期刊
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
卷 34, 期 8, 页码 1484-1490出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pnpbp.2010.08.009
关键词
CCK; CCKB; Clozapine; Olanzapine; Weight gain; Association
资金
- Abbott Labs
- ACADIA
- Bristol Myers Squibb
- Eli Lilly
- Jansse
- Pfizer
- Astra Zeneca
- Glaxo Smith Kline
- Memory
- Cephalon
- Minster
- Aryx
- BiolineRx
- AstraZeneca
- Forest
- Janssen
- Novartis
- Solvay
- Centre for Addiction and Mental Health Canadian Institutes of Health Research (CIHR)
- Canadian Institutes of Health Research [MOP89853, MOP15007]
- NARSAD
- Prentiss Foundation
- Ritter Foundation
- Hintz family
- Peterson Family
- Bebensee Foundation
Cholecystokinin (CCK) gene and its receptors play an important role in several biological processes including satiety signaling. Administration of exogenous or endogenously secreted CCK leads to decreased food intake in both rats and humans. Similarly, in rats pretreated with intraperitoneal CCK, antagonists of the CCKA receptor prevent decrease in food intake. The CCKB receptor plays an important role in anxiety and gastric acid secretion. We investigated the role of polymorphisms in the CCK gene (2 SNPs) and its receptors CCKA (4 SNPs) and CCKB (4SNPs, 1 microsatellite, an) in antipsychotic induced weight gain (n = 215). Weight change (%) from baseline was compared across genotypic groups using analysis of covariance. In the European ancestry patients treated with clozapine or olanzapine a trend of association was observed with the SNP rs2929183 (p = 0.10) in CCKBR gene. Carriers of the genotype AA (3.23% +/- 4.8) gained less weight than the AG and GG genotypes (6.50% +/- 6.5; p = 0.035). A similar trend was observed for the CTn repeat, where carriers of the LL genotype gained less weight (3.73% +/- 5.41) than the S allele carrying genotypes (6.29% +/- 6.2, p = 0.05). In the subjects of African ancestry we observed similar marginal association although with the opposite allele. However, none of these observations would survive corrections for multiple testing. None of the other polymorphisms in either CCK or CCKA receptor genes was associated with weight change (%). In conclusion, CCKB receptor gene may play a role in antipsychotic induced weight gain. However, these observations need to be replicated in a larger and independent sample set. (C) 2010 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据