Article
Psychiatry
Jinjun Lu, Ye Yang, Jian Lu, Zuqing Wang, Yiping He, Yeliang Yan, Kai Fu, Wenjuan Jiang, Yunqing Xu, Renrong Wu, Wenqing Liu, Jingping Zhao
Summary: The genotype of CYP2D6 significantly influences the plasma concentration of risperidone, which in turn may affect the adverse side-effects following risperidone treatment, while also exerting a slight influence on clinical outcomes. The study found that the CYP2D6*10 allele was very common among patients, while CYP2D6*2 and CYP2D6*5 were relatively rare. Significant differences were observed between different genotypes in terms of clinical outcomes and adverse reactions.
Article
Microbiology
Mahmoud Tareq Abdelwahab, Richard Court, Daniel Everitt, Andreas H. Diacon, Rodney Dawson, Elin M. Svensson, Gary Maartens, Paolo Denti
Summary: Clofazimine, a WHO group B drug for rifampin-resistant tuberculosis, can cause QT prolongation. However, using 200mg and 300mg doses of clofazimine does not significantly increase the risk of QT prolongation compared to standard treatment.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Ana Alarcia-Lacalle, Helena Barrasa, Javier Maynar, Andres Canut-Blasco, Carmen Gomez-Gonzalez, Maria Angeles Solinis, Arantxazu Isla, Alicia Rodriguez-Gascon
Summary: This study developed a rapid, simple and reproducible HPLC-UV method for quantifying ceftaroline in plasma samples, which was accurate and stable, successfully applied in two critically ill patients.
Article
Infectious Diseases
Magnus Bock, Johan G. C. Van Hasselt, Franziska Schwartz, Hengzhuang Wang, Niels Hoiby, Kurt Fuursted, Nikolaj Ihlemann, Sabine Gill, Ulrik Christiansen, Niels Eske Bruun, Hanne Elming, Jonas A. Povlsen, Lars Kober, Dan E. Hofsten, Emil L. Fosbol, Mia M. Pries-Heje, Jens Jorgen Christensen, Flemming S. Rosenvinge, Christian Torp-Pedersen, Jannik Helweg-Larsen, Niels Tonder, Kasper Iversen, Henning Bundgaard, Claus Moser
Summary: This study characterized the population pharmacokinetics of linezolid in patients with infective endocarditis and found that there is a substantial interaction between linezolid and rifampicin, which increases the clearance of linezolid. Model-based simulations showed that increasing the linezolid dose can compensate for the interaction without increasing the risk of adverse effects.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Veterinary Sciences
Carl Ekstrand, Peter Michanek, Ronette Gehring, Anna Sundell, Annika Kallse, Mikael Hedeland, Lena Strom
Summary: This study suggests that the use of atropine to treat equine uveitis may result in decreased intestinal motility and abdominal pain in horses. Different dosing regimens have varying effects on horses, with dosing every 6 hours predicted to be a safer approach.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Veterinary Sciences
Carl Ekstrand, Helena Pettersson, Ronette Gehring, Mikael Hedeland, Sara Adolfsson, Inger Lilliehook
Summary: This study quantitatively characterized the concentration-effect relationship for prednisolone in dogs, showing pharmacokinetic parameters such as clearance rate, volume of distribution, and half-life, as well as pharmacodynamic parameters for neutrophil and lymphocyte trafficking, and cortisol suppression in this species. The effective concentrations of prednisolone on neutrophil, lymphocyte, and cortisol responses in dogs were determined to be 10, 22.5, and 0.04 ng/mL, respectively.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Anesthesiology
Young-Eun Jang, Sang-Hwan Ji, Ji-Hyun Lee, Eun-Hee Kim, Jin-Tae Kim, Hee-Soo Kim
Summary: The pharmacodynamic relationship between the effect-site concentration of propofol and UMSS score in children was quantified in this study, providing a helpful prediction for sedation score at the target C-e of propofol.
BMC ANESTHESIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Michael Tagen, Linda E. Klumpers
Summary: This review summarizes the pharmacological studies of Delta-8-tetrahydrocannabinol (Delta(8)-THC), including receptor binding, cannabimimetic activity, and pharmacokinetics. The findings suggest that Delta(8)-THC has similar pharmacokinetics and pharmacodynamics to Delta(9)-THC, but lower affinity for the cannabinoid CB1 receptor. The reduced potency of Delta(8)-THC in clinical studies compared to Delta(9)-THC may be explained by this weaker affinity.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Microbiology
Nilesh Kumta, Aaron J. Heffernan, Menino Osbert Cotta, Steven C. Wallis, Amelia Livermore, Therese Starr, Wai Tat Wong, Gavin M. Joynt, Jeffrey Lipman, Jason A. Roberts
Summary: Morbidity and mortality related to ventriculitis in neurocritical care patients remain high. Antibiotic dose optimization, particularly higher doses of meropenem, can improve therapeutic outcomes for critically ill patients with ventriculitis or extracranial infection by ensuring targeted cerebrospinal fluid exposures. Individualized dosing regimens need to be tailored based on factors such as renal function and pathogen susceptibility.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Shin-Yi Lin, Sung-Chun Tang, Ching-Hua Kuo, Li-Ting Ho, Yen-Bin Liu, Yu-Fong Peng, Li-Kai Tsai, Chih-Fen Huang, Jiann-Shing Jeng
Summary: This study reports on the association between direct oral anticoagulant (DOAC) concentration and clinical outcomes in Asian patients with atrial fibrillation (AF). The proportion of DOAC concentrations falling outside the expected range was higher than reported in clinical trials. Low trough concentration was associated with increased risk of systemic thromboembolism (SSE), while high trough concentration was associated with major bleeding. Measurement of trough DOAC concentration should be considered for patients at risk of concentration deviations.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Microbiology
Sinenhlanhla Mtshali, Byron A. Jacobs
Summary: Physiologically based pharmacokinetic models have gained popularity in drug development and regulatory science. This study validates the model's effectiveness in predicting drug-drug interaction and the pharmacokinetics of antiretroviral and anti-TB drugs through mathematical solving and sensitivity analysis.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Microbiology
Claire Pressiat, Nawel Ait-Ammar, Matthieu Daniel, Anne Hulin, Francoise Botterel, Eric Levesque
Summary: This study analyzed the pharmacokinetics/pharmacodynamics of caspofungin in plasma and peritoneal fluid samples from liver transplant recipients. The results showed that the concentration of caspofungin in peritoneal fluid was low, suggesting a potential risk of resistance.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Review
Microbiology
Bruce R. Dalton
Summary: Therapeutic drug monitoring for vancomycin has shifted its focus from trough concentrations to area under the curve (AUC(24)). However, the evidence for this change is weak, with retrospective analyses and animal studies lacking conviction. In vitro data also present conflicting results. Therefore, the adoption of AUC(24):MIC based on animal experiments and in vitro evidence may be premature for vancomycin.
Article
Clinical Neurology
Yun Kim, Anhye Kim, Jae-Yong Chung
Summary: A population PK/PD model was developed to characterize the delayed QT prolongation effect of escitalopram, with findings suggesting a relatively constant drug effect on QTc change over 24 hours post-dosing. The study provides useful information for monitoring electrocardiograms in patients receiving intensive care after drug administration.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Microbiology
Roxane Rohani, Paul R. Yarnold, Marc H. Scheetz, Michael N. Neely, Mengjia Kang, Helen K. Donnelly, Kay Dedicatoria, Sophie H. Nozick, Rachel L. Medernach, Alan R. Hauser, Egon A. Ozer, Estefani Diaz, Alexander V. Misharin, Richard G. Wunderink, Nathaniel J. Rhodes
Summary: This study aimed to investigate the difference in target attainment of meropenem between plasma and epithelial lining fluid (ELF). The study found that some patients did not achieve the target attainment in both plasma and ELF, and those who achieved target attainment in plasma did not necessarily have the same effect in ELF. Patients with a higher creatinine clearance rate may have poorer target attainment in ELF. Additionally, the dosage and loading dose may also affect the target attainment.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Meeting Abstract
Clinical Neurology
N. Fukui, Y. Suzuki, S. Ono, T. Sugai, J. Watanabe, N. Tsuneyama, M. Saito, M. Tajiri, T. Someya
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2016)
Meeting Abstract
Clinical Neurology
S. Ono, Y. Suzuki, N. Fukui, T. Sugai, J. Watanabe, N. Tsuneyama, M. Saito, M. Tajiri, T. Someya
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2016)
Article
Multidisciplinary Sciences
Nobuto Tsuneyama, Yutaro Suzuki, Kazushi Sawamura, Takuro Sugai, Naoki Fukui, Junzo Watanabe, Shin Ono, Mami Saito, Toshiyuki Someya
Article
Pharmacology & Pharmacy
Junzo Watanabe, Naoki Fukui, Yutaro Suzuki, Takuro Sugai, Shin Ono, Nobuto Tsuneyama, Mami Saito, Misuzu Tajiri, Toshiyuki Someya
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
(2017)
Article
Psychiatry
Shin Ono, Takuro Sugai, Yutaro Suzuki, Manabu Yamazaki, Kazutaka Shimoda, Takao Mori, Yuji Ozeki, Hiroshi Matsuda, Norio Sugawara, Norio Yasui-Furukori, Kurefu Okamoto, Toyoaki Sagae, Toshiyuki Someya
Article
Clinical Neurology
Yutaro Suzuki, Takuro Sugai, Naoki Fukui, Junzo Watanabe, Shin Ono, Nobuto Tsuneyama, Mami Saito, Toshiyuki Someya
HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
(2013)
Article
Clinical Neurology
Yutaro Suzuki, Takuro Sugai, Naoki Fukui, Junzo Watanabe, Shin Ono, Nobuto Tsuneyama, Mami Saito, Toshiyuki Someya
HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
(2013)
Article
Pharmacology & Pharmacy
Shin Ono, Yutaro Suzuki, Naoki Fukui, Takuro Sugai, Junzo Watanabe, Nobuto Tsuneyama, Mami Saito, Toshiyuki Someya
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
(2013)
Article
Pharmacology & Pharmacy
Yutaro Suzuki, Nobuto Tsuneyama, Naoki Fukui, Takuro Sugai, Junzo Watanabe, Shin Ono, Mami Saito, Toshiyuki Someya
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
(2013)
Article
Genetics & Heredity
Y. Suzuki, N. Tsuneyama, N. Fukui, T. Sugai, J. Watanabe, S. Ono, M. Saito, Y. Inoue, T. Someya
PHARMACOGENOMICS JOURNAL
(2014)
Article
Clinical Neurology
Yutaro Suzuki, Takuro Sugai, Naoki Fukui, Junzo Watanabe, Shin Ono, Nobuto Tsuneyama, Mami Saito, Toshiyuki Someya
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2014)
Article
Clinical Neurology
Yutaro Suzuki, Takuro Sugai, Shin Ono, Kazushi Sawamura, Naoki Fukui, Junzo Watanabe, Nobuto Tsuneyama, Mami Saito, Toshiyuki Someya
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2014)
Letter
Psychiatry
Yutaro Suzuki, Shin Ono, Nobuto Tsuneyama, Kazushi Sawamura, Takuro Sugai, Naoki Fukui, Junzo Watanabe, Toshiyuki Someya
SCHIZOPHRENIA RESEARCH
(2014)
Article
Medicine, General & Internal
Atsunori Sugimoto, Yutaro Suzuki, Naoki Orime, Taketsugu Hayashi, Kiyohiro Yoshinaga, Jun Egawa, Shin Ono, Takuro Sugai, Yoshimasa Inoue, Toshiyuki Someya
Summary: The study found that in ADHD patients receiving atomoxetine treatment, when the plasma concentration exceeded 64.60 ng/mL, scores on the ADHD-Rating Scale improved by 50% or more.
Article
Clinical Neurology
Masataka Otake, Shin Ono, Yuichiro Watanabe, Koichiro Kumagai, Koji Matsuzawa, Hiroyuki Kasahara, Masaya Ootake, Takuro Sugai, Toshiyuki Someya
Summary: This study found significant associations between the number of remaining teeth and BMI, as well as between antipsychotic polypharmacy and BMI, in inpatients with schizophrenia. In addition, inpatients with schizophrenia had significantly fewer remaining teeth compared to the general population.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2022)
Article
Clinical Neurology
Nadia Deflorin, Ulrike Ehlert, Rita T. Amiel Castro
Summary: Changes in the gut microbiome of infants have been associated with maternal psychological symptoms during pregnancy. This study found that maternal prenatal depressive symptoms are associated with lower diversity of the infant's microbiome, while maternal saliva cortisol levels are linked to increased diversity and changes in specific bacterial groups. Further research is needed to understand the implications of these microbiota alterations for child health.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zheng Ma, Hui-Xia Zhou, Da-Chun Chen, Dong-Mei Wang, Xiang-Yang Zhang
Summary: The impaired glucose metabolism in drug-na & iuml;ve schizophrenia patients is strongly associated with suicidal behavior, suggesting that glucose metabolism abnormalities may be potential biomarkers of suicide in schizophrenia patients. Regular monitoring of glucose metabolism variables is essential for suicide prevention.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Katie M. Lavigne, Jiaxuan Deng, Delphine Raucher-Chene, Adele Hotte-Meunier, Chloe Voyer, Lisa Sarraf, Martin Lepage, Genevieve Sauve
Summary: Psychiatric disorders are characterized by cognitive deficits and cognitive biases, which are associated with specific symptoms. While cognitive biases are present across diagnoses, their severity varies.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Yong-Yu Yin, Jiao-Zhao Yan, Shi-Xin Lai, Qian-Qian Wei, Si-Rui Sun, Li-Ming Zhang, Yun-Feng Li
Summary: This study found that gamma oscillations are closely associated with depression and may serve as predictive biomarkers of depression. Chronic restraint stress and lipopolysaccharide induced significant depression-like behaviors in mice and reduced gamma oscillations in the medial prefrontal cortex. Administration of ketamine, scopolamine, or fluoxetine increased gamma oscillations and exhibited rapid-acting antidepressant effects.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Veronica Begni, Moira Marizzoni, Kerstin Camile Creutzberg, Diana Morena Silipo, Mariusz Papp, Annamaria Cattaneo, Marco Andrea Riva
Summary: Exposure to stressful experiences is a significant risk factor for mental disorders, and pharmacological interventions targeting stress-induced alterations can help restore brain function. Lurasidone, an antipsychotic drug, has been shown to normalize the impairments caused by stress exposure and could be a valuable treatment for stress-induced mental illnesses. However, the mechanisms underlying the therapeutic effects of lurasidone are not well understood. This study found that chronic lurasidone treatment counteracted some of the transcriptional changes induced by chronic mild stress exposure, providing new insights into the potential therapeutic effects of lurasidone.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Esther E. Palacios-Barrios, Kunal Patel, Jamie L. Hanson
Summary: This review examines the association between early life interpersonal stress (ELIS) and depression, as well as the underlying mechanisms. The research shows that ELIS affects how youth respond to social rewards, and similar impairments in social reward processing are observed in youth with depression. The authors propose a preliminary model that suggests neurobehavioral disruptions in social reward processing as a mediating factor in the connection between ELIS and depression.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Rui Li, Jiaming Tang, Yizhuo Wang, Ying Wang, Hua Yang, Hongen Wei
Summary: Restricted and repetitive behaviors (RRBs) are characteristic features of neuropsychiatric disorders. This study focused on repetitive self-grooming behavior and investigated the involvement of the Pax2 gene in its control. Through the use of Pax2 neuron-specific deletion mice, the study found that the deletion of Pax2 gene affects the expression of the Arc gene in the prefrontal cortex, leading to impaired synaptic plasticity and excitatory/inhibitory imbalance, thereby contributing to the occurrence of repetitive self-grooming behavior.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Sara Derosa, Paulina Misztak, Jessica Mingardi, Giulia Mazzini, Heidi Kaastrup Muller, Laura Musazzi
Summary: This study investigated the involvement of neurotrophic signaling pathways in stress vulnerability/resilience and fast antidepressant response/non-response to ketamine in a rat model of depression. The findings showed that stress and ketamine induced specific changes in these pathways in different brain areas and subcellular fractions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Georgia F. Caruana, Sean P. Carruthers, Michael Berk, Susan L. Rossell, Tamsyn E. Van Rheenen
Summary: Cognitive impairment is related to both white matter macrostructure and microstructure in bipolar disorder patients. However, there is inconsistency in the results of the studies examining this relationship. Some studies have found an association between higher fractional anisotropy in white matter and better complex attention skills and executive functioning in bipolar disorder patients, while others have found no associations. Further research with increased statistical power and standardized methods is needed.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Alberto Galimberti, Martin Tik, Giovanni Pellegrino, Anna-Lisa Schuler
Summary: This study provides a systematic review and meta-analysis on the effectiveness of repetitive transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) for post-traumatic brain injury (TBI) symptoms. The results show that non-invasive brain stimulation techniques have a small overall effect on TBI sequelae, with significant effects observed for anxiety and headache. However, larger randomized controlled trials with longer follow-ups, optimized stimulation parameters, and standardized methodology are needed to establish the efficacy of these techniques in addressing TBI sequelae.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Amanda J. Sales, Pedro H. Gobira, Joa F. C. Pedrazzi, Joao R. Silveia, Elaine Del Bel, Felipe V. Gomes, Francisco S. Guimaraes
Summary: The study found that doxycycline can inhibit metalloproteinase in the brain and attenuate the rewarding effects and locomotor sensitization of drug abuse. This suggests that doxycycline could be repurposed for the treatment of substance use disorders.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Alejandro Borrego-Ruiz, Juan J. Borrego
Summary: There is substantial evidence that the development of the nervous system is related to the composition and functions of the gut microbiome. The communication between the central nervous system (CNS) and the gut microbiota is bidirectional, with various routes such as immune, endocrine, and neural circuits. Dysbiosis of the gut microbiota has been associated with neuropsychiatric diseases and psychological disorders. Fecal microbiota transplantation (FMT) therapy has shown a causal-effect relationship between the gut microbiota and behavioral features. Interventions based on prebiotics, probiotics, or synbiotics have demonstrated their influence on neurological disorders through the synthesis of neuroactive compounds and regulation of inflammatory and endocrine processes. Further research is needed to explore the impact of gut microbiota dysbiosis on psychiatric and psychological disorders and the potential therapeutic role of microbiota-based interventions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zhinan Li, Zhuang Kang, Xiaowei Xia, Leijun Li, Junyan Wu, Jiamin Dai, Tong Liu, Cai Chen, Yong Qiu, Ming Chen, Yanxi Liu, Ziyi Zhang, Zili Han, Zhengjia Dai, Qinling Wei
Summary: This study found that patients with schizophrenia showed lower levels of resilience and cognitive functions compared to healthy controls, as well as abnormal global properties and nodal metrics in brain networks. Furthermore, characteristic path length might moderate the relationship between resilience and working memory in these patients.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
David H. Adamowicz, Tsung-Chin Wu, Rebecca Daly, Michael R. Irwin, Dilip Jeste, Xin M. Tu, Lisa T. Eyler, Ellen E. Lee
Summary: This study aimed to explore the relationship between executive functioning and inflammatory biomarkers in people with schizophrenia. The results showed that systemic inflammation did not predict long-term declines in executive functioning. This suggests the need for further research to better understand the relationship and mechanisms between inflammation and cognition in schizophrenia.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Nina Walter, Julian Wenzel, Shalaila S. Haas, Letizia Squarcina, Carolina Bonivento, Anne Ruef, Dominic Dwyer, Theresa Lichtenstein, Oeznur Bastruek, Alexandra Stainton, Linda A. Antonucci, Paolo Brambilla, Stephen J. Wood, Rachel Upthegrove, Stefan Borgwardt, Rebekka Lencer, Eva Meisenzahl, Raimo K. R. Salokangas, Christos Pantelis, Alessandro Bertolino, Nikolaos Koutsouleris, Joseph Kambeitz, Lana Kambeitz-Ilankovic
Summary: Clinical and neuroimaging data can be used to predict the potential of cognitive training to improve social functioning in recent onset psychosis patients. The use of multivariate pattern analysis and support vector machine classifier allows for the prediction of social functioning improvement based on baseline cognitive data. The findings suggest that cognitive data can provide a robust individual estimate of future social functioning for patients with recent onset psychosis.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)