Review
Clinical Neurology
Iven-Alex von Muecke-Heim, Clemens Ries, Lidia Urbina, Jan M. Deussing
Summary: Depression affects around 320 million people worldwide, with growing evidence suggesting the immune system as the key interface between psychosocial stress and depression. Studies have shown the importance of purinergic signalling via the P2X7 receptor in depression genesis and the efficacy of P2X7 receptor antagonists in chronic stress-induced depression models.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2021)
Review
Neurosciences
Joelle Lopez, Rosemary C. Bagot
Summary: Women are twice as likely to experience depression than men, but previous studies have predominantly focused on male rodents. As interest in sex differences grows, new chronic stress models are being applied to female rodents, though not all have been systematically validated.
BIOLOGICAL PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Julia Wollenhaupt, Janina Frisch, Eva Harlacher, Dickson W. L. Wong, Han Jin, Corinna Schulte, Sonja Vondenhoff, Julia Moellmann, Barbara Mara Klinkhammer, Li Zhang, Adelina Baleanu-Curaj, Elisa A. Liehn, Thimoteus Speer, Andrey Kazakov, Christian Werner, Emiel P. C. van der Vorst, Simina-Ramona Selejan, Mathias Hohl, Michael Bohm, Rafael Kramann, Erik A. L. Biessen, Michael Lehrke, Nikolaus Marx, Joachim Jankowski, Christoph Maack, Peter Boor, Leticia Prates Roma, Heidi Noels
Summary: CKD increases cardiac oxidative stress responses in the heart, but additional hits are required to induce uremic cardiomyopathy.
Article
Pharmacology & Pharmacy
Hong Huang, Yiwen Zhang, Caihong Yao, Qinghu He, Fang Chen, Han Yu, Guanghua Lu, Ning Jiang, Xinmin Liu
Summary: This study evaluated the effects of Fresh Gastrodia elata Blume (FG) on cognitive deficits induced by chronic restraint stress (CRS) and found that FG improved learning and memory abilities by regulating mitochondrial apoptosis-related proteins and proinflammatory cytokines.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Food Science & Technology
Piotr Bartochowski, Nathalie Gayrard, Stephanie Bornes, Celine Druart, Angel Argiles, Magali Cordaillat-Simmons, Flore Duranton
Summary: Chronic kidney disease affects the gut microbiota, and animal models can be used to study the gut-kidney axis. Murine models replicate the symptoms of chronic kidney disease, including slowed gut transit and altered intestinal barrier function.
Review
Veterinary Sciences
Rachel Layton, Daniel Layton, David Beggs, Andrew Fisher, Peter Mansell, Kelly J. Stanger
Summary: The impact of stress and general anesthesia on the organism's response to infectious diseases is essential in understanding and mitigating these diseases. Optimizing animal welfare in disease research is crucial due to increasing societal scrutiny. Utilizing appropriate animal monitoring strategies is imperative to better understand the effects of stress and anesthesia on disease study and welfare outcomes.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Ecology
Andrea Falcon-Cortes, Denis Boyer, Evelyn Merrill, Jacqueline L. Frair, Juan Manuel Morales
Summary: The use of spatial memory is crucial for the emergence of spatial learning in animals, as adaptive behaviors based on learning rely on the interdependence between acquiring information over time and making movement decisions. Animals are observed to exhibit preferential returns to previously visited patches, indicating a mild or negligible memory decay over time and a tendency to seek places with predictable resources and reduced mortality risks.
FRONTIERS IN ECOLOGY AND EVOLUTION
(2021)
Article
Neurosciences
Miguel Farinha-Ferreira, Nadia Rei, Joao Fonseca-Gomes, Catarina Miranda-Lourenco, Paula Serrao, Sandra H. Vaz, Joana I. Gomes, Valeria Martins, Beatriz de Alves Pereira, Ana M. Sebastiao
Summary: Chronic exposure to adolescent cannabinoid receptor agonists can lead to persistent increases in depressive-like behaviors. However, different compounds may have different effects. In this study, the highly potent CB1R/CB2R agonist HU-210 did not significantly affect adult anxious or depressive behaviors, but induced short-term increases in stress-induced reactivity.
Article
Behavioral Sciences
Elham Akbari, Dawood Hossaini, Ghulam Yahya Amiry, Mustafa Ansari, Murtaza Haidary, Farimah Beheshti, S. Mohammad Ahmadi-Soleimani
Summary: There is increasing evidence that the adolescent brain is affected by the use of psychostimulant agents, such as alcohol. Long-term alcohol exposure has been found to impair cognitive functions, and this is thought to be mediated by oxidative damage to the central nervous system. However, treatment with Vitamin B12 has been shown to improve cognitive performance by suppressing oxidative parameters. In this study, the researchers aimed to test whether Vitamin B12 treatment could prevent ethanol-induced complications in adolescent mice. The results indicated that adolescent ethanol intake impairs learning and memory function through exacerbation of oxidative stress, but treatment with Vitamin B12 improves these complications by restoring the oxidant/antioxidant balance. Additionally, Vitamin B12 was found to prevent the reduction of BDNF and the enhancement of GFAP and acetylcholinesterase activity induced by ethanol. In conclusion, Vitamin B12 supplementation could be an effective therapeutic strategy to prevent learning and memory defects caused by chronic alcohol intake during adolescence.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Barry J. Sessle
Summary: Diagnosing and treating chronic orofacial pain conditions can be challenging due to their complexity. Variability between individuals in risk factors and pain expression suggests a role for genetic and environmental factors. Understanding underlying mechanisms and individual differences is crucial for effective management of chronic orofacial pain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Ana Catarina Neto, Mariana Santos-Pereira, Pedro Abreu-Mendes, Delminda Neves, Henrique Almeida, Francisco Cruz, Ana Charrua
Summary: The definitions of chronic pelvic/visceral pain have changed within international societies, greatly impacting research approaches. Recent studies highlight the significance of systemic changes and the central nervous system in the perpetuation of pelvic/visceral pain. As a result, researchers are utilizing animal models that replicate systemic changes, rather than organ- or tissue-specific models. This review discusses the advantages and disadvantages of bladder-centric and systemic models, highlighting central nervous system changes and pain-related behaviors. It also raises concerns about potential investigator bias and suggests new approaches for studying chronic pelvic/visceral pain through refined or novel animal models.
Article
Behavioral Sciences
Suelen Santos Alves, Gabriel Servilha-Menezes, Leticia Rossi, Rui Milton Patricio da Silva Junior, Norberto Garcia-Cairasco
Summary: Since glucose reuptake by neurons is mostly independent of insulin, it has been a question whether insulin has any roles in the brain. The identification of insulin receptors in the central nervous system has fueled investigations of insulin functions in the brain. It is known that insulin can influence glucose reuptake by neurons, especially during high energy-demand activities. The high density of insulin receptors in the hippocampus suggests important roles of insulin related to memory. In this context, disturbed insulin signaling in experimental animal models of Alzheimer's disease (AD) is reviewed.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Review
Biochemistry & Molecular Biology
Amina Basha, Sarah C. C. May, Ryan M. M. Anderson, Niharika Samala, Raghavendra G. G. Mirmira
Summary: Nonalcoholic fatty liver disease (NAFLD) is a common liver disease caused by fat accumulation in the liver without excess alcohol use or other liver disease causes. Its complications include cirrhosis, liver failure, hepatocellular carcinoma, and death. The pathophysiology of NAFLD, including insulin resistance and inflammation, remains poorly understood. Animal models have played a crucial role in defining these mechanisms and developing therapies for NAFLD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Behavioral Sciences
Susana Lima, Nuno Sousa, Patricia Patricio, Luisa Pinto
Summary: Major depression is a common psychiatric disorder affecting millions worldwide, with a complex etiology involving genetics and environmental factors. While depression is more prevalent in women, most preclinical studies are conducted in male rodents, highlighting the need for more research on female animal models of depression.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Review
Clinical Neurology
Amanda Larosa, Tak Pan Wong
Summary: Understanding individual variability in the development of stress-related psychopathologies is crucial for studying their neurobiology. This article focuses on the hippocampus, which is highly influenced by chronic stress and is linked to disorders like depression and post-traumatic stress disorder. The article outlines animal models used to categorize animals into susceptible and resilient groups, and reviews molecular and functional markers in the hippocampus associated with susceptibility and resilience. The authors propose that the hippocampus plays a key role in how animals with different stress susceptibilities process and store stress-related information, and these markers can potentially be targeted for new treatments.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Iva B. Zovkic, Brandon J. Walters
Editorial Material
Neurosciences
Iva B. Zovkic, J. David Sweatt
Review
Neurosciences
B. J. Walters, I. B. Zovkic
Review
Genetics & Heredity
Brandon J. Walters, Amber B. Azam, Colleen J. Gillon, Sheena A. Josselyn, Iva B. Zovkic
FRONTIERS IN GENETICS
(2016)
Article
Neurosciences
Minesh Kapadia, M. Firoz Mian, Bernadeta Michalski, Amber B. Azam, Donglai Ma, Patrick Salwierz, Adam Christopher, Elyse Rosa, Iva B. Zovkic, Paul Forsythe, Margaret Fahnestock, Boris Sakic
JOURNAL OF ALZHEIMERS DISEASE
(2018)
Article
Multidisciplinary Sciences
Mariela Faykoo-Martinez, D. Ashley Monks, Iva B. Zovkic, Melissa M. Holmes
Article
Cell Biology
Gilda Stefanelli, Amber B. Azam, Brandon J. Walters, Mark A. Brimble, Caroline P. Gettens, Pascale Bouchard-Cannon, Hai-Ying M. Cheng, Andrew M. Davidoff, Klotilda Narkaj, Jeremy J. Day, Andrew J. Kennedy, Iva B. Zovkic
Article
Developmental Biology
Iva Z. Mathews, Cheryl M. McCormick
DEVELOPMENTAL NEUROBIOLOGY
(2012)
Article
Neurosciences
Cheryl M. McCormick, Catherine M. Thomas, Cheryl S. Sheridan, Feather Nixon, Jennifer A. Flynn, Iva Z. Mathews
Article
Behavioral Sciences
Firyal Ramzan, Amber B. Azam, D. Ashley Monks, Iva B. Zovkic
HORMONES AND BEHAVIOR
(2018)
Review
Neurosciences
Iva B. Zovkic, Mikael C. Guzman-Karlsson, J. David Sweatt
Article
Multidisciplinary Sciences
Iva B. Zovkic, Brynna S. Paulukaitis, Jeremy J. Day, Deepa M. Etikala, J. David Sweatt
Review
Neurosciences
Iva B. Zovkic, J. David Sweatt
NEUROPSYCHOPHARMACOLOGY
(2013)
Article
Behavioral Sciences
Firyal Ramzan, Jennet Baumbach, Ashley D. Monks, Iva B. Zovkic
NEUROBIOLOGY OF LEARNING AND MEMORY
(2020)
Article
Neurosciences
Klotilda Narkaj, Gilda Stefanelli, Malak Wahdan, Amber B. Azam, Firyal Ramzan, Carl Frank David Jr Steininger, Brandon J. Walters, Iva B. Zovkic
Article
Clinical Neurology
Nadia Deflorin, Ulrike Ehlert, Rita T. Amiel Castro
Summary: Changes in the gut microbiome of infants have been associated with maternal psychological symptoms during pregnancy. This study found that maternal prenatal depressive symptoms are associated with lower diversity of the infant's microbiome, while maternal saliva cortisol levels are linked to increased diversity and changes in specific bacterial groups. Further research is needed to understand the implications of these microbiota alterations for child health.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zheng Ma, Hui-Xia Zhou, Da-Chun Chen, Dong-Mei Wang, Xiang-Yang Zhang
Summary: The impaired glucose metabolism in drug-na & iuml;ve schizophrenia patients is strongly associated with suicidal behavior, suggesting that glucose metabolism abnormalities may be potential biomarkers of suicide in schizophrenia patients. Regular monitoring of glucose metabolism variables is essential for suicide prevention.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Katie M. Lavigne, Jiaxuan Deng, Delphine Raucher-Chene, Adele Hotte-Meunier, Chloe Voyer, Lisa Sarraf, Martin Lepage, Genevieve Sauve
Summary: Psychiatric disorders are characterized by cognitive deficits and cognitive biases, which are associated with specific symptoms. While cognitive biases are present across diagnoses, their severity varies.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Yong-Yu Yin, Jiao-Zhao Yan, Shi-Xin Lai, Qian-Qian Wei, Si-Rui Sun, Li-Ming Zhang, Yun-Feng Li
Summary: This study found that gamma oscillations are closely associated with depression and may serve as predictive biomarkers of depression. Chronic restraint stress and lipopolysaccharide induced significant depression-like behaviors in mice and reduced gamma oscillations in the medial prefrontal cortex. Administration of ketamine, scopolamine, or fluoxetine increased gamma oscillations and exhibited rapid-acting antidepressant effects.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Veronica Begni, Moira Marizzoni, Kerstin Camile Creutzberg, Diana Morena Silipo, Mariusz Papp, Annamaria Cattaneo, Marco Andrea Riva
Summary: Exposure to stressful experiences is a significant risk factor for mental disorders, and pharmacological interventions targeting stress-induced alterations can help restore brain function. Lurasidone, an antipsychotic drug, has been shown to normalize the impairments caused by stress exposure and could be a valuable treatment for stress-induced mental illnesses. However, the mechanisms underlying the therapeutic effects of lurasidone are not well understood. This study found that chronic lurasidone treatment counteracted some of the transcriptional changes induced by chronic mild stress exposure, providing new insights into the potential therapeutic effects of lurasidone.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Esther E. Palacios-Barrios, Kunal Patel, Jamie L. Hanson
Summary: This review examines the association between early life interpersonal stress (ELIS) and depression, as well as the underlying mechanisms. The research shows that ELIS affects how youth respond to social rewards, and similar impairments in social reward processing are observed in youth with depression. The authors propose a preliminary model that suggests neurobehavioral disruptions in social reward processing as a mediating factor in the connection between ELIS and depression.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Rui Li, Jiaming Tang, Yizhuo Wang, Ying Wang, Hua Yang, Hongen Wei
Summary: Restricted and repetitive behaviors (RRBs) are characteristic features of neuropsychiatric disorders. This study focused on repetitive self-grooming behavior and investigated the involvement of the Pax2 gene in its control. Through the use of Pax2 neuron-specific deletion mice, the study found that the deletion of Pax2 gene affects the expression of the Arc gene in the prefrontal cortex, leading to impaired synaptic plasticity and excitatory/inhibitory imbalance, thereby contributing to the occurrence of repetitive self-grooming behavior.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Sara Derosa, Paulina Misztak, Jessica Mingardi, Giulia Mazzini, Heidi Kaastrup Muller, Laura Musazzi
Summary: This study investigated the involvement of neurotrophic signaling pathways in stress vulnerability/resilience and fast antidepressant response/non-response to ketamine in a rat model of depression. The findings showed that stress and ketamine induced specific changes in these pathways in different brain areas and subcellular fractions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Georgia F. Caruana, Sean P. Carruthers, Michael Berk, Susan L. Rossell, Tamsyn E. Van Rheenen
Summary: Cognitive impairment is related to both white matter macrostructure and microstructure in bipolar disorder patients. However, there is inconsistency in the results of the studies examining this relationship. Some studies have found an association between higher fractional anisotropy in white matter and better complex attention skills and executive functioning in bipolar disorder patients, while others have found no associations. Further research with increased statistical power and standardized methods is needed.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Alberto Galimberti, Martin Tik, Giovanni Pellegrino, Anna-Lisa Schuler
Summary: This study provides a systematic review and meta-analysis on the effectiveness of repetitive transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) for post-traumatic brain injury (TBI) symptoms. The results show that non-invasive brain stimulation techniques have a small overall effect on TBI sequelae, with significant effects observed for anxiety and headache. However, larger randomized controlled trials with longer follow-ups, optimized stimulation parameters, and standardized methodology are needed to establish the efficacy of these techniques in addressing TBI sequelae.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Amanda J. Sales, Pedro H. Gobira, Joa F. C. Pedrazzi, Joao R. Silveia, Elaine Del Bel, Felipe V. Gomes, Francisco S. Guimaraes
Summary: The study found that doxycycline can inhibit metalloproteinase in the brain and attenuate the rewarding effects and locomotor sensitization of drug abuse. This suggests that doxycycline could be repurposed for the treatment of substance use disorders.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Alejandro Borrego-Ruiz, Juan J. Borrego
Summary: There is substantial evidence that the development of the nervous system is related to the composition and functions of the gut microbiome. The communication between the central nervous system (CNS) and the gut microbiota is bidirectional, with various routes such as immune, endocrine, and neural circuits. Dysbiosis of the gut microbiota has been associated with neuropsychiatric diseases and psychological disorders. Fecal microbiota transplantation (FMT) therapy has shown a causal-effect relationship between the gut microbiota and behavioral features. Interventions based on prebiotics, probiotics, or synbiotics have demonstrated their influence on neurological disorders through the synthesis of neuroactive compounds and regulation of inflammatory and endocrine processes. Further research is needed to explore the impact of gut microbiota dysbiosis on psychiatric and psychological disorders and the potential therapeutic role of microbiota-based interventions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zhinan Li, Zhuang Kang, Xiaowei Xia, Leijun Li, Junyan Wu, Jiamin Dai, Tong Liu, Cai Chen, Yong Qiu, Ming Chen, Yanxi Liu, Ziyi Zhang, Zili Han, Zhengjia Dai, Qinling Wei
Summary: This study found that patients with schizophrenia showed lower levels of resilience and cognitive functions compared to healthy controls, as well as abnormal global properties and nodal metrics in brain networks. Furthermore, characteristic path length might moderate the relationship between resilience and working memory in these patients.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
David H. Adamowicz, Tsung-Chin Wu, Rebecca Daly, Michael R. Irwin, Dilip Jeste, Xin M. Tu, Lisa T. Eyler, Ellen E. Lee
Summary: This study aimed to explore the relationship between executive functioning and inflammatory biomarkers in people with schizophrenia. The results showed that systemic inflammation did not predict long-term declines in executive functioning. This suggests the need for further research to better understand the relationship and mechanisms between inflammation and cognition in schizophrenia.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Nina Walter, Julian Wenzel, Shalaila S. Haas, Letizia Squarcina, Carolina Bonivento, Anne Ruef, Dominic Dwyer, Theresa Lichtenstein, Oeznur Bastruek, Alexandra Stainton, Linda A. Antonucci, Paolo Brambilla, Stephen J. Wood, Rachel Upthegrove, Stefan Borgwardt, Rebekka Lencer, Eva Meisenzahl, Raimo K. R. Salokangas, Christos Pantelis, Alessandro Bertolino, Nikolaos Koutsouleris, Joseph Kambeitz, Lana Kambeitz-Ilankovic
Summary: Clinical and neuroimaging data can be used to predict the potential of cognitive training to improve social functioning in recent onset psychosis patients. The use of multivariate pattern analysis and support vector machine classifier allows for the prediction of social functioning improvement based on baseline cognitive data. The findings suggest that cognitive data can provide a robust individual estimate of future social functioning for patients with recent onset psychosis.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)