Review
Zoology
Ming Li
Summary: This paper proposes that the lateral habenula (LHb) acts as an interface between the stress response system and maternal neural network, transmitting stress signals to the neural circuitry that mediates maternal behavior. The hypothesis suggests that maternal stress affects LHb and its downstream targets, compromising maternal care and contributing to postpartum mental disorders. Confirmation of this hypothesis is expected to enhance our understanding of the neurocircuit mechanisms mediating stress effects on maternal behavior.
ZOOLOGICAL RESEARCH
(2022)
Article
Neurosciences
Heming Cheng, Yingbei Qi, Nanxi Lai, Lin Yang, Cenglin Xu, Shuang Wang, Yi Guo, Zhong Chen, Yi Wang
Summary: Inhibition of hyperactivity of DR 5-HTergic neuron may present promising anti-seizure effect, and DR may be a potential DBS target for the therapy of TLE.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Neurosciences
Matthew E. Glover, Keaton A. Unroe, Mohamad M. Moughnyeh, Chelsea McCoy, Ilan A. Kerman, Sarah M. Clinton
Summary: Serotonin plays a crucial role in regulating various functions and neurodevelopmental processes, and its genetic and environmental factors can have an impact on brain structure and behavior, potentially contributing to neuropsychiatric disorders.
NEUROSCIENCE LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Noam Schneck, Tao Tu, Harry Rubin Falcone, Jeffrey M. Miller, Francesca Zanderigo, M. Elizabeth Sublette, Maria A. Oquendo, Barbara Stanley, Ainsley Burke, Kevin Ochsner, Paul Sajda, J. John Mann
Summary: The study found that patients with major depressive disorder (MDD) exhibit specific connectivity patterns between brain regions during the viewing of negative images, which differ from healthy volunteers. In MDD patients, hippocampal signaling inhibits other regions involved in processing negative emotions, and this inhibition is related to hippocampal 5-HT1A receptor binding, but not raphe 5-HT1A binding.
MOLECULAR PSYCHIATRY
(2021)
Article
Endocrinology & Metabolism
Zachary A. Grieb, Emma G. Ford, Mahircan Yagan, Billy Y. B. Lau, Fredric P. Manfredsson, Keerthi Krishnan, Joseph S. Lonstein
Summary: Oxytocin receptors in the midbrain dorsal raphe have been identified as a potential target for treating psychiatric disorders, but their role in female social and affective behaviors postpartum is largely unknown. Knockdown of OTRs in the maternal DR resulted in pup loss, decreased nursing, increased aggression, and behavioral despair, suggesting the importance of OTRs in midbrain DR for postpartum maternal behaviors and cortical plasticity.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Pharmacology & Pharmacy
Aitziber Mendiguren, Erik Aostri, Irati Rodilla, Iker Pujana, Ekaterina Noskova, Joseba Pineda
Summary: The pharmacological profile of cannabigerol (CBG), particularly its effect on alpha(2)-adrenoceptor and 5-HT1A receptor, is poorly understood. In this study, male Sprague-Dawley rat brain slices were used to investigate the impact of CBG on firing rate of LC NA cells and DRN 5-HT cells, as well as its interaction with alpha(2)-adrenergic and 5-HT1A autoreceptors. CBG was also evaluated for its anxiolytic-like effects using behavior tests. The findings indicate that CBG inhibits the suppressive effects of alpha(2)-adrenoceptor and 5-HT1A receptor agonists on NA-LC and 5-HT-DRN neurons, and produces anxiolytic-like effects through the 5-HT1A receptor.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Engineering, Biomedical
Canwen Wu, Jiaru He, Yiyue Zhu, Junwei Wu, Yan Chen, Maodan Yuan, Zhongwen Cheng, Lvming Zeng, Xuanrong Ji
Summary: This study aimed to investigate whether transcranial ultrasound stimulation (TUS) can ameliorate depression with anxiety in mice by regulating brain monoamine levels. Results showed that TUS effectively improved depression and anxiety-like behaviors by increasing 5-HT levels and decreasing NE levels.
JOURNAL OF NEURAL ENGINEERING
(2023)
Article
Immunology
Kanza M. Khan, Gabrielle Bierlein-De La Rosa, Natalie Biggerstaff, Govindhasamy Pushpavathi Selvakumar, Ruixiang Wang, Suzanne Mason, Michael E. Dailey, Catherine A. Marcinkiewcz
Summary: Adolescent alcohol use can permanently alter brain function and lead to poor health outcomes in adulthood. Emerging evidence suggests that alcohol use can predispose individuals to pain disorders or exacerbate existing pain conditions, but the underlying neural mechanisms are currently unknown.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Psychology, Developmental
Wanjiku F. M. Njoroge, Emily D. Gerstein, Rachel E. Lean, Rachel Paul, Christopher D. Smyser, Cynthia E. Rogers
Summary: This study aimed to examine distress profiles of mothers of preterm infants in the neonatal intensive care unit (NICU) and their relationship to maternal and child outcomes at child age 5 years. The results revealed four distinct maternal profiles: low symptomatology, high NICU stress, high depression and anxiety, and high state anxiety. Social determinants of health factors were found to distinguish these profiles. Mothers in the high depression and anxiety profile reported more anxiety and life stress at follow-up, and their children experienced more anxious/depressed symptoms.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Amina Benhadda, Celia Delhaye, Imane Moutkine, Xavier Marques, Marion Russeau, Corentin Le Magueresse, Anne Roumier, Sabine Levi, Luc Maroteaux
Summary: Many psychiatric diseases are associated with dysfunction of serotonin (5-HT) neurons. This study shows that 5-HT1A and 5-HT2B receptors can form heterodimers and co-cluster at the plasma membrane of dendrites. Stimulation of these receptors prevents 5-HT1A receptor internalization and increases 5-HT2B receptor membrane clustering, regulating the excitability of serotonergic neurons.
Article
Endocrinology & Metabolism
Jing He, Jing-Jing Yan, Xi Zha, Xiao-Jing Ding, Yan-li Zhang, Zheng Lu, Xiao-Hong Xu
Summary: Sex differences in emotional behaviors and affective disorders are influenced by gonadal steroid hormones. This study reveals the role of estrogen receptor 2 (Esr2) in the dorsal raphe nucleus (DRN) in regulating emotional behaviors, showing sex-specific effects on anxiety and depression-like behaviors. Targeted manipulation of DRN Esr2 signaling may provide a potential therapeutic strategy for sex-biased affective disorders.
JOURNAL OF NEUROENDOCRINOLOGY
(2023)
Article
Neurosciences
Sitong Li, Xinxin Zhang, Yueqin Liu, Zonghui Shan, Hanxiao Liu, Wei Wu, Yupeng Yang
Summary: Maternal separation in mammals has been found to impact the brain structure and function in various regions, but its effect on visual system development is not well understood. This study used a mouse model and found that maternal separation delayed the opening of the critical period for ocular dominance plasticity in female mice, but not in males. It also extended the closure of the critical period in both sexes. Only female mice that experienced maternal separation maintained a juvenile-like ocular dominance plasticity into adulthood.
NEUROSCIENCE LETTERS
(2022)
Article
Psychology, Biological
Tamires Gregorio, Flaviano Lorenzon, Fernanda Niebisch, Rafaela Carla Kachel Stolte, Alex Rafacho, Gustavo Jorge dos Santos, Cilene Lino de Oliveira, Fernanda Barbosa Lima
Summary: Overexposure to glucocorticoids during gestation can lead to long-term mental disorders, and this study investigates the effects of late gestational administration of dexamethasone and vitamin D on depressive-like behavior in adult female rats. The results show that prenatal vitamin D and dexamethasone can affect sucrose preference, and prenatal vitamin D has an antidepressant-like effect in rats overexposed to dexamethasone, although this effect is blunted at a later stage. The protein content of certain receptors in the dorsal raphe nucleus is also affected by prenatal dexamethasone exposure. The study concludes that prenatal overexposure to dexamethasone can modify the effects of prenatal vitamin D on depressive behavior in a time-dependent manner, and these effects are not related to alterations in the serotonergic system or glucocorticoid receptor expression in the dorsal raphe nucleus.
PHYSIOLOGY & BEHAVIOR
(2022)
Article
Neurosciences
Burak Yaman, Ramazan Bal
Summary: This study suggests that pindolol may enhance the antidepressant effect of venlafaxine by inhibiting the response of DRN neurons to 5-HT, leading to reduced immobility time in mice. Therefore, pindolol has the potential to prevent the inhibition of serotonergic neurons after antidepressant use, making it a promising addition to mood disorder treatment.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2021)
Article
Behavioral Sciences
Yue-Ming Zhang, Meng-Ying Zhang, Ru-Meng Wei, Jing-Ya Zhang, Kai-Xuan Zhang, Bao-Ling Luo, Yi-Jun Ge, Xiao-Yi Kong, Xue-Yan Li, Gui-Hai Chen
Summary: ObjectiveStudies have shown that prenatal exposure to inflammation increases the risk of neuropsychiatric disorders, while pregnant women often experience sleep dysfunction. This study aimed to investigate the effects of maternal sleep deprivation on prenatal inflammation exposure-induced behavioral phenotypes in offspring, as well as the underlying mechanisms.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Matthieu Colom, Nicolas Costes, Jerome Redoute, Frederic Dailler, Florent Gobert, Didier Le Bars, Thierry Billard, Adrian Newman-Tancredi, Luc Zimmer
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2020)
Article
Neurosciences
Benjamin Vidal, Radu Bolbos, Jerome Redoute, Jean-Baptiste Langlois, Nicolas Costes, Adrian Newman-Tancredi, Luc Zimmer
Article
Physiology
Benjamin Portal, Sarah Delcourte, Renaud Rovera, Camille Lejards, Sebastien Bullich, Cecile E. Malnou, Nasser Haddjeri, Nicole Deglon, Bruno P. Guiard
Article
Radiology, Nuclear Medicine & Medical Imaging
Stephane Emery, Sylvain Fieux, Benjamin Vidal, Pierre Courault, Sandrine Bouvard, Christian Tourvieille, Thibaut Iecker, Thierry Billard, Luc Zimmer, Sophie Lancelot
NUCLEAR MEDICINE AND BIOLOGY
(2020)
Article
Neurosciences
Benjamin Vidal, Marine Droguerre, Ludovic Venet, Luc Zimmer, Marco Valdebenito, Franck Mouthon, Mathieu Charveriat
Review
Pharmacology & Pharmacy
Pierre Courault, Genevieve Demarquay, Luc Zimmer, Sophie Lancelot
Summary: Cluster headache is the most common form of trigeminal autonomic cephalalgia, with current treatments having limitations and new drugs required. Research is limited by lack of knowledge of pathophysiology and lack of animal models, with no brand-new treatment emerging in the past 5 years, but promising drugs under study.
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2021)
Review
Psychiatry
Oriane Razakarivony, Adrian Newman-Tancredi, Luc Zimmer
Summary: The PET neuroimaging study targeting the 5-HT1A receptor can specifically visualize and quantify functionally active receptors using a specific radioligand [F-18]-F13640, helping researchers to track receptor changes and correlate them with disease states. This approach has the potential to improve differentiation of different schizophrenia phenotypes and deepen understanding of the basis of therapeutic responses.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Neurosciences
Matthieu Colom, Benjamin Vidal, Sylvain Fieux, Jerome Redoute, Nicolas Costes, Franck Lavenne, Ines Merida, Zacharie Irace, Thibaud Iecker, Caroline Bouillot, Thierry Billard, Adrian Newman-Tancredi, Luc Zimmer
Summary: The study evaluated the sensitivity of the radiopharmaceutical [F-18]F13640 to endogenous serotonin release, demonstrating its effectiveness in measuring neurotransmitter fluctuations but highlighting the importance of longer PET scans for accurate displacement measurements.
FRONTIERS IN NEUROSCIENCE
(2021)
Editorial Material
Pharmacology & Pharmacy
Luc Zimmer
Summary: Neuropharmacology studies the effects of drugs on the central nervous system, with recent developments focusing on the clinical application of psychopharmacology and exploration of neurotransmission.
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2021)
Article
Neurosciences
Marine Droguerre, Benjamin Vidal, Marco Valdebenito, Franck Mouthon, Luc Zimmer, Mathieu Charveriat
Summary: This study used functional ultrasound imaging to investigate the neural activity and functional connectivity changes in an ADHD animal model. The results revealed abnormal neural activity and altered connectivity patterns, providing insights into the pathophysiology of ADHD. The study also demonstrated the potential of functional ultrasound imaging as a translational tool in ADHD research.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Benjamin Vidal, Mickael Pereira, Marco Valdebenito, Louis Vidal, Franck Mouthon, Luc Zimmer, Mathieu Charveriat, Marine Droguerre
Summary: This study utilized functional ultrasound neuroimaging to monitor the effects of donepezil in a scopolamine-induced mouse model of cognitive impairment. The results demonstrated that scopolamine decreased functional connectivity between brain areas, while donepezil counteracted this effect.
JOURNAL OF PSYCHOPHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Sarah Delcourte, Amel Bouloufa, Renaud Rovera, Cecile Betry, Erika Abrial, Ouria Dkhissi-Benyahya, Christophe Heinrich, Guillaume Marcy, Olivier Raineteau, Nasser Haddjeri, Guillaume Lucas, Adeline Etievant
Summary: This study reveals the significant role of prefrontal cortex astroglia in memory performance and synaptic plasticity.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Editorial Material
Neurosciences
Benjamin Vidal, Luc Zimmer
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Caroline Bouillot, Sebastien Daligault, Radu Bolbos, Nicolas Costes, Luc Zimmer
Summary: This study designed a low-cost support system for simultaneous dynamic PET scanning of two lying rats and found that it does not affect brain image quantification. The dual support system can reduce the cost and duration of the experiment.
Meeting Abstract
Pharmacology & Pharmacy
Pierre Courault, Sophie Lancelot, Nicolas Costes, Jerome Redoute, Adrian Newman-Tancredi, Ines Merida, Luc Zimmer
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Clinical Neurology
Nadia Deflorin, Ulrike Ehlert, Rita T. Amiel Castro
Summary: Changes in the gut microbiome of infants have been associated with maternal psychological symptoms during pregnancy. This study found that maternal prenatal depressive symptoms are associated with lower diversity of the infant's microbiome, while maternal saliva cortisol levels are linked to increased diversity and changes in specific bacterial groups. Further research is needed to understand the implications of these microbiota alterations for child health.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zheng Ma, Hui-Xia Zhou, Da-Chun Chen, Dong-Mei Wang, Xiang-Yang Zhang
Summary: The impaired glucose metabolism in drug-na & iuml;ve schizophrenia patients is strongly associated with suicidal behavior, suggesting that glucose metabolism abnormalities may be potential biomarkers of suicide in schizophrenia patients. Regular monitoring of glucose metabolism variables is essential for suicide prevention.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Katie M. Lavigne, Jiaxuan Deng, Delphine Raucher-Chene, Adele Hotte-Meunier, Chloe Voyer, Lisa Sarraf, Martin Lepage, Genevieve Sauve
Summary: Psychiatric disorders are characterized by cognitive deficits and cognitive biases, which are associated with specific symptoms. While cognitive biases are present across diagnoses, their severity varies.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Yong-Yu Yin, Jiao-Zhao Yan, Shi-Xin Lai, Qian-Qian Wei, Si-Rui Sun, Li-Ming Zhang, Yun-Feng Li
Summary: This study found that gamma oscillations are closely associated with depression and may serve as predictive biomarkers of depression. Chronic restraint stress and lipopolysaccharide induced significant depression-like behaviors in mice and reduced gamma oscillations in the medial prefrontal cortex. Administration of ketamine, scopolamine, or fluoxetine increased gamma oscillations and exhibited rapid-acting antidepressant effects.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Veronica Begni, Moira Marizzoni, Kerstin Camile Creutzberg, Diana Morena Silipo, Mariusz Papp, Annamaria Cattaneo, Marco Andrea Riva
Summary: Exposure to stressful experiences is a significant risk factor for mental disorders, and pharmacological interventions targeting stress-induced alterations can help restore brain function. Lurasidone, an antipsychotic drug, has been shown to normalize the impairments caused by stress exposure and could be a valuable treatment for stress-induced mental illnesses. However, the mechanisms underlying the therapeutic effects of lurasidone are not well understood. This study found that chronic lurasidone treatment counteracted some of the transcriptional changes induced by chronic mild stress exposure, providing new insights into the potential therapeutic effects of lurasidone.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Esther E. Palacios-Barrios, Kunal Patel, Jamie L. Hanson
Summary: This review examines the association between early life interpersonal stress (ELIS) and depression, as well as the underlying mechanisms. The research shows that ELIS affects how youth respond to social rewards, and similar impairments in social reward processing are observed in youth with depression. The authors propose a preliminary model that suggests neurobehavioral disruptions in social reward processing as a mediating factor in the connection between ELIS and depression.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Rui Li, Jiaming Tang, Yizhuo Wang, Ying Wang, Hua Yang, Hongen Wei
Summary: Restricted and repetitive behaviors (RRBs) are characteristic features of neuropsychiatric disorders. This study focused on repetitive self-grooming behavior and investigated the involvement of the Pax2 gene in its control. Through the use of Pax2 neuron-specific deletion mice, the study found that the deletion of Pax2 gene affects the expression of the Arc gene in the prefrontal cortex, leading to impaired synaptic plasticity and excitatory/inhibitory imbalance, thereby contributing to the occurrence of repetitive self-grooming behavior.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Sara Derosa, Paulina Misztak, Jessica Mingardi, Giulia Mazzini, Heidi Kaastrup Muller, Laura Musazzi
Summary: This study investigated the involvement of neurotrophic signaling pathways in stress vulnerability/resilience and fast antidepressant response/non-response to ketamine in a rat model of depression. The findings showed that stress and ketamine induced specific changes in these pathways in different brain areas and subcellular fractions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Georgia F. Caruana, Sean P. Carruthers, Michael Berk, Susan L. Rossell, Tamsyn E. Van Rheenen
Summary: Cognitive impairment is related to both white matter macrostructure and microstructure in bipolar disorder patients. However, there is inconsistency in the results of the studies examining this relationship. Some studies have found an association between higher fractional anisotropy in white matter and better complex attention skills and executive functioning in bipolar disorder patients, while others have found no associations. Further research with increased statistical power and standardized methods is needed.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Alberto Galimberti, Martin Tik, Giovanni Pellegrino, Anna-Lisa Schuler
Summary: This study provides a systematic review and meta-analysis on the effectiveness of repetitive transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) for post-traumatic brain injury (TBI) symptoms. The results show that non-invasive brain stimulation techniques have a small overall effect on TBI sequelae, with significant effects observed for anxiety and headache. However, larger randomized controlled trials with longer follow-ups, optimized stimulation parameters, and standardized methodology are needed to establish the efficacy of these techniques in addressing TBI sequelae.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Amanda J. Sales, Pedro H. Gobira, Joa F. C. Pedrazzi, Joao R. Silveia, Elaine Del Bel, Felipe V. Gomes, Francisco S. Guimaraes
Summary: The study found that doxycycline can inhibit metalloproteinase in the brain and attenuate the rewarding effects and locomotor sensitization of drug abuse. This suggests that doxycycline could be repurposed for the treatment of substance use disorders.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Alejandro Borrego-Ruiz, Juan J. Borrego
Summary: There is substantial evidence that the development of the nervous system is related to the composition and functions of the gut microbiome. The communication between the central nervous system (CNS) and the gut microbiota is bidirectional, with various routes such as immune, endocrine, and neural circuits. Dysbiosis of the gut microbiota has been associated with neuropsychiatric diseases and psychological disorders. Fecal microbiota transplantation (FMT) therapy has shown a causal-effect relationship between the gut microbiota and behavioral features. Interventions based on prebiotics, probiotics, or synbiotics have demonstrated their influence on neurological disorders through the synthesis of neuroactive compounds and regulation of inflammatory and endocrine processes. Further research is needed to explore the impact of gut microbiota dysbiosis on psychiatric and psychological disorders and the potential therapeutic role of microbiota-based interventions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zhinan Li, Zhuang Kang, Xiaowei Xia, Leijun Li, Junyan Wu, Jiamin Dai, Tong Liu, Cai Chen, Yong Qiu, Ming Chen, Yanxi Liu, Ziyi Zhang, Zili Han, Zhengjia Dai, Qinling Wei
Summary: This study found that patients with schizophrenia showed lower levels of resilience and cognitive functions compared to healthy controls, as well as abnormal global properties and nodal metrics in brain networks. Furthermore, characteristic path length might moderate the relationship between resilience and working memory in these patients.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
David H. Adamowicz, Tsung-Chin Wu, Rebecca Daly, Michael R. Irwin, Dilip Jeste, Xin M. Tu, Lisa T. Eyler, Ellen E. Lee
Summary: This study aimed to explore the relationship between executive functioning and inflammatory biomarkers in people with schizophrenia. The results showed that systemic inflammation did not predict long-term declines in executive functioning. This suggests the need for further research to better understand the relationship and mechanisms between inflammation and cognition in schizophrenia.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Nina Walter, Julian Wenzel, Shalaila S. Haas, Letizia Squarcina, Carolina Bonivento, Anne Ruef, Dominic Dwyer, Theresa Lichtenstein, Oeznur Bastruek, Alexandra Stainton, Linda A. Antonucci, Paolo Brambilla, Stephen J. Wood, Rachel Upthegrove, Stefan Borgwardt, Rebekka Lencer, Eva Meisenzahl, Raimo K. R. Salokangas, Christos Pantelis, Alessandro Bertolino, Nikolaos Koutsouleris, Joseph Kambeitz, Lana Kambeitz-Ilankovic
Summary: Clinical and neuroimaging data can be used to predict the potential of cognitive training to improve social functioning in recent onset psychosis patients. The use of multivariate pattern analysis and support vector machine classifier allows for the prediction of social functioning improvement based on baseline cognitive data. The findings suggest that cognitive data can provide a robust individual estimate of future social functioning for patients with recent onset psychosis.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
