therapy, psychoeducation, and any family interventions show positive effects on symptom reduction, relapse prevention, and functional improvement.
MOLECULAR PSYCHIATRY
(2023)
Article
Psychiatry
J. Fernandez-Fernandez, L. Jimenez-Trevino, E. Seijo-Zazo, F. Sanchez Lasheras, M. P. Garcia-Portilla, P. A. Saiz, J. Bobes
Summary: This research aims to study the influence of the COVID-19 pandemic on the incidence of hospital-treated suicide attempts in Oviedo, Spain in 2020. The results show that there was a similar trend in hospital-treated suicide rates compared to a non-COVID-19 year, but the number of adolescents hospitalized for suicide attempts increased during the lockdown period.
EUROPEAN PSYCHIATRY
(2023)
Article
Psychology, Clinical
T. Sanchez-Gutierrez, E. Rodriguez-Toscano, L. Roldan, L. Ferraro, M. Parellada, A. Calvo, G. Lopez, M. Rapado-Castro, D. La Barbera, C. La Cascia, G. Tripoli, M. Di Forti, R. M. Murray, D. Quattrone, C. Morgan, J. van Os, P. Garcia-Portilla, S. Al-Halabi, J. Bobes, L. de Haan, M. Bernardo, J. L. Santos, J. Sanjuan, M. Arrojo, A. Ferchiou, A. Szoke, B. P. Rutten, S. Stilo, G. D'Andrea, I. Tarricone, C. M. Diaz-Caneja, C. Arango
Summary: This study analyzed the relationship between tobacco use and first-episode psychosis, age at onset of psychosis, and specific diagnosis of psychosis. The findings showed that patients with first-episode psychosis were more likely to use tobacco and smoke heavily compared to controls. Tobacco use was associated with an earlier age at psychosis onset and a diagnosis of schizophrenia, but these associations were no longer significant after controlling for cannabis use.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Clinical
Giulia Trotta, Victoria Rodriguez, Diego Quattrone, Edoardo Spinazzola, Giada Tripoli, Charlotte Gayer-Anderson, Tom P. Freeman, Hannah E. Jongsma, Lucia Sideli, Monica Aas, Simona A. Stilo, Caterina La Cascia, Laura Ferraro, Daniele La Barbera, Antonio Lasalvia, Sarah Tosato, Ilaria Tarricone, Giuseppe D'Andrea, Andrea Tortelli, Franck Schuerhoff, Andrei Szoeke, Baptiste Pignon, Jean-Paul Selten, Eva Velthorst, Lieuwe de Haan, Pierre-Michel Llorca, Paulo Rossi Menezes, Cristina M. Del Ben, Jose Luis Santos, Manuel Arrojo, Julio Bobes, Julio Sanjuan, Miquel Bernardo, Celso Arango, James B. Kirkbride, Peter B. Jones, Alexander Richards, Bart P. Rutten, Jim Van Os, Isabelle Austin-Zimmerman, Zhikun Li, Craig Morgan, Pak C. Sham, Evangelos Vassos, Chloe Wong, Richard Bentall, Helen L. Fisher, Robin M. Murray, Luis Alameda, Marta Di Forti
Summary: This study aims to explore the relationship between childhood adversity and psychosis, and whether cannabis use acts as a mediator between adversity and psychotic disorders. Data from 881 first-episode psychosis patients and 1231 controls were analyzed, and it was found that the association between household discord and psychosis was partially mediated by the use of cannabis. Children exposed to challenging environments could benefit from psychosocial interventions aimed at preventing cannabis misuse.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Microbiology
Emilio Bouza, Celso Arango, Carmen Moreno, Diego Gracia, Manuel Martin, Victor Perez, Luisa Lazaro, Francisco Ferre, Gonzalo Salazar, Francisco Tejerina-Picado, Mercedes Navio, Javier Granda Revilla, Esteban Palomo, Pedro R. Gil-Monte
Summary: The Health Sciences Foundation has conducted research on the impact of the COVID-19 pandemic on mental health, specifically on the general population and healthcare workers. Mental disorders such as anxiety, depression, and sleep disorders have become more prevalent, alongside an increase in suicidal behavior and substance abuse. Vulnerable groups include adolescents and individuals with autism spectrum disorders. Healthcare workers, especially those exposed during the early stages of the pandemic, have experienced higher levels of depression, anxiety, and post-traumatic stress, with factors such as gender, occupation, and previous illnesses playing a role. The media has shown awareness of these issues, highlighting both physical and moral challenges brought on by the crisis.
REVISTA ESPANOLA DE QUIMIOTERAPIA
(2023)
Article
Psychiatry
Lucia Sideli, Monica Aas, Diego Quattrone, Daniele La Barbera, Caterina La Cascia, Laura Ferraro, Luis Alameda, Eva Velthorst, Giulia Trotta, Giada Tripoli, Adriano Schimmenti, Andrea Fontana, Charlotte Gayer-Anderson, Simona Stilo, Fabio Seminerio, Crocettarachele Sartorio, Giovanna Marrazzo, Antonio Lasalvia, Sarah Tosato, Ilaria Tarricone, Domenico Berardi, Giuseppe D'Andrea, Celso Arango, Manuel Arrojo, Miguel Bernardo, Julio Bobes, Julio Sanjuan, Jose Luis Santos, Paulo Rossi Menezes, Cristina Marta Del-Ben, Hannah E. Jongsma, Peter B. Jones, James B. Kirkbride, Pierre-Michel Llorca, Andrea Tortell, Baptiste Pignon, Lieuwe de Haan, Jean-Paul Selten, Jim Van Os, Bart P. Rutten, Richard Bentall, Marta Di Fort, Robin M. Murray, Craig Morgan, Helen L. Fisher
Summary: This study aimed to investigate whether the relationship between childhood maltreatment and cognition in patients with psychosis and community controls was influenced by genetic factors related to psychosis. The study included first-episode psychosis patients (N=755) and unaffected controls (N=1219) from the EU-GEI study, who were assessed for childhood maltreatment, intelligence quotient (IQ), family history of psychosis (FH), and polygenic risk score for schizophrenia (SZ-PRS). The results showed that controlling for FH and SZ-PRS did not weaken the association between childhood maltreatment and IQ in either cases or controls, suggesting that genetic liability factors do not explain the lower levels of cognition in adults who experienced childhood maltreatment.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2023)
Article
Psychology, Clinical
Ana Izquierdo, Maria Cabello, Itziar Leal, Iosune Torio, Jose L. M. Madrigal, Karina S. MacDowell, Roberto Rodriguez-Jimenez, David Rentero, Angela Ibanez, Miriam Ayora, Covadonga M. Diaz-Caneja, Renzo Abregii-Crespo, Blanca Mellor-Marsa, Marina Diaz-Marsa, Norberto Malpica, Maria-Fe Bravo-Ortiz, Enrique Baca-Garcia, Celso Arango, Jose Luis Ayuso-Mateos, AGES-CM Grp
Summary: This study aimed to assess whether neighborhood vulnerability and risk of social exclusion could predict functional outcomes in patients with first episode of psychosis. The results showed that patients with first episode of psychosis are more vulnerable to the effects of neighborhood-level characteristics, and higher neighborhood vulnerability is related to greater functional disability in these patients.
JOURNAL OF CLINICAL PSYCHIATRY
(2023)
Article
Psychiatry
Judit Simon, Patrice Boyer, Jose M. Caldas-de-Almeida, Martin Knapp, Paul McCrone, Philip Gorwood, Wolfgang Oertel, Celso Arango, Janet Treasure, Allan H. Young, Frederic Destrebecq, Vinciane Quoidbach
Summary: One in eight individuals worldwide and one in four individuals in many European countries have mental health problems. Three-quarters of mental health disorders develop before age 25, with undiagnosed symptoms often presenting in the mid-teens and lasting into old age. Evidence suggests that people frequently have multiple mental health disorders.
EUROPEAN PSYCHIATRY
(2023)
Article
Neurosciences
Mercedes Valtuena-Garcia, Elena Martin-Gil, Leticia Gonzalez-Blanco, Lorena de la Fuente-Tomas, Francesco Dal Santo, Clara Alvarez-Vazquez, Carlota Moya-Lacasa, Clara Martinez-Cao, Leticia Garcia-Alvarez, Pilar A. Saiz, Julio Bobes, Maria Paz Garcia-Portilla
Summary: This study examined the psychological impact on people with an anxiety disorder during the COVID-19 pandemic and lockdown in Spain. The results showed that women experienced a greater psychological impact, particularly in terms of depression, anxiety, and symptoms related to post-traumatic stress disorder.
ACTAS ESPANOLAS DE PSIQUIATRIA
(2023)
Article
Psychiatry
Inge Winter-van Rossum, Mark Weiser, Silvana Galderisi, Stefan Leucht, Istvan Bitter, Birte Glenthoj, Alkomiet Hasan, Jurjen Luykx, Marina Kupchik, Georg Psota, Paola Rocca, Nikos Stefanis, Alexander Teitelbaum, Mor Bar Haim, Claudia Leucht, Georg Kemmler, Timo Schurr, Michael Davidson, Rene S. Kahn, W. Wolfgang Fleischhacker
Summary: This study aimed to compare the efficacy of long-acting injectable (LAI) antipsychotics and oral medication in preventing medication discontinuation in patients with early-phase schizophrenia. The findings showed no substantial advantage of LAI treatment over oral treatment regarding time to discontinuation.
Article
Psychiatry
Amanda Worker, Pierre Berthert, Andrew J. Lawrence, Seyed Mostafa Kia, Celso Arango, Richard Dinga, Silvana Galderisi, Birte Glenthoj, Rene S. Kahn, Anoushka Leslie, Robin M. Murray, Carmine M. Pariante, Christos Pantelis, Mark Weiser, Inge Winter-van Rossum, Philip Mcguire, Paola Dazzan, Andre F. Marquand
Summary: This study utilized normative modeling of cortical thickness in first-episode psychosis patients to identify individualized cortical markers associated with high biological heterogeneity and deviations in cortical thickness related to the severity of negative symptoms.
TRANSLATIONAL PSYCHIATRY
(2023)
Meeting Abstract
Psychiatry
C. Cachan-Vega, E. Antuna, C. Garcia-Gonzalez, J. C. Bermejo-Millo, F. Baena-Huerta, L. Gonzalez-Blanco, B. Caballero, I. Vega-Naredo, J. Bobes, M. P. Garcia-Portilla, A. Coto-Montes, Y. Potes
EUROPEAN PSYCHIATRY
(2023)
Article
Clinical Neurology
Nadia Deflorin, Ulrike Ehlert, Rita T. Amiel Castro
Summary: Changes in the gut microbiome of infants have been associated with maternal psychological symptoms during pregnancy. This study found that maternal prenatal depressive symptoms are associated with lower diversity of the infant's microbiome, while maternal saliva cortisol levels are linked to increased diversity and changes in specific bacterial groups. Further research is needed to understand the implications of these microbiota alterations for child health.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zheng Ma, Hui-Xia Zhou, Da-Chun Chen, Dong-Mei Wang, Xiang-Yang Zhang
Summary: The impaired glucose metabolism in drug-na & iuml;ve schizophrenia patients is strongly associated with suicidal behavior, suggesting that glucose metabolism abnormalities may be potential biomarkers of suicide in schizophrenia patients. Regular monitoring of glucose metabolism variables is essential for suicide prevention.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Katie M. Lavigne, Jiaxuan Deng, Delphine Raucher-Chene, Adele Hotte-Meunier, Chloe Voyer, Lisa Sarraf, Martin Lepage, Genevieve Sauve
Summary: Psychiatric disorders are characterized by cognitive deficits and cognitive biases, which are associated with specific symptoms. While cognitive biases are present across diagnoses, their severity varies.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Yong-Yu Yin, Jiao-Zhao Yan, Shi-Xin Lai, Qian-Qian Wei, Si-Rui Sun, Li-Ming Zhang, Yun-Feng Li
Summary: This study found that gamma oscillations are closely associated with depression and may serve as predictive biomarkers of depression. Chronic restraint stress and lipopolysaccharide induced significant depression-like behaviors in mice and reduced gamma oscillations in the medial prefrontal cortex. Administration of ketamine, scopolamine, or fluoxetine increased gamma oscillations and exhibited rapid-acting antidepressant effects.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Veronica Begni, Moira Marizzoni, Kerstin Camile Creutzberg, Diana Morena Silipo, Mariusz Papp, Annamaria Cattaneo, Marco Andrea Riva
Summary: Exposure to stressful experiences is a significant risk factor for mental disorders, and pharmacological interventions targeting stress-induced alterations can help restore brain function. Lurasidone, an antipsychotic drug, has been shown to normalize the impairments caused by stress exposure and could be a valuable treatment for stress-induced mental illnesses. However, the mechanisms underlying the therapeutic effects of lurasidone are not well understood. This study found that chronic lurasidone treatment counteracted some of the transcriptional changes induced by chronic mild stress exposure, providing new insights into the potential therapeutic effects of lurasidone.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Esther E. Palacios-Barrios, Kunal Patel, Jamie L. Hanson
Summary: This review examines the association between early life interpersonal stress (ELIS) and depression, as well as the underlying mechanisms. The research shows that ELIS affects how youth respond to social rewards, and similar impairments in social reward processing are observed in youth with depression. The authors propose a preliminary model that suggests neurobehavioral disruptions in social reward processing as a mediating factor in the connection between ELIS and depression.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Rui Li, Jiaming Tang, Yizhuo Wang, Ying Wang, Hua Yang, Hongen Wei
Summary: Restricted and repetitive behaviors (RRBs) are characteristic features of neuropsychiatric disorders. This study focused on repetitive self-grooming behavior and investigated the involvement of the Pax2 gene in its control. Through the use of Pax2 neuron-specific deletion mice, the study found that the deletion of Pax2 gene affects the expression of the Arc gene in the prefrontal cortex, leading to impaired synaptic plasticity and excitatory/inhibitory imbalance, thereby contributing to the occurrence of repetitive self-grooming behavior.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Sara Derosa, Paulina Misztak, Jessica Mingardi, Giulia Mazzini, Heidi Kaastrup Muller, Laura Musazzi
Summary: This study investigated the involvement of neurotrophic signaling pathways in stress vulnerability/resilience and fast antidepressant response/non-response to ketamine in a rat model of depression. The findings showed that stress and ketamine induced specific changes in these pathways in different brain areas and subcellular fractions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Georgia F. Caruana, Sean P. Carruthers, Michael Berk, Susan L. Rossell, Tamsyn E. Van Rheenen
Summary: Cognitive impairment is related to both white matter macrostructure and microstructure in bipolar disorder patients. However, there is inconsistency in the results of the studies examining this relationship. Some studies have found an association between higher fractional anisotropy in white matter and better complex attention skills and executive functioning in bipolar disorder patients, while others have found no associations. Further research with increased statistical power and standardized methods is needed.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Alberto Galimberti, Martin Tik, Giovanni Pellegrino, Anna-Lisa Schuler
Summary: This study provides a systematic review and meta-analysis on the effectiveness of repetitive transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) for post-traumatic brain injury (TBI) symptoms. The results show that non-invasive brain stimulation techniques have a small overall effect on TBI sequelae, with significant effects observed for anxiety and headache. However, larger randomized controlled trials with longer follow-ups, optimized stimulation parameters, and standardized methodology are needed to establish the efficacy of these techniques in addressing TBI sequelae.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Amanda J. Sales, Pedro H. Gobira, Joa F. C. Pedrazzi, Joao R. Silveia, Elaine Del Bel, Felipe V. Gomes, Francisco S. Guimaraes
Summary: The study found that doxycycline can inhibit metalloproteinase in the brain and attenuate the rewarding effects and locomotor sensitization of drug abuse. This suggests that doxycycline could be repurposed for the treatment of substance use disorders.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Alejandro Borrego-Ruiz, Juan J. Borrego
Summary: There is substantial evidence that the development of the nervous system is related to the composition and functions of the gut microbiome. The communication between the central nervous system (CNS) and the gut microbiota is bidirectional, with various routes such as immune, endocrine, and neural circuits. Dysbiosis of the gut microbiota has been associated with neuropsychiatric diseases and psychological disorders. Fecal microbiota transplantation (FMT) therapy has shown a causal-effect relationship between the gut microbiota and behavioral features. Interventions based on prebiotics, probiotics, or synbiotics have demonstrated their influence on neurological disorders through the synthesis of neuroactive compounds and regulation of inflammatory and endocrine processes. Further research is needed to explore the impact of gut microbiota dysbiosis on psychiatric and psychological disorders and the potential therapeutic role of microbiota-based interventions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zhinan Li, Zhuang Kang, Xiaowei Xia, Leijun Li, Junyan Wu, Jiamin Dai, Tong Liu, Cai Chen, Yong Qiu, Ming Chen, Yanxi Liu, Ziyi Zhang, Zili Han, Zhengjia Dai, Qinling Wei
Summary: This study found that patients with schizophrenia showed lower levels of resilience and cognitive functions compared to healthy controls, as well as abnormal global properties and nodal metrics in brain networks. Furthermore, characteristic path length might moderate the relationship between resilience and working memory in these patients.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
David H. Adamowicz, Tsung-Chin Wu, Rebecca Daly, Michael R. Irwin, Dilip Jeste, Xin M. Tu, Lisa T. Eyler, Ellen E. Lee
Summary: This study aimed to explore the relationship between executive functioning and inflammatory biomarkers in people with schizophrenia. The results showed that systemic inflammation did not predict long-term declines in executive functioning. This suggests the need for further research to better understand the relationship and mechanisms between inflammation and cognition in schizophrenia.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Nina Walter, Julian Wenzel, Shalaila S. Haas, Letizia Squarcina, Carolina Bonivento, Anne Ruef, Dominic Dwyer, Theresa Lichtenstein, Oeznur Bastruek, Alexandra Stainton, Linda A. Antonucci, Paolo Brambilla, Stephen J. Wood, Rachel Upthegrove, Stefan Borgwardt, Rebekka Lencer, Eva Meisenzahl, Raimo K. R. Salokangas, Christos Pantelis, Alessandro Bertolino, Nikolaos Koutsouleris, Joseph Kambeitz, Lana Kambeitz-Ilankovic
Summary: Clinical and neuroimaging data can be used to predict the potential of cognitive training to improve social functioning in recent onset psychosis patients. The use of multivariate pattern analysis and support vector machine classifier allows for the prediction of social functioning improvement based on baseline cognitive data. The findings suggest that cognitive data can provide a robust individual estimate of future social functioning for patients with recent onset psychosis.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)