Article
Biochemistry & Molecular Biology
Krzysztof Gomulka, Ewa Wojcik, Jacek Cezary Szepietowski
Summary: Atopic dermatitis is a chronic, highly pruritic, relapsing-remitting inflammatory skin disease. This study found that the serum levels of EDN and VEGF were significantly increased in patients with AD, while the level of PAF showed no significant difference. In AD patients, there was a positive correlation between the EDN level and the severity of the disease.
Article
Biochemistry & Molecular Biology
Krzysztof Gomulka, Wojciech Medrala
Summary: This study aimed to investigate the serum levels of VEGF, PAF, and EDN in relation to disease activity and pruritus intensity in adult patients with CSU. The results showed higher levels of VEGF, PAF, and EDN in CSU patients compared with healthy subjects, but these cytokines were not significantly correlated with disease activity or pruritus intensity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Krzysztof Gomulka, Jerzy Liebhart, Wojciech Medrala
Summary: The study revealed the correlation between the severity of airway obstruction in asthmatics and depression symptoms, as well as the significant relationship between serum VEGF concentration levels. Depression symptoms in asthmatics with reversible airway obstruction showed a significant association with VEGF concentration, while this was not observed in patients with irreversible airway obstruction.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Materials Science, Biomaterials
Alena Maria Wolkersdorfer, Isabelle Jugovic, Lena Scheller, Marcus Gutmann, Lukas Hahn, Joachim Diessner, Tessa Luehmann, Lorenz Meinel
Summary: VEGF-A(165) positively affects hyperplasia, stenosis, and neovascularization, but its short half-life limits its potential therapeutic use. To address this issue, we designed VEGF-A(165) bioconjugates carrying PEG. After purification, two PEGylated species were obtained, with one or two PEG attached per VEGF-A(165) dimer. Both bioconjugates exhibited high purity, wild-type bioactivity, and increased hydrodynamic radii.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Review
Biochemistry & Molecular Biology
Xi Guo, Hong Yi, Tin Chiu Li, Yu Wang, Huilin Wang, Xiaoyan Chen
Summary: VEGF is a well-known angiogenic factor that plays a critical role in embryo implantation by enhancing embryo development and facilitating interactions between the embryo and endometrium. Changes in VEGF expression are correlated with reproductive failure, including recurrent implantation failure and recurrent miscarriage. This study aimed to clarify the role of VEGF in embryo implantation by reviewing recent literature and exploring its effects and underlying mechanisms.
Article
Psychiatry
Peng Zhang, Yuyuan Xiong, Bangjun Wang, Yi Zhou, Zijian Wang, Jiaqi Shi, Chao Li, Xinyan Lu, Gang Chen
Summary: Serum BDNF, VEGF, and S100B may serve as potential biomarkers for identifying MDD in OA patients. Meanwhile, serum BDNF and S100B show great potential in predicting the risk of MDD in OA patients.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Cell Biology
Xiaoya Zhao, Zhenwu Zhang, Qian Zhu, Yurui Luo, Qinying Ye, Shuxiang Shi, Xueyang He, Jing Zhu, Duo Zhang, Wei Xia, Yiqin Zhang, Linlin Jiang, Long Cui, Yinghui Ye, Yangfei Xiang, Junhao Hu, Jian Zhang, Chao-Po Lin
Summary: Ruptured ectopic pregnancy (REP) occurs when embryos aberrantly implant, invade deeply, and overgrow in the fallopian tubes, resulting in tube rupture and accounting for 4%-10% of pregnancy-related deaths. The lack of ectopic pregnancy phenotypes in rodents hinders our understanding of its pathological mechanisms. This study utilized cell culture and organoid models to investigate the interaction between human trophoblast development and intravillous vascularization in REP. The findings demonstrate the crucial role of WNT-mediated angiogenesis and provide insights into the intricate communication between trophoblasts and endothelial/endothelial progenitor cells using an organoid co-culture model.
Article
Pharmacology & Pharmacy
Qing-Yun Xie, Lu-Ping Huang, Feng-Wei Gao, Da-Qing Liu, Xia Wang, Kang-Yi Jiang, Jie Gong, Xin Zhao, Ben-Jian Gao, Ze-Hua Lei
Summary: This study investigated the therapeutic efficacy of lenvatinib combined with sequential TACE on primary HCC and its effects on serum bFGF and VEGF. The results showed that the combination treatment group had a higher objective response rate, lower serum bFGF and VEGF levels, and better survival rates.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Benjamin M. Kahn, Alfredo Lucas, Rohan G. Alur, Maximillian D. Wengyn, Gregory W. Schwartz, Jinyang Li, Kathryn Sun, H. Carlo Maurer, Kenneth P. Olive, Robert B. Faryabi, Ben Z. Stanger
Summary: Through studying the tumor vascular environment, the use of the endothelial index (EI) and vascular microenvironment signatures (VMS) can better assess tumor vascular density, which is associated with prognosis in certain cancer types. These findings suggest that these metrics may enable more precise deployment of antiangiogenesis therapy.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Medicine, Research & Experimental
Lei Xi
Summary: Ocular ischemia is a vision-threatening disease associated with various ocular diseases. This study investigated the effects of pigment epithelium derived factor (PEDF) and anti-vascular endothelial growth factor (anti-VEGF) therapy, as well as their combined use, on an ex vivo ischemic rat eye model. The results showed that the combination of PEDF and anti-VEGF significantly reduced the staining intensity of VEGF and GFAP, and decreased the number of TUNEL-positive nuclei, indicating its potential as a therapeutic strategy for ischemic retinal and choroidal diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Reproductive Biology
Kazuki Takasaki, Takayuki Ichinose, Yuko Miyagawa, Shiho Fukui, Kei Hashimoto, Haruka Nishida, Yuko Takahashi, Haruko Hiraike, Koji Saito, Yuko Sasajima, Kazunori Nagasaka
Summary: This study investigated two cases of granulosa cell tumors (GCTs) to find a biomarker for evaluating treatment and predicting recurrence. The findings suggest that serum vascular endothelial growth factor (VEGF) levels can be used as a clinical biomarker for disease progression in GCTs and to determine the efficacy of bevacizumab therapy.
JOURNAL OF OVARIAN RESEARCH
(2023)
Article
Multidisciplinary Sciences
Flavia A. Graca, Anna Stephan, Benjamin A. Minden-Birkenmaier, Abbas Shirinifard, Yong-Dong Wang, Fabio Demontis, Myriam Labelle
Summary: Skeletal muscle regeneration requires coordinated interactions between different cell types. Platelet-rich plasma has been widely used as an aid for muscle repair, but the specific role of platelets in regeneration remains unknown. This study shows that platelet-released chemokines play a crucial role in muscle repair by recruiting neutrophils to injured muscles in mice. The depletion of platelets reduces the levels of neutrophil chemoattractants, resulting in impaired neutrophil infiltration and compromised muscle regeneration.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, Research & Experimental
Andrei Radu Dan Cosnita, Marius Raica, Mihai Poenaru Sava, Anca Maria Cimpean
Summary: The study on gene expression profile of normal pig cornea revealed the lack of VEGFR2 and VEGFR3 gene expression, while MK2 and AKT1 genes were significantly overexpressed. Multiple genes in the PDGF pathway were also found to be overexpressed, indicating the avascular state of the cornea is related to the down-regulation of growth factor receptors.
Article
Multidisciplinary Sciences
Ju Tian, Xiong Jie Li, Yongshi Ma, Zhiming Mai, Yao Yang, Min Luo, Wenping Xu, Kui Chen, Xuri Chen, Jianbing Tang, Biao Cheng, Xiao Cui
Summary: This study compared the concentrations of bioactive components in platelet-rich plasma (PRP) derived from umbilical cord blood (UCB) and healthy female adults. UCB-derived PRP contained various active ingredients and showed potential as a research direction for anti-ageing therapy.
SCIENTIFIC REPORTS
(2023)
Letter
Medicine, General & Internal
Benjamin Sommer Thinggaard, Frederik Pedersen, Jakob Grauslund, Lonny Stokholm
Summary: This cohort study examines the use and forecast of intravitreal injections of vascular endothelial growth factor inhibitor in Denmark from 2007 through 2022.
Article
Clinical Neurology
Hanae Tainaka, Nagahide Takahashi, Tomoko Nishimura, Akemi Okumura, Taeko Harada, Toshiki Iwabuchi, Md Shafiur Rahman, Yoko Nomura, Kenji J. Tsuchiya
Summary: The study found that persistent postpartum depression is associated with children's internalizing problems, but the impact is not long-lasting as there was no association at 8-9 years old. There were no clear associations found between postpartum depression severity and children's internalizing and externalizing problems.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Multidisciplinary Sciences
Takeo Kato, Tomoko Nishimura, Nagahide Takahashi, Taeko Harada, Akemi Okumura, Toshiki Iwabuchi, Yoko Nomura, Atsushi Senju, Kenji J. Tsuchiya, Nori Takei
Summary: This study examines the stability of neurodevelopmental progress from infancy to early childhood and the risk factors associated with the descending transition patterns. The results show that maternal pre-pregnancy overweight, low maternal educational history, and infant overweight status at 18 months are associated with decelerated growth in neurodevelopment. Children with descending transition patterns exhibit poorer adaptive behaviors at 40 months.
SCIENTIFIC REPORTS
(2022)
Article
Psychiatry
Tomoko Nishimura, Takeo Kato, Akemi Okumura, Taeko Harada, Toshiki Iwabuchi, Md. Shafiur Rahman, Tomoya Hirota, Michio Takahashi, Masaki Adachi, Hitoshi Kuwabara, Shu Takagai, Yoko Nomura, Nagahide Takahashi, Atsushi Senju, Kenji J. Tsuchiya
Summary: This study investigated trajectory patterns and sex differences in adaptive behaviors in the general population. The results showed that there were differences between males and females in adaptive behaviors, with females scoring higher in the communication domain. In the daily living skills and socialization domains, males and females in the higher adaptive classes had similar trajectories, while in the lower adaptive behavior classes, females scored higher than males. Furthermore, different trajectories were found between females and males, suggesting the need for sex-specific adjustments when standardizing scores for better early detection of skill impairment.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychiatry
Toshiki Iwabuchi, Nagahide Takahashi, Tomoko Nishimura, Md Shafiur Rahman, Taeko Harada, Akemi Okumura, Hitoshi Kuwabara, Shu Takagai, Yoko Nomura, Hideo Matsuzaki, Norio Ozaki, Kenji J. Tsuchiya
Summary: The study found an association between umbilical cord leptin levels and autistic symptoms in children, while maternal metabolic conditions did not directly influence the outcome. Prenatal pro-inflammatory environments affected by maternal metabolic conditions may contribute to the development of autistic symptoms in children.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Endocrinology & Metabolism
Naoko Umeda, Takaharu Hirai, Takayo Ohto-Nakanishi, Kenji J. J. Tsuchiya, Hideo Matsuzaki
Summary: The study investigated the association between umbilical cord serum EpFA and low-birth-weight infants. Results showed significant correlations between linoleate diol concentrations and low-birth-weight. The study suggests that CYP and sEH involved in PUFA metabolism may influence infant birth weight.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Clinical Neurology
Tomoko Nishimura, Nagahide Takahashi, Akemi Okumura, Taeko Harada, Toshiki Iwabuchi, Chikako Nakayasu, Mohammad Shafiur Rahman, Satoshi Uchiyama, Manabu Wakuta, Yoko Nomura, Nori Takei, Atsushi Senju, Kenji J. Tsuchiya
Summary: This study aimed to explore early manifestations of autism spectrum disorders (ASD) in females and investigate sex differences in cognitive and motor functions and adaptive behaviors. The results showed that males with high autistic traits experienced a temporary decline in expressive language around the age of 2 years, while females in the high-autistic-trait group showed a downward trend in the adaptive behavior communication domain after 3.5 years. These findings suggest that females and males with higher autistic traits may have different phenotypes in certain neurodevelopmental domains during infancy and early childhood.
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2023)
Article
Multidisciplinary Sciences
Taeko Harada, Toshiki Iwabuchi, Atsushi Senju, Chikako Nakayasu, Ryuji Nakahara, Kenji J. Tsuchiya, Yoko Hoshi
Summary: The study found that rule selection, including prior evaluation of a stimulus, activated broader areas of the prefrontal and premotor regions than response selection based on a given rule.
SCIENTIFIC REPORTS
(2022)
Article
Pediatrics
Mika Sugiyama, Kenji J. Tsuchiya, Yusuke Okubo, Mohammad Shafiur Rahman, Satoshi Uchiyama, Taeko Harada, Toshiki Iwabuchi, Akemi Okumura, Chikako Nakayasu, Yuko Amma, Haruka Suzuki, Nagahide Takahashi, Barbara Kinsella-Kammerer, Yoko Nomura, Hiroaki Itoh, Tomoko Nishimura
Summary: This study explores the association between higher screen time at age 2 and neurodevelopmental outcomes at age 4, and whether outdoor play can mitigate this association. The findings suggest that more screen time is related to poorer communication skills, but frequent outdoor play can alleviate this effect. Outdoor play also has a mediating effect on daily living skills.
Article
Multidisciplinary Sciences
Kiran Acharya, Md. Shafiur Rahman, Md. Rashedul Islam, Stuart Gilmour, Bibha Dhungel, Rajendra P. P. Parajuli, Tomoko Nishimura, Atsushi Senju, Kenji J. J. Tsuchiya
Summary: Failure to meet early childhood developmental milestones can lead to difficulties in schooling and social functioning. This study examined the inequality in the prevalence of suspected developmental delays (SDD) among Nepalese children, focusing on socioeconomic and maternal education-based factors. The findings showed that the national prevalence of SDD was 34.8%, with higher rates in rural areas and Karnali Province. Poverty and low maternal education were identified as significant risk factors for SDD.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Masatoshi Yamashita, Kuriko Kagitani-Shimono, Yoshiyuki Hirano, Sayo Hamatani, Shota Nishitani, Akiko Yao, Sawa Kurata, Hirotaka Kosaka, Minyoung Jung, Tokiko Yoshida, Tsuyoshi Sasaki, Koji Matsumoto, Yoko Kato, Mariko Nakanishi, Masaya Tachibana, Ikuko Mohri, Kenji J. Tsuchiya, Tetsuya Tsujikawa, Hidehiko Okazawa, Eiji Shimizu, Masako Taniike, Akemi Tomoda, Yoshifumi Mizuno
Summary: This study aims to correct site differences in MRI scanners and clarify brain structure and network characteristics of children with ADHD and ASD using large samples collected in a multi-centre collaboration. Additionally, the relationship between these characteristics and genetic, epigenetic, biochemical markers, and behavioral and psychological measures will be investigated.
Letter
Pediatrics
Kenji J. Tsuchiya, Yusuke Okubo, Tomoko Nishimura
Article
Public, Environmental & Occupational Health
Naho Morisaki, Taku Obara, Aurelie Piedvache, Sumitaka Kobayashi, Chihiro Miyashita, Tomoko Nishimura, Mami Ishikuro, Fumihiro Sata, Reiko Horikawa, Chisato Mori, Hirohito Metoki, Kenji J. Tsuchiya, Shinichi Kuriyama, Reiko Kishi
Summary: This study examines the association between maternal smoking and hypertensive disorders in pregnancy and preeclampsia, and finds that the protective effects of smoking observed among Europeans and North Americans do not hold for the Japanese population.
JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Psychiatry
Nagahide Takahashi, Kenji J. Tsuchiya, Akemi Okumura, Taeko Harada, Toshiki Iwabuchi, Md Shafiur Rahman, Hitoshi Kuwabara, Yoko Nomura, Tomoko Nishimura
Summary: Using longitudinal cohort data, it was found that longer screen time in infancy was associated with increased genetic risk of autism spectrum disorder (ASD) and that an increase in screen time over time was associated with increased genetic risk of attention-deficit/hyperactivity disorder (ADHD). These findings suggest that prolonged screen time may not be a causal factor for genetic risk of neurodevelopmental disorders (NDDs), but rather an early sign of NDDs.
PSYCHIATRY RESEARCH
(2023)
Article
Pediatrics
Ippei Takahashi, Taku Obara, Mami Ishikuro, Keiko Murakami, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Genki Shinoda, Tomoko Nishimura, Kenji J. Tsuchiya, Shinichi Kuriyama
Summary: This study found that excessive screen time in 1-year-old children is associated with developmental delays in communication and problem-solving skills at the ages of 2 and 4.
Article
Immunology
Nagahide Takahashi, Tomoko Nishimura, Taeko Harada, Akemi Okumura, Toshiki Iwabuchi, Md Shafiur Rahman, Hitoshi Kuwabara, Shu Takagai, Noriyoshi Usui, Manabu Makinodan, Hideo Matsuzaki, Norio Ozaki, Hiroaki Itoh, Yoko Nomura, Jeffrey H. Newcorn, Kenji J. Tsuchiya
Summary: In this study, the relationship between perinatal inflammation and genetic risk for ADHD was examined in children aged 8-9. The results showed that perinatal inflammation and ADHD polygenic risk score (ADHD-PRS) were associated with ADHD symptoms, and there was an interaction between the two factors. The impact of perinatal inflammation on ADHD symptoms was particularly pronounced in children with a higher genetic risk for ADHD.
BRAIN, BEHAVIOR, & IMMUNITY - HEALTH
(2023)
Article
Clinical Neurology
Nadia Deflorin, Ulrike Ehlert, Rita T. Amiel Castro
Summary: Changes in the gut microbiome of infants have been associated with maternal psychological symptoms during pregnancy. This study found that maternal prenatal depressive symptoms are associated with lower diversity of the infant's microbiome, while maternal saliva cortisol levels are linked to increased diversity and changes in specific bacterial groups. Further research is needed to understand the implications of these microbiota alterations for child health.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zheng Ma, Hui-Xia Zhou, Da-Chun Chen, Dong-Mei Wang, Xiang-Yang Zhang
Summary: The impaired glucose metabolism in drug-na & iuml;ve schizophrenia patients is strongly associated with suicidal behavior, suggesting that glucose metabolism abnormalities may be potential biomarkers of suicide in schizophrenia patients. Regular monitoring of glucose metabolism variables is essential for suicide prevention.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Katie M. Lavigne, Jiaxuan Deng, Delphine Raucher-Chene, Adele Hotte-Meunier, Chloe Voyer, Lisa Sarraf, Martin Lepage, Genevieve Sauve
Summary: Psychiatric disorders are characterized by cognitive deficits and cognitive biases, which are associated with specific symptoms. While cognitive biases are present across diagnoses, their severity varies.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Yong-Yu Yin, Jiao-Zhao Yan, Shi-Xin Lai, Qian-Qian Wei, Si-Rui Sun, Li-Ming Zhang, Yun-Feng Li
Summary: This study found that gamma oscillations are closely associated with depression and may serve as predictive biomarkers of depression. Chronic restraint stress and lipopolysaccharide induced significant depression-like behaviors in mice and reduced gamma oscillations in the medial prefrontal cortex. Administration of ketamine, scopolamine, or fluoxetine increased gamma oscillations and exhibited rapid-acting antidepressant effects.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Veronica Begni, Moira Marizzoni, Kerstin Camile Creutzberg, Diana Morena Silipo, Mariusz Papp, Annamaria Cattaneo, Marco Andrea Riva
Summary: Exposure to stressful experiences is a significant risk factor for mental disorders, and pharmacological interventions targeting stress-induced alterations can help restore brain function. Lurasidone, an antipsychotic drug, has been shown to normalize the impairments caused by stress exposure and could be a valuable treatment for stress-induced mental illnesses. However, the mechanisms underlying the therapeutic effects of lurasidone are not well understood. This study found that chronic lurasidone treatment counteracted some of the transcriptional changes induced by chronic mild stress exposure, providing new insights into the potential therapeutic effects of lurasidone.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Esther E. Palacios-Barrios, Kunal Patel, Jamie L. Hanson
Summary: This review examines the association between early life interpersonal stress (ELIS) and depression, as well as the underlying mechanisms. The research shows that ELIS affects how youth respond to social rewards, and similar impairments in social reward processing are observed in youth with depression. The authors propose a preliminary model that suggests neurobehavioral disruptions in social reward processing as a mediating factor in the connection between ELIS and depression.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Rui Li, Jiaming Tang, Yizhuo Wang, Ying Wang, Hua Yang, Hongen Wei
Summary: Restricted and repetitive behaviors (RRBs) are characteristic features of neuropsychiatric disorders. This study focused on repetitive self-grooming behavior and investigated the involvement of the Pax2 gene in its control. Through the use of Pax2 neuron-specific deletion mice, the study found that the deletion of Pax2 gene affects the expression of the Arc gene in the prefrontal cortex, leading to impaired synaptic plasticity and excitatory/inhibitory imbalance, thereby contributing to the occurrence of repetitive self-grooming behavior.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Sara Derosa, Paulina Misztak, Jessica Mingardi, Giulia Mazzini, Heidi Kaastrup Muller, Laura Musazzi
Summary: This study investigated the involvement of neurotrophic signaling pathways in stress vulnerability/resilience and fast antidepressant response/non-response to ketamine in a rat model of depression. The findings showed that stress and ketamine induced specific changes in these pathways in different brain areas and subcellular fractions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Georgia F. Caruana, Sean P. Carruthers, Michael Berk, Susan L. Rossell, Tamsyn E. Van Rheenen
Summary: Cognitive impairment is related to both white matter macrostructure and microstructure in bipolar disorder patients. However, there is inconsistency in the results of the studies examining this relationship. Some studies have found an association between higher fractional anisotropy in white matter and better complex attention skills and executive functioning in bipolar disorder patients, while others have found no associations. Further research with increased statistical power and standardized methods is needed.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Alberto Galimberti, Martin Tik, Giovanni Pellegrino, Anna-Lisa Schuler
Summary: This study provides a systematic review and meta-analysis on the effectiveness of repetitive transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) for post-traumatic brain injury (TBI) symptoms. The results show that non-invasive brain stimulation techniques have a small overall effect on TBI sequelae, with significant effects observed for anxiety and headache. However, larger randomized controlled trials with longer follow-ups, optimized stimulation parameters, and standardized methodology are needed to establish the efficacy of these techniques in addressing TBI sequelae.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Amanda J. Sales, Pedro H. Gobira, Joa F. C. Pedrazzi, Joao R. Silveia, Elaine Del Bel, Felipe V. Gomes, Francisco S. Guimaraes
Summary: The study found that doxycycline can inhibit metalloproteinase in the brain and attenuate the rewarding effects and locomotor sensitization of drug abuse. This suggests that doxycycline could be repurposed for the treatment of substance use disorders.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Alejandro Borrego-Ruiz, Juan J. Borrego
Summary: There is substantial evidence that the development of the nervous system is related to the composition and functions of the gut microbiome. The communication between the central nervous system (CNS) and the gut microbiota is bidirectional, with various routes such as immune, endocrine, and neural circuits. Dysbiosis of the gut microbiota has been associated with neuropsychiatric diseases and psychological disorders. Fecal microbiota transplantation (FMT) therapy has shown a causal-effect relationship between the gut microbiota and behavioral features. Interventions based on prebiotics, probiotics, or synbiotics have demonstrated their influence on neurological disorders through the synthesis of neuroactive compounds and regulation of inflammatory and endocrine processes. Further research is needed to explore the impact of gut microbiota dysbiosis on psychiatric and psychological disorders and the potential therapeutic role of microbiota-based interventions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zhinan Li, Zhuang Kang, Xiaowei Xia, Leijun Li, Junyan Wu, Jiamin Dai, Tong Liu, Cai Chen, Yong Qiu, Ming Chen, Yanxi Liu, Ziyi Zhang, Zili Han, Zhengjia Dai, Qinling Wei
Summary: This study found that patients with schizophrenia showed lower levels of resilience and cognitive functions compared to healthy controls, as well as abnormal global properties and nodal metrics in brain networks. Furthermore, characteristic path length might moderate the relationship between resilience and working memory in these patients.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
David H. Adamowicz, Tsung-Chin Wu, Rebecca Daly, Michael R. Irwin, Dilip Jeste, Xin M. Tu, Lisa T. Eyler, Ellen E. Lee
Summary: This study aimed to explore the relationship between executive functioning and inflammatory biomarkers in people with schizophrenia. The results showed that systemic inflammation did not predict long-term declines in executive functioning. This suggests the need for further research to better understand the relationship and mechanisms between inflammation and cognition in schizophrenia.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Nina Walter, Julian Wenzel, Shalaila S. Haas, Letizia Squarcina, Carolina Bonivento, Anne Ruef, Dominic Dwyer, Theresa Lichtenstein, Oeznur Bastruek, Alexandra Stainton, Linda A. Antonucci, Paolo Brambilla, Stephen J. Wood, Rachel Upthegrove, Stefan Borgwardt, Rebekka Lencer, Eva Meisenzahl, Raimo K. R. Salokangas, Christos Pantelis, Alessandro Bertolino, Nikolaos Koutsouleris, Joseph Kambeitz, Lana Kambeitz-Ilankovic
Summary: Clinical and neuroimaging data can be used to predict the potential of cognitive training to improve social functioning in recent onset psychosis patients. The use of multivariate pattern analysis and support vector machine classifier allows for the prediction of social functioning improvement based on baseline cognitive data. The findings suggest that cognitive data can provide a robust individual estimate of future social functioning for patients with recent onset psychosis.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)