Editorial Material
Psychology, Clinical
Robin M. Murray, Anthony S. David, Olesya Ajnakina
Summary: The value of services for those with the 'At Risk Mental State for Psychosis' (ARMS) remains disputed, but there is a trend towards transforming clinics into youth mental health services. However, these services are unlikely to make major inroads into preventing psychosis as they only reach a small proportion of those at risk. The most effective approach for psychosis prevention is avoiding exposure to risk-increasing factors.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Psychology, Clinical
Alison R. Yung, Stephen J. Wood, Ashok Malla, Barnaby Nelson, Patrick McGorry, Jai Shah
Summary: This paper discusses the importance of ARMS (At Risk Mental State) services, points out the shortcomings of some criticisms, and emphasizes the need and value of such services in improving the health of young people.
PSYCHOLOGICAL MEDICINE
(2021)
Review
Psychiatry
Alexandre Andrade Loch, Ana Caroline Lopes-Rocha, Feten Fekih-Romdhane, Martinus Theodorus van de Bilt, Gonzalo Salazar de Pablo, Paolo Fusar-Poli
Summary: This article systematically reviews studies on individuals at clinical high-risk for psychosis (CHR) in low and middle-income countries (LAMIC). The review found limitations in conducting CHR research in LAMIC, such as small sample sizes, cross-sectional designs, and follow-up issues. The results of an online poll indicate that 75% of researchers believe that CHR research should be approached differently in LAMIC due to structural and cultural issues.
FRONTIERS IN PSYCHIATRY
(2023)
Review
Psychology, Developmental
Ulla Lang, Kathryn Yates, Finbarr P. Leacy, Mary C. Clarke, Fiona McNicholas, Mary Cannon, Ian Kelleher
Summary: The At Risk Mental State (ARMS) approach to psychosis has had a major impact on psychosis services internationally. However, this systematic review and meta-analysis found no evidence that the diagnosis of ARMS was associated with an increased risk of psychosis in children and adolescents up to the age of 18.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2022)
Article
Health Care Sciences & Services
Yuko Higuchi, Tomiki Sumiyoshi, Takahiro Tateno, Suguru Nakajima, Daiki Sasabayashi, Shimako Nishiyama, Yuko Mizukami, Tsutomu Takahashi, Michio Suzuki
Summary: The study found that patients with schizophrenia showed smaller P300 amplitudes compared to healthy controls and subjects with at-risk mental states (ARMS), while subjects with ARMS had prolonged P300 latency. During follow-up, 8 out of 33 ARMS subjects developed overt psychosis while 25 did not. ARMS-P exhibited worse cognitive functions at baseline compared to ARMS-NP.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Neurosciences
Yoichiro Takayanagi, Sue Kulason, Daiki Sasabayashi, Tsutomu Takahashi, Naoyuki Katagiri, Atsushi Sakuma, Noriyuki Ohmuro, Masahiro Katsura, Shimako Nishiyama, Mikio Kido, Atsushi Furuichi, Kyo Noguchi, Kazunori Matsumoto, Masafumi Mizuno, J. Tilak Ratnanather, Michio Suzuki
Summary: This study found that reduced gray matter volume in the right dorsal lateral prefrontal cortex (DLPFC) may be a potential marker for future onset of psychosis in individuals with at-risk mental states (ARMS).
Review
Psychiatry
Bernd Hinney, Anna Walter, Soheila Aghlmandi, Christina Andreou, Stefan Borgwardt
Summary: A meta-analysis compared the baseline hippocampal volume of CHR patients who developed psychosis with those who did not, finding no statistically significant effect of hippocampal volume on the risk of transitioning to psychosis.
FRONTIERS IN PSYCHIATRY
(2021)
Review
Endocrinology & Metabolism
Claudia Aymerich, Borja Pedruzo, Malein Pacho, Marta Laborda, Jon Herrero, Toby Pillinger, Robert A. McCutcheon, Daniel Alonso-Alconada, Marta Bordenave, Maria Martinez-Querol, Ainara Arnaiz, Javier Labad, Paolo Fusar-Poli, Miguel Angel Gonzalez-Torres, Ana Catalan
Summary: Alterations in prolactin and cortisol levels have been found in antipsychotic naive patients with first episode psychosis. This study aims to provide estimates for the standardized mean differences and inter-group variability of these hormone levels in this patient group compared to healthy controls.
PSYCHONEUROENDOCRINOLOGY
(2023)
Article
Psychiatry
Tara Burke, Andrew Thompson, Nathan Mifsud, Alison R. Yung, Barnaby Nelson, Patrick McGorry, Brian O'Donoghue
Summary: This study found that a significant proportion of young people initially attended other specialist youth mental health services, and these individuals had lower rates of hospital admission at the time of transition to first-episode psychosis.
SCHIZOPHRENIA RESEARCH
(2022)
Article
Psychiatry
Erich Studerus, Sarah Ittig, Katharina Beck, Nuria Del Cacho, Regina Vila-Badia, Anna Butjosa, Judith Usall, Anita Riecher-Roessler
Summary: The study found that CHR-P and FEP patients had significantly higher levels of self-perceived stress and prolactin compared to healthy controls, and that self-perceived stress was significantly positively associated with affective symptoms but not with other symptoms. Some patients had hyperprolactinemia, but it was not necessarily caused by stress.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Review
Neurosciences
Shrujna Patel, Brooke A. Keating, Russell C. Dale
Summary: Mental health and neurodevelopmental disorders are common and complex conditions that affect wellbeing. There is evidence suggesting a role of maternal inflammation in these disorders, and it is now known that commonly used psychiatric drugs have anti-inflammatory properties. This review summarizes the human evidence of the anti-inflammatory mechanisms of psychiatric drugs and highlights the potential therapeutic implications.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Psychiatry
Latoya Clarke, Katharine Chisholm, Francesco P. Cappuccio, Nicole K. Y. Tang, Michelle A. Miller, Farah Elahi, Andrew D. Thompson
Summary: The study found that young individuals at risk of illness reported poorer sleep quality and reduced sleep duration compared to healthy controls. Sleep disturbances were associated with psychotic symptoms and functional outcomes, but further research is needed to explore the longitudinal relationship between sleep and quality of life.
SCHIZOPHRENIA RESEARCH
(2021)
Article
Psychiatry
Sheeba Arnold Anteraper, Xavier Guell, Guusje Collin, Zhenghan Qi, Jingwen Ren, Atira Nair, Larry J. Seidman, Matcheri S. Keshavan, Tianhong Zhang, Yingying Tang, Huijun Li, Robert W. McCarley, Margaret A. Niznikiewicz, Martha E. Shenton, William S. Stone, Jijun Wang, Susan Whitfield-Gabrieli
Summary: The study suggests that abnormalities in RsFc of the DN may precede the onset of psychosis, and these abnormalities are not found in individuals at risk but not yet developed psychosis.
SCHIZOPHRENIA BULLETIN
(2021)
Review
Psychology, Clinical
Jesus Perez, Peter B. Jones
Summary: Psychiatry's recent exploration into risk and prevention in mental disorders has reshaped the clinical understanding of at-risk mental states, challenging the boundary between childhood and adulthood by adopting a developmental perspective. Despite challenges such as the rarity of transition from risk to full syndrome, there is potential for these mental states to provide valuable insights into the nature of psychopathology and new treatment paradigms when viewed beyond mere diagnostic pointers.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Psychology, Multidisciplinary
Lourdes Nieto, Tecelli Dominguez-Martinez, Mauricio Rosel-Vales, Ricardo Saracco-Alvarez, Cesar Celada-Borja, Maria Luisa Rascon-Gasca
Summary: This study compares the sociodemographic, clinical, and functional characteristics of At-Risk Mental State (ARMS) youth and those with a first- or second-degree relative with psychosis (Familial High-Risk: FHR) in a Mexican sample. The findings indicate that ARMS individuals are younger, have less education, and are more likely to be male than those in the FHR group. The ARMS group also exhibits more severe prodromal symptoms, schizotypal personality traits, and general psychopathology. Additionally, their premorbid adjustment deficit from early adolescence is higher compared to the FHR group. The study emphasizes the need for early detection and intervention programs in Mexico to support this vulnerable group.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Neurosciences
Danai Dima, Amirhossein Modabbernia, Efstathios Papachristou, Gaelle E. Doucet, Ingrid Agartz, Moji Aghajani, Theophilus N. Akudjedu, Anton Albajes-Eizagirre, Dag Alnaes, Kathryn Alpert, Micael Andersson, Nancy C. Andreasen, Ole A. Andreassen, Philip Asherson, Tobias Banaschewski, Nuria Bargallo, Sarah Baumeister, Ramona Baur-Streubel, Alessandro Bertolino, Aurora Bonvino, Dorret Boomsma, Stefan Borgwardt, Josiane Bourque, Daniel Brandeis, Alan Breier, Henry Brodaty, Rachel M. Brouwer, Jan K. Buitelaar, Geraldo F. Busatto, Randy L. Buckner, Vincent Calhoun, Erick J. Canales-Rodriguez, Dara M. Cannon, Xavier Caseras, Francisco X. Castellanos, Simon Cervenka, Tiffany M. Chaim-Avancini, Christopher R. K. Ching, Victoria Chubar, Vincent P. Clark, Patricia Conrod, Annette Conzelmann, Benedicto Crespo-Facorro, Fabrice Crivello, Eveline A. Crone, Anders M. Dale, Cristopher Davey, Eco J. C. de Geus, Lieuwe de Haan, Greig de Zubicaray, Anouk den Braber, Erin W. Dickie, Annabella Di Giorgio, Nhat Trung Doan, Erlend S. Dorum, Stefan Ehrlich, Susanne Erk, Thomas Espeseth, Helena Fatouros-Bergman, Simon E. Fisher, Jean-Paul Fouche, Barbara Franke, Thomas Frodl, Paola Fuentes-Claramonte, David C. Glahn, Ian H. Gotlib, Hans-Joergen Grabe, Oliver Grimm, Nynke A. Groenewold, Dominik Grotegerd, Oliver Gruber, Patricia Gruner, Rachel E. Gur, Ruben C. Gur, Ben J. Harrison, Catharine A. Hartman, Sean N. Hatton, Andreas Heinz, Dirk J. Heslenfeld, Derrek P. Hibar, Ian B. Hickie, Beng-Choon Ho, Pieter J. Hoekstra, Sarah Hohmann, Avram J. Holmes, Martine Hoogman, Norbert Hosten, Fleur M. Howells, Hilleke E. Hulshoff Pol, Chaim Huyser, Neda Jahanshad, Anthony James, Terry L. Jernigan, Jiyang Jiang, Erik G. Jonsson, John A. Joska, Rene Kahn, Andrew Kalnin, Ryota Kanai, Marieke Klein, Tatyana P. Klyushnik, Laura Koenders, Sanne Koops, Bernd Kraemer, Jonna Kuntsi, Jim Lagopoulos, Luisa Lazaro, Irina Lebedeva, Won Hee Lee, Klaus-Peter Lesch, Christine Lochner, Marise W. J. Machielsen, Sophie Maingault, Nicholas G. Martin, Ignacio Martinez-Zalacain, David Mataix-Cols, Bernard Mazoyer, Colm McDonald, Brenna C. McDonald, Andrew M. McIntosh, Katie L. McMahon, Genevieve McPhilemy, Jose M. Menchon, Sarah E. Medland, Andreas Meyer-Lindenberg, Jilly Naaijen, Pablo Najt, Tomohiro Nakao, Jan E. Nordvik, Lars Nyberg, Jaap Oosterlaan, Victor Ortiz-Garcia De la Foz, Yannis Paloyelis, Paul Pauli, Giulio Pergola, Edith Pomarol-Clotet, Maria J. Portella, Steven G. Potkin, Joaquim Radua, Andreas Reif, Daniel A. Rinker, Joshua L. Roffman, Pedro G. P. Rosa, Matthew D. Sacchet, Perminder S. Sachdev, Raymond Salvador, Pascual Sanchez-Juan, Salvador Sarro, Theodore D. Satterthwaite, Andrew J. Saykin, Mauricio H. Serpa, Lianne Schmaal, Knut Schnell, Gunter Schumann, Kang Sim, Jordan W. Smoller, Iris Sommer, Carles Soriano-Mas, Dan J. Stein, Lachlan T. Strike, Suzanne C. Swagerman, Christian K. Tamnes, Henk S. Temmingh, Sophia Thomopoulos, Alexander S. Tomyshev, Diana Tordesillas-Gutierrez, Julian N. Trollor, Jessica A. Turner, Anne Uhlmann, Odile A. van den Heuvel, Dennis van den Meer, Nic J. A. van der Wee, Neeltje E. M. van Haren, Dennis Van't Ent, Theo G. M. van Erp, Ilya M. Veer, Dick J. Veltman, Aristotle Voineskos, Henry Voelzke, Henrik Walter, Esther Walton, Lei Wang, Yang Wang, Thomas H. Wassink, Bernd Weber, Wei Wen, John D. West, Lars T. Westlye, Heather Whalley, Lara M. Wierenga, Steven C. R. Williams, Katharina Wittfeld, Daniel H. Wolf, Amanda Worker, Margaret J. Wright, Kun Yang, Yulyia Yoncheva, Marcus Zanetti, Georg C. Ziegler, Paul M. Thompson, Sophia Frangou
Summary: Age has a significant impact on brain volume, with different regions showing varying trajectories. Basal ganglia volume decreases with age, while lateral ventricles continue to enlarge. These findings provide important insights into the functional significance of age-related morphometric patterns in the brain.
HUMAN BRAIN MAPPING
(2022)
Article
Neurosciences
Sophia Frangou, Amirhossein Modabbernia, Steven C. R. Williams, Efstathios Papachristou, Gaelle E. Doucet, Ingrid Agartz, Moji Aghajani, Theophilus N. Akudjedu, Anton Albajes-Eizagirre, Dag Alnaes, Kathryn Alpert, Micael Andersson, Nancy C. Andreasen, Ole A. Andreassen, Philip Asherson, Tobias Banaschewski, Nuria Bargallo, Sarah Baumeister, Ramona Baur-Streubel, Alessandro Bertolino, Aurora Bonvino, Dorret Boomsma, Stefan Borgwardt, Josiane Bourque, Daniel Brandeis, Alan Breier, Henry Brodaty, Rachel M. Brouwer, Jan K. Buitelaar, Geraldo F. Busatto, Randy L. Buckner, Vincent Calhoun, Erick J. Canales-Rodriguez, Dara M. Cannon, Xavier Caseras, Francisco X. Castellanos, Simon Cervenka, Tiffany M. Chaim-Avancini, Christopher R. K. Ching, Victoria Chubar, Vincent P. Clark, Patricia Conrod, Annette Conzelmann, Benedicto Crespo-Facorro, Fabrice Crivello, Eveline A. Crone, Anders M. Dale, Christopher Davey, Eco J. C. de Geus, Lieuwe de Haan, Greig de Zubicaray, Anouk den Braber, Erin W. Dickie, Annabella Di Giorgio, Nhat Trung Doan, Erlend S. Dorum, Stefan Ehrlich, Susanne Erk, Thomas Espeseth, Helena Fatouros-Bergman, Simon E. Fisher, Jean-Paul Fouche, Barbara Franke, Thomas Frodl, Paola Fuentes-Claramonte, David C. Glahn, Ian H. Gotlib, Hans-Joergen Grabe, Oliver Grimm, Nynke A. Groenewold, Dominik Grotegerd, Oliver Gruber, Patricia Gruner, Rachel E. Gur, Ruben C. Gur, Ben J. Harrison, Catharine A. Hartman, Sean N. Hatton, Andreas Heinz, Dirk J. Heslenfeld, Derrek P. Hibar, Ian B. Hickie, Beng-Choon Ho, Pieter J. Hoekstra, Sarah Hohmann, Avram J. Holmes, Martine Hoogman, Norbert Hosten, Fleur M. Howells, Hilleke E. Hulshoff Pol, Chaim Huyser, Neda Jahanshad, Anthony James, Terry L. Jernigan, Jiyang Jiang, Erik G. Jonsson, John A. Joska, Rene Kahn, Andrew Kalnin, Ryota Kanai, Marieke Klein, Tatyana P. Klyushnik, Laura Koenders, Sanne Koops, Bernd Kraemer, Jonna Kuntsi, Jim Lagopoulos, Luisa Lazaro, Irina Lebedeva, Won Hee Lee, Klaus-Peter Lesch, Christine Lochner, Marise W. J. Machielsen, Sophie Maingault, Nicholas G. Martin, Ignacio Martinez-Zalacain, David Mataix-Cols, Bernard Mazoyer, Colm McDonald, Brenna C. McDonald, Andrew M. McIntosh, Katie L. McMahon, Genevieve McPhilemy, Jose M. Menchon, Sarah E. Medland, Andreas Meyer-Lindenberg, Jilly Naaijen, Pablo Najt, Tomohiro Nakao, Jan E. Nordvik, Lars Nyberg, Jaap Oosterlaan, Victor Ortiz-Garcia de la Foz, Yannis Paloyelis, Paul Pauli, Giulio Pergola, Edith Pomarol-Clotet, Maria J. Portella, Steven G. Potkin, Joaquim Radua, Andreas Reif, Daniel A. Rinker, Joshua L. Roffman, Pedro G. P. Rosa, Matthew D. Sacchet, Perminder S. Sachdev, Raymond Salvador, Pascual Sanchez-Juan, Salvador Sarro, Theodore D. Satterthwaite, Andrew J. Saykin, Mauricio H. Serpa, Lianne Schmaal, Knut Schnell, Gunter Schumann, Kang Sim, Jordan W. Smoller, Iris Sommer, Carles Soriano-Mas, Dan J. Stein, Lachlan T. Strike, Suzanne C. Swagerman, Christian K. Tamnes, Henk S. Temmingh, Sophia Thomopoulos, Alexander S. Tomyshev, Diana Tordesillas-Gutierrez, Julian N. Trollor, Jessica A. Turner, Anne Uhlmann, Odile A. van den Heuvel, Dennis van den Meer, Nic J. A. van der Wee, Neeltje E. M. van Haren, Dennis van't Ent, Theo G. M. van Erp, Ilya M. Veer, Dick J. Veltman, Aristotle Voineskos, Henry Voelzke, Henrik Walter, Esther Walton, Lei Wang, Yang Wang, Thomas H. Wassink, Bernd Weber, Wei Wen, John D. West, Lars T. Westlye, Heather Whalley, Lara M. Wierenga, Katharina Wittfeld, Daniel H. Wolf, Amanda Worker, Margaret J. Wright, Kun Yang, Yulyia Yoncheva, Marcus Zanetti, Georg C. Ziegler, Paul M. Thompson, Danai Dima
Summary: The study used data from the ENIGMA Consortium to explore the relationship between age and cortical thickness, finding that most regions peak in cortical thickness during childhood, with a negative association between age and cortical thickness where the slope is steeper before the age of 30 and more gradual afterwards.
HUMAN BRAIN MAPPING
(2022)
Article
Psychology, Clinical
J. S. Wrege, D. Carcone, A. C. H. Lee, C. Cane, U. E. Lang, S. Borgwardt, M. Walter, A. C. Ruocco
Summary: Patients with BPD show disruptions in frontoparietal regions related to a combination of response inhibition and attentional saliency or saliency processing alone. However, there are no specific neural activation differences related to response inhibition when attentional saliency is controlled. This suggests a neural dysfunction in BPD specifically underlying attention to salient or infrequent stimuli, supported by a negative correlation with self-rated impulsiveness.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Psychology, Clinical
Theresa K. Haidl, Dennis M. Hedderich, Marlene Rosen, Nathalie Kaiser, Mauro Seves, Thorsten Lichtenstein, Nora Penzel, Julian Wenzel, Lana Kambeitz-Ilankovic, Anne Ruef, David Popovic, Frauke Schultze-Lutter, Katharine Chisholm, Rachel Upthegrove, Raimo K. R. Salokangas, Christos Pantelis, Eva Meisenzahl, Stephen J. Wood, Paolo Brambilla, Stefan Borgwardt, Stephan Ruhrmann, Joseph Kambeitz, Nikolaos Koutsouleris
Summary: The study found that childhood trauma is a transdiagnostic risk factor for mental health disorders, possibly related to depressive symptoms. However, it is not possible to differentiate between different diagnosis-dependent psychopathologies, suggesting a multi-factorial pathogenesis.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Frederike Schirmbeck, Nadine C. van der Burg, Matthijs Blankers, Jentien M. Vermeulen, Philip McGuire, Lucia R. Valmaggia, Matthew J. Kempton, Mark van der Gaag, Anita Riecher-Rossler, Rodrigo A. Bressan, Neus Barrantes-Vidal, Barnaby Nelson, G. Paul Amminger, Patrick McGorry, Christos Pantelis, Marie-Odile Krebs, Stephan Ruhrmann, Gabriele Sachs, Bart P. F. Rutten, Jim van Os, Merete Nordentoft, Birte Glenthoj, Paolo Fusar-Poli, Lieuwe de Haan
Summary: This study found that a past depressive episode in UHR individuals is associated with a higher risk of an unfavorable course of APS, while past or current anxiety disorders may be associated with a lower risk of an unfavorable course. Additionally, past depression is significantly associated with a higher risk of transitioning to psychosis.
SCHIZOPHRENIA BULLETIN
(2022)
Article
Substance Abuse
Gallus Bischof, Anja Bischof, Richard Velleman, Jim Orford, Ronny Kuhnert, Jennifer Allen, Stefan Borgward, Hans-Jurgen Rumpf
Summary: This study aimed to estimate the prevalence of family members affected by addictive disorders in the general population of Germany and found that this group is characterized by poor self-rated health and higher rates of depression. The study highlights the need for better addressing the treatment of addictive disorders among family members in Germany.
Article
Clinical Neurology
Jan Philipp Klein, Rachel Dale, Sarah Glanert, Ulrike Grave, Svenja Surig, Bartosz Zurowski, Stefan Borgwardt, Ulrich Schweiger, Eva Fassbinder, Thomas Probst
Summary: The study found that in patients with depression, reporting childhood emotional abuse (CEA) moderates the treatment effects of CBASP and MCT. For patients with CEA, CBASP did not offer additional benefits above other depression-specific psychotherapies. Under routine practice conditions, CBASP and MCT were equally beneficial for individuals with depression.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Multidisciplinary Sciences
Sou Bouy Lo, Christian G. Huber, Andrea Meyer, Stefan Weinmann, Regula Luethi, Frieder Dechent, Stefan Borgwardt, Roselind Lieb, Undine E. Lang, Julian Moeller
Summary: This study aimed to investigate the association between patients' psychological characteristics and their utilization of psychiatric inpatient treatment. The results indicate no link between psychological characteristics and inpatient treatment utilization in patients diagnosed with schizophrenia spectrum or bipolar affective disorders.
Article
Multidisciplinary Sciences
Lisa Hochstrasser, Erich Studerus, Anita Riecher-Rossler, Benno G. Schimmelmann, Martin Lambert, Undine E. Lang, Stefan Borgwardt, Rolf-Dieter Stieglitz, Christian G. Huber
Summary: This study investigates the longitudinal latent state-trait structure of psychosis symptoms in individuals at clinical high-risk state and those with first episode psychosis over a one-year period. The results show that the trait component of psychosis symptoms increases over time, highlighting the importance of early intervention programs for individuals with psychotic disorders.
SCIENTIFIC REPORTS
(2022)
Article
Psychiatry
Stefania Tognin, Ana Catalan, Matthew J. Kempton, Barnaby Nelson, Patrick McGorry, Anita Riecher-Rossler, Rodrigo Bressan, Neus Barrantes-Vidal, Marie-Odile Krebs, Merete Nordentoft, Stephan Ruhrmann, Gabriele Sachs, Bart P. F. Rutten, Jim van Os, Lieuwe de Haan, Mark van der Gaag, Philip R. McGuire, Lucia Valmaggia
Summary: Research shows that adverse childhood experiences (ACE) can impact educational achievements in individuals at clinical high risk of psychosis (CHR). Specifically, CHR individuals with ACE had lower education levels, employment rates, and estimated IQ compared to healthy controls. Early intervention programs for psychosis should integrate interventions to support the educational and vocational recovery of young CHR individuals, and public health and social interventions to prevent or reduce the impact of ACE are recommended.
EUROPEAN PSYCHIATRY
(2023)
Article
Neurosciences
Peter Bedford, Daniel J. Hauke, Zheng Wang, Volker Roth, Monika Nagy-Huber, Friederike Holze, Laura Ley, Patrick Vizeli, Matthias E. Liechti, Stefan Borgwardt, Felix Mueller, Andreea O. Diaconescu
Summary: This study investigated the neural mechanisms of LSD using rDCM and found that LSD disrupts the excitatory/inhibitory balance of the brain. Whole-brain effective connectivity was correlated with the subjective effects of LSD and could potentially be used to decode or predict these effects in the future.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Dragana Filipovic, Julica Inderhees, Alexandra Korda, Predrag Tadic, Markus Schwaninger, Dragos Inta, Stefan Borgwardt
Summary: The study investigated the potential markers and therapeutic effectiveness of fluoxetine in a rat model of depression induced by chronic social isolation. Metabolomics analysis identified several candidate markers for depressive behavior and fluoxetine efficacy. This approach provides a new perspective for the identification of markers and prediction of treatment outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Psychiatry
Christina Andreou, Sofia Eickhoff, Marco Heide, Renate de Bock, Jonas Obleser, Stefan Borgwardt
Summary: Diagnosing a clinical high-risk state can lead to timely treatment for those at risk for psychosis, resulting in better outcomes. However, only a small number of patients diagnosed with clinical high-risk will actually develop psychosis. To identify those who would benefit most from early intervention, studies have investigated predictors and biomarkers assessed at baseline. This study aimed to summarize evidence from systematic reviews and meta-analyses to determine the most consistent predictors of transition to psychosis in clinical high-risk patients.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Medicine, General & Internal
Caroline Conchon, Elodie Sprungli-Toffel, Luis Alameda, Anne Edan, Barbara Bailey, Alessandra Solida, Kerstin Jessica Plessen, Philippe Conus, Afroditi Kapsaridi, Davina Genoud, Aureliano Crameri, Sondes Jouabli, Camille Caron, Carmina Grob, Julia Gros, Smeralda Senn, Logos Curtis, Ana Liso Navarro, Remy Barbe, Nathalie Nanzer, Evelyn Herbrecht, Christian G. Huber, Nadia Micali, Marco Armando, Stefan Borgwardt, Christina Andreou
Summary: The PsyYoung project aims to optimize the detection of an at-risk mental state (ARMS) and reduce unnecessary psychiatric treatments. It investigates the effects of service changes on referrals and outcomes of young people with ARMS or a first episode of psychosis (FEP). By implementing a standardized stepped care model, increasing awareness and training of professionals, the project aims to harmonize clinical practices in early intervention of psychosis on a national level.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Psychiatry
Shalaila S. Haas, Gaelle E. Doucet, Mathilde Antoniades, Amirhossein Modabbernia, Cheryl M. Corcoran, Rene S. Kahn, Joseph Kambeitz, Lana Kambeitz-Ilankovic, Stefan Borgwardt, Paolo Brambilla, Rachel Upthegrove, Stephen J. Wood, Raimo K. R. Salokangas, Jarmo Hietala, Eva Meisenzahl, Nikolaos Koutsouleris, Sophia Frangou
Summary: This study investigated whether social dysfunction in individuals at clinical high risk for psychosis is distinct from the lower end of the normal distribution of social functioning. The findings suggest that there are divergent brain structural underpinnings of social dysfunction in clinical and non-clinical samples. Although the neuroanatomical pattern associated with impaired social function outcome was found in some non-clinical samples, it was not associated with adverse social outcomes or higher levels of psychopathology. However, participants whose neuroanatomical profiles aligned more closely with the pattern showed subtle disadvantages in cognitive functioning.
SCHIZOPHRENIA RESEARCH-COGNITION
(2022)
Article
Clinical Neurology
Nadia Deflorin, Ulrike Ehlert, Rita T. Amiel Castro
Summary: Changes in the gut microbiome of infants have been associated with maternal psychological symptoms during pregnancy. This study found that maternal prenatal depressive symptoms are associated with lower diversity of the infant's microbiome, while maternal saliva cortisol levels are linked to increased diversity and changes in specific bacterial groups. Further research is needed to understand the implications of these microbiota alterations for child health.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zheng Ma, Hui-Xia Zhou, Da-Chun Chen, Dong-Mei Wang, Xiang-Yang Zhang
Summary: The impaired glucose metabolism in drug-na & iuml;ve schizophrenia patients is strongly associated with suicidal behavior, suggesting that glucose metabolism abnormalities may be potential biomarkers of suicide in schizophrenia patients. Regular monitoring of glucose metabolism variables is essential for suicide prevention.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Katie M. Lavigne, Jiaxuan Deng, Delphine Raucher-Chene, Adele Hotte-Meunier, Chloe Voyer, Lisa Sarraf, Martin Lepage, Genevieve Sauve
Summary: Psychiatric disorders are characterized by cognitive deficits and cognitive biases, which are associated with specific symptoms. While cognitive biases are present across diagnoses, their severity varies.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Yong-Yu Yin, Jiao-Zhao Yan, Shi-Xin Lai, Qian-Qian Wei, Si-Rui Sun, Li-Ming Zhang, Yun-Feng Li
Summary: This study found that gamma oscillations are closely associated with depression and may serve as predictive biomarkers of depression. Chronic restraint stress and lipopolysaccharide induced significant depression-like behaviors in mice and reduced gamma oscillations in the medial prefrontal cortex. Administration of ketamine, scopolamine, or fluoxetine increased gamma oscillations and exhibited rapid-acting antidepressant effects.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Veronica Begni, Moira Marizzoni, Kerstin Camile Creutzberg, Diana Morena Silipo, Mariusz Papp, Annamaria Cattaneo, Marco Andrea Riva
Summary: Exposure to stressful experiences is a significant risk factor for mental disorders, and pharmacological interventions targeting stress-induced alterations can help restore brain function. Lurasidone, an antipsychotic drug, has been shown to normalize the impairments caused by stress exposure and could be a valuable treatment for stress-induced mental illnesses. However, the mechanisms underlying the therapeutic effects of lurasidone are not well understood. This study found that chronic lurasidone treatment counteracted some of the transcriptional changes induced by chronic mild stress exposure, providing new insights into the potential therapeutic effects of lurasidone.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Esther E. Palacios-Barrios, Kunal Patel, Jamie L. Hanson
Summary: This review examines the association between early life interpersonal stress (ELIS) and depression, as well as the underlying mechanisms. The research shows that ELIS affects how youth respond to social rewards, and similar impairments in social reward processing are observed in youth with depression. The authors propose a preliminary model that suggests neurobehavioral disruptions in social reward processing as a mediating factor in the connection between ELIS and depression.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Rui Li, Jiaming Tang, Yizhuo Wang, Ying Wang, Hua Yang, Hongen Wei
Summary: Restricted and repetitive behaviors (RRBs) are characteristic features of neuropsychiatric disorders. This study focused on repetitive self-grooming behavior and investigated the involvement of the Pax2 gene in its control. Through the use of Pax2 neuron-specific deletion mice, the study found that the deletion of Pax2 gene affects the expression of the Arc gene in the prefrontal cortex, leading to impaired synaptic plasticity and excitatory/inhibitory imbalance, thereby contributing to the occurrence of repetitive self-grooming behavior.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Sara Derosa, Paulina Misztak, Jessica Mingardi, Giulia Mazzini, Heidi Kaastrup Muller, Laura Musazzi
Summary: This study investigated the involvement of neurotrophic signaling pathways in stress vulnerability/resilience and fast antidepressant response/non-response to ketamine in a rat model of depression. The findings showed that stress and ketamine induced specific changes in these pathways in different brain areas and subcellular fractions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Georgia F. Caruana, Sean P. Carruthers, Michael Berk, Susan L. Rossell, Tamsyn E. Van Rheenen
Summary: Cognitive impairment is related to both white matter macrostructure and microstructure in bipolar disorder patients. However, there is inconsistency in the results of the studies examining this relationship. Some studies have found an association between higher fractional anisotropy in white matter and better complex attention skills and executive functioning in bipolar disorder patients, while others have found no associations. Further research with increased statistical power and standardized methods is needed.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Alberto Galimberti, Martin Tik, Giovanni Pellegrino, Anna-Lisa Schuler
Summary: This study provides a systematic review and meta-analysis on the effectiveness of repetitive transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) for post-traumatic brain injury (TBI) symptoms. The results show that non-invasive brain stimulation techniques have a small overall effect on TBI sequelae, with significant effects observed for anxiety and headache. However, larger randomized controlled trials with longer follow-ups, optimized stimulation parameters, and standardized methodology are needed to establish the efficacy of these techniques in addressing TBI sequelae.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Amanda J. Sales, Pedro H. Gobira, Joa F. C. Pedrazzi, Joao R. Silveia, Elaine Del Bel, Felipe V. Gomes, Francisco S. Guimaraes
Summary: The study found that doxycycline can inhibit metalloproteinase in the brain and attenuate the rewarding effects and locomotor sensitization of drug abuse. This suggests that doxycycline could be repurposed for the treatment of substance use disorders.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Alejandro Borrego-Ruiz, Juan J. Borrego
Summary: There is substantial evidence that the development of the nervous system is related to the composition and functions of the gut microbiome. The communication between the central nervous system (CNS) and the gut microbiota is bidirectional, with various routes such as immune, endocrine, and neural circuits. Dysbiosis of the gut microbiota has been associated with neuropsychiatric diseases and psychological disorders. Fecal microbiota transplantation (FMT) therapy has shown a causal-effect relationship between the gut microbiota and behavioral features. Interventions based on prebiotics, probiotics, or synbiotics have demonstrated their influence on neurological disorders through the synthesis of neuroactive compounds and regulation of inflammatory and endocrine processes. Further research is needed to explore the impact of gut microbiota dysbiosis on psychiatric and psychological disorders and the potential therapeutic role of microbiota-based interventions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zhinan Li, Zhuang Kang, Xiaowei Xia, Leijun Li, Junyan Wu, Jiamin Dai, Tong Liu, Cai Chen, Yong Qiu, Ming Chen, Yanxi Liu, Ziyi Zhang, Zili Han, Zhengjia Dai, Qinling Wei
Summary: This study found that patients with schizophrenia showed lower levels of resilience and cognitive functions compared to healthy controls, as well as abnormal global properties and nodal metrics in brain networks. Furthermore, characteristic path length might moderate the relationship between resilience and working memory in these patients.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
David H. Adamowicz, Tsung-Chin Wu, Rebecca Daly, Michael R. Irwin, Dilip Jeste, Xin M. Tu, Lisa T. Eyler, Ellen E. Lee
Summary: This study aimed to explore the relationship between executive functioning and inflammatory biomarkers in people with schizophrenia. The results showed that systemic inflammation did not predict long-term declines in executive functioning. This suggests the need for further research to better understand the relationship and mechanisms between inflammation and cognition in schizophrenia.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Nina Walter, Julian Wenzel, Shalaila S. Haas, Letizia Squarcina, Carolina Bonivento, Anne Ruef, Dominic Dwyer, Theresa Lichtenstein, Oeznur Bastruek, Alexandra Stainton, Linda A. Antonucci, Paolo Brambilla, Stephen J. Wood, Rachel Upthegrove, Stefan Borgwardt, Rebekka Lencer, Eva Meisenzahl, Raimo K. R. Salokangas, Christos Pantelis, Alessandro Bertolino, Nikolaos Koutsouleris, Joseph Kambeitz, Lana Kambeitz-Ilankovic
Summary: Clinical and neuroimaging data can be used to predict the potential of cognitive training to improve social functioning in recent onset psychosis patients. The use of multivariate pattern analysis and support vector machine classifier allows for the prediction of social functioning improvement based on baseline cognitive data. The findings suggest that cognitive data can provide a robust individual estimate of future social functioning for patients with recent onset psychosis.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
