Article
Neurosciences
Christian Baeuchl, Franka Gloeckner, Christoph Koch, Johannes Petzold, Nicolas W. Schuck, Michael N. Smolka, Shu-Chen Li
Summary: The aging process leads to changes in spatial navigation behavior, with older adults relying more on proximal location cues instead of environmental boundaries. Deficient dopaminergic modulation may contribute to errors during spatial navigation in older adults. Administering levodopa in young and older adults affected brain responses and memory retrieval differently, with older adults showing upregulation in the medial temporal lobe and brainstem. While L-DOPA had no effect on older adults' overall memory performance, it improved spatial memory and increased boundary processing in some individuals.
Review
Behavioral Sciences
Sang Ah Lee
Summary: Our minds are constantly travelling through time and space, organizing memories into contexts and episodes. This paper reviews evidence suggesting that spatial boundary representations play a crucial role in structuring both spatial and temporal memories. The connection between hippocampal spatial mapping and temporal sequencing of episodic memory highlights the relationship between navigational mechanisms and cognitive processes like mental time travel and conceptual mapping, which are shared by humans and nonhuman animals. Understanding hippocampal function across species provides insights into the origins of uniquely human cognitive abilities.
Article
Neurosciences
Minjae Kwon, Sang Wan Lee, Sue-Hyun Lee
Summary: The hippocampus is involved in both integration and separation processes during associative memory formation. These processes have different temporal dynamics, with integration being prominent in the anterior hippocampus and separation being obvious in the posterior hippocampus. These findings demonstrate the dynamic hippocampal processing during learning that contributes to the maintenance of associative memory.
HUMAN BRAIN MAPPING
(2023)
Article
Neurosciences
Bethany E. Frost, Sean K. Martin, Matheus Cafalchio, Md Nurul Islam, John P. Aggleton, Shane M. O'Mara
Summary: Lesions affecting the anterior thalamic nuclei may be responsible for diencephalic amnesia, similar to how hippocampal lesions cause temporal lobe amnesia. The core element of diencephalic amnesia seems to be the loss of information in hippocampal output regions following anterior thalamic pathology, possibly due to the direct connections between the two areas.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Jeremy M. Wolfe, Farahnaz A. Wick, Maruti Mishra, Joseph DeGutis, Wanyi Lyu
Summary: It is well known that humans have a massive memory for pictures and scenes. In addition, three experiments show that humans have a spatial massive memory for where stimuli have been seen and a temporal massive memory for when stimuli have been seen. Previous work has suggested good memory for stimulus location, but there have been no concerted efforts to measure the extent of this memory. Moreover, our method involves recalling item locations rather than just recognizing the correct location, which is interesting.
Article
Environmental Sciences
Mohsen Shamsi, Maliheh Soodi, Shirin Shahbazi, Ameneh Omidi
Summary: The study found that Acetamiprid reduces glutamate levels, affects the expression of NMDA receptor subunits in the hippocampus, leading to impaired memory consolidation at low doses, and loss of neural cells in the dentate gyrus area at high doses.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Multidisciplinary Sciences
Larry R. Squire, Jennifer C. Frascino, Charlotte S. Rivera, Nadine C. Heyworth, Biyu J. He
Summary: One-trial, long-lasting perceptual learning relies on hippocampus-independent (nondeclarative) memory, independent of any requirement to consciously remember. Patients with hippocampal lesions or larger medial temporal lobe (MTL) lesions show intact perceptual learning but impaired memory for the images presented.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Neurosciences
Darya Frank, Alex Kafkas, Daniela Montaldi
Summary: The brain efficiently processes information by shifting between encoding and retrieval states and triggering an adaptive encoding mechanism when encountering unexpected events, enhancing memory for future related events.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Psychology, Experimental
Xing Xing, Jeffrey A. Saunders
Summary: This study tested whether connections between non-spatial properties can distort judgments about spatial distance. The results showed that similar houses were drawn closer on reconstructed maps, and pairwise distance judgments were smaller for similar houses. These findings support theories that space is represented with other properties, suggesting that the mechanism for encoding space in the hippocampal-entorhinal system has a broader function.
Article
Environmental Sciences
Pilar Simmons, Christa Corley, Antino R. Allen
Summary: Understanding the effects of H-1 exposure on hippocampal-dependent cognition is crucial for developing protective strategies for future missions. Research on female mice subjected to H-1 irradiation showed no impairment in spatial or short-term memory.
Review
Neurosciences
Cen Yang, He Chen, Yuji Naya
Summary: For living organisms, acquiring information about the external space is crucial for future actions. This review focuses on the brain mechanisms in nonhuman primates that link self-referenced and allocentric spatial representations. It proposes two types of neural substrates - view-center background signals and hippocampal neurons' dynamic activity - that facilitate the translation of stored location memory from an allocentric frame to a first-person perspective.
Article
Neurosciences
Anna-Maria Grob, Branka Milivojevic, Arjen Alink, Christian F. Doeller, Lars Schwabe
Summary: Memories are not stored in isolation. Insight into the relationship of initially unrelated events may trigger a flexible reconfiguration of the mnemonic representation of these events. However, stress impairs this process and leads to fragmented memories in PTSD. In this study, acute stress was found to reduce brain activity and disrupt the reconfiguration of memories, but interestingly, it enhanced long-term memory performance. These findings have implications for understanding memory distortions in stress-related mental disorders.
Review
Neurosciences
Leah G. Mann, Daniel O. Claassen
Summary: Dopamine plays a crucial role not only in pleasure, reward, and affect, but also in proficient action control. The mesolimbic pathway, connecting regions such as the hippocampus and amygdala to the motor cortex via the substantia nigra and thalamus, has been less studied compared to the nigrostriatal pathway. Dopaminergic activity in the mesial temporal lobe is involved in memory, impulsivity, and emotional regulation, and alterations in this system can contribute to neurological disorders.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Marcus K. Benna, Stefano Fusi
Summary: The study proposes a memory model of the hippocampus, suggesting that the hippocampus is a memory device that compresses correlations between sensory experiences into compressed representations of episodes stored in memory. This model naturally produces place cells similar to those observed in experiments, with predictions that the activity of these cells is variable.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Nutrition & Dietetics
Marta Portero-Tresserra, Neus Galofre-Lopez, Elisabet Pallares, Claudia Gimenez-Montes, Carlos Barcia, Roser Granero, Divka Rojic-Becker, Anna Vale-Martinez, Margarita Marti-Nicolovius, Gemma Guillazo-Blanch
Summary: Age-related changes in the brain significantly impact hippocampal structure and function, leading to cognitive impairments such as deteriorating spatial object recognition (SOR) memory. Both intrinsic factors like neuroinflammation and lifestyle factors like diet can influence aging-related brain function and cognitive performance. This study aimed to evaluate the effects of caloric restriction (CR) on SOR memory, hippocampal neuron loss, neurogenesis, and inflammation in aged male rats. The results showed that CR attenuated the decline in SOR memory, hippocampal neuron loss, and microglial activation associated with aging, while also reducing neurogenesis in the dentate gyrus.
Article
Neurosciences
S. H. Takada, C. A. Dos Santos Haemmerle, L. C. Motta-Teixeira, A. V. Machado-Nils, V. Y. Lee, L. F. Takase, R. J. Cruz-Rizzolo, A. H. Kihara, G. F. Xavier, I. -S. Watanabe, M. I. Nogueira
Article
Multidisciplinary Sciences
Larissa Helena Torres, Raphael C. T. Garcia, Anne M. M. Blois, Livia M. M. Dati, Ana Carolina Durao, Adilson Silva Alves, Maurilio Pacheco-Neto, Thais Mauad, Luiz R. G. Britto, Gilberto Fernando Xavier, Rosana Camarini, Tania Marcourakis
Article
Multidisciplinary Sciences
Elisa Mari Akagi Jordao, Barbara Kazue Amaral Onishi, Gilberto Fernando Xavier
Article
Behavioral Sciences
Silvia Honda Takada, Livia Clemente Motta-Teixeira, Aline Vilar Machado-Nils, Vitor Yonamine Lee, Carlos Alberto Sampaio, Roberson Saraiva Polli, Jackeline Moraes Malheiros, Luiz Fernando Takase, Alexandre Hiroaki Kihara, Luciene Covolan, Gilberto Fernando Xavier, Maria Ines Nogueira
BEHAVIOURAL BRAIN RESEARCH
(2016)
Article
Neurosciences
Livia Clemente Motta-Teixeira, Silvia Honda Takada, Aline Vilar Machado-Nils, Maria Ines Nogueira, Gilberto Fernando Xavier
Article
Biochemistry & Molecular Biology
Luciane Valeria Sita, Giovanne Baroni Diniz, Newton Sabino Canteras, Gilberto Fernando Xavier, Jackson Cioni Bittencourt
Article
Multidisciplinary Sciences
Rodrigo Pavao, Joice P. Savietto, Joao R. Sato, Gilberto F. Xavier, Andre F. Helene
SCIENTIFIC REPORTS
(2016)
Article
Clinical Neurology
Denise Troise, Simone Yoneyama, Maria Bernadette Resende, Umbertina Reed, Gilberto Fernando Xavier, Renata Hasue
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2014)
Article
Behavioral Sciences
Livia Clemente Motta-Teixeira, Aline Vilar Machado-Nils, Daniella Sabino Battagello, Giovanne Baroni Diniz, Jessica Andrade-Silva, Sinesio Silva Jr, Raphael Afonso Matos, Fernanda Gaspar do Amaral, Gilberto Fernando Xavier, Jackson Cioni Bittencourt, Russel J. Reiter, Paul John Lucassen, Aniko Korosi, Jose Cipolla-Neto
HORMONES AND BEHAVIOR
(2018)
Article
Neurosciences
Ana Maria Orellana, Jacqueline Alves Leite, Paula Fernanda Kinoshita, Andrea Rodrigues Vasconcelos, Diana Zukas Andreotta, Larissa de Sa Lima, Gilberto Fernando Xavier, Elisa Mitiko Kawamoto, Cristoforo Scavone
Article
Developmental Biology
Amrita Jha Kumar, Livia Clemente Motta-Teixeira, Silvia Honda Takada, Vitor Yonamine-Lee, Aline Vilar Machado-Nils, Gilberto Fernando Xavier, Maria Ines Nogueira
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
(2019)
Article
Developmental Biology
Natalia Andrea Cruz-Ochoa, Julieta Esperanza Ochoa-Amaya, Sandy Lorena Pulecio, Gilberto Fernando Xavier, Maria Ines Nogueira
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
(2019)
Article
Developmental Biology
Amrita Jha Kumar, Ammir Yacoub Helou, Bruna Arruda Petrucelli, Gilberto Fernando Xavier, Daniel Oliveira Martins, Marucia Chacur, Maria Ines Nogueira
Summary: Neonatal hypoxic-ischemic encephalopathy (HIE) is a significant cause of morbidity and mortality in term-born infants, impacting early somatic, neurological, and motor development, as well as social abilities. This study evaluated sex differences in Wistar rats and observed short- and long-term impairments associated with HIE. The results indicate that anoxic males are more affected than anoxic females, with long-lasting effects predominantly affecting males, and a decrease in the number of substantia nigra cells in both sexes.
DEVELOPMENTAL PSYCHOBIOLOGY
(2022)
Article
Behavioral Sciences
Amrita Jha Kumar, Silvia Honda Takada, Livia Clemente Motta-Teixeir, Vitor Yonamine Lee, Gilberto Fernando Xavier, Maria Ines Nogueira
BEHAVIOURAL BRAIN RESEARCH
(2017)
Article
Psychology, Biological
Antonio Jaeger, Gilberto Fernando Xavier
LEARNING AND MOTIVATION
(2016)
Article
Clinical Neurology
Nadia Deflorin, Ulrike Ehlert, Rita T. Amiel Castro
Summary: Changes in the gut microbiome of infants have been associated with maternal psychological symptoms during pregnancy. This study found that maternal prenatal depressive symptoms are associated with lower diversity of the infant's microbiome, while maternal saliva cortisol levels are linked to increased diversity and changes in specific bacterial groups. Further research is needed to understand the implications of these microbiota alterations for child health.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zheng Ma, Hui-Xia Zhou, Da-Chun Chen, Dong-Mei Wang, Xiang-Yang Zhang
Summary: The impaired glucose metabolism in drug-na & iuml;ve schizophrenia patients is strongly associated with suicidal behavior, suggesting that glucose metabolism abnormalities may be potential biomarkers of suicide in schizophrenia patients. Regular monitoring of glucose metabolism variables is essential for suicide prevention.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Katie M. Lavigne, Jiaxuan Deng, Delphine Raucher-Chene, Adele Hotte-Meunier, Chloe Voyer, Lisa Sarraf, Martin Lepage, Genevieve Sauve
Summary: Psychiatric disorders are characterized by cognitive deficits and cognitive biases, which are associated with specific symptoms. While cognitive biases are present across diagnoses, their severity varies.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Yong-Yu Yin, Jiao-Zhao Yan, Shi-Xin Lai, Qian-Qian Wei, Si-Rui Sun, Li-Ming Zhang, Yun-Feng Li
Summary: This study found that gamma oscillations are closely associated with depression and may serve as predictive biomarkers of depression. Chronic restraint stress and lipopolysaccharide induced significant depression-like behaviors in mice and reduced gamma oscillations in the medial prefrontal cortex. Administration of ketamine, scopolamine, or fluoxetine increased gamma oscillations and exhibited rapid-acting antidepressant effects.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Veronica Begni, Moira Marizzoni, Kerstin Camile Creutzberg, Diana Morena Silipo, Mariusz Papp, Annamaria Cattaneo, Marco Andrea Riva
Summary: Exposure to stressful experiences is a significant risk factor for mental disorders, and pharmacological interventions targeting stress-induced alterations can help restore brain function. Lurasidone, an antipsychotic drug, has been shown to normalize the impairments caused by stress exposure and could be a valuable treatment for stress-induced mental illnesses. However, the mechanisms underlying the therapeutic effects of lurasidone are not well understood. This study found that chronic lurasidone treatment counteracted some of the transcriptional changes induced by chronic mild stress exposure, providing new insights into the potential therapeutic effects of lurasidone.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Esther E. Palacios-Barrios, Kunal Patel, Jamie L. Hanson
Summary: This review examines the association between early life interpersonal stress (ELIS) and depression, as well as the underlying mechanisms. The research shows that ELIS affects how youth respond to social rewards, and similar impairments in social reward processing are observed in youth with depression. The authors propose a preliminary model that suggests neurobehavioral disruptions in social reward processing as a mediating factor in the connection between ELIS and depression.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Rui Li, Jiaming Tang, Yizhuo Wang, Ying Wang, Hua Yang, Hongen Wei
Summary: Restricted and repetitive behaviors (RRBs) are characteristic features of neuropsychiatric disorders. This study focused on repetitive self-grooming behavior and investigated the involvement of the Pax2 gene in its control. Through the use of Pax2 neuron-specific deletion mice, the study found that the deletion of Pax2 gene affects the expression of the Arc gene in the prefrontal cortex, leading to impaired synaptic plasticity and excitatory/inhibitory imbalance, thereby contributing to the occurrence of repetitive self-grooming behavior.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Sara Derosa, Paulina Misztak, Jessica Mingardi, Giulia Mazzini, Heidi Kaastrup Muller, Laura Musazzi
Summary: This study investigated the involvement of neurotrophic signaling pathways in stress vulnerability/resilience and fast antidepressant response/non-response to ketamine in a rat model of depression. The findings showed that stress and ketamine induced specific changes in these pathways in different brain areas and subcellular fractions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Georgia F. Caruana, Sean P. Carruthers, Michael Berk, Susan L. Rossell, Tamsyn E. Van Rheenen
Summary: Cognitive impairment is related to both white matter macrostructure and microstructure in bipolar disorder patients. However, there is inconsistency in the results of the studies examining this relationship. Some studies have found an association between higher fractional anisotropy in white matter and better complex attention skills and executive functioning in bipolar disorder patients, while others have found no associations. Further research with increased statistical power and standardized methods is needed.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Alberto Galimberti, Martin Tik, Giovanni Pellegrino, Anna-Lisa Schuler
Summary: This study provides a systematic review and meta-analysis on the effectiveness of repetitive transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) for post-traumatic brain injury (TBI) symptoms. The results show that non-invasive brain stimulation techniques have a small overall effect on TBI sequelae, with significant effects observed for anxiety and headache. However, larger randomized controlled trials with longer follow-ups, optimized stimulation parameters, and standardized methodology are needed to establish the efficacy of these techniques in addressing TBI sequelae.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Amanda J. Sales, Pedro H. Gobira, Joa F. C. Pedrazzi, Joao R. Silveia, Elaine Del Bel, Felipe V. Gomes, Francisco S. Guimaraes
Summary: The study found that doxycycline can inhibit metalloproteinase in the brain and attenuate the rewarding effects and locomotor sensitization of drug abuse. This suggests that doxycycline could be repurposed for the treatment of substance use disorders.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Alejandro Borrego-Ruiz, Juan J. Borrego
Summary: There is substantial evidence that the development of the nervous system is related to the composition and functions of the gut microbiome. The communication between the central nervous system (CNS) and the gut microbiota is bidirectional, with various routes such as immune, endocrine, and neural circuits. Dysbiosis of the gut microbiota has been associated with neuropsychiatric diseases and psychological disorders. Fecal microbiota transplantation (FMT) therapy has shown a causal-effect relationship between the gut microbiota and behavioral features. Interventions based on prebiotics, probiotics, or synbiotics have demonstrated their influence on neurological disorders through the synthesis of neuroactive compounds and regulation of inflammatory and endocrine processes. Further research is needed to explore the impact of gut microbiota dysbiosis on psychiatric and psychological disorders and the potential therapeutic role of microbiota-based interventions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zhinan Li, Zhuang Kang, Xiaowei Xia, Leijun Li, Junyan Wu, Jiamin Dai, Tong Liu, Cai Chen, Yong Qiu, Ming Chen, Yanxi Liu, Ziyi Zhang, Zili Han, Zhengjia Dai, Qinling Wei
Summary: This study found that patients with schizophrenia showed lower levels of resilience and cognitive functions compared to healthy controls, as well as abnormal global properties and nodal metrics in brain networks. Furthermore, characteristic path length might moderate the relationship between resilience and working memory in these patients.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
David H. Adamowicz, Tsung-Chin Wu, Rebecca Daly, Michael R. Irwin, Dilip Jeste, Xin M. Tu, Lisa T. Eyler, Ellen E. Lee
Summary: This study aimed to explore the relationship between executive functioning and inflammatory biomarkers in people with schizophrenia. The results showed that systemic inflammation did not predict long-term declines in executive functioning. This suggests the need for further research to better understand the relationship and mechanisms between inflammation and cognition in schizophrenia.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Nina Walter, Julian Wenzel, Shalaila S. Haas, Letizia Squarcina, Carolina Bonivento, Anne Ruef, Dominic Dwyer, Theresa Lichtenstein, Oeznur Bastruek, Alexandra Stainton, Linda A. Antonucci, Paolo Brambilla, Stephen J. Wood, Rachel Upthegrove, Stefan Borgwardt, Rebekka Lencer, Eva Meisenzahl, Raimo K. R. Salokangas, Christos Pantelis, Alessandro Bertolino, Nikolaos Koutsouleris, Joseph Kambeitz, Lana Kambeitz-Ilankovic
Summary: Clinical and neuroimaging data can be used to predict the potential of cognitive training to improve social functioning in recent onset psychosis patients. The use of multivariate pattern analysis and support vector machine classifier allows for the prediction of social functioning improvement based on baseline cognitive data. The findings suggest that cognitive data can provide a robust individual estimate of future social functioning for patients with recent onset psychosis.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)